Articles tagged with Adverse Reactions
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A recent review found that over-the-counter head lice treatments have declined in effectiveness, likely due to widespread use leading to pyrethroid resistance. Prescription products such as malathion and spinosad are safer alternatives with proven efficacy.
Researchers have identified gene variants associated with a serious adverse reaction to antithyroid drugs used for hyperthyroidism treatment. The study found that certain immune genes increase the risk of agranulocytosis, a life-threatening condition.
A study found significant racial disparities in adverse reactions to the medication allopurinol, which is commonly prescribed for gout. The risk of severe cutaneous adverse reactions was 12 times higher for Asian patients and 5 times higher for black patients compared to white patients.
Researchers found that St John's Wort produces the same adverse reactions as antidepressants, including anxiety, panic attacks, and dizziness. The study highlights the need for people to seek advice from qualified healthcare practitioners when using herbal medicines like St John's Wort.
A study found that genetic variants of the CYP2C gene, including CYP2C9*3, are associated with severe cutaneous adverse reactions to phenytoin. Delayed clearance of plasma phenytoin was detected in patients with these reactions, suggesting a clinical link between the variants and the disease.
A recent study by NJIT Assistant Professor Mei Liu has validated previously reported adverse drug reactions and identified new ones using data mining from electronic medical records (EMRs). The research correlated abnormal laboratory results with specific drug administrations to detect adverse reactions.
A study by Brigham and Women's Hospital found that over 90% of patients who stopped taking statins due to adverse reactions were able to tolerate them again. The researchers examined clinical data from over 107,835 patients and identified a pattern where most people who experienced symptoms or events related to the drug stopped taking ...
A new study published in the Journal of Rheumatology shows that KRYSTEXXA significantly improves pain, physical function, and health-related quality of life in adult patients with refractory chronic gout. The treatment resulted in clinically meaningful improvements in these areas compared to placebo.
A Michigan State University study found that only 50% of patients looked directly at the warning labels, highlighting the need for redesign. Researchers suggest moving warnings to the main label or repositioning them for better visibility, especially for older patients who take multiple medications daily.
Trimethoprim-sulfamethoxazole, a widely prescribed antibiotic, can cause life-threatening reactions and kidney issues due to drug interactions. Physicians should be aware of these risks when prescribing the drug, especially in pregnant women or patients with underlying conditions.
Researchers found that 51% of all ADRs among adult out-patients were preventable, with a higher rate among the elderly. Preventable ADRs can take many forms, including internal bleeding and gastrointestinal bleeding.
A study by Asita De Silva and colleagues found that low-dose adrenaline given before antivenom treatment significantly reduces acute severe reactions in snakebite patients. This finding highlights the importance of improving antivenom quality in countries where snakebites are common.
A recent study published in the Journal of the American Geriatrics Society found no association between frailty and an increased risk of adverse drug reactions among elderly patients. Instead, researchers discovered that the greatest risk factor for adverse reactions was the number of new medications recently added to a patient's regimen.
A new study published in CMAJ found that people over 65 undergoing latent tuberculosis infection therapy are at a higher risk of severe adverse reactions requiring hospitalization. The study provides age-stratified estimates of the risk of these events, accounting for comorbidities and similar health events in the general population.
The European Medicines Agency (EMA) has faced criticism for refusing to release documentation on severe adverse reactions, despite a complaint from a father who lost his son to a drug. The EMA's handling of licensing decisions and transparency is being questioned, with some experts calling for more openness.
A recent study published in the American Journal of Roentgenology found that acute adverse reactions from gadolinium-based contrast agents used during MRI are rare, occurring in only 0.16 percent of all administrations. The majority of reactions were mild, while six moderate and two severe reactions were reported.
Research finds that long-distance travel significantly increases the risk of venous thromboembolism, prompting recommendations for low-cost interventions. Stepped-dosing of efavirenz also decreases incidence and severity of neuropsychiatric adverse events while maintaining efficacy.
