Articles tagged with Stimulants
Researchers are evaluating the health and economic consequences of subpar buprenorphine dosing among Medicaid-covered pregnant women to improve maternal and infant outcomes. Data suggest that up to 90% of pregnant women require higher doses of buprenorphine.
Researchers propose using carefully designed combinations of approved drugs to create a more convincing placebo, limiting participant disclosure, and rigorous testing to ensure effective masking. This approach, called UMBRAA, aims to overcome the challenge of distinguishing between psychedelic effects and the power of expectation.
Patients exposed to medetomidine report extreme sedation, severe withdrawal symptoms, and treatment challenges, highlighting the need for improved surveillance and clinical protocols. The study emphasizes the importance of awareness and tailored treatment for patients with opioid use disorder.
A decision analytical model and microsimulation study found that expanding alcohol screening and brief interventions in primary care could reduce premature mortality from major alcohol-related causes of death in US adults. By 2030, this expanded approach is projected to decrease annual alcohol-related potential years of life lost by −5...
A recent study published by the University of the Basque Country found that girls are the biggest consumers of psychotropic drugs among adolescents in most European countries. The research team analyzed data from 32 European countries and discovered a significant link between consumption rates, gender equality, and economic level.
The US overdose death rate declined by 24.4% in 2024, primarily driven by falling fentanyl-related deaths. However, deaths involving only stimulants continued to rise, and racial disparities remain severe. The study highlights the need for targeted public health interventions to address persistent inequities.
Researchers conducted a meta-analysis of nine randomized clinical trials to evaluate the effectiveness of methylphenidate-type psychostimulants in reducing cancer-related fatigue. The study found significant improvements in fatigue scores, with benefits increasing over time.
A new study finds that prenatal opioid exposure in babies does not predict future classroom performance. Despite previous research suggesting a link between NAS and adverse developmental outcomes, this study found no significant differences in standardized test scores between students with and without a history of NAS.
A study found that prescription stimulants primarily affect brain's reward and wakefulness centers, rather than attention circuitry. This leads to improved focus through increased motivation and reduced sleep deprivation effects.
A repeated cross-sectional study found a significant increase in stimulant prescribing for ADHD, with the largest acceleration observed among female adolescents and young adults aged 18 to 64. The study's findings are consistent with prior research but provide new insights into population-level trends.
A new study found a significant rise in ADHD stimulant prescriptions in Ontario, with a 157% increase from 2015 to 2023. The study calls for better clinical guidance to ensure medications are prescribed appropriately and prevent adverse health effects.
Among youth aged 15-24, polysubstance-involved opioid overdose deaths rose steadily with age, driven by fentanyl and synthetic opioids. By age 21, polysubstance involvement surpassed opioid-only fatalities, primarily due to stimulants like methamphetamine and cocaine.
A recent University of Michigan study found that nonmedical use of prescription ADHD drugs among adolescents has dropped from 10% in 2005 to 6% in 2023. Lifetime medical use also increased slightly during the same period, but overall trends suggest a decrease in misusing these prescriptions.
Among US adolescents, current medical use of prescription stimulants for ADHD increased from 2005 to 2023, while nonmedical use decreased. Lifetime nonmedical use was more prevalent than medical use in early cohorts but shifted to being less prevalent in recent cohorts.
A JAMA Psychiatry study recommends increasing contingency management incentives to improve opioid addiction recovery outcomes. The research team suggests using evidence-based incentive amounts, such as $128 per week for vouchers or $55 per week for prizes over 12 weeks, to effectively reduce stimulant and/or opioid use.
A new study found that new psychoactive substances (NPS) are a significant concern in roadway crashes in California. NPS, also known as ‘designer drugs’, were detected in the blood of 17 patients, with most frequent being designer benzodiazepines and fentanyl analogs.
A study of 7,944 ADHD patients found that telehealth-based relationships did not increase the risk of substance use disorder. However, patients aged 26 and above who received initial stimulant prescriptions during telehealth appointments were at higher risk.
A new study published in The Lancet Psychiatry found that ADHD medications have small but significant effects on blood pressure and heart rate. While there were concerns about the side effects of these medications, the study suggests that their benefits outweigh the risks.
A recent study found that nearly one-tenth of US adults using prescription stimulants have a prescription stimulant use disorder. Additionally, one-fourth of users reported misuse, suggesting potential progress in addressing the mental health care gap for middle-aged women.
A study found that starting stimulant medications via telehealth increases substance use disorder (SUD) risk, particularly among young adults aged 26-34. Ongoing screening and monitoring are crucial to mitigate this risk.
