Articles tagged with Antibiotics
A study of 24 patients found that repeated exposure to fluoroquinolone and azithromycin antibiotics increased resistance to multiple drugs, including older- and newer-generation antibiotics. This raises concerns about the judicious use of ophthalmic antibiotics to prevent antimicrobial resistance.
Researchers analyzed the genome of a superbug called vancomycin-resistant enterococci (VRE) to understand its resistance to antibiotics. They identified changes in genes that led to daptomycin resistance, offering insights into developing new drugs to combat this growing health threat.
Researchers have identified a system for targeted amplification of gene clusters in bacteria, which can significantly increase the production of antibiotics. This discovery has the potential to revolutionize the commercial production of antibiotics and may also uncover new, undiscovered antibiotics.
Scientists have discovered that antibiotic-resistant genes existed in ancient DNA from 30,000-year-old permafrost. This finding suggests that resistance is a natural phenomenon that predates modern clinical antibiotic use.
The new guidelines prioritize preventing bacterial pneumonia in children, recommending yearly flu vaccines and targeted antibiotic therapy. The guidelines also emphasize the importance of accurately diagnosing pneumonia to avoid unnecessary medical interventions.
Researchers at Stanford and UCSF have developed a novel method to grow large volumes of modified malaria parasites that no longer cause the disease, revealing how the parasite's survival depends on isopentenyl pyrophosphate. This breakthrough could speed up drug development and provide a basis for an effective vaccine against malaria.
A lack of well-conducted research on widely used acne treatments could be limiting their effectiveness and putting patients at risk of ineffective treatment. The authors call for new studies to test the comparative effectiveness of common therapies and improve understanding of the natural history of acne.
A common antibiotic has been found to help reduce severe wheezing and acute symptoms of chronic obstructive pulmonary disease (COPD) in a large multicenter clinical trial. Patients who received the antibiotic experienced a 27% reduction in acute flare-ups compared to those who received a placebo.
Researcher Martin Blaser warns that widespread antibiotic use can cause permanent damage to the body's natural defense system. This can lead to increased susceptibility to infections and disease, as well as conditions like asthma, inflammatory bowel disease, and type 1 diabetes.
Researchers at Scripps Research Institute successfully designed a new antibiotic that can target and kill the most resistant bacterial infections. The compound, an analogue of vancomycin, overcomes the resistance mechanism by altering the key atom in the peptidoglycan structure.
A new study found that a combination of minocycline and EDTA can prevent bacterial infections in dialysis patients using catheters, improving patient outcomes. The treatment reduced the risk of infection by half compared to traditional heparin use.
Researchers found that Salmonella cells use a beta form of amino acid lysine to cause illness, making it an attractive drug target. Deleting genes involved in this process or inserting alpha lysine instead renders the bacteria non-virulent and sensitive to antibiotics.
A study by the University of Maryland School of Public Health found that organic poultry farms have lower levels of drug-resistant enterococci bacteria compared to conventional farms. This suggests that removing antibiotics from large-scale U.S. poultry farms can lead to immediate and significant reductions in antibiotic resistance for...
A Vietnamese PhD student, Tung Le, has made a breakthrough in understanding how an antibiotic-producing organism controls resistance to its own antibiotic. His research shows that the SimR protein regulates antibiotic export by binding to DNA or the antibiotic itself.
A review of five studies found that monitoring procalcitonin levels can guide the duration of antibiotic treatment, reducing courses by two days without affecting patient health. This could lead to significant cost savings for healthcare systems.
A new biodegradable antibiotic pellet can be implanted in the middle ear to target glue ear infections, potentially reducing the need for repeated grommet operations. The pellet slowly releases antibiotics over three weeks, addressing biofilms that cause up to 20% of cases.
University of New Hampshire researchers, led by Bradley Moore, found genetic structures in Frankia that resemble valuable natural product categories. The study reveals the potential for Frankia to produce antibiotics, herbicides, and other useful compounds, offering a new area of exploration for natural product drug discovery.
Research shows that bacterial resistance mechanisms increase survival and reproduction rates when both genetic mutations and plasmid insertions occur simultaneously. Bacteria like Escherichia coli exhibit faster reproduction in up to 32% of mutation-plasmid combinations.
A study published in Clinical Infectious Diseases found that simple guidelines decreased unnecessary antibiotic use in Quebec, Canada. The guidelines, which emphasized proper antibiotic use and selection of shortest treatment duration, resulted in a 4.2% decrease in outpatient antibiotic prescriptions.
