Articles tagged with Bacterial Infections
A UK awareness campaign has shown some success in delaying the onset of drug-resistant gonorrhea by prompting healthcare professionals and policy-makers to change treatment practices. However, resistance to cefixime and ceftriaxone is still a concern, and continued vigilance is necessary to prevent widespread emergence.
Scientists have discovered how Yersinia pestis alters cell death pathways to kill host cells and cause pneumonic plague. The study reveals that the bacterium destroys Fas ligand, a molecule that stimulates apoptosis, allowing it to overwhelm the lungs and kill its host.
A study by Max Planck Institute for Chemical Ecology reveals that beewolves control transmission of their bacterial symbionts to mother-to-offspring, stabilizing the alliance over millions of years. The symbiosis originated in the late Cretaceous and has persisted through 170 species of wasps.
A study published in Cell Death & Disease found that an overabundance of c-FLIPR protein disrupts the immune system's balance. Researchers discovered that this imbalance leads to autoantibodies attacking the body's own tissues, resulting in autoimmune diseases like systemic lupus erythematosus.
A study used genome sequencing to predict which MRSA isolates were highly toxic, allowing for personalized treatment. Researchers identified over 100 genetic loci associated with toxicity and found that highly toxic isolates shared a common signature, enabling prediction of disease severity.
Researchers found that triclosan, an antimicrobial agent in soaps and toothpastes, promotes the colonization of Staphylococcus aureus bacteria in human noses. This could predispose some people to infection, particularly those undergoing surgery.
A new study finds that binge drinkers heal from wounds at a slower rate due to impaired immune function. Binge alcohol exposure reduces key immune system components, making wounds more susceptible to infection.
A global study reveals that E. coli clone ST131 originated from a single ancestor prior to 2000 and has spread rapidly due to genetic exchange with other bacteria. The research provides insights into the development of effective screening and vaccination strategies to combat antibiotic-resistant infections.
Researchers discovered that antibiotics like gentamicin can cause abnormal proteins to be presented to the immune system, potentially triggering autoimmune disease. This approach, used to treat diseases in genes with truncated proteins, may come with a risk of initiating autoimmunity.
A new method for studying the relationship between skin cells and good bacteria was developed, revealing certain bacterial communities alter HIV's ability to infect. The discovery has potential applications in understanding how vaginal products interact with good and bad bacteria.
Cancer kills flies in a dose-dependent manner, similar to bacterial and viral infections. Researchers have established a system to disentangle the resistance and tolerance mechanisms to cancer in the Drosophila model.
Researchers found that combining chitosan with antibiotics reduced reservoir populations of bacteria in mouse bladders, making them susceptible to treatment. The compound might one day serve as an augmentation therapy for recurrent UTIs.
The study found an increase in community-acquired and healthcare-associated infections due to ESBL-producing bacteria, with high levels of resistance to commonly used antibiotics. Many strains of E. coli are also becoming increasingly resistant.
Researchers at the University of Leicester have developed an artificial version of a naturally occurring protein, properdin, which successfully combats bacterial pneumonia and meningitis in mice. The treatment offers significant protection against life-threatening infections.
A daily high dose of statins over six months significantly improved coughing symptoms in 12 out of 30 patients with bronchiectasis. The treatment also reduced inflammation and enabled patients to tolerate gentle exercise better. Larger studies are now needed to confirm these findings.
Research finds that protein TG2 enables bacteria Porphyromonas gingivalis to adhere to cells, and blocking its associations prevents bacterial adhesion. The study provides insight into a potential target for preventing gum disease.
Researchers at UCL have created a new antibacterial material using simple dyes and nanogold particles, showing potent bactericidal effects even in total darkness. The innovative surface technology has potential to reduce hospital-acquired infections.
Researchers at Case Western Reserve University have found a novel population of neutrophils that produce Interleukin 17 (IL-17) and exhibit enhanced microbial killing activity. These cells may contribute to both controlling infection and causing tissue damage, highlighting the need for further regulation.
An international team of academics has identified a single bacteria as the cause of sepsis through genetic evidence. The study found that in most cases, a single pneumococcal cell was responsible for causing sepsis.
The prevalence of antibiotic-resistant bacteria, particularly ESBL-producing bacteria, is increasing in US children, raising concerns about dwindling treatment options. These infections can lead to longer hospital stays, higher healthcare costs, and increased mortality.
The threat of antimicrobial resistance is a global crisis that requires a multi-faceted approach, including strong basic, clinical and translational research. NIAID's new directions in antimicrobial resistance research aim to develop vaccines, point-of-care diagnostics, and new antibiotics to prevent and treat infections.
