Arteriosclerosis
Articles tagged with Arteriosclerosis
A hidden switch in artery cells fuels plaque instability in atherosclerosis
Researchers identified interferon regulatory factor 7 (IRF7) as a central regulator of smooth muscle cell plasticity in atherosclerosis. This transition accelerates plaque growth and destabilization, offering new insight into the risk of plaque rupture and cardiovascular events.
Family Heart Foundation teams up with former NFL quarterback Matt Hasselbeck to launch “tackle cholesterol™: Get into the LDL Safe Zone®”
The Family Heart Foundation, led by Matt Hasselbeck, aims to educate Americans about the risks of high LDL cholesterol and its connection to early heart disease. The campaign promotes free at-home screenings and offers support for individuals to protect themselves and their families from cardiovascular disease.
Scientists uncover how immune cell “fuel” shapes atherosclerosis
Two studies reveal that insufficient glutamine in macrophages drives atherosclerosis progression. Researchers identified new ways to detect high-risk plaques using protein markers like TREM2 and SLC7A7, which could lead to PET imaging and blood tests for early detection.
Breakthrough nanomedicine mPEG@ELA-11 shows promise in atherosclerosis treatment
Researchers have developed a novel nanomedicine, mPEG@ELA-11, which demonstrates significant potential in treating atherosclerosis by suppressing macrophage foam cell formation and inflammation. The study found that mPEG@ELA-11 reduces atherosclerotic plaque area and necrotic core size compared to free ELA-11.
Landmark study reveals hidden frailty crisis in young heart attack patients
Researchers have identified a distinct type of frailty in younger people driven by cardiovascular and metabolic illnesses, leading to poor outcomes and premature death. The study calls for routine frailty assessments in all heart attack patients, regardless of age.
New CAR T strategy targets most common form of heart disease
Researchers have developed a new CAR T cell therapy that targets the underlying cause of atherosclerosis, the most common form of heart disease. The treatment has shown significant promise in mice, reducing arterial plaque buildup by over two-thirds.
‘Artery on a chip': 3D printed blood vessels could unravel secrets of strokes
Researchers created a miniaturized replica of carotid arteries using 3D printing, mimicking the geometry and fluid dynamics of human blood vessels. The model revealed that platelet movement is crucial in blood clot formation, and high stress on blood vessels triggers significant platelet activity.
Study links genetic variants to higher 'bad' cholesterol and heart attack risk
A new resource identifies genetic variants associated with elevated 'bad' cholesterol, a major contributor to heart disease. Clinicians can now predict patient risk for heart attacks and strokes, allowing for prevention and early treatment.
CRF and Fogarty Innovation announce strategic merger
The merger strengthens CRF's leadership in medtech, integrating Fogarty's expertise in early-stage innovation. The unified platform will accelerate breakthroughs into patient care, driving global progress in cardiovascular medicine.
Family Heart Foundation announces recommendations to improve universal screening for underdiagnosed genetic condition in children, which causes early onset cardiovascular disease
A multidisciplinary panel published in the Journal of Pediatrics advocates for accelerated diagnosis of familial hypercholesterolemia, a life-threatening genetic condition. Universal lipid screening is recommended to identify affected children at high risk of heart disease decades earlier than those without the condition.
After weight loss regular exercise rather than GLP-1 weight-loss drug reduces leading cause of heart attack and strokes
A randomised trial found that regular exercise reduced inflammation and improved endothelial function, leading to lower risk of heart attack and strokes. Exercise maintained weight loss without GLP-1 receptor agonist liraglutide.
Graz researchers discover what stiffens the aorta
Graz researchers investigate homocysteine's impact on the aorta, finding elevated levels lead to stiffer and less elastic vessels. This discovery contributes to understanding of cardiovascular diseases like atherosclerosis.
CRF announces TCT 2025 late-breaking clinical trials and science
Late-breaking clinical trials and science at TCT 2025 will present pivotal data on novel therapies, devices, and techniques aimed at preventing and treating cardiovascular conditions. The symposium delivers high-impact findings that shape clinical practice and enhance outcomes for patients with heart and vascular disease.
Two decades of progress in heart failure care
The American Heart Association's Get With The Guidelines - Heart Failure registry reveals lasting benefits for hospitalized heart failure patients and hospitals. Hospitals engaging with the program consistently outperform peers on process measures and patient outcomes.
Study links residual inflammation in psoriasis patients to obesity and fatty liver disease
Researchers found that residual inflammation in psoriasis patients is linked to obesity, metabolic dysfunction, and increased systemic inflammation. This study suggests that despite good skin response to biologics, patients may still exhibit broader health implications, such as cardiovascular disease and fatty liver disease.
Family Heart Foundation announces results of real-world study in 273,770 individuals with cardiovascular disease demonstrating that risk of subsequent cardiovascular event increases with rising lipoprotein(a) levels
A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.
