$1.25 million grant lays groundwork for synthetic tendon and ligament implants
Researchers aim to replicate natural tendon development using embryonic chicken and mouse models, with a focus on mechanical stimulation and nanoparticle design.
Biomaterials
Articles tagged with Biomaterials
Chemical engineer receives grant to develop novel tumor-mimicking biomaterial
A chemical engineer is developing a novel biomaterial that can mimic the response of pediatric brain cancers to different approaches, allowing for customized treatment plans. The material will be designed to simulate the growth environment of cancer cells inside a tumor and can be used with patient-derived cells.
New $1.25 million grant enables investigation into vital role of sex hormones in tissue repair
A University of Kansas researcher is investigating how estrogen interacts with cells to promote tissue repair and regeneration after injury. The study aims to understand why male and female tissues regenerate differently, which could lead to the development of new tailored therapies.
Improving biomaterials design for bone regeneration
The study found that a specific type of glycosaminoglycan in the scaffold led to greater blood vessel development and immune cell activation. Researchers aim to further understand these interactions to develop biomaterials for bone repair.
Sharpness-enabling materials help insects with small muscles puncture tough skin
Researchers discovered that insects like scorpions and ants use zinc- and manganese-enriched materials to create sharp edges, allowing them to penetrate tough skin with less force. This biomaterial property enables small organisms to obtain food with smaller muscles and less energy.
How ant teeth cut like a scalpel
A recent study reveals that ants, worms, spiders, and other tiny creatures have a built-in set of tools that maximize cutting efficiency thanks to the arrangement of individual atoms of zinc. This biomaterial allows animals to use less force, making their smaller muscles spend less energy.
Improving strength, stretchiness and adhesion in hydrogels for wound healing
Researchers from Terasaki Institute for Biomedical Innovation develop methods to enhance mechanical properties of hydrogels, including toughness, stretchiness, and adhesive strength. By introducing dopamine and alkaline conditions, they create gel-like materials with improved biocompatibility and regenerative capabilities.
CHOP researchers develop coating for endotracheal tubes that releases antimicrobial peptides
Researchers created a polymer coating that releases Lasioglossin-III, an AMP with broad-spectrum antibacterial activity, targeting specific infectious bacteria and preventing airway complications. The coating demonstrated significant antibacterial activity and prevented bacterial adherence to the tube.
Oncotarget: A platform to control HNSCC recurrence following tumor resection
Researchers found that local delivery of tumor-specific T-cells is an efficient option to convert tumors unresponsive to checkpoint inhibitors to permit tumor cures. Locally delivered T-cells showed similar control of established tumors as intravenous adoptive T-cell transfer.
$2.4M NIH grant will develop biomaterials to repair skulls and promote regeneration
A new research project aims to create strong, malleable biomaterials that support stem cell growth for improved skull reconstruction surgeries. The $2.4 million grant will help accelerate bone regeneration and reduce complications.
Rice team creating insulin-producing implant for Type 1 diabetes
Rice University bioengineers are developing an insulin-producing implant to regulate blood glucose levels in Type 1 diabetics. The implant uses human stem cells and 3D printing to mimic the natural behavior of the pancreas, with the goal of achieving consistent target blood glucose levels.
Alvaro Della Bona named 2021 recipient of the Wilmer Souder Award
Alvaro Della Bona, University of Passo Fundo Professor, received the 2021 Wilmer Souder Award for his contributions to dental biomaterials research. He is recognized internationally for his publications and invited presentations on the topic.
IADR/AADR announce recipients of the 2021 IADR/AADR William J. Gies Awards
The IADR/AADR presented awards to researchers in three categories: Biological Research, Biomaterials & Bioengineering Research, and Clinical Research. The winners were recognized for their contributions to advancing dental health and well-being worldwide.
Developing new techniques to build biomaterials
Scientists at the University of Leeds have developed an approach to control the structure and mechanics of synthetic biomaterials made from proteins. By removing specific chemical bonds, known as 'protein staples,' they altered the structure of a protein network, resulting in different mechanical properties.
In a supramolecular realm: Advances in intracellular spaces with de novo designed peptide
Researchers develop a de novo peptide Y15 that readily forms secondary structures to enable bottom-up synthesis of functional protein assemblies in live cells. The peptide enables the formation of fibrous structures and clusters in test tubes and live cells, facilitating protein assembly and reconstitution of natural complexes.