Researchers found that even with large doses of bacteria, sepsis often starts with just one bacterium. The immune system efficiently clears most bacteria, but sometimes a single founder bacterium survives and multiplies to cause disease. Macrophages play a key role in this process.
Antibiotic-resistant Gram-negative superbugs are on the rise in US children, particularly those aged 1-5 years old. The prevalence of these bacteria increased from 0.28% to 0.92% between 1999 and 2011.
Researchers characterized the gut bacteria of premature infants who developed sepsis, suggesting a new approach to early detection and prevention. Genetic matches were found between bacteria in stool samples and those in blood samples, indicating that gut bacteria are responsible for these infections.
Researchers find trimethoprim to be an effective antibiotic against streptococcal infections in some regions, with a lower frequency of resistance than previously believed. The study also identifies three causes for rapid spread of resistance, highlighting the need for responsible antibiotic use.
Researchers at Washington University School of Medicine found three types of potentially harmful gut microbes in preterm babies who developed late-onset sepsis: E. coli, group B strep, and S. marcescens. These findings suggest new strategies to detect and prevent severe bloodstream infections in neonatal intensive care units (NICUs).
A surveillance study found that pregnancy is associated with a greater risk of Haemophilus influenzae infection, which can cause serious complications such as premature birth, stillbirth, and fetal loss. The study also suggests that pregnant women are at higher risk of developing unencapsulated H influenzae disease.
A study published in PLOS ONE found that 56% of bloodstream infections were healthcare-associated, but symptoms began prior to hospital admission. The most common pathogens were S. aureus and E. coli, with multidrug-resistant pathogens occurring in 23% of patients.
Researchers used genome sequencing to reveal genetic diversity in hospital-acquired bacterium ST258, which causes carbapenem-resistant Enterobacteriaceae infections. The study found two distinct groups with different evolutionary histories and unique outer coat genes.
Caucasians 55+ are at greatest risk of a deadly lung infection caused by nontuberculous mycobacteria (NTM), which affects over 2,990 people in the US each year. The infection is treatable but expensive antibiotic therapy can take up to two years.
Gut bacteria help develop immune cells that can fight infections, study finds. The beneficial bugs also increase immune cell populations and enhance survival rates when mice are infected with harmful bacteria.
A recent study reveals that early childhood caries are caused by the partnership of Streptococcus mutans bacteria and Candida albicans fungus, leading to increased cavities and severe tooth decay. The fungus was previously thought to be harmless but now appears to play a crucial role in the development of this painful condition.
Research at the University of Copenhagen reveals that cosmetic fillers can act as incubators for bacterial infection, causing lesions and tough film-like material resistant to antibiotics. Prophylactic antibiotic treatment during procedures can prevent these complications.
The gut microbiota's complex relationships with different microorganisms contribute to both health and disease, according to recent advances in DNA sequencing technology. Non-bacterial microbes like viruses and meiofauna also play a crucial role in shaping the gut ecosystem.
A four-year study in Ireland found that five percent of badgers traveled over 7.5km from their setts, with the longest recorded distance being 22.1km. This information is crucial for designing policies to tackle tuberculosis within cattle populations and understanding how infection is maintained and spread within badger populations.
Researchers found significant variations in definitions and isolation procedures for multidrug-resistant gram-negative bacteria across hospitals. The inconsistent detection and treatment practices may hinder communication between healthcare centers, contributing to the spread of these deadly pathogens.
Researchers at the University of Copenhagen have used 3D scans to map the widespread fish disease enteric redmouth disease. The study reveals that the bacteria infects fish through their ultra-thin gills, providing a new understanding of the infection pathway and potential solutions.
Scientists explored how Staphylococcus cells adhere to nanostructures and found that surface features can inhibit bacterial adhesion. The researchers developed nickel nanostructures with various shapes, including tubular-shaped pillars, which showed higher bacteria survival rates.
Research reveals that seminal plasma enhances bacterial movement, promoting infection; increased bacterial density on human epithelial cells also facilitate infection. More than 100 million new gonorrhea cases annually worldwide.
A new study published in Mayo Clinic Proceedings found that physicians' stethoscopes are more contaminated than the palms of their hands with bacteria such as MRSA. The researchers discovered that the stethoscope's diaphragm and tube were heavily contaminated, emphasizing the need for frequent disinfection after each use.
