Articles tagged with Bacterial Infections
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A pioneering study has identified interleukin-6 (IL-6) as a powerful diagnostic biomarker for the early detection of sepsis in high-risk patient groups. IL-6 outperformed traditional biomarkers in distinguishing bacterial from non-bacterial infections and stratifying sepsis severity.
A new class of antibiotic has been shown to be effective in treating MRSA infections, with a daily dose of epidermicin NI01 demonstrating equal efficacy to the current standard of care. The findings justify further pre-clinical development and could lead to new gel-type therapies for skin infections.
Recent cases of multi-drug resistant cholera in the UK and Germany are linked to exposure to contaminated holy water from Ethiopia. The study found a connection between pilgrims consuming or bathing in the holy well and the spread of the disease.
A University of Ottawa-led team examines the punishing costs of TB care, finding that patients face 'catastrophic' expenses despite free treatment being available in many countries. The review identifies areas for intervention to reduce patient costs and improve sustainable TB mitigation strategies.
A study in the journal Cell Host & Microbe found that a diet rich in soluble fiber can protect against pathogenic bacteria like Clostridioides difficile. Consuming soluble fiber produces compounds like acetate, which regulates immune response and reduces inflammation.
Tulane University scientists developed a handheld device to deliver rapid and accurate tuberculosis diagnoses in under an hour. The device, called the lab-in-tube assay (LIT), can detect Mycobacterium tuberculosis DNA in saliva, blood, and sputum samples, offering a cost-effective tool for improving TB diagnoses in resource-limited areas.
A new artificial intelligence-based method detects genetic markers of antibiotic resistance in bacteria, potentially leading to faster and more effective treatments. The method, called Group Association Model, uses machine learning to identify key mutations linked to drug resistance, reducing false positives and misdiagnoses.
Researchers at La Trobe University have discovered how enteropathogenic E. coli (EPEC) bacteria use a molecular toxin called EspC to destroy gut cells. This breakthrough could lead to the development of targeted drugs to combat EPEC infections and their devastating consequences, including severe dehydration and death.
A study by Umea University researchers identifies genes in Staphylococcus aureus that confer immunity against virus infection, a key mechanism to understand antibiotic resistance. Understanding this system could help develop new treatments for serious infections.
A new study found that Clostridium difficile infection spreads more than three times more than previously thought within intensive care units, with bacteria moving between patients and hospital surfaces. The researchers tracked bacterial movement using whole genome DNA sequencing and discovered cases of potential transmission that woul...
Researchers created a bacterial evolutionary map that tracks plasmid gene exchange and identifies barriers to treatment. The study reveals new insights into the co-evolution of plasmids and E. coli strains, paving the way for targeted therapies against antibiotic-resistant infections.
A new study developed an AI model that can predict whether bacteria will become antibiotic-resistant by analyzing their genetic data. The model shows that antibiotic resistance is more easily transmitted between genetically similar bacteria and mainly occurs in wastewater treatment plants and inside the human body.
A research team has identified a previously unknown defense mechanism in Pseudomonas syringae, enabling the bacterium to produce chemical compounds that attract amoebae, which are then killed by toxic substances produced by the bacteria. This 'chemical radar' system also helps the bacteria infect plants in the presence of predators.
Researchers have identified a new class of antibiotic that targets Neisseria gonorrhoeae, the bacterium causing gonorrhoea. The novel substance uses a unique mechanism to activate a self-destruction program in gonococci, killing the bacteria without harming other microorganisms or human cells.
A new class of agents has been developed to inhibit hospital germs, particularly targeting the toxin α-hemolysin produced by Staphylococcus aureus. The compound H052 showed high effectiveness in cell culture and animal models, increasing survival rates in infected mice.
A study reveals that most Acinetobacter baumannii infections in a Malaysian hospital belonged to the Global Clone 2 lineage, which is also dominant worldwide. The majority of bacterial samples were resistant to multiple antibiotics, including carbapenems.
A new study found that reported tuberculosis diagnoses among incarcerated people in Europe and the Americas plummeted by up to 100% during the pandemic, despite consistent incarceration rates. This reduction was distinct from general population trends, highlighting the need for improved healthcare systems within prisons.
Researchers have studied the mechanism of action of bioactive compounds from papaya, passion fruit, and medicinal plant extracts. Modified pectins extracted from these plants show potential as supplements or food ingredients to boost biological activity against colon cancer and gut microbiota.
Researchers at Vanderbilt University Medical Center discovered how C. diff converts a poisonous compound into a usable nutrient, increasing its competitive advantage in the infected gut. The findings point to novel therapeutic strategies, including targeting the TudS enzyme to preserve healthy gut microbiota.
Childhood tuberculosis cases in the EU/EEA have increased by 26% over the past three years, with young children under 15 accounting for 4.3% of all TB cases. The rise in pediatric TB has raised concerns about incomplete treatment, drug-resistant TB, and further transmission.
