Screening the herbal pharmacy
Researchers have identified 18 plants with substantial anti-cancer properties, including Rangoon Creeper and Red-Root Sage, which outperform conventional treatments against specific tumor cell lines.
Cancer Medication
Articles tagged with Cancer Medication
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U-M researchers ID promising new cancer drug
Researchers at the University of Michigan have designed a small molecule that activates the p53 protein to kill tumor cells without causing damage to normal cells. The new drug, MI-219, is highly effective in cell cultures and appears safe for use in animals.
New study of targeted therapies for breast cancer -- model for global clinical trials
A new study, ALTTO, is testing two targeted medications to treat aggressive breast cancer in 8,000 participants across 50 countries. The trial will compare four different regimens of targeted therapy and provide insights into individualized patient care.
Gene expression differences between Europeans and Africans affect response to drugs, infections
Differences in gene expression levels between people of European and African ancestry can impact how they respond to certain drugs. The study found significant differences in several unrelated processes, including genes involved in producing antibodies to microbial invaders.
Weill Cornell team identifies potential new drug targets against hormone-dependent breast cancer
A Weill Cornell team discovered that EP2 and EP4 receptors play a key role in boosting estrogen production in fat and breast cancer cells. This pathway increases the risk of hormone receptor-positive breast cancer. The study's findings suggest new targets for pharmaceutical research, including drugs that target these receptors.
U of Minnesota study finds thalidomide shows promise for treatment of recurrent ovarian cancer
A University of Minnesota study has shown promising results for thalidomide as a treatment for recurrent ovarian cancer. Patients who received the combination of thalidomide and topotecan had a higher overall response rate and longer cancer-free period compared to those receiving topotecan alone.
Inverted DNA turns quiet developmental gene into a potent driver of t-cell lymphoma
Researchers at Fox Chase Cancer Center have discovered that a genetic misalignment can turn a normally quiet developmental gene into a potent driver of T-cell lymphoma in adult mice. The study found that the Dlx5 protein, which is not typically active in healthy adult cells, can be targeted for inhibition to slow cancer growth.
Drugs used for cancer-associated anemia linked with increased risk of blood clots, death
Treating anemia with ESAs increases risk of VTE and death among cancer patients, according to a review of phase 3 trials. There was a significantly increased risk (57") of VTE among patients treated with ESA, while the risk of death was higher for ESA-treated patients compared to the control group.
Drug for anemic cancer patients raises risk of death
A Northwestern University study found that cancer patients taking erythropoiesis-stimulating agents (ESAs) have a 10% increased risk of death compared to those who did not take the drugs. The study's findings suggest that ESAs may stimulate the growth of cancer cells, leading to shorter survival rates.
Protein shines light on cancer response
Researchers at Vanderbilt University Medical Center have identified a small protein that specifically recognizes tumors responding to chemotherapy, allowing for rapid visualization of cancer response in mice. This breakthrough could enable more efficient treatment customization and accelerate the development of new cancer drugs.
Moving beyond tamoxifen: Drug discovery and the future of selective hormone receptor modulators
Researchers are developing new drugs that can modulate male hormone receptors to improve muscle weight without stimulating prostate glands. Studies have shed light on the complex mechanisms behind estrogen receptors in different tissues.
Patient with rare disorder responds to cancer drug
Researchers at NIH have successfully treated a patient with a rare disorder using cancer drug imatinib, which is also effective against systemic mastocytosis and chronic basophilic leukemia. The study's findings offer new treatment options for patients with these complex conditions.
New Jefferson trial to test radiation-emitting beads against advanced liver cancer
A new clinical trial at Thomas Jefferson University aims to test the effectiveness of radioembolization using radiation-emitting beads in treating advanced liver cancer. The treatment, which blocks blood supply and emits targeted radiation, has shown promise in shrinking tumors and improving patient survival.
MIT develops thin-film 'micro pharmacy'
The MIT-developed thin-film coating can deliver precise, remote-controlled doses of drugs to specific targets in the body. The film is made from alternating layers of materials and can be activated by applying a small electric field.
UCSD research team identifies novel anticancer drug from the sea
A collaborative team of researchers has identified somocystinamide A, a highly potent cancer-fighting compound isolated from cyanobacteria L. Majuscula, which inhibits neovascularization and tumor cell proliferation.