A team of French investigators discovered viruses containing antibiotic resistance genes in a fossilized fecal sample from 14th century Belgium. The findings suggest that the viral community plays a fundamental role in maintaining human health, unchanged over centuries.
Researchers at UCLA discovered that vitamin A and a specific gene assist the immune system by reducing cholesterol levels in TB-infected cells, allowing lysosomes to kill bacteria effectively. This finding may lead to new treatment approaches for tuberculosis.
A new study aims to identify the causes of oral health problems in HIV-positive patients, including tooth decay, gum disease, and yeast infections. The researchers are analyzing samples from 440 patients to compare their microbiota with uninfected individuals.
A Kansas State University epidemiologist has found that climate, physical environment, and socio-ecologic conditions contribute to tularemia infections among domestic cats. The study identified newly urbanized areas, residential locations surrounded by grassland, and high-humidity environments as key factors in the disease's prevalence.
Loyola researchers have identified a marker to predict necrotizing enterocolitis (NEC), a life-threatening condition affecting up to 10% of extremely low birth weight infants. Simple changes to blood transfusion practices and feeding patterns may significantly reduce NEC incidence.
The Vanderbilt team has deciphered the 3-D structure of a key MRSA protein, FosB, which inactivates an antibiotic called fosfomycin. This discovery may enable the design of inhibitors that can improve the effectiveness of fosfomycin and combat MRSA infections.
Researchers discovered that bacterial LPS components directly activate pain sensors, triggering immediate pain and inflammatory responses. This finding reveals a new target for drugs designed to treat bacterial infections, such as pneumonia and meningitis.
A new study reveals a previously undefined immune pathway in humans that provides vital information for designing vaccines and medicines to combat bacterial infections. The research found that T-cells can respond defensively to bacterial attacks without specific antigens, leading to a maximal response and improved survival.
A new study examines Avian pathogenic Escherichia coli (APEC) and finds that bacterial fibers, such as common pilus, play a crucial role in its ability to cause infection and form biofilms. The research also highlights the importance of understanding the virulence traits shared between APEC and human ExPEC strains.
The University of Liverpool has launched an Open Innovation Hub for Antimicrobial Surfaces to design and develop new anti-infective materials. The hub aims to combat the spread of bacterial, viral, and fungal infections in various sectors, including healthcare and food processing.
Researchers at the University of Bonn have decoded a new immunoregulatory mechanism controlling defense in urinary tract infections. The mechanism involves two types of macrophages regulating neutrophils, with sentinel macrophages triggering an alarm and helper macrophages providing a safety mechanism to prevent collateral damage.
Researchers at the University of Iowa have developed a non-invasive chemical probe that can detect Staphylococcus aureus bacteria in the body, potentially leading to quicker and more accurate diagnoses. The probe uses the bacteria's propensity to cleave DNA, allowing doctors to pinpoint its location and detect infections sooner.
Researchers identified components of the C. difficile bacteria that can be used to develop a rapid diagnostic test, potentially leading to more timely initiation of antibiotics and improved outcomes for patients. The study's technology can also help quickly detect and identify hypervirulent strains of the bacterium.
Researchers at VIB have identified a chemical substance that can disarm pathogenic bacteria, allowing them to treat urinary tract infections without destroying beneficial bacteria. This approach could provide a lower risk of resistance development and spread.
Scientists are conducting a Phase 1 clinical trial of EDP-788, an oral antibiotic targeting methicillin-resistant Staphylococcus aureus (MRSA) infections. The trial will evaluate the safety and pharmacokinetics of the drug in healthy participants.
Researchers at SISSA investigated the structural elements of prion proteins, finding that misfolding originates in the N-terminal region. This knowledge is crucial for developing drugs and therapeutic strategies against diseases like Creutzfeldt-Jakob disease.
A study published in Infection and Immunity reveals that Salmonella infection can reduce asthma inflammation by regulating immune cells. Researchers hope to develop treatments based on probiotics or therapeutic applications of myeloid cells.
Researchers found that females who mated with preferred males produced more offspring and were better able to cope with infection from Salmonella compared to offspring sired by non-preferred males. The fitness benefits were due to tolerance to infection rather than immune resistance.
Scientists will analyze 510 archived isolates of Campylobacter from human faeces to better understand its sources and transmission routes. The study aims to prevent Campylobacter-related illnesses, which cause over 21,000 hospital admissions and 100 deaths in the UK each year.
Research found significantly higher levels of infectious pathogens in water from faucet taps with aerators compared to deeper in the plumbing system. Contaminated water threatens immunocompromised patients with increased infection risk.