A study published in Archives of Internal Medicine found that trimethoprim-sulfamethoxazole was more effective than cranberry capsules in preventing recurrent urinary tract infections. However, the use of antibiotics increased the risk of developing drug-resistant bacteria.
Researchers used computer simulations to study bacterial resistance against aminoglycoside antibiotics, revealing the physical basis of one mechanism - mutations of the antibiotic target site. The findings suggest possible drug modifications to combat resistant bacteria.
Researchers found that early infection with H. pylori bacteria impairs immune system maturation and triggers the accumulation of regulatory T-cells that suppress asthma. Mice infected at an early age enjoyed effective protection, but lost resistance if antibiotics were used later.
Researchers at Van Andel Research Institute have uncovered a possible explanation for the toxicity of anti-cancer antibiotics. The discovery could lead to new and improved drugs for several types of cancer, reducing side effects and improving treatment outcomes.
A Danish chemist has created a synthetic version of a bacterial endotoxin, revealing the mechanism behind deadly Gram-positive infections. The breakthrough could lead to the development of new and effective types of antibiotics.
A new Northwestern Medicine study finds that attending physicians in intensive care units can reduce mortality rates by 50% when using a checklist and prompted to address overlooked details. The prompting system cut ventilator-associated pneumonia cases and reduced ICU length of stay.
In a structured community of Escherichia coli bacteria, restrained strains thrived by curbing pursuit of producers, while unrestrained strains faced long-term demise. The phenomenon has implications for other ecological systems.
A team of Canadian scientists discovered that specific mixtures of antimicrobial agents presented in lipid (fatty) mixtures can significantly boost the effectiveness of those agents to kill multidrug-resistant bacteria. This new therapy has the potential to combat bacterial multidrug resistance, a growing clinical problem.
A Canadian study suggests doctors may be overprescribing antibiotics for home-care patients, with younger and sicker individuals being at a higher risk of misuse. The most common class of antibiotics prescribed was fluoroquinolones, which could weaken their efficacy against emerging infections.
A recent study found that E. coli bacteria are more likely to develop resistance to antibiotics when exposed to low levels of these medications, rather than high concentrations. This finding challenges previous assumptions about the safety of using antibiotics in food animals and highlights the growing threat of antibiotic resistance.
A new strain of methicillin-resistant Staphylococcus aureus (MRSA) has been discovered in both human and dairy cow populations. The genetic makeup of the new strain differs from previous strains, making current molecular tests ineffective in detecting it.
A new study finds that corticosteroid treatment can reduce disease severity and improve recovery rates in patients with community-acquired pneumonia. Corticosteroids were added to standard antibiotic treatment, resulting in faster patient recovery and reduced length of hospital stay.
A subset of severe asthmatics harbor infectious C. pneumoniae in their lungs, resulting in antibody production and increased asthma severity. Antibiotic treatment can significantly improve symptoms and even lead to a complete abolition of asthma symptoms.
Scientists at Berkeley Lab derived atomic-scale resolution structures of the ribosome, a protein-making machine. The high-resolution structures reveal molecular-scale compression springs and torsion springs made of RNA, keeping the subunits tethered together during large-scale motions.
Researchers found PCR testing for Borrelia burgdorferi DNA in joint fluid confirms diagnosis but is not a reliable indicator of active joint infection. Patients with persistent arthritis require more intensive antibiotic and DMARD therapy.
Research suggests that linezolid is a more effective treatment than vancomycin for ventilator-associated pneumonia caused by MRSA. Linezolid showed higher clinical and microbiologic success rates, with cure rates being higher at the end of treatment.
Researchers at Boston University discovered that adding sugar to antibiotics increases their effectiveness in targeting 'persisters' - bacteria that survive antibiotic onslaughts. This approach has the potential to improve lives and reduce healthcare costs for millions.
A recent study published in The Lancet found that treating acute appendicitis with antibiotics is not as effective as surgically removing the appendix. In the study, patients who received antibiotics were more likely to develop post-intervention peritonitis, a serious inflammation of the abdominal cavity.
A study of 150 children on temporary breathing devices found that shorter antibiotic courses were just as effective in treating respiratory infections without increasing the risk of drug-resistant infections. Careful evaluation of the need for antibiotics and shortest treatment duration are recommended to curb antibiotic resistance.
A large clinical trial found gatifloxacin to be equally effective as chloramphenicol in treating typhoid, but with fewer side effects. The new antibiotic is more affordable and only needs to be taken once a day.
A new study found that nonperforating appendicitis and nonperforating diverticulitis share many similarities, including association with colon hygiene and low fiber intake. The study suggests that antibiotics may be a better treatment option for these conditions than surgery.