Predictors of inaccurate online breast cancer information
A new study found that 41 false statements appeared on 18 web pages (5.2%) and that websites with complementary or alternative medicine were 15.6 times more likely to have inaccuracies. The authors advise patients to be skeptical of online health information and consult a clinician before taking action.
Kidney cancer drug attacks a major type of acute myeloid leukemia
Researchers at MD Anderson Cancer Center report a new kidney cancer drug that targets the FLT3-ITD mutation in AML, reducing leukemia cells by 90% in patients. The drug has shown minimal side effects and is being tested in combination with chemotherapy.
New nanotube findings by Stanford researchers give boost to potential biomedical applications
Researchers found that carbon nanotubes leave the body primarily through the feces, with some by way of the urine. The study also allays worries that the nanotubes would prove toxic to mice, as none died or showed any anomalies in blood chemistry.
Feds fund study of drug that may prevent radiation injury
A new study funded by the Defense Department aims to develop a drug based on carbon nanotubes to prevent acute radiation injury deaths. The experimental drug, Nanovector Trojan Horses (NTH), has shown promising results in preliminary tests, with mice showing enhanced protection when given first-generation NTH drugs prior to exposure.
Turning on adult stem cells may help repair bone
A study published in the Journal of Clinical Investigation found that a medication used to treat bone marrow cancer improves bone density in a mouse model of osteoporosis by activating mesenchymal stem cells. This breakthrough could lead to new treatments for osteoporosis and other degenerative conditions.
Scientists use nanomaterials to localize and control drug delivery
Researchers create a localized and controlled drug delivery system that is invisible to the immune system, providing a potential solution for cancer and other diseases. The system uses nanoscale polymer films to slowly release anti-inflammatory drugs, reducing side effects and enhancing treatment efficacy.
Patients given sorafenib need close monitoring for hypertension
A systematic review found sorafenib significantly increases the risk of developing hypertension, particularly high-grade hypertension. Patients receiving sorafenib require close monitoring and effective management to prevent cardiovascular complications.
Pros, cons of drug proven to prevent prostate cancer should be considered, researchers recommend
Researchers analyzed data from the National Cancer Institute's Prostate Cancer Prevention Trial, showing that finasteride reduces prostate cancer risk by 25% but also causes side effects like impotence. The study encourages men to consider both benefits and drawbacks before taking the drug to prevent prostate cancer.
Diet and lifestyle critical to recovery, says study
A new study published in Nature Genetics reveals that diet and lifestyle can significantly impact the effectiveness of certain drugs, including those used for cancer therapies. The research found that nutrient availability can either enhance or harm cell fitness, depending on the surrounding environment.
Plant pathogen yields substance to fight neuroblastoma
Scientists have found a promising anti-cancer drug candidate in HC-toxin, isolated from a fungal maize pathogen. The substance inhibits histone deacetylases, altering genetic material packaging and reducing cancer cell properties.
Hormonal dietary supplements might promote prostate cancer progression
Researchers at UT Southwestern Medical Center found that hormonal components in over-the-counter dietary supplements can stimulate cancer-cell growth and make anti-cancer drugs less effective. The study's findings highlight the need for patients to inform their doctors about any herbal or hormonal supplements they are taking.
Fruit flies all aglow light the way to cancer prevention
Scientists found that a green glow in fruit flies indicates the activation of cancer-prevention signals similar to those in broccoli and cabbage. The discovery uses Drosophila as a model organism to develop novel approaches for studying the NRF2 pathway, which triggers anti-oxidant activity to fight off toxic assaults.
UT Southwestern scientist honored among best in Texas research
Dr. Beth Levine, a renowned specialist in autophagy, received the award for medicine for her groundbreaking work that has propelled forward medical research on cancer, Alzheimer's disease, and infectious diseases. Her investigations have identified key genes involved in autophagy, contributing to various diseases.
Other highlights in the Jan. 8 JNCI
Researchers found patients taking statins had a lower incidence of cancer compared to non-statin users. Additionally, a new receptor may be targeted for colon cancer treatment, while a mouse model of rare kidney disorder shows promise for studying cancer development.
Novel anticancer strategy moves from laboratory to clinic
Researchers developed a novel anticancer strategy targeting PI-3 kinases, which are crucial for cancer cell growth and survival. The compound, SF1126, showed efficacy in seven types of tumors in mice and is being tested in human clinical trials.
Research suggests new treatment suitable for all patients
Researchers developed a three-drug cocktail targeting glioblastoma multiforme tumors, which showed significant benefits in killing cancer cells and sparing healthy brain tissue. The treatment is based on the first-ever documented molecular signature of GBM tumors and may be tested in patients within five years.