TCT 2025 Master Operator Award to be presented to Kenneth Rosenfield, MD, MSc
Dr. Kenneth Rosenfield is a distinguished interventional cardiologist recognized for his seminal work in endovascular therapy and pioneering innovative techniques. He has made significant contributions to the field of vascular medicine, including the development of self-expanding stents and drug-coated balloons.
TCT 2025 Career Achievement Award to be presented to Stephan Windecker, MD
Stephan Windecker, a world-renowned cardiologist, will be honored with the TCT 2025 Career Achievement Award for his extraordinary contributions to interventional cardiology. His extensive research has shaped clinical practice worldwide and influenced the future of cardiovascular medicine.
New York Valves: The Structural Heart Summit is back!
The summit features live case demonstrations, interactive debates, hands-on training, and the latest evidence-based practices in structural heart care. Attendees will witness innovation in action, exploring breakthroughs in surgical techniques, transcatheter interventions, and personalized treatment strategies.
Ozone exposure linked to hypoxia and arterial stiffness
Researchers found that brief ozone exposure reduces blood oxygen saturation, triggers hypoxia-related biomarkers, and increases arterial stiffness. Ozone pollution is a worldwide health issue, linked to increased risk of cardiovascular diseases.
MMRI scientist publishes breakthrough study detailing how ketones improves blood flow to the heart
A recent study published by Dr. Matthew Nystoriak of Masonic Medical Research Institute has uncovered groundbreaking insights into heart health. Elevated levels of β-hydroxybutyrate, a ketone body produced by the liver, have been shown to improve cardiac blood flow and reduce ischemic heart disease.
Persistent racial disparities in vascular surgery outcomes
A recent study published in the Journal of Vascular Surgery found that non-white patients have twice the risk of dying within 30 days of carotid endarterectomy compared to white patients. The study analyzed data from over half a million patients and highlights persistent racial disparities in medical outcomes.
High blood pressure reduces respiratory capacity owing to hardening of bronchi, study shows
A Brazilian study found that high blood pressure hardens the bronchi and increases airway resistance, reducing respiratory capacity. Regular physical activity may partially protect against this hardening.
Compact “gene scissor” enables effective genome editing
Researchers developed a compact 'gene scissor' tool, TnpB, which shows a 4.4-fold increase in efficiency of modifying DNA, making it more effective as a gene editing tool. The tool can be used to treat patients with familial hypercholesterolemia, reducing cholesterol levels by nearly 80%.
Metal exposure can increase cardiovascular disease risk
A study published in JACC found that metal exposure is associated with progression of plaque buildup in the arteries, comparable to traditional risk factors like smoking and diabetes. The findings support considering metal exposure as a significant risk factor for atherosclerosis and cardiovascular disease.
A heart of stone: Study defines the process of and defenses against cardiac valve calcification
Researchers discovered a step-by-step process of calcification in aortic valves, revealing two defense mechanisms: osteopontin and collagen fibers. The study provides new insights into understanding cardiovascular calcification and potential therapeutic applications.
Study reveals how 'forever chemicals' may impact heart health in older women
Research from the University of Illinois has found a link between per- and polyfluoroalkyl substances (PFAS) and cardiovascular diseases in postmenopausal women. The study reveals how PFAS chemicals interact with pro-inflammatory pathways, providing potential explanations for the increased risk.
Google Street View reveals how built environment correlates with risk of cardiovascular disease
Researchers used Google Street View to analyze built environment factors and found they can predict 63% of coronary heart disease variation between neighborhoods. Features like green spaces and walkable roads are associated with lower risk, while poorly paved roads with higher risk.
Cleveland Clinic-led study discovers link between high levels of niacin - a common b vitamin - and heart disease
A recent study by Cleveland Clinic researchers discovered a connection between elevated niacin levels and an increased risk of heart disease. The study found that high levels of 4PY, a breakdown product from excess niacin, were strongly linked to the development of heart attacks and strokes.
Eating too much protein is bad for your arteries, and this amino acid is to blame
Researchers discovered that consuming over 22% of daily calories from protein can lead to increased activation of immune cells contributing to atherosclerotic plaque formation. Leucine, an amino acid found in animal-derived foods, plays a disproportionate role in driving pathological pathways linked to atherosclerosis.
Natto consumption suppresses arteriosclerosis
A study revealed that natto consumption significantly reduced atherosclerotic lesions in mouse models, altering intestinal microflora and regulating cytokine production. High vitamin K2 natto showed the most significant effect, decreasing pro-inflammatory cytokines while increasing anti-inflammatory IL-10 production.
Updated Canadian Cardiovascular Society Guidelines advise against routinely taking aspirin daily for primary prevention of heart attack or death but acknowledge there may be a role for some people
The Canadian Cardiovascular Society has updated its guidelines to no longer recommend routine daily aspirin use for primary prevention of heart attacks or death. However, daily aspirin may be considered for people with high risk factors for heart attack, such as diabetes, high cholesterol, and smoking. The new guidelines emphasize the ...
