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JNCI May 26 issue tip sheet

Researchers discovered that CIP2A expression is associated with reduced overall survival in gastric cancer patients, as well as increased proliferation and anchorage-independent growth. Meanwhile, a RasGAP-derived peptide has been shown to improve responses to chemotherapy in mouse models of colon cancer.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateMay 26, 2009

Breast cancer: To screen or not to screen?

Researchers found that breast cancer screening's life-saving benefit gradually increases with age, but the majority of women do not need regular mammograms to save lives. The study estimated that around 1 in 5,000 women will be saved by screening between ages 40-59.

SourceBMC (BioMed Central)·JournalBMC Medical Informatics and Decision Making·DateApr 1, 2009

Early detection of second breast cancers halves women's risk of death

A recent study found that early detection of second breast cancers in women who have already had the disease can significantly improve their chances of survival. The research revealed that mammography was more sensitive than clinical examination for detecting second cancers, with a sensitivity of 86%. Early detection at an asymptomatic...

SourceEuropean Society for Medical Oncology·JournalAnnals of Oncology·DateMar 17, 2009

Obese women play cancer roulette

Research finds that obese women, especially white ones, are less likely to have undergone a recent mammography compared to normal weight women. The study highlights poor self-esteem, body image issues, and racial disparities in obesity-related body image as reasons for the disparity.

SourceSpringer·JournalJournal of General Internal Medicine·DateMar 16, 2009

Also in the Jan. 27 JNCI

A study found a potential genetic link between a germ-line mutation in the TTF-1 gene and an increased risk of developing multi-nodular goiter (MNG) and papillary thyroid cancer (PTC). The researchers also explored the effects of early mammography on breast cancer risk in BRCA mutation carriers.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateJan 27, 2009

Mammography facility characteristics associated with accuracy of screening

A study found that certain mammography facility characteristics, such as breast imaging specialists and screening/diagnostic services, are associated with improved interpretive accuracy. The analysis of 44 facilities performed over 484,463 screenings revealed variations in cancer detection rates between locations.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateJun 10, 2008

Other highlights in the Feb. 26 JNCI

A large randomized trial of personalized interventions found that two behavioral interventions did not significantly increase regular mammograms in female veterans. The study's findings support the generalizability to the US female population, which has seen a decline in mammography rates. Meanwhile, another study suggests that viral D...

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateFeb 26, 2008

LA BioMed study finds hormone therapy increases frequency of abnormal mammograms, breast biopsies

A recent study published in Archives of Internal Medicine found that combined hormone therapy significantly increases the risk of abnormal mammograms and breast biopsies, compromising their diagnostic performance. The research involved 16,608 post-menopausal women and revealed a four percent greater risk of mammogram abnormalities afte...

SourceLA BioMed·JournalArchives of Internal Medicine·DateFeb 25, 2008

Single reader with CAD more efficient, yields fewer false positives, and possibly more sensitive

A study by Charlotte Radiology found that single reading of screening mammograms with computer-aided detection (CAD) is more efficient and yields higher sensitivity than double reading. The use of CAD resulted in a lower recall rate compared to double reading, making it an effective alternative for increasing sensitivity.

SourceAmerican College of Radiology·JournalAmerican Journal of Roentgenology·DateFeb 14, 2008

Health insurance co-payments deter mammography use

A study by Brown University and Harvard Medical School found that health insurance co-payments significantly reduce mammography use among women. The researchers analyzed data from Medicare managed-care plans and found a 8-11% decrease in breast cancer screening rates among women with co-payments, compared to those with full coverage.

SourceBrown University·JournalNew England Journal of Medicine·DateJan 23, 2008

MRI finds breast cancer before it becomes dangerous

Researchers at the University of Bonn found that MRI is substantially more accurate than mammography in detecting very early stages of breast cancer, including preinvasive DCIS. The study detected 167 cases of early breast cancer, with MRI identifying 152 cases and mammography detecting only 93 cases.

SourceUniversity of Bonn·JournalThe Lancet·DateAug 10, 2007

Breast cancer and hormone therapy -- A looking-glass mirror?

A new Kaiser Permanente study suggests a possible link between breast cancer incidence and postmenopausal hormone therapy (HT) use, but concludes that the association is complex and influenced by various factors, including mammography screening rates. Long-term HT may slightly increase breast cancer risk, particularly in younger women.

SourceInternational Menopause Society·JournalJNCI Journal of the National Cancer Institute·DateJul 24, 2007

Mammography rates declining in the United States

A new study reveals that mammography rates have declined significantly in the US between 2000 and 2005, with a notable decrease among women aged 50-64 and higher socioeconomic levels. The decline in screening rates coincides with a reduction in reported breast cancer incidence, raising concerns about potential impact on mortality rates.

SourceWiley·JournalCancer·DateMay 14, 2007

Mammograms for women in their 40s should be based on individual

The American College of Physicians recommends that mammography screening decisions be made on a case-by-case basis, considering each woman's individual cancer risk and preference. The new guidelines acknowledge the benefits and harms of screening, recommending periodic assessment of breast cancer risk to inform decision-making.

SourceStanford Medicine·JournalAnnals of Internal Medicine·DateApr 2, 2007