Lung cancer cells' survival gene seen as drug target
Researchers have identified a key gene, 14-3-3zeta, that enables lung cancer cells to survive on their own. Silencing this gene has been shown to inhibit the growth and survival of lung cancer cells, making it a potential target for selective anti-cancer drugs.
Bevacizumab found to improve survival for patients with advanced breast cancer
A large clinical trial found that bevacizumab significantly prolongs progression-free survival for women with recurrent breast cancer when combined with chemotherapy. The study showed a doubling of delay in worsening of the disease and improved remission rates compared to chemotherapy alone.
Ireland Cancer Center researcher finds standard treatment for breast cancer not followed
A study published in Journal of Clinical Oncology found that nearly 50% of women over 65 with early stage hormone-positive breast cancer discontinue Tamoxifen treatment before five years. Factors predicting premature discontinuation include age, medical illnesses, and lack of radiation after surgery.
You can teach an old dog new tricks: anti-malarial prevents cancer in mice
Researchers found that the antimalarial drug chloroquine effectively prevents cancer in mouse models of two human cancer syndromes, Burkitt lymphoma and ataxia telangiectasia. Chloroquine inhibited the development of Myc-induced lymphomas and ATM-deficient mice, but not p53-deficient mice.
Agent orange chemical, dioxin, attacks the mitochondria to cause cancer, says Penn research team
Researchers at the University of Pennsylvania have identified that dioxin targets the mitochondria, disrupting normal cellular function and promoting tumor progression. The study's findings suggest that understanding this mechanism could lead to new ways to block the propagation of mitochondrial stress signaling and inhibit cancer growth.
Drug study for brain cancer shows promising results
A clinical study at Henry Ford Hospital found that Avastin significantly extended the survival of patients with glioblastoma multiforme, with over half living without disease progression for six months. The use of Avastin also showed no new adverse effects.
Another 'smart' cancer drug can have toxic effects on the heart
A retrospective analysis of sunitinib patients found a risk for heart failure, myocardial infarction, and hypertension. Patients with preexisting coronary artery disease were more likely to develop cardiac problems.
Cancer research giants collaborate to present the CTRC-AACR San Antonio Breast Cancer Symposium
The CTRC-AACR San Antonio Breast Cancer Symposium combines basic, translational, and clinical research to advance breast cancer research. The symposium aims to attract thought-leaders and high-quality papers in basic and translational breast cancer research.
3-drug combination 'extremely promising' as first-line therapy for multiple myeloma
A new 3-drug combination of bortezomib, lenalidomide, and dexamethasone has achieved an impressive overall response rate of 98% in newly diagnosed multiple myeloma patients. The regimen has also shown a high-quality response rate of 52%.
OHSU Cancer Institute researcher develops test for targeted therapy in acute myeloid leukemia
A new test, called RAPID, has been developed to identify proteins that drive cancer growth in acute myeloid leukemia. This breakthrough technology enables researchers to quickly compile a database of mutant genes and potentially match targeted drugs with patients.
New drug candidate knocks out resistant form of chronic myeloid leukemia
Researchers at Oregon Health & Science University Cancer Institute have discovered a new drug candidate, SGX393, effective against highly resistant mutations in CML. Combining SGX393 with existing drugs Sprycel and Tasigna suppresses resistant growth, raising the possibility of 'cocktail' therapies to prevent drug resistance.
Cancer risks of eating red and processed meat
A new study published in PLoS Medicine found that consuming high amounts of red and processed meats increases the risk of developing bowel and lung cancer. The research, conducted by Amanda Cross and colleagues, analyzed data from a large US diet and health study involving nearly half a million men and women aged 50-71.
Growth factor receptor affects prostate cancer progression
Researchers at Baylor College of Medicine developed a mouse model to study prostate cancer progression, revealing the role of fibroblast growth factor receptor 1 in initiating cancer. The study identified key genes involved in cell plasticity and discovered a new marker for human prostate cancer.
Keeping at-risk cells from developing cancer
Scientists at Johns Hopkins Medicine discovered that epigenetic changes in gene activation can lead to cancer development, and found a way to block the 'addiction' to growth factors, preventing cancer growth. The study shows that blocking this response can greatly reduce precancerous lesions in animals.