Abdominal aortic aneurysm: new treatment may reduce size; COVID infection may speed growth
Researchers found that immune-modulating cells may slow the expansion of bulges in the aorta by creating a less-inflammatory environment. A second study discovered evidence that a COVID-19 infection promotes the enlargement of abdominal aortic aneurysms, which are extremely dangerous and potentially fatal if they rupture.
Physical activity trajectories and functional recovery after stroke
A study of 1,300 participants found that increased physical activity 6 months after stroke was associated with better functional outcomes. Interventions targeting individuals with decreasing physical activity in the subacute phase may play a role in improved functional recovery.
New statement suggests more patients may benefit from surgery for pulmonary embolism
A new American Heart Association scientific statement suggests that surgery should be considered for patients with high-risk pulmonary embolism to improve survival rates. The statement also calls for increased research and data quality registries to better understand the disease process and effective treatments.
Family Heart Foundation study shows most familial hypercholesterolemia patients remain undiagnosed
A new analysis from the Family Heart Foundation shows that only 31.3% of individuals with familial hypercholesterolemia (FH) in its database had been diagnosed as of June 2020. This represents a significant increase since 2016, but highlights the ongoing challenge of diagnosing and managing the condition.
Revealing the individual immune cells inside the plaque that causes life-threatening heart attacks
A study by Kobe University researchers has illuminated the characteristics of Myeloid immune cells in coronary plaque, a major contributor to acute coronary syndrome. The findings suggest that macrophages and monocytes accumulate in the plaques of patients with acute coronary syndrome, leading to increased inflammation.
Understanding arteriosclerosis: How blood vessels restructure under pressure
High blood pressure can cause long-lasting changes in the structure of vascular smooth muscle cells, stiffening arterial walls and increasing the risk of cerebrovascular disease. Researchers found that a signaling pathway triggered by E–T coupling is involved in this process, leading to inflammation and vascular remodeling.
Could gene networks resembling air traffic explain arteriosclerosis?
A study suggests that nearly 60 percent of the risk associated with coronary artery disease may be explained by changes in hundreds of genes working together in networks across several organs. Fat processing hormones may play a central role in coordinating this activity.
New discovery on how omega-3 fatty acids can reduce atherosclerosis
Researchers at Karolinska Institutet discovered that omega-3 fatty acids activate the GPR32 receptor, which reduces inflammation in blood vessels and prevents atherosclerosis. This breakthrough discovery paves the way for new strategies to treat and prevent cardiovascular disease using omega-3 fatty acids.
Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders
A collaborative research group identified an inhibitor of the glutamate metabolic enzyme GLS1 that selectively eliminates senescent cells in vivo. Administration of GLS1 inhibitors to aged mice removed senescent cells from various organs, ameliorating tissue dysfunction and age-related diseases such as obese diabetes and arteriosclerosis.
Incretin hormone levels linked to arteriosclerosis
High levels of GIP are linked to an increased risk of early arteriosclerosis signs, while GLP-1 is associated with a lower risk. The study suggests a potential link between raised GIP levels and cardiovascular disease in diabetic patients, highlighting the need for further investigation.
Bathroom scales will inform about life threatening conditions
Researchers at Kaunas University of Technology are developing multifunctional scales to monitor health and detect potentially life-threatening conditions. The scales can measure arterial stiffness and even recognize the development of hyperkalemia, a condition that requires dialysis.
Danish researchers' breakthrough identification of important protein
Researchers from the University of Copenhagen have developed a secure way to measure the protein apo-M, which may hold clues to diseases such as multiple sclerosis, arteriosclerosis, and diabetes. The new method uses commercially available antibodies to unfold the protein's complex structure, making it easier to identify.
Inflammatory processes in arteriosclerosis revealed
New research from Karolinska Institutet reveals the role of substances like cytokines and leukotriene B4 in inflammation and arteriosclerosis. The study identifies three enzymes that contribute to the formation of LTB4, a powerful chemotactic substance that reinforces inflammation.
University of Pittsburgh study finds carbon monoxide has therapeutic benefits
Researchers found that exposing rats to low levels of carbon monoxide significantly reduced intimal hyperplasia and leukocyte accumulation, indicating a protective effect against arteriosclerosis. The study suggests potential therapeutic benefits for treating vascular diseases.
Vitamin supplementation could slow arteriosclerosis in heart-transplant patients
Researchers found that vitamin supplementation reduced intimal index growth after heart transplantation, a common cause of arteriosclerosis. Vitamin C and E also maintained stable coronary endothelial function.
Hardening of arteries is caused, not prevented by the protein Interferon-gamma, Yale study finds
A new study from Yale University reveals that interferon-gamma protein causes hardening of arteries, rather than prevents it. The research used an animal model to show that the protein leads to muscle cell growth and lesions in artery walls.