A multicenter study found targeted next-generation sequencing to significantly outperform traditional culture methods in detecting urinary tract infections, including polymicrobial cases. The method's detection time was notably shorter, with high concordance rates for both culture-positive and negative samples.
Researchers have made progress in understanding how Streptococcus pneumoniae constructs its capsule, a critical target for vaccine development. The study identified three categories of transporters that facilitate sugar building block transport, with relaxed specificity transporters posing potential risks to bacterial growth.
Researchers discovered that a drug-resistant type of bacteria has adapted to produce antimicrobial genetic tools, eliminating its cousins and replacing them as the dominant strain. The finding validates a system developed at Pitt and UPMC for detecting infectious disease outbreaks.
The European Centre for Disease Prevention and Control (ECDC) reports a rise in tuberculosis cases among children and adolescents in the EU/EEA, with a slight increase in the notification rate from 2.0 to 2.5 per 100,000 population. The highest proportion of paediatric TB was observed in children aged 1 to 4 years old.
The Chinese Medical Association has released updated guidelines for pediatric mycoplasma pneumoniae infection, emphasizing a multi-faceted diagnostic approach and evidence-based treatment strategies. The guidelines highlight the importance of accurate diagnosis and responsible antibiotic use to combat rising resistance.
Researchers found that curcumin enhances the effectiveness of bedaquiline in combating M. abscessus infections, with the combination showing synergistic enhancement of antibacterial activity. The study suggests potential new treatment pathways for resistant infections, particularly in immunocompromised populations.
Researchers found that disrupting bacterial metabolism can help the body tolerate infection and heal more effectively. By inhibiting a specific metabolic pathway, they successfully reduced tissue damage in a mouse model of necrotizing skin infection.
Fidaxomicin and fecal microbiota transplantation are effective treatments for Clostridioides difficile infection, reducing recurrence rates. Emerging strategies like vaccines, bacteriophage therapies, and AI-based risk models hold promise for better management and prevention of CDI.
A study has established the importance of immunoglobulin A in generating a response to pneumonia vaccines. The research found that poor regulation of gut microbiota can lead to an inadequate immune response, leaving individuals vulnerable to respiratory infections.
Researchers have developed a new method to deliver antibiotics directly into the bladder tissue, eliminating over 90% of bacteria from the bladder. The nanogel-based drug delivery system shows promise in treating UTIs and could potentially lead to an eventual cure.
Researchers have discovered a family of genes essential for tuberculosis survival during airborne transmission, providing new drug targets. The study sheds light on the bacterium's protective mechanisms, which could prevent infection spread and treat existing cases.
Researchers at Weill Cornell Medicine and MIT discovered a family of genes necessary for tuberculosis bacteria to survive airborne transmission. These genes help the bacteria adapt to changes in temperature, oxygen levels, and humidity, providing new targets for therapies that could treat infection and prevent spread.
The Shimadzu – DxD Hub Diagnomics Centre aims to accelerate the development of high-quality, cost-effective diagnostic solutions. It focuses on three key areas: infectious diseases, cancer, and metabolic disorders, with efforts to develop solutions for early disease detection and precision medicine approaches.
A new study from Weizmann Institute of Science reveals an immune mechanism involving proteasome products, which can kill bacteria and offer a promising treatment for infections. The researchers discovered that certain peptides produced by the proteasome have antibacterial properties and can be used to develop personalized treatments.
Professor Robert T. Schooley will present a talk at the 8th World Congress on Targeting Phage Therapy, exploring phage therapy advancements and necessary steps for widespread adoption. The congress will gather experts to discuss latest advances, challenges, and clinical applications of bacteriophage therapy.
A novel therapeutic strategy for superbug infections has been discovered using the siRNA-AGO2 complex. This complex inhibits bacterial gene translation by delivering AGO2-loaded siRNA into bacterial cytoplasm, downregulating resistance genes and converting multidrug-resistant bacteria into methicillin-sensitive ones.
A new study by Weill Cornell Medicine researchers has identified a potential biomarker for joint inflammation in Crohn's disease patients, the bacterium Mediterraneibacter gnavus. The study found that M. gnavus is associated with increased immune cell responses and disease activity scores in patients with joint inflammation.
A study by Flinders University found that certain bacteria in the throat may indicate greater health vulnerability in older adults. The presence of Staphylococcus aureus was linked to higher mortality rates, even after adjusting for other health factors.
Researchers developed a synthetic microbiome therapy using limited strains of gut bacteria to effectively protect against C. difficile infections in mice. The treatment was as effective as traditional fecal transplants and had fewer safety concerns, offering a new alternative for treating this notoriously difficult-to-treat infection.
