Articles tagged with Microfluidics
Researchers developed a lab-on-a-chip device that can diagnose Cryptosporidium infections in as little as 10 minutes, offering potential improvements in treatment outcomes for rural areas in China. The device is easy to use and has diagnostic capabilities comparable to current standards, with the potential to reduce costs and timeframe.
Researchers are developing microfluidic solutions for easy-to-use, disposable, inexpensive, and high-throughput sperm selection. These methods offer promising results for single-sperm genomics, in-home male fertility testing, and wildlife conservation efforts.
A microfluidic system enables serial formation of cell membranes and measurement of processes taking place on them. The system allows for the creation of stable and functional membranes, opening the road to high-throughput studies of cell membrane mechanisms.
Nadine Aubry recognized for innovative research in fluid mechanics, pioneering work on low dimensional modeling of turbulent flow, and invention of micromixers enabling efficient fluid combination at low cost
Researchers at Oregon State University have identified a method to rapidly prepare frozen red blood cells for transfusions, reducing the time-consuming process of thawing and removing glycerol from the blood. This breakthrough could make it feasible to use frozen blood in emergency situations, solving inefficiencies in the current system.
Researchers at UT Arlington demonstrate direct fluid flow influences neuron growth, challenging the long-held idea that chemical cues are primarily responsible for axonal pathfinding. The study found that 35% of growth cones responded to microfluidic flow from a microtube, turning towards the direction of the flow.
Researchers developed modular components that can be snapped together to build 3-D microfluidic systems, simplifying the construction process and reducing costs. The components are inspired by electronics industry technology and use 3D printing to create standardized modules with various functions.
A research team led by Alberto Fernandez-Nieves has figured out how to convert the standard chaotic waveform to a stable helical form. By controlling the viscosity and speed of the secondary liquid surrounding the jets, they were able to stabilize the structure associated with the whipping behavior.
Scientists at MIT and Saudi Arabia have created a new system to make surfaces active, using external fields like magnetic fields to exert precise control over particle movement. This technology could enable new biomedical or microfluidic devices and self-cleaning solar panels.
A new microfluidic chip produced by NIST can detect the presence of molecules in a complex mixture using polarized xenon gas. The device has been demonstrated to detect weak signals corresponding to fewer than 1 trillion polarized xenon atoms, rivaling low-field optical magnetometry.
A new 3D capillary device has been developed to improve the manufacture of high-quality liposomes, a crucial step in delivering drugs directly to cancer cells. The device increases production threefold while reducing costs, offering a significant breakthrough for the field.
Engineers at the University of Illinois and Northwestern University have developed thin, soft stick-on patches that incorporate commercial chip-based electronics for sophisticated wireless health monitoring. The patches are wirelessly powered and can send high-quality data about human body to a computer in real-time.
Researchers at NIST developed a method to incorporate pneumatic microvalves into microfluidic devices made from plastic films and tape. The new valved microfluidic device can be used for dynamic control of fluid flow, enabling the creation of complex configurations with multiple functions.
Researchers at the University of Toronto have developed a tool that allows for cost-efficient, three-dimensional microgels to study cells in a naturalistic manner. The digital microfluidics platform enables flexible incorporation of different cell types and shapes, with potential applications in personalized medicine.
A team of researchers has created a microfluidic device that sorts sperm cells based on their motility and ability to swim through narrow channels. This approach shows promising results in increasing the concentration of highly motile sperm, which could enhance the success of assisted reproductive technologies like in vitro fertilization.
Researchers at the University of Illinois have developed a new microfluidic approach to assemble functional materials, including polypeptides and nanostructures. The technique uses tailored flows in microfluidic devices to control the assembly process, enabling reproducible fabrication of advanced materials.
Researchers at NIST and Applied Research Associates developed a microfluidic technique to recover DNA from complex mixtures like dirt. This method delivers optimal DNA concentrations for human identification procedures, potentially miniaturized for use outside the laboratory.
Researchers develop a new microfluidic chip that can capture over 90% of circulating tumor cells from patient blood, providing potential applications for cancer screenings, treatment assessments, and disease progression determination. The technique shortens processing time and improves efficiency compared to existing methods.
A portable diagnostic device developed by Chinese researchers can travel to patients anywhere in the world, providing an opportunity for early cancer detection. The device uses microfluidics technology and is designed to be low-cost, easy-to-use, and power-independent.
Researchers from the Institute of Physical Chemistry of the Polish Academy of Sciences have developed a microfluidic system that can merge, transport and split microdroplets, allowing for the simultaneous cultivation of hundreds of different bacteria cultures. This breakthrough could speed up research on antibiotic resistance by reduci...
