Articles tagged with Bacterial Infections
A computer simulation found that health care facilities using a patient registry could reduce CRE spread by 15.5% over three years, even with modest participation rates. The study suggests that maintaining a registry can help contain the enemy of antibiotic-resistant bacteria.
A 15-year-old girl with cystic fibrosis was treated with genetically engineered bacteriophages to combat a life-threatening, drug-resistant infection. The treatment led to the clearance of skin nodules and improvement in liver function, demonstrating the safety and effectiveness of phage therapy.
A team of researchers at POSTECH has developed a fluorescent probe called BacGo that can detect Gram-positive bacteria precisely and promptly. The probe is more sensitive than the traditional Gram staining method, which has several limitations, including slow detection and limited selectivity against Gram-positive bacteria.
Researchers developed a microchannel trapping device to detect bacteria in patient samples quickly, reducing testing time from days to minutes. The device can classify bacteria into three main shapes and identify antimicrobial susceptibility directly from clinical samples.
Researchers at the University of Sheffield have discovered a mechanism used by bacteria E. faecalis to hide from the immune system, paving the way for new treatments. The study found that the bacteria modifies its cell surface to evade recognition by host immune cells.
Fecal transplants could block C. diff's spore from germinating and propagating disease via its toxins, repopulating the gut with diverse microbes. However, current fecal transplant products are not FDA-approved, and patients should refer to clinical trials instead.
A new triplex TaqMan assay has been developed to improve the reliability of Xylella fastidiosa diagnostics, targeting two loci for increased specificity. Next-generation sequencing technology was also used to analyze DNA extracts from infected and healthy plants.
Researchers identified a new way C. difficile causes severe disease by triggering an immune response through Th17 cells, explaining why patients with inflammatory bowel disease are more susceptible to severe infections and increasing mortality rates.
Researchers found that a 'superbug' clone of E. coli called ST131 has evolved to prevent itself from becoming the sole dominant clone, allowing it to colonize the human gut more competitively than other strains. The discovery provides insight into how this process happens and may help develop strategies to prevent it.
Researchers have identified a gut microbe, Mucispirillum schaedleri, that helps protect against Salmonella infections. The bacterium competes with Salmonella for nutrients, such as nitrate, and prevents the growth of pathogens by reducing their ability to express virulence factors.
Researchers estimated that bacterial infections resistant to antibiotics resulted in a 20% higher death rate and an additional €1100 hospital stay cost. Infections accounted for 12% of all hospitalizations, with the majority caused by E.coli, MRSA, and P.areuginosa.
Researchers at North Carolina State University discovered that key cell-killing proteins can block certain bacterial infections like Listeria without harming the host cells. The RIPK3 and MLKL proteins recognize the bacteria's chemical composition and bind to it, preventing its spread while keeping the host cells alive.
Certain bacteriophages exacerbate bacterial infections in cystic fibrosis patients, particularly with Pseudomonas aeruginosa. These phage-carrying bacteria are more resistant to standard antibiotics, highlighting potential therapeutic targets.
A genomic study of a 1980s hospital outbreak in Wisconsin reveals how Enterococcus faecalis bacteria adapts to the modern hospital environment and causes repeated antibiotic-resistant bloodstream infections. Researchers identified mutations that allow the bacteria to resist antibiotics and develop new strategies for prevention and trea...
Researchers discovered a link between filamentous phages and antibiotic-resistant Pseudomonas aeruginosa infections in cystic fibrosis patients. The viruses form biofilms that sequester antibiotics, allowing resistant bacteria to thrive.
Researchers found a new, more powerful variant of an antimicrobial resistance gene in Staphylococcus epidermidis, making it harder for the bacteria to be killed by chlorhexidine bathing. The discovery was an unexpected result of a study on central venous catheter infections.
Researchers discovered a gene that enables bacteria to resist linezolid in cats and dogs at a UK animal hospital, suggesting potential transmission between animals and humans.
A study of 230 travelers found that staying in hotels increases the risk of contracting multi-drug resistant bacteria by four times. Younger travelers aged 20-30 are particularly at risk, and people visiting certain regions face a higher risk of infection with ESBL-producing Enterobacteriaceae.
A new study found low hand hygiene compliance on ICUs, with healthcare workers more likely to move from dirtier to cleaner tasks, increasing the risk of transmitting infections to patients. Interventions should teach workers to move in the opposite direction to minimize risks.
A new study found that nearly a third of hospital room surfaces had antibiotic-resistant bacteria on them, suggesting rapid transmission from patients to their environment. The research team suggests expanding hand hygiene efforts to include patients, as healthcare workers' hands remain the primary mode of microbe transmission.