'On/off' switches for self-assembling hydrogels could advance wound healing and more
Researchers at NYU Tandon School of Engineering developed stimuli-responsive coiled-coil fibrous hydrogels that can be triggered by temperature, pH, or light. These smart biomaterials have potential for tissue engineering, drug delivery, and wound healing applications.
Proton's travel route in polymers could lead the way to clean fuels
A team of researchers from Japan discovered that high COOH concentration facilitates internal proton transport while lower concentrations favor interfacial transport. The study may contribute to developing bio-conductive materials for biological devices and eco-friendly fuel cells.
Engineering diseased human skin in vitro
A research team has developed an in vitro diseased skin model that displays the pathophysiological hallmarks of type 2 diabetes using 3D cell printing technology. The model exhibits slow re-epithelialization, insulin resistance, and pro-inflammatory response, similar to diabetic skin.
New biomaterial regrows blood vessels and bone, RCSI research
Scientists have developed a new biomaterial that regrows both blood vessels and bone, potentially providing an alternative to current systems. The biomaterial was inspired by the natural way in which bone defects regenerate and uses a mechanobiology-informed approach to promote both angiogenesis and osteogenesis.
3D biomaterial used as 'sponge' for stem cell therapy to reverse arthritis
Researchers develop a 3D biomaterial scaffold that slowly releases stem cells, reducing dosages and improving therapeutic effects in mice with osteoarthritis. The cryogel 'sponge' ensures implanted stem cells stay in the knee joint area longer, allowing for more effective treatment.
New hydrogel that cuts in half recovery time from muscle injuries
A new biomaterial, a boron-loaded alginate hydrogel, has been designed to accelerate muscle regeneration after injury. The hydrogel stimulates integrins, which promotes tissue formation and reduces recovery time by half.
Keep it moving: How a biomaterial mobility may revolutionize immunomodulation
Scientists have identified a polymer with fine-tuned mobility properties that alter the immune activity of specific liver cells, offering potential for regenerative medicine. The study found that surface mobility significantly affects the movement and gene expression profile of Kupffer cells.
'Walking' molecule superstructures could help create neurons for regenerative medicine
Northwestern University researchers create novel biomaterial that enhances neuron growth, a crucial finding for regenerative medicine. The material's bioactive properties allow cells to penetrate and interact with bioactive signals, potentially treating neurodegenerative diseases such as Parkinson's and Alzheimer's disease.
New biomaterials can be 'fine-tuned' for medical applications
Researchers have developed a thermoplastic biomaterial that can be controlled to degrade at varying rates and maintain mechanical properties. The material is suitable for soft tissue repair or flexible bioelectronics and has been shown to promote healthy tissue growth.
Fungal wearables and devices: biomaterials pave the way towards science fiction-like future
A team of scientists has developed objects made with living materials, using fungi as a key component. The research demonstrates that fungi can sense and process various external stimuli, including light, temperature, and electrical signals, making them suitable for creating sustainable smart wearables.
Researchers identify a rare genetic bone disorder through massive sequencing methods
Researchers have identified a rare genetic bone disorder by using precision medicine strategies, uncovering mutations in the LAMA5 gene that cause extreme bone fragility and skeletal deformity. The study also revealed a new signaling pathway governing skeleton formation, which could be used for common bone conditions.
Researchers develop new biomaterial that helps bones heal faster
Researchers develop a biomaterial that enhances adult stem cell regenerative ability, repairing large bone defects and reducing inflammation. The material incorporates nanoparticles that activate JNK3, a key driver of children's stem cells' regenerative capacity.
New protein imaging method paves way for next generation biomaterials and tissue analysis
Scientists at the University of Nottingham have developed a new protein imaging method that allows for the accurate analysis of biomaterials and tissue. This breakthrough technology has the potential to lead to the development of more effective drug delivery systems and medical devices.
A new species of spider
A new species of spider, Ocrepeira klamt, has been discovered by a University of Bayreuth researcher in the highlands of Colombia. The spider differs from related species in its reproductive organs and is native to an altitude of over 3,500 meters above sea-level.
New biomaterial could shield against harmful radiation
Researchers at Northwestern University have synthesized a new form of melanin enriched with selenium, called selenomelanin, which shows promise as a shield for human tissue against harmful radiation. The new biomaterial offers better protection than traditional forms of melanin and has potential applications in space travel
Regenerating the body from within using biomaterials
Researchers are developing biomaterials to boost the body's natural healing process, with two approaches: incorporating cells or designing materials to stimulate cellular response. This can lead to improved success rates in tissue regeneration, reducing regulatory barriers and increasing available options.