Researchers discovered that erucamide inhibits Type III Secretion injectisome assembly in Gram-negative bacteria, enhancing plant immunity and reducing disease susceptibility. Exogenous application of erucamide protects crops from bacterial diseases, offering a potential biopesticide for sustainable agriculture.
Researchers at Kyoto University investigated the effects of two-hit stress on mouse behavior, revealing significant changes in the cerebellum. The study found increased microglia turnover, neuronal loss, and decreased brain connectivity, correlating with anxiety-like behaviors and mental disorders.
The University of Cambridge has launched an Engineered Pandemics Risk Management Programme to address the urgent challenge of managing future engineered pandemics. The programme aims to build a network of experts from academia, government, and industry to understand social and biological factors that drive engineered pandemic risks.
Researchers studied how bacteria like Klebsiella pneumoniae cause systemic infection by tracking its movement in mouse models using a barcoding system. They found that bacteria can spread through two routes: metastatic dissemination and direct dissemination, with the former correlating to a stronger infection.
A pioneering study identified a crucial interaction between Helicobacter pylori and non-H. pylori bacteria in pre-cancerous stage of gastric cancer. Researchers found that bacterial leakage into deeper gastric tissues may represent a previously overlooked factor in cancer progression.
Researchers at Weill Cornell Medicine develop two strains of mycobacteria with 'kill switches' that can be triggered to stop the bacteria after they activate an immune response. The new approach aims to accelerate vaccine development and overcome safety concerns.
Scientists discovered that specific gut cells, BEST4/CA7+ cells, regulate electrolyte and water balance in response to bacterial toxins. These cells greatly increase in number when exposed to interferon-γ, presenting a potential target for therapies.
A recent study found a significant negative correlation between neutrophil-to-lymphocyte ratio (NLR) and the risk of tuberculosis infection, especially in males and individuals with hypertension. NLR may serve as a biomarker for assessing TBI risk.
A groundbreaking study published in eBioMedicine has shown that a new mRNA vaccine is effective in boosting immunity against tuberculosis. The vaccine demonstrated potent immune responses in infected mice and improved long-term protection when combined with the BCG vaccine.
Swimming in lakes with still water can lead to infection with Legionella bacteria, causing pneumonia. Risk factors include age over 50, smoking history, and compromised immune systems. Clinicians should suspect legionnaires' disease in patients with severe pneumonia and recent travel history.
Researchers at Virginia Tech have developed a method to convert gut bacteria into mini protein factories that produce and release sustained flows of targeted proteins within the lower intestine. This approach eliminates a major roadblock in delivering drugs to this part of the body, offering potential treatment for chronic diseases.
Researchers developed novel antibiotic BTZ-043 to target drug-resistant tuberculosis. The study showed that BTZ-043 effectively penetrates TB lesions and accumulates there in high concentrations, making it a promising treatment option for TB patients.
A study found that even with impeccable cleaning, hospital sink drains can host bacterial populations that change over time. Dominant species include Stenotrophomonas and Pseudomonas aeruginosa, known to cause ventilator-associated pneumonia and sepsis.
Researchers at Salk Institute discover SSRIs like Prozac regulate immune response, preventing sepsis in mice. The findings suggest a potential new use for the popular drug, which could lead to life-saving treatments and enhanced global preparedness for pandemics.
Researchers found that people with diabetes are more likely to develop antibiotic-resistant strains of Staphylococcus aureus, which can spread rapidly and evade treatment. Controlling blood sugar levels through insulin use may be key in preventing antibiotic resistance.
Researchers at Virginia Tech have developed a way to convert gut bacteria into miniature protein factories that produce and release targeted proteins inside the lower intestine. This breakthrough could potentially treat chronic diseases.
A new retrospective study found that nearly half of patients with fever of unknown origin in sub-Saharan Africa had a detectable pathogen, including bacterial strains and hemorrhagic fever viruses. The study highlights the need for strengthened laboratory capacity to improve diagnosis and treatment.
Researchers at Texas A&M University have developed a low-cost technology using curcumin to curb bacterial resistance. The study shows that photodynamic inactivation can trigger deleterious reactions within bacteria, killing them and reducing the number of antibiotic-resistant strains.
A global 'sisterhood' of citizen scientists sheds light on the complex vaginal microbiome, highlighting associations between microbial composition and clinical conditions like preterm birth and urinary tract infections. The study emphasizes the importance of considering whole complexity and continuity in vaginal microbiota composition ...
Researchers at UCSF have discovered how a unique type of virus called a jumbo phage protects itself inside bacteria. The shield works via a set of secret handshakes that allow only useful proteins to pass through, giving the phage an advantage over regular phages when fighting infections.
Researchers developed a next-generation technology, MycoBCP, using artificial intelligence to screen for antimicrobial compound candidates. This method has already vastly accelerated the team's TB research capabilities and helped identify optimal candidate compounds for drug development.