A majority of reusable tourniquets inspected contained microbes that could compromise patient safety and care quality. The most prevalent contaminant microorganism was coagulase-negative staphylococci, found on 441 of the analysed tourniquets.
Researchers at Lund University developed a new approach to treating bacterial meningitis by cutting up neutrophil extracellular traps (NETs) with DNase, exposing bacteria to the immune system and antibiotics. This method has shown promise in reducing bacterial loads without antibiotic intervention.
A genetic study of an outbreak of Enterococcus faecalis revealed how the organism became resistant to new antibiotics and adapted to infect human blood. The research identified multiple mutations that enabled the bacteria to resist host immune systems and antibiotics.
A new study reveals how Salmonella bacteria flip an electric switch within immune cells, causing them to migrate out of the gut and into the bloodstream. This mechanism contributes to the severity of food-borne illnesses, with over 400,000 deaths worldwide each year.
Researchers found that three closely related species of bacteria outlived other oral bacteria in a 'doomsday' experiment, surviving for over 100 days without nutrients. The discovery sheds light on how certain pathogens persist in hospital environments and can cause infections.
A cluster of four NYC hospital patients harboring highly resistant E. coli with the MCR-1 gene were identified, highlighting the risk of spread and need for ongoing surveillance of this rare antibiotic resistance gene.
A mass drug administration study in the Solomon Islands found a 90% reduction in scabies cases and a 75% decrease in impetigo cases after treating entire communities. The strategy is effective in reducing both diseases, especially in children aged five to nine years old.
A study led by Case Western Reserve University aims to identify genetic biomarkers for corneal ulcer infections, which can lead to blindness. The research focuses on contact lens wearers and will explore the genetic profile of those who contract infections versus those who don't.
Researchers at Purdue University have discovered that blue light can render MRSA bacteria defenseless against antiseptics like hydrogen peroxide. This new method uses photobleaching to reduce pigment production in the bacteria, making it a promising alternative to traditional antibiotics.
A plant pathologist at UC Riverside has secured a $4 million grant from the USDA to develop a cure for citrus-destroying disease. The research focuses on a novel class of peptides that can directly kill the bacteria and protect healthy trees from infection, offering hope for California's multibillion-dollar citrus industry.
Researchers tracked the spread of K. pneumoniae bacteria in a Beijing hospital and found they were highly transmissible and adaptable to antibiotics. The study highlights the importance of genomic data in understanding multi-drug resistant infections, which are predicted to rise to 10 million per year by 2050.
Researchers studied viruses that infect pathogenic bacteria called bacteriophages to develop a vaccine against bacterial infection. They found that some bacteriophages induce an anti-viral response in humans, which can hinder the clearance of bacterial infections.
Researchers found a link between 'leaky gut' and autoantibody production in HIV-positive patients, with high levels of Staphylococcus products in the blood. A 'leaky gut' allows bacteria to enter the bloodstream, triggering an immune response that can lead to autoimmunity.
A Stanford study finds that a bacterial pathogen produces a virus that increases its ability to infect humans and causes the immune system to mount an antiviral response. The discovery could lead to new ways of preventing chronic infections by keeping antibiotic-resistant bacteria from getting a foothold in wounds.
Researchers found that populations with high HIV/AIDS prevalence are more susceptible to antibiotic-resistant bacterial infections due to frequent antibiotic use. This increases the risk of drug-resistant diseases, posing a serious public health threat worldwide.
Researchers at Stevens Institute of Technology have developed a self-defensive surface for medical implants that releases micro-doses of antibiotics when bacteria approach. The microgels' behavior is regulated by electrical charges and can be applied to various medical devices, potentially reducing surgical infections.
Gram-negative bacteria's outer membrane is constructed with lipopolysaccharide (LPS) using an integral machine that builds each bacterium's powerful protection. Researchers have discovered how LPS gets to the outer membrane, including a protein bridge and ATP shuttling mechanism.
A study found considerable microbial colonization in ball pits, including bacteria and yeast that can cause disease. The research highlights the need for regular cleaning protocols to reduce the risk of transmission of these organisms.
Researchers at Rice University suggest that fluctuating growth rates of bacteria can increase the time it takes to eradicate a bacterial infection, giving the surviving bugs a better chance to develop resistance. This approach could lead to more accurate dosing and improved treatment outcomes.
Researchers discovered a new mechanism by which influenza A viruses alter host immune systems, making them more susceptible to deadly bacterial infections. The PDZ-binding motif regulates cytokine production, controlling the severity of secondary bacterial infections.
