Nicotinamide for skin cancer chemoprevention
A cohort study suggests nicotinamide reduces skin cancer risk, with greatest effect seen after initial skin cancer diagnosis, indicating potential chemopreventive properties of the vitamin B3 derivative
Chemoprevention
Articles tagged with Chemoprevention
Optogenetic platform illuminates new antiviral strategies
Researchers used an optogenetic platform to discover dozens of molecules that can act as pan-antivirals, including two chemical scaffolds that could serve as development candidates. The compounds were tested on Zika, Respiratory Syncytial Virus (RSV) and herpes, showing promising results.
More young adults than ever take HIV-prevention medication, but gaps remain
A new study found that eight times more American young adults now take HIV-prevention medication than a decade ago, but inconsistent use and barriers persist. PrEP can reduce the chances of acquiring HIV by 99%, emphasizing the need for healthcare providers and public health agencies to promote consistent use among high-risk patients.
25-year review highlights stomach cancer-fighting potential of Brazilian plants
A 25-year review highlights the stomach cancer-fighting potential of Brazilian plant species, which contain bioactive compounds with potential anticancer properties. The studies suggest that regular consumption of fruits and vegetables rich in polyphenols and flavonoids may help lower the risk of stomach cancer.
World Leprosy Day: Tailored guidelines and reduced stigma needed to tackle leprosy, Irish case study reveals
A recent case report in Ireland shows the challenges of responding to leprosy in high-income countries where it is rare. The study recommends prioritizing education, stigma reduction, and harmonized public health guidelines for sporadic cases.
Research Spotlight: association of statin, metformin, and aspirin use with hepatocellular carcinoma in the all of us research program
A recent study published in Gastro Hep Advances found that statin use was associated with a reduced risk of hepatocellular carcinoma (HCC). The research, conducted using data from the All of Us Research Program, suggests that lipophilic statins may be an effective strategy for chemoprevention in HCC. Patients with indications for stati...
Targeting factors for chemoprevention and cancer interception to tackle mesothelioma
This research perspective reviews the current state of chemoprevention and cancer interception progress in asbestos-induced mesothelioma. The study identifies potential targets for prevention, including inflammatory factors and novel chemoprevention agents.
Effective malaria prevention in pregnant women despite drug resistance
A study in southern Mozambique found that sulfadoxine-pyrimethamine (SP) remains effective for preventing malaria infections in pregnant women, even in areas with high drug resistance. The study showed increased clearance of P. falciparum infections and lower antibodies resulting from parasite colonisation.
“From Osimertinib to Preemptive Combinations” by Dr. Blagosklonny
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
As cancer therapies improve, more patients with rectal cancer forego surgery
A growing number of rectal cancer patients are choosing a watch-and-wait approach over surgery, with the number increasing nearly 10% between 2006 and 2020. This approach requires frequent follow-ups but may allow patients to avoid long-term bowel dysfunction.
Natural molecule enhances sunscreen efficacy without increasing concentration of conventional UV filters
A study found that adding rosmarinic acid to sunscreen increases sun protection factor by over 41% and reduces the need for synthetic chemicals. The natural antioxidant also provides anti-aging benefits, making it a potential multifunctional compound for improved skin health.
Breast cancer risk models may incorrectly classify many women
A recent study found that breast cancer risk models can lead to vastly different recommendations for individual women, depending on the model used and threshold applied. The study highlighted the importance of considering both sensitivity and inaccurate classification when using these models.
Actinidia arguta (sarunashi) juice inhibits lung cancer in mice
Researchers from Okayama University found that Actinidia arguta (Sarunashi) juice and its component isoquercetin inhibit lung cancer development in mice, accelerating DNA repair and suppressing Akt-mediated growth signaling. The study suggests Sarunashi juice as an attractive candidate for chemoprevention.
Oncotarget: Ibuprofen disrupts protein complex in colorectal cells
Researchers found that ibuprofen inhibits the alternative splicing event generating RAC1B, overexpressed in BRAF-mutated colorectal tumors. Ibuprofen disrupts a WNK1/GSK3β/SRPK1 protein kinase complex, promoting nuclear exclusion of SRPK1 and SRSF1.
Leprosy declines in Morocco after implementation of preventive drug
Since 2012, the number of leprosy cases in Morocco has decreased significantly, with an average annual decline of -16.83%. This improvement is attributed to the implementation of single dose rifampicin chemoprophylaxis, which has helped to interrupt transmission and reduce disability.