Researchers at Harvard's Wyss Institute developed a microfluidic circulatory system for windows that can cool the glass while letting in sunlight. The system uses water to absorb heat and could reduce air-conditioning costs dramatically, cutting energy consumption by up to 8C.
Researchers created a range of predictable flows by placing tiny pillars in microfluidic channels, allowing for separation of white blood cells and increased mixing. The method has potential to revolutionize microfluidics and form the foundation for multi-million dollar industries.
Researchers at Virginia Tech have developed a new three-dimensional microfluidic device that can customize channel shapes to mimic natural conditions. The technology has potential applications in water and food safety, as well as biological terrorism detection.
Researchers have developed a fully integrated microfluidic test-bed to evaluate and optimize solar-driven electrochemical energy conversion systems. The system has been used to study schemes for photovoltaic electrolysis of water and can be adapted to study artificial photosynthesis and fuel cell technologies.
Researchers at the University of Illinois developed a new flow-based method for manipulating and confining single particles in free solution, addressing current challenges in nanoscience. The microfluidic trap enables precise positioning control over tiny nanoparticles, enabling exploration of new technologies.
The new fabric uses microfluidic technology to form excess sweat into droplets that drain away automatically. The fabric's water-repellent properties and controlling patterns of conductive threads enable targeted sweat collection and removal.
Amar Basu's techniques enable rapid testing of biological liquids with nanoliter-picoliter volumes, reducing costs and improving assay speed. His projects focus on controlling droplet motion using lasers and sorting droplets based on chemical composition without labels.
The researchers developed elastic, self-healing wires with a liquid-metal core and polymer sheath that reconnect at the molecular level after being severed. This technology has potential for use in technologies exposed to high-stress environments, such as reconfigurable circuit wiring and 3D microfluidics.
Scientists have developed a new micropump capable of producing pressures up to 17,000 pounds per square inch for 'labs-on-a-chip' in handheld devices. This innovation could enable instant analysis of blood and urine at patient bedside, reducing the need for central lab waiting periods.
Researchers have developed a new microfluidic device that can separate rare cells and blood components with high accuracy and speed. The device uses inertial microfluidics to sort blood into different streams, allowing for rapid diagnosis of conditions such as anemia, malaria, or leukemia.
Stephen Quake's work has revolutionized biophysics, biological automation, genome analysis, and personalized medicine with innovative physical techniques. His pioneering efforts have enabled answers to previously impossible questions and had profound impact on nearly every area of biology.
An international team of researchers has developed a way to manipulate cells using fluid flow patterns generated by mechanical oscillations in a microfluidic channel. This technique combines the precision of direct physical contact with the speed of non-contact methods, allowing for high-level control over individual cells.
Researchers at National Taiwan University created a two-phase microfluidics technique to systematically stretch polymer strings suspended in fluid flow. By varying wall wettability, flow rate ratio, and Reynolds number, they controlled polymer extension, providing insights into biomolecule structure and behavior.
Dr. Quake recognized for revolutionary work in drug discovery, genome analysis, and personalized medicine, enabling large-scale automation of biology and improving human health outcomes. His microfluidic technology has enabled non-invasive prenatal testing and single-cell gene expression analysis.
Engineers developed glucose-sensing microbeads using droplet microfluidics, allowing for non-invasive monitoring of cell cultures. The technique enables detection of local glucose concentrations and gradual changes due to cell metabolism.
Researchers at MIT and NUS have developed a microfluidic system that uses natural margination to separate red blood cells from unwanted cellular components. The system demonstrates highly efficient removal of bacteria and inflammatory cells, with potential applications in treating sepsis.
Researchers found that internal friction significantly slows down the protein folding process, making it easier for proteins to get stuck in unfolded states. This understanding could lead to new insights into diseases like Alzheimer's, where misfolded proteins contribute to amyloid plaques.
Researchers developed a disposable microfluidic chip that provides accurate, point-of-care flu diagnosis, replacing expensive lab tests. The chip extracts RNA from Influenza A virus and replicates the sample for detection, producing faster and cheaper results.
The new device, created by Javier Atencia, features a diffusion-based gradient generator that reduces the risk of cell damage and offers simplicity. In experiments, cells were exposed to cycloheximide, resulting in increased fluorescence levels as the chemical concentration decreased.
Researchers have developed a novel microfluidics system using magnetic switches to trap and transport magnetic beads. The technology offers random access control and a memory that lasts even with power off, making it suitable for biotechnology and medical diagnostics applications.