Researchers at Texas A&M University discovered that certain bacteria can render themselves dormant in response to antibiotic stress, degrading internal antitoxins and damaging metabolic processes. This 'sleeping' mechanism allows the bacteria to avoid antibiotics, but could potentially be awakened by a complementary chemical.
A nationwide study found nearly half of US meat and poultry samples contaminated with drug-resistant Staphylococcus aureus. The bacteria can cause serious illnesses like pneumonia, endocarditis, and sepsis, highlighting the need for a more comprehensive inspection program.
A US Department of Agriculture study suggests that dietary yeast extract has good potential as a non-antibiotic alternative for decreasing pathogens in organic turkey production. The researchers are looking for a balance between enhancing immune response and maintaining growth.
Researchers found that manuka honey can inhibit bacterial attachment to tissues and make MRSA more sensitive to antibiotics, reversing antibiotic resistance. This discovery could lead to the development of cheaper and more effective treatments for wound infections.
A study found that long-term antibiotic use for acne decreased S. aureus colonization by nearly 70%, with no increased resistance to tetracycline antibiotics observed. This contradicts current dogma about long-term antibiotic use, suggesting further research is needed.
Scientists discover that bacteria in wasp antennae produce a cocktail of antibiotics to protect against fungal threats, a strategy similar to human combination therapy. This finding has potential clinical benefits and may yield novel antimicrobial compounds useful for human medicine.
The Infectious Diseases Society of America warns that antibiotic-resistant super bugs threaten public health, citing a need for urgent action. The organization recommends initiatives to combat resistance, including incentivizing R&D, recalibrating FDA requirements, and promoting judicious use of antibiotics.
New technology encasing antibiotics in nanofibers kills a variety of disease-causing bacteria and fungi, including Escherichia coli and Pseudomonas aeruginosa. The treatment boosts the power of antibiotics, making them effective for longer periods.
A Cardiff University study found that antibiotics have no significant impact on alleviating symptoms or speeding recovery in patients with yellow or green phlegm. The research suggests that clinicians and patients overestimate the importance of phlegm color in deciding whether to prescribe antibiotics.
Researchers found that plant buffers can slow down the runoff of veterinary antibiotics in surface water, reducing transport by 58-72% for herbicides and 70% for antibiotics. The use of certain species like hybrid poplar can further enhance degradation of deposited antibiotics.
A large randomized trial found that preventive antibiotic use significantly reduces the risk of infection with highly resistant microorganisms in intensive care patients. Patients treated with selective digestive tract decontamination (SDD) were 59% less likely to develop bacteraemia and 38% less likely to colonize respiratory tracts.
A new UCSF study forecasts a far worse-than-expected cholera epidemic in Haiti, predicting nearly twice the number of cases as the United Nations' initial projections. The study suggests that extending access to antibiotics could save thousands of lives and prevent widespread fatalities.
A new study predicts nearly 800,000 cases and 11,100 deaths in Haiti due to cholera, significantly underestimating official projections. Combining available disease control strategies such as clean water access, oral vaccination, and expanded antibiotic use could prevent thousands of deaths.
A study finds that widespread discharge of inefficiently treated wastewater into rivers could occur if existing plans for antiviral and antibiotic use are implemented during a pandemic. This could lead to water quality deterioration at drinking water abstraction points, potentially causing eutrophication and environmental toxicity.
Iowa State researchers have identified and described two parts of the three-part system that pumps toxins from bacteria and allows them to resist antibiotics. The discoveries provide novel insights into how the transporter functions and could lead to ways to block its activity, heightening bacteria's sensitivity to antibiotics.
Swedish scientists reveal that pollutants from Indian factories are breeding resistance genes in river bacteria, posing a global risk for untreatable diseases. The study's novel DNA sequencing approach may also aid future hospital research.
A new Johns Hopkins Children's study suggests that timely and proper wound cleaning and draining may be more important than the choice of antibiotic in treating MRSA skin infections. The researchers found that 95% of children recovered completely within a week, regardless of which antibiotic they received.
University of Houston professors have developed a computerized modeling system to accelerate the development of new antibiotics. The system aims to identify effective dosing regimens and prioritize clinical investigations.
Scientists at Washington University School of Medicine have identified a protective mechanism in Streptococcus pyogenes that could be exploited to create new antibiotics. The discovery reveals how the antitoxin blocks the toxin's activity, sparing the bacteria from self-destruction.
Lyme arthritis can be treated successfully with oral antibiotics, but early diagnosis is crucial to prevent joint damage. Patients who develop the condition should look for symptoms like aching joints, fever, and rash, and report them to their physician.