New plastic biomaterials could lead to tougher, more versatile medical implants
Researchers at the University of Birmingham have created a new thermoplastic biomaterial with shape memory properties, enabling it to be stretched and molded but reforming into its original shape when heated. The material offers a stable, long-lasting option for medical devices such as bone replacements.
New biomaterial has potential to repair damaged bone with lower risk of inflammation
Scientists at RCSI University of Medicine and Health Sciences have developed a biomaterial that promotes an immune response to encourage repair and lowers the risk of inflammation in damaged bone tissue. The technology is designed to deliver microRNA silencers, increasing cells responsible for bone repair.
Combinatorial screening approach opens path to better-quality joint cartilage
A collaborative research team has developed a multi-component biomaterial-based screening approach that identifies material compositions and mechanical stimuli enabling human stem cells to differentiate into cells capable of generating higher-quality articular cartilage. The study uses high-throughput screening with multiple combinatio...
New bone-graft biomaterial gives patients a nicer smile and less pain
A new bone-graft biomaterial supercooled before application could eliminate pain and improve smile outcomes for dental patients. The material, combining octacalcium phosphate with collagen, has shown superior bone regenerative properties compared to earlier substitutes.
A genetic nano-toolkit for the generation of new biomaterials
A team of microbiologists at the University of Bayreuth created a modular system for genetic reprogramming of bacteria, turning them into cell factories for multifunctional magnetic nanoparticles. These nanoparticles combine various useful functions and properties, offering a promising new material in biomedicine and biotechnology.
Wyss Institute announces 'Immuno-engineering to Improve Immunotherapy' Center
Researchers at Wyss Institute and collaborating institutions aim to develop biomaterials-based approaches to enable anti-cancer immuno-therapies. The center will focus on boosting tumor-specific activities of cytotoxic T cells using innovative biomaterials and DNA origami.
A better way to rebuild cartilage
A team of scientists has created a new class of 3D-printed biomaterials that can direct the regeneration of functional tissue in damaged cartilage. The materials are designed to provide cells with the exact cues they need to form tissue organized in the same way as natural cartilage.
Programmed vascular endothelium remodeling using a remote-controlled 'smart' platform
Scientists create a bilayer platform that can alter surface topographies using shape-memory polymers and gold nanorods to promote cell polarization and collective migration of vascular endothelial cells. This approach enables dynamic manipulation of cell functions, mimicking the native ECM-mediated effects in the human body.
Anson Ong elected Fellow, Biomaterials Science and Engineering
Biomaterials Science and Engineering Fellow Anson Ong recognized for outstanding contributions to biomaterials research, education, and service. His primary focus areas include implant surface modifications and tissue-engineered bioceramic scaffolds.
NAU engineer developing biomaterial for improved treatment of cerebral aneurysms
Researchers at NAU are developing a polypropylene glycol-based biomaterial to treat cerebral aneurysms, aiming to improve outcomes and reduce recurrence rates. The material, PPODA-QT, is designed to fill the aneurysm space effectively, leaving a smooth surface for healing.
Artificial 'inclusion bodies' created for controlled drug release
Scientists at the Universitat Autonoma de Barcelona have developed artificial protein granules that can sustainably release therapeutic proteins in lab animals. These 'artificial inclusion bodies' mimic natural bacterial structures and hold great potential for vaccines and controlled-release drug delivery systems.
Bone bandage soaks up pro-healing biochemical to accelerate repair
Engineers at Duke University create a bandage that traps and holds the pro-healing molecule adenosine, accelerating callus formation and vascularization to improve bone repair. The results show better bone formation, higher bone volume, and better vascularization in mice treated with adenosine-laced bandages.
New remote-controlled 'smart' platform helps in cardiovascular disease treatment
Researchers developed a remote-controlled 'smart' platform to mimic natural extracellular matrix-mediated endothelialization. The platform uses shape-memory polymers and gold nanorods to direct programmed vascular endothelium remodeling in a temporally controllable manner, offering new possibilities for treating cardiovascular disease.
Chemists create new route to PHAs: naturally degradable bioplastics
Colorado State University scientists create a novel chemical catalysis pathway for producing PHAs with enhanced mechanical and physical properties. This breakthrough offers a scalable solution to the plastics crisis, enabling faster production and tunability of biodegradable materials.