A major review found that only two per cent of paediatric drug trials had independent safety monitoring committees to detect adverse drug reactions. Clinical drug trials in children are essential for developing medicines and treatments, but greater safety measures and awareness are needed.
A review of over 700 pediatric drug trials found that only 13 studies had independent safety monitoring committees. The trials reported various adverse events and reactions, highlighting the need for greater safety measures and awareness in clinical trials involving children.
A Taiwanese study suggests that Four-Agents Decoction, an 800-year-old traditional Chinese herbal formula, may exhibit a beneficial effect on primary dysmenorrhea after extended treatment. However, the study did not detect significant pain reduction in the initial cycle. The authors recommend further research with larger sample sizes a...
A study by the University of Alberta finds that adverse reactions to natural health products are being under-reported, with only 1.5% of pharmacists reporting suspected events to Health Canada. The lack of data on interactions makes it difficult to provide useful advice for managing adverse reactions.
A UK study found that BBC Panorama programmes airing in 2002-04 led to a marked increase in reported adverse drug reactions for paroxetine, an SSRI used to treat depression. This effect was short-lived and less pronounced after regulatory announcements.
A study of 37,901 civilians who received smallpox vaccine between 2003 and 2004 found 822 reports of adverse events, with 100 serious cases reported. No preventable life-threatening adverse reactions were identified, highlighting the effectiveness of vaccination screening and education.
The updated data show that 51% of patients originally assigned to the Betaseron 250 mcg group can walk with or without assistance, compared to 45% in the placebo group. Additionally, 95% of patients in the Betaseron 250 mcg group are still alive after 16 years, compared to 83% in the placebo group.
The Research on Adverse Drug Events and Reports (RADAR) Project has identified serious adverse drug reactions with 14 commonly prescribed drugs and cardiac stents, affecting almost 1,700 patients. RADAR reviews have been published in leading medical journals and have helped save hundreds to thousands of patient lives.
A genetic marker has been identified that predicts with 100% accuracy individuals at risk of severe adverse reactions to the anti-epilepsy drug carbamazepine. This discovery highlights the promise of pharmacogenomics in avoiding serious side effects and may lead to advances in clinical trials for new drugs.
A recent study highlights the importance of nurses in reporting adverse drug reactions (ADRs). The research found that the proportion and quality of reports received from nurses were similar to those from doctors. This suggests that nurses can play a valuable part in enhancing pharmacovigilance within the UK.
A study by Dr. David Veenstra at the University of Washington identified two genetic variants associated with an increased risk of severe bleeding incidents in patients taking warfarin. Patients with these variants required longer time to achieve stable dosing, suggesting potential for dose adjustment and closer monitoring.
Georgetown University Medical Center's research found that 53% of medical schools lack training in clinical pharmacology and adverse drug reactions for third- and fourth-year students. Most residency programs offer lectures on the topic but have limited reporting of adverse events.
A study found that UK family doctors under-report suspected adverse drug reactions, with only 9% of events reported to the CSM. However, serious events were five times more likely to be reported than non-serious ones.
A new agency is proposed to enhance postmarketing surveillance and dissemination of information on adverse drug reactions. The current system relying on pharmaceutical companies' voluntary warnings may not be adequate, highlighting the need for a parallel agency to protect patients.
A study found that 74% of patients taking Ziagen/Combivir had viral loads below 400 copies/ml at 24 weeks, compared to 57% on the PI-containing regimen. Patients on Ziagen/Combivir also reported fewer difficulties with their triple regimen. The study assessed efficacy, safety, and patient adherence in therapy-naive patients.
Researchers may consider a new concept proposing the immune system responds only to foreign substances causing damage, rather than traditional views. This approach could lead to better understanding of hypersensitivity reactions and development of predictive tests for drug interactions.
The FDA analyzed 94,120 adverse event reports on silicone gel breast implants from 1984-1995. Reports increased significantly after media coverage in 1991-1992, with a shift towards more complex and varied symptom reports.