Research reveals nearly 10% of individuals with disabilities misused prescription drugs in the past year, compared to 4.4% without disabilities. Young adults and those with cognitive disabilities are particularly vulnerable to prescription drug misuse.
A study analyzing millions of U.S. prescriptions over 10 years found that co-prescribed stimulants and opioids are associated with escalating opioid intake. Patients taking both stimulants and opioids had a higher average monthly intake of morphine milligram equivalents (MME) compared to those taking only opioids.
A narrative review of over 1,700 papers found only seven papers addressing dexamphetamine addiction directly. The study raises questions about the evidence underpinning its restriction by regulatory agencies. Dexamphetamine is effective in treating ADHD and narcolepsy but may have benefits in treating obesity.
A national study suggests that the Adderall shortage may have led to an increase in the use of alternative ADHD medications in children. The research found that while prescription fills for ADHD treatments among children aged 5-17 fell during the pandemic, they increased again after the shortage was announced. The study's findings high...
Archaeologists have found evidence that Roman-era barbarian warriors used stimulants before battle, including small spoon-shaped objects attached to their belts. The researchers believe that these stimulants may have been widely used throughout history to motivate soldiers and reduce stress and fear during warfare.
A systematic review and network meta-analysis found spinal cord stimulation therapies to be more effective in reducing chronic back and leg pain. These findings suggest spinal cord stimulation as a valuable option for chronic pain management.
A cross-sectional study found increasing concentrations of fentanyl, cocaine, and methamphetamine in urine specimens from 2013 to 2023, highlighting a shift in illicit substance use patterns. Heroin concentration decreased during this period, emphasizing the need for updated surveillance initiatives and treatment strategies.
A large federally funded study found a 37% reduction in overdose deaths from opioids combined with stimulant drugs other than cocaine, primarily fentanyl and methamphetamine. Intervention communities implemented evidence-based practices, including naloxone distribution and education campaigns, which led to lower death rates.
Prescription volumes for stimulant and antidepressant medications rose, while opioid volumes decreased between 2019 and 2022. Telehealth prescriptions climbed across medications, with a notable increase in opioids.
A significant increase in drug overdose rates was recorded in Colombia between 2010 and 2021, with a notable rise among young women. The study found that the pandemic contributed to higher levels of anxiety and mental health problems, leading to overuse of drugs, particularly tranquilizers/sedatives/antidepressants.
Researchers will investigate the therapeutic potential of psychedelics to treat methamphetamine addiction, with a focus on serotonin receptors and potentially leading to new treatments. The project aims to advance psychedelics as a promising option for treating stimulant use disorder.
A study at Columbia University Mailman School of Public Health reports a 500% increase in drug-involved overdose deaths in 2022, primarily attributed to synthetic opioids. Income protection policies have been found to have a supportive role in preventing fatal drug overdoses.
Researchers used C. elegans to investigate the underlying mechanisms of embryonal exposure to addictive doses of amphetamine, discovering epigenetic modifications that alter gene and protein expression. This leads to increased susceptibility to amphetamine-induced behaviors in adult animals.
A study presented at the American College of Cardiology's Annual Scientific Session found that young adults prescribed ADHD stimulants were significantly more likely to develop cardiomyopathy. The overall risk remained low, but researchers suggested further studies could identify subgroups at greater risk.
Research found a significant increase in cardiovascular disease deaths related to substance use, particularly among young adults and certain racial and ethnic groups. The study highlights the need for comprehensive public health efforts to address substance use and its impact on heart health.
Researchers adapted a COVID-19 collaboration to monitor near-real-time trends in substance use-related hospital and emergency department visits. Detailed data shows large increases in methamphetamine- and opioid-involved hospital and ED visits among Native American, Black, and multiple-race populations.
A micro-longitudinal study found financial traders use caffeine and alcohol to regulate their sleep patterns. This self-medication approach balances the stimulating and sedating effects of these substances.
A new meta-analysis suggests that high-dose prescription psychostimulants like methylphenidate and dextroamphetamine can lower cravings and reduce stimulant use in people with amphetamine-type stimulant use disorder. The study analyzed ten randomized controlled trials and found that effects may increase with higher dosage.
US overdose deaths involving fentanyl and stimulants increased 50-fold from 2010 to 2021, with stimulants becoming most common drug class found in fentanyl-involved overdoses. The trend disproportionately affects racial/ethnic minority communities, particularly Black and African American people.
US overdose deaths involving fentanyl and stimulants have increased by 50-fold since 2010, with stimulants becoming the most common drug class found in fentanyl-involved overdoses. The rise poses new challenges for healthcare providers due to the complexity of treating polysubstance use.