Gleevec, the targeted cancer pill, delivers more good news to patients
Researchers announced new data showing Gleevec improves outcomes for children with Ph+ ALL, reversing the poor prognosis, and prevents disease progression in adults with CML. Continuous treatment with Gleevec has shown a declining rate of relapse over time, with no patients progressing to advanced phase in CML.
Multiple myeloma clinical trial shows distinct survival benefit with lower dose of steroids
A clinical trial by Mayo Clinic found a lower dose of steroids to be as effective as the standard high-dose treatment in improving overall survival rates for multiple myeloma patients. The new regimen, lenalidomide plus low-dose dexamethasone, showed significantly better results with less toxicity.
OHSU Cancer Institute research discovery opens new window to understanding chronic myeloid leukemia
Abnormal stem cells with deletions of chromosome 7 or duplications of chromosome 8 have been found in some CML patients, suggesting new targets for therapy. The discovery opens a new window into understanding the roots of chronic myeloid leukemia.
Complete response with oblimersen combination improves survival of CLL patients
A Phase III clinical trial shows that patients with relapsed CLL who achieve complete response with oblimersen combination therapy live significantly longer than those treated with chemotherapy alone. The median survival time for oblimersen-treated patients is estimated to exceed 49 months, whereas it was 35 months for those on F/C alone.
Study of African traditional medicine will begin world-first clinical trial
Researchers are studying the safety and effectiveness of African plants used by traditional healers for treating various ailments, including AIDS and respiratory infections. The study aims to uncover the medicinal properties and potential benefits of these plants, with a focus on South Africa's vast botanical diversity.
Patients need to know that nuclear medicine procedures can trigger radiation alarms
A study highlights the need for improved patient information and counseling on nuclear medicine procedures, which can trigger radiation alarms in public places. Healthcare professionals, especially those in outpatient facilities, require formal training and standardization of instructions to ensure patient safety.
Protein found that may provide relief from neuropathic pain
Researchers from the University of California, San Diego, have identified a protein called LRP1 that may help ease neuropathic pain by blocking the response of glial cells. The study found that administering LRP1 into injured peripheral nerves decreased the level and activity of proinflammatory cytokines, leading to reduced pain.
Genes identified that protect against heart damage from chemotherapy
A series of genes has been identified as protecting cells from the harmful effects of doxorubicin, a commonly used chemotherapeutic agent. The long-term goal is to develop ways to turn these genes off in cancer cells and on in heart cells to prevent or mitigate heart damage.
Study: Re-engineered Gleevec reduces heart risks
Researchers re-engineered imatinib to specifically target gastrointestinal stromal tumor and reduce cardiotoxic side effects. The new drug, WBZ-4, was found to be equally effective against gastrointestinal cancer while significantly reducing the risk of heart failure in animal tests.
Other Highlights in the Nov. 27 JNCI
Male BRCA1 and BRCA2 mutation carriers have a higher risk of developing breast cancer compared to noncarriers. A high carbohydrate diet may also promote prostate tumor growth in mice, while infection with human papillomavirus (HPV) is associated with an increased risk of head and neck cancers but does not further increase the risk when...
A new computational technique predicts side-effects of a major cancer drug
A novel computer technique predicts side effects of major pharmaceuticals, including SERMs for breast cancer treatment. The approach shortens drug development and reduces costly recalls by identifying off-target proteins.
Oral drug sets a new survival standard for bone marrow cancer
Findings from two large clinical trials demonstrate significant improvement in patients with multiple myeloma who received Revlimid, an oral cancer drug, compared to those receiving a placebo. The study showed improved median survival and response rates, offering new hope for patients with this challenging disease.
Penn's Abramson Cancer Center part of major phase III study for myeloma
Researchers found unprecedented survival for patients with multiple myeloma when treated with lenalidomide and dexamethasone, achieving a median survival of nearly three years. The study shows promise for early treatment and has changed official guidelines to add REVLIMID as an initial treatment.
Cancer drug works by overactivating cancer gene
Researchers found that bortezomib selectively inhibits melanoma tumor cells by overactivating the cancer-promoting gene c-MYC, leading to increased production of NOXA and promoting cell death. The study suggests a novel treatment strategy for various types of cancer.
MIT: Remote-control nanoparticles deliver drugs directly into tumors
Researchers develop nanoparticles that can be controlled by electromagnetic pulses to release therapeutic drugs directly into tumors, a potential breakthrough in cancer treatment. The system uses heat-sensitive DNA tethers to release drugs, allowing for customizable and targeted delivery.