Researchers at the University of Cincinnati have developed a method to isolate and collect fragile prostate cancer cells using inertial microfluidic technology. The approach uses cell size for separation, eliminating the need for biological markers or external forces.
Researchers from NIST and Applied Research Associates Inc. have expanded the reach of their novel microfluidic system for analyzing chemical components of complex samples. The new work demonstrates how the system can analyze negatively charged components as well, overcoming a major challenge in sample analysis.
A new microfluidic-based diagnostic device, mChip, can perform complex laboratory assays and diagnose infectious diseases like HIV and syphilis in remote regions with a tiny finger prick of blood. The device significantly reduces testing time and cost, providing immediate results for medical workers.
Researchers at Berkeley Lab have developed a portable system for highly sensitive multi-dimensional chemical analysis by pairing NMR/MRI technology with microfluidic chromatography. This breakthrough enables real-time peak detection and chemical shift information for small molecules, demonstrating the unique power of magnetic resonance...
In the annual MEMS student design contest, Texas Tech University won for their novel insect-inspired micro-dragonfly design that generates aerodynamic lift and thrust. Carnegie Mellon University took the educational category with a highly sensitive microvalve that requires picoJoules of energy to switch its state.
A team of researchers at MIT has discovered a simple yet efficient method to mix fluids in small or confined spaces using viscosity contrast. By injecting a thin fluid into a thicker one, the two liquids can be mixed uniformly quickly, overcoming challenges in microfluidics technology and lab-on-a-chip applications.
Researchers at UCLA have created a lens-free optical microscope that can produce high-resolution 3D images of microscopic objects. The system uses tomography and digital sensor arrays to capture detailed sub-cellular structures without using a lens.
Researchers developed SIMBAS, a self-powered chip that can analyze whole blood samples without external components. The device captures blood cells and separates plasma using gravity-driven flow, enabling disease diagnosis within minutes.
The NC State team has created microfluidic devices with inherently aligned electrodes composed of liquid metal alloy, allowing for easier and faster electrode creation. This approach enables the creation of useful electrode configurations that were previously difficult or impossible to achieve.
Researchers developed a planar microfluidic reactor that harnesses sunlight to break down contaminants in water using photocatalysis. The technology has shown dramatic improvements in efficiency, with plans to scale up the process for industrial water treatment applications.
A new microfluidic device enables the rapid orientation of hundreds of embryos, allowing for large-scale quantitative analyses of protein positional information along the dorsoventral axis. This innovation facilitates studies on complex structures from single cells and has the potential to adapt for other model organisms.
UC Davis engineers have developed a universal microfluidics connector to bridge biological tests with electronic devices, enabling compact medical diagnostic tools. The 'fit-to-flow' interface could enable cell phones to function as mini microscopes.
Researchers have developed a simple method to fabricate free-standing polymer membranes with precisely patterned holes, opening up potential applications in microfluidics. The technique uses photolithography and prepolymer, allowing for easy fabrication of membranes with accurate sizes and shapes.
A new microfluidics-imaging platform can detect cancer growth signaling in tiny biopsy samples, allowing for faster and more efficient screening. This method uses an integrated platform to measure kinase activity from as few as 3,000 cells, enabling direct experimentation on patient samples.
A new development in NMR/MRI technology enables scientists to image microscopic objects with high spatial and time resolutions, recording images up to one million times faster than conventional MRI experiments. This breakthrough paves the way for portable chemical and biomedical analysis.
Researchers at Stevens Institute of Technology have developed a new method to generate three-dimensional tissue models for studying bacterial infection of orthopedic implants. The microfluidic devices mimic the human body's conditions, allowing for realistic bone tissue growth and analysis of antibiotic delivery.
A microfluidic device developed in Hong Kong enables non-invasive testing of anti-tumor drugs by subjecting cancerous cells to different concentration gradients. The device integrates a previously validated analysis method that quantifies cell apoptosis in real-time, allowing for precise control and reduced costs.
Paul Li's new technique combines DNA microarrays with microfluidic devices, allowing for faster and more efficient DNA analysis at room temperature. The method uses gold nanoparticles to separate single strands of DNA, enabling quicker detection and identification of specific genetic sequences.
Researchers discovered that different cells respond differently to stimuli, contradicting previous uniformity assumptions. The study used microfluidics to monitor individual cells' reactions and found nuanced variations in responses.
Using Popsicle-type craft sticks to form channels in Jell-O, students can create large-scale microfluidic devices. This method makes hands-on experience with microfluidics possible, reducing the need for expensive equipment and toxic chemicals.