Sahmyook University researchers discovered a correlation between methamphetamine-induced behavior and the expression of specific genes in mice models lacking Period 2 gene. They identified 19 genes that were activated only in response to repeated doses of methamphetamine.
A French study found that recreational drug use was associated with a nearly 9-fold higher rate of death or need for emergency intervention in cardiac intensive care patients. The study detected various substances in 1 in 10 patients, with cannabis being the most frequently detected substance.
Researchers found that blocking dopamine transporters during mid-adolescence increases adult aggression, impulsivity, and the behavioral response to amphetamine in mice. Artificially stimulating dopaminergic neurons also exacerbated impulsive behavior in tasks. The study suggests potential harm from stimulant exposure in healthy teens ...
The Canadian Medical Association Journal recommends prescribing psychostimulants to help reduce illegal stimulant use. This approach is based on growing evidence from clinical trials in Australia, Europe, and the United States. Implementing this practice can help address the ongoing unregulated drug poisoning crisis in Canada.
Researchers at the University of Pittsburgh School of Medicine found no evidence that prescription stimulant treatment in childhood increases the risk of substance use disorder (SUD) later in life. The study, published in JAMA Psychiatry, suggests that stimulants are an effective treatment for ADHD with few side effects.
A study by Penn State researchers found that minority communities bore the brunt of the opioid crisis, with Black men and American Indian/Native Alaskan men and women disproportionately affected. The researchers suggest that race- and gender-specific interventions may be more effective in preventing overdose deaths.
A new study analyzing death records data found that men had a 2–3 times greater rate of overdose mortality from opioids and psychostimulants. The researchers noted that biological, behavioral, and social factors likely combined to increase the mortality risk for men.
A new study found a strong association between the prevalence of prescription stimulant therapy for ADHD and rates of prescription stimulant misuse among middle and high school students. Schools with higher numbers of students on stimulant therapy had significantly higher rates of misused stimulants, highlighting the need for education...
Researchers found evidence of ancient drug use in Europe using human hair analysis, revealing the presence of scopolamine, ephedrine and atropine in Bronze Age containers from Menorca. The substances may have been derived from nightshade plants used in shamanic rituals.
A dramatic rise in unregulated amphetamine use has been observed in Ontario's emergency departments, with a nearly 15-fold increase in ED visits between 2003 and 2020. Individuals accessing EDs for amphetamine-related concerns grew from 233 to 4,146 annually by 2020.
Researchers investigated psychostimulants' effects on dopamine transporter, discovering persistent binding determines sustained effects. The study found that varying binding times between substances result in different durations and intensities of effects.
A new WVU study found nearly one in eight West Virginia infants had in utero exposure to opioids, stimulants, and/or cannabis between 2020 and 2022. The study showed a 40% increased risk of preterm birth among infants exposed to stimulants alone and a 70% increase with concurrent stimulant and cannabis exposures.
Researchers have created a chemical compound, Pillar[6]MaxQ (P6AS), which can counteract the effects of fentanyl and methamphetamine in lab experiments. The compound works as a molecular container, binding to drugs and reversing their biological properties.
The prevalence of methamphetamine-associated heart failure is rising worldwide, affecting a wide range of socio-economic and racial groups. Meth users are more likely to develop severe disease, with longer hospital stays and readmissions, compared to non-users.
A research team has identified a specific cell group in the brain that regulates shifts in the sleep-wake rhythm caused by psychostimulants. The hypothalamic dopamine locus is responsible for modulating circadian rhythms and gates the effect of psychostimulants, leading to increased alertness and activity.
A new study by Human Brain Project researchers unravels the mechanisms of psychostimulants like methylphenidate on attention and learning. The findings suggest that dopamine enhances task-relevant cortical signals, explaining variability in drug's cognitive effects across individuals.
A new study by Northwestern University predicts a worsening wave of opioid overdoses globally, with no geographic distinction between rural and urban areas. The lethal combination of synthetic opioids and stimulants like cocaine and methamphetamines will be particularly deadly.
A study published in the Journal of Marketing found that drinking caffeinated beverages before shopping leads to more items purchased and increased spending, particularly for high hedonic products. The researchers also discovered that the effects of caffeine are stronger for certain types of products and weaker for others.
Researchers discovered that blocking certain acetylcholine receptors in the lateral habenula balances reward and aversion, making it harder to resist seeking cocaine. This finding identifies a new role for these receptors as a potential target for treating cocaine use disorder.
The University of Rochester Recovery Center of Excellence brings together diverse experts to discuss strategies for overcoming stigma and health inequity barriers to substance use disorder care. The summit aims to address the 'fourth wave' of the opioid epidemic, driven by synthetic opioids and multiple substances in combination.