HIV: The benefits of prophylaxis of tuberculosis are confirmed
Long-term follow-up confirms that isoniazid prophylaxis reduces both severe morbidity and mortality among HIV-infected individuals. The study provides evidence for the WHO recommendation of isoniazid preventive therapy in HIV-positive patients, even with early antiretroviral treatment.
Seasonal malaria chemoprevention in Senegalese children lowers overall malaria burden
A randomized trial found that preventive antimalarial drugs for children up to 10 years old reduced malaria cases and deaths, especially among older children. The study also showed a significant reduction in severe malaria incidence.
Target for lung cancer chemoprevention identified
Researchers have identified a biomarker for measuring the success of lung cancer chemoprevention, using abnormal cell development (endobronchial dysplasia). The study found that measurements of endobronchial dysplasia can predict how well a chemoprevention agent is working in former smokers.
Paired drugs kill precancerous colon polyps, spare normal tissue
A combination of Vitamin A acetate and TRAIL kills precancerous colon polyps while sparing normal tissue, providing a potential new avenue for chemoprevention. The regimen, tested in mouse models and human colon cancer tissue, appears to address the issue of continuous long-term therapy required for current chemopreventive drugs.
Is short-term Celecoxib intervention a effective method for preventing gastric carcinogenesis?
A new study found that short-term Celecoxib intervention can effectively prevent gastric carcinogenesis in Mongolian gerbils. The research team suggests that COX-2 inhibitors may be used as chemoprevention for people older than 40 years old, especially those with refractory H. pylori infections at high risk of gastric cancer.
Individualized strategies needed for prevention of malaria in long-term travelers
Long-term travelers face higher risk of malaria due to diverse itineraries and varying medical care quality. Individualized strategies are crucial, with advice from travel medicine specialists, focusing on personal protective measures and reliable medical facilities.
Some US soldiers returning from Afghanistan should be screened for malaria
A study found that US Army personnel deployed to eastern Afghanistan between June and September 2002 had a significant risk of malaria infection upon return. The researchers identified 38 patients infected with malaria, resulting in an attack rate of 52.4 cases per 1,000 soldiers.
Leader in cancer treatment and prevention research honored
Dr. David S. Alberts, a renowned cancer researcher, has been honored with the 2004 American Association for Cancer Research (AACR) – Cancer Research and Prevention Foundation Award for Excellence in Cancer Prevention Research. He is recognized for his groundbreaking work on chemoprevention and treatment of various types of cancer.
Cancer prevention pioneer receives AACR/Cancer Research and Prevention Foundation Award
Dr. Hong's work has accelerated the pace of growth in cancer prevention research, opening doors to less toxic and more effective chemopreventive agents and regimens. His research has demonstrated the effectiveness of biochemoprevention in reducing both primary and recurrent cancers.
More than two million women stand to benefit from breast cancer prevention drug
According to a new study, nearly 10 million US women aged 35-79 could benefit from tamoxifen chemoprevention for breast cancer. White women are more likely to benefit than black or Hispanic women due to differences in risk factors and comorbidities.
The Lancet Oncology (TLO)
Imatinib mesylate has shown significant effectiveness in treating gastrointestinal stromal tumours (GISTs), a previously difficult-to-treat cancer type. The drug's success is attributed to its ability to target KIT tyrosine kinase mutations, which are present in most GISTs.
Dartmouth researcher Michael B. Sporn, M.D. honored for pioneering work in cancer prevention
Sporn's groundbreaking research on chemoprevention has revolutionized the field of cancer prevention, exploring novel approaches to prevent or treat cancer. His work has led to strategies with vast potential for reducing cancer incidence and death, and continues to inspire new directions in cancer prevention research.
The Lancet Oncology press release
The Lancet Oncology editorial discusses the EPA's 10-year report on diesel exhaust fumes' toxic effects, emphasizing public health implications. The article also reviews mathematical models identifying breast cancer risk factors and explores chemoprevention strategies.
Michael B. Sporn, M.D., to receive inaugural cancer prevention award
Dr. Michael Sporn, a renowned cancer researcher, has made significant contributions to cancer prevention through his work on chemoprevention and the development of new strategies to reduce cancer incidence and death. He is recognized for his pioneering studies on the role of Vitamin A and retinoids in cancer prevention.