New 3D printing technique for biomaterials
Researchers at the University of Birmingham have developed a new 3D printing technique called Suspended Layer Additive Manufacturing (SLAM) that can create soft biomaterials for repairing body defects. The technique uses a polymer-based hydrogel with self-healing properties, allowing for precise detail and support without sagging.
First-ever spider glue genes sequenced, paving way to next biomaterials breakthrough
Researchers at the University of Maryland Baltimore County have successfully sequenced two genes that allow spiders to produce their sticky glue. This achievement could lead to new applications in organic pest control and biomaterials, building on previous discoveries about spider silk genes.
A new technology developed to detect and analyze colorless and transparent biomaterials
A new biosensor developed by DGIST's Professor Jae Eun Jang's team can detect biomaterials in real-time without secondary processing or an analyzer. The technology uses plasmonic nanostructures and image signal processing to reveal the colors of colorless biomaterials.
Citrate-based biomaterial fuels bone healing with less rejection
Researchers at Penn State have discovered that citrate, a natural product found in bones and citrus fruit, can fuel bone healing by providing extra energy for stem cells. This understanding will help develop slow-release biomaterials to speed up bone repair and reduce inflammation.
Biomaterials with 'Frankenstein proteins' help heal tissue
Researchers have created biomaterials that combine ordered and disordered segments to form a stable, porous scaffold that promotes cell growth and vascularization. The material's unique properties enable it to integrate into tissue with minimal inflammation and hold its volume well.
Biomaterial particles educate immune system to accept transplanted islets
Researchers have developed a new approach using synthetic hydrogel particles to educate the immune system to accept transplanted insulin-producing islets. The technique could allow for an 'off-the-shelf' therapy for type 1 diabetes without long-term immune suppression, potentially treating millions of people worldwide.
Modified biomaterials self-assemble on temperature cues
Biomaterials with precisely ordered structures could be used for various biomedical applications due to their precise control of self-assembly. The hybrid approach allows researchers to expand the chemical diversity of protein-based materials by combining different alphabets, such as amino acids and lipids.
Beta cell-seeded implant restores insulin production in type 1 diabetes mouse model
Researchers created a biomaterial that can be seeded with insulin-producing beta cells, reversing diabetes in a mouse model. The study found normalized glucose levels and increased survival in treated mice, without triggering an immune response.
NIH funding to improve devices and safeguard cardiovascular health
A $3.4 million grant will help researchers study endocrine-disrupting chemicals in medical devices, with a focus on improving transfusion safety and understanding the impact on cardiovascular health.
Boosting a key protein to help bones that won't heal
Researchers have developed a new therapeutic approach to enhance bone healing by delivering additional Jagged-1 protein at the site of injury. In a study published in npj Regenerative Medicine, rodents treated with Jagged-1 showed improvements in skull and femoral bone injuries, unlike BMPs which caused excessive bone growth.
Bioengineers imagine the future of vaccines and immunotherapy
Researchers explore the use of nanoparticles, microneedle patches, and polymer particles to enhance vaccine effectiveness and delivery. These innovative biomaterials may improve responses in HIV, cancer, and autoimmune disorders, reducing medical waste and expanding vaccine accessibility.
New biomaterial could replace plastic laminates, greatly reduce pollution
Researchers at Penn State have developed a new biomaterial that can replace plastic barrier coatings in packaging and other applications, offering strong oil and water barrier properties. The material, comprised of treated cellulose pulp and chitosan, is compostable and has the potential to greatly reduce pollution if widely adopted.
Russian Science Foundation grant winners: Dry storage of biomaterials
Researchers at Kazan Federal University (KFU) have won a Russian Science Foundation grant to develop dry storage technology for biomaterials. They are studying the anhydrobiosis mechanism of mosquitoes, which can survive without water, and plan to apply it to store oocytes, proteins, or vaccines.
Sea shells for sale: A new source of sustainable biomaterials
Researchers are exploring the potential of mollusc shells to restore damaged oyster reefs and cultivate new oysters. The shells contain over 95% calcium carbonate, a valuable biomaterial used in various applications, offering a sustainable alternative to mined limestone.
Millions in funding for TU Dresden
TU Dresden will establish two new Collaborative Research Centres (CRCs) and continue a third CRC, receiving significant funding from the German Research Foundation (DFG). The new CRCs focus on interdisciplinary research topics such as vituperations and insults, and the adrenal's role in stress and disease.