The Infectious Diseases Society of America (IDSA) has released updated guidelines for asymptomatic bacteriuria (ASB), suggesting that testing should be limited to high-risk patients. This shift aims to reduce unnecessary antibiotic treatment and minimize the risk of promoting antibiotic resistance.
Researchers discovered drug-resistant E. faecium in untreated and treated wastewater from hospital sewage recipients, highlighting genetic relatedness to human disease-causing strains. Terminal ultraviolet light disinfection may reduce environmental contamination with these pathogens.
A multi-disciplinary team of researchers at Harvard's Wyss Institute for Biologically Inspired Engineering discovered four human microbiome metabolites that enhance colon injury by enterohemorrhagic E. coli (EHEC) in a human-mouse comparative study using Organ-on-a-Chip technology.
A recent study found that 39% of healthcare workers made errors in removing personal protective equipment (PPE), leading to contamination with multi-drug resistant organisms. The study suggests reevaluation of PPE removal strategies and education on proper techniques.
Researchers tested a silver- and ruthenium-based coating on the International Space Station, finding it highly effective in reducing bacteria growth by up to 80% compared to bare steel. The AGXX® coating may provide a solution to combating antibiotic-resistant superbugs in deep space missions.
A new study identifies CD40 as a key entry point for two dangerous bacteria, Staphylococcus aureus and Streptococcus pyogenes. Blocking the interaction between CD40 and superantigens may represent a universal strategy for preventing life-threatening illnesses.
A case study by North Carolina State University researchers reveals that an adolescent diagnosed with rapid onset schizophrenia was actually infected with Bartonella henselae, leading to full recovery after treatment. The discovery suggests a potential link between bacterial infections and mental disorders.
A study published in The Lancet Respiratory Medicine found that the composition of a child's nose microbiome is altered in cases of respiratory infections compared to healthy peers. This difference can predict disease severity, hospital stay duration, and likelihood of recovery without antibiotics.
A research team at Osaka University has identified a genetic factor essential for the virulence of Streptococcus pneumoniae, a major threat to public health globally. The study reveals that the cbpJ gene is under strict negative selective pressure, making it an attractive target for drugs to combat antibiotic-resistant bacteria.
Researchers discovered zinc's role in fighting UTI bacteria, identifying its toxic effects on UPEC cells and potential avenues for non-antibiotic treatment strategies. This knowledge could lead to new therapies that don't develop resistance like traditional antibiotics.
Researchers at Brown University have developed a germ-fighting catheter coating that can kill MRSA bacteria and prevent biofilm formation. The coating, which releases the drug auranofin, has shown promising results in lab tests, inhibiting MRSA growth for up to 26 days.
A pre-clinical trial of InnovoSep has demonstrated potential to stop sepsis-causing bacteria from triggering organ damage. The drug also showed effectiveness in preventing sepsis progression and treating advanced sepsis.
Researchers at UC San Diego have found a new mechanism that allows bacteria to survive antibiotics by controlling magnesium ion uptake. This discovery could lead to new treatments for infectious diseases and boost the potency of existing antibiotic drugs.
Hospital admissions for drug-related infective endocarditis increased by 436% at a medical center in the US, with heroin implicated in most cases. Patients who inject drugs are at risk of developing this condition due to contaminated needles introducing bacteria into their bloodstream.
A new study found that diagnostic uncertainty in febrile children results in increased observation times, inpatient admissions, and precautionary use of antibiotics. The development of rapid diagnostic tests could significantly reduce financial burden on the NHS and avoid unnecessary distress to children and parents.
Researchers at Ohio State University have discovered a new way to destroy bacteria that can prevent wounds from healing. By using electroceutical bandages, the team found that electrical impulses can break down biofilms and kill bacteria, leading to faster wound healing.
A randomized clinical trial found that daily bathing with chlorhexidine (CHG) and nasal antibiotic mupirocin significantly reduced bloodstream infections and antibiotic-resistant bacteria in patients with medical devices. However, no significant benefit was seen for the overall population.
New technology from the University of South Australia uses silver-loaded microneedle patches to create a 24-hour bacteria-free zone around the injection site, reducing infection risk. The dissolvable feature ensures no reuse and eliminates one of the greatest causes of infection.
Researchers found that using antibiotic soap and nasal ointment reduces infections in non-ICU patients with medical devices. The study showed a 30% decrease in bloodstream infections and nearly 40% decrease in antibiotic-resistant bacteria infections.
The ABATE Infection Trial found that daily antiseptic bathing with nasal ointment reduced hospital-acquired bloodstream infections by 30% in patients with central venous catheters, a high-risk group. This intervention also decreased antibiotic-resistant organisms, including MRSA and vancomycin-resistant enterococcus, in this patient po...