Research on cancer as a disease, from cause to care. Covers tumor biology, small-cell lung cancer, cancer-linked stroke risk, and cancer center research.
The European Association of Urology warns that bladder cancer is often overlooked due to lack of awareness. A new survey found that over half of adults do not recognize common symptoms such as changes in urine color, leading to delayed diagnosis and poorer treatment outcomes.
Mayo Clinic researchers identified critical genomic changes associated with abiraterone acetate/prednisone resistance in advanced prostate cancer. An 11-gene drug panel predicted a worse prognosis for a subset of patients, and whole-exome sequencing data revealed mechanisms of acquired resistance.
A study published in JCI Insight has found that genetic variation plays a crucial role in the racial disparity of esophageal cancer cases. Researchers used artificial intelligence-guided tools to pinpoint a specific type of immune cell as the disease driver, and a protective genetic factor associated with African Americans.
A large study of former smokers found that those adhering to evidence-based recommendations for body weight, diet, physical activity, and alcohol intake had a significantly lower risk of death. The study included nearly 160,000 older U.S. adults and showed that better lifestyle habits can reduce mortality risk from various causes.
Researchers have discovered that a type of pediatric brain tumour, medulloblastoma, develops in a pre-malignant form during human fetal brain development. This finding suggests that medulloblastomas could be preventable by identifying the genetic variations that cause them and acting before they develop.
Researchers at the University of Basel have successfully differentiated triple-negative breast cancer cells into normal-like cells, opening a new avenue for treatment. The breakthrough uses inhibitors of polo-like kinase 1 to induce estrogen receptor expression, leading to reduced cell growth and tumorigenicity.
Researchers at UMC Utrecht will investigate how intestinal microbiota impacts cancer immunotherapy and therapy side effects. The project aims to develop microbiota-targeted therapies to improve ICI treatment effectiveness and reduce severe inflammation.
A new study from Michigan Medicine found that adults with more chronic health conditions are at higher risk of serious financial problems, including late payments, poor credit scores, and bankruptcy. The study analyzed nearly 3 million privately insured adults and found that those with seven or more chronic conditions had three to four...
A UTHSC-led research team has been awarded $5.2 million by the National Cancer Institute to investigate the relationship between obesity and cancer risk. The team, led by Dr. Liza Makowski, aims to understand how obesity affects the immune system's ability to fight cancer.
Researchers at Nagoya University have identified new agents involved in DNA damage tolerance pathways, including RFWD3, which may contribute to anticancer treatment. The study's findings suggest that inhibiting these pathways could sensitize cancer cells to conventional chemotherapeutic agents.
A team from The Institute of Industrial Science at The University of Tokyo has developed a new platform that uses organorhodium(III) phthalocyanine complexes to achieve the combination of traits necessary for photodynamic therapy. The new system shows toxicity to HeLa cells, indicating its potential as a cancer treatment.
Researchers at Ludwig Lausanne have identified a combination of three existing drugs that significantly extends survival in mouse models of GBM. The combination, which includes an antidepressant, immune checkpoint blockade antibody, and a cancer therapy analog, unleashes powerful anti-tumor immune responses.
The Montefiore Einstein Cancer Center has received a $10 million grant from the National Cancer Institute to study lung metastasis in breast cancer. The research aims to understand the mechanisms of tumor cells seeding tumors in the lungs, a key site for triple-negative breast cancer metastasis.
A Yale study published in PLOS ONE reveals a significant association between incarceration and higher cancer mortality among adults. Those diagnosed with invasive cancer while incarcerated and within one year after release were more likely to experience worse outcomes due to limited access to quality care, social determinants of health...
A new wearable device called FAST can measure tumor size changes to the hundredth of a millimeter, providing a fast, accurate, and inexpensive way to test cancer drugs. This technology represents a significant advance in cancer treatment, offering continuous monitoring, flexibility, and non-invasiveness.
Researchers create a new, non-invasive wearable device that can measure tumor size changes in real-time. The 'Flexible Autonomous Sensor measuring Tumors' (FAST) device provides continuous monitoring and accurate results, offering a promising approach to cancer treatment.
A UC San Diego study found that cancer patients experiencing housing instability had a significantly increased risk of mortality. The research suggests that integrating health and social care can improve patient outcomes by identifying and addressing underlying social risk factors.
Schwann cells in nerve healing take over immune cell functions to prevent excessive tissue damage and promote regeneration. Similarly, they may stop chronic inflammation in childhood nerve tumors, making them benign. Schwann cells can also regulate T-cell activity, potentially curbing cancer growth.
Researchers at UVA will study organelles in cancer cells to identify new pathways for understanding and fighting cancer. By focusing on the interactions between genes, proteins, and organelles within cells, they hope to develop fresh clues about therapies.
A recent study by Washington State University researchers has identified distinct genetic patterns among the most prevalent types of canine soft tissue sarcomas, potentially leading to more accurate diagnoses and effective treatments. The findings suggest that a single treatment approach may not be effective for all subtypes of the tumor.
Researchers at University of California - San Francisco have developed a new therapy that overcomes cancer cell barriers and marks them for destruction by the immune system. By pulling mutated KRAS protein to the surface, the drug acts as an “eat me” flag, allowing immunotherapy to eliminate all cells bearing this flag.
Researchers at Cleveland Clinic link HSD3B1 genotype to higher risk of type 2 endometrial cancer, which is more aggressive and has lower survival rates than type 1. The study builds on previous associations with breast and prostate cancer, suggesting the gene could serve as a biomarker for certain subtypes.
A cross-sectional study of over 25,000 adults found that approximately 70% of identified adrenal tumors were nonfunctioning, regardless of participant's age. The prevalence of adrenal tumors increased with age, from 0.2% in young adults to 3.2% in older adults.
Researchers at Osaka Metropolitan University developed a cold perfusion method to isolate hepatic stellate cells (HSCs) from both murine and human fatty liver-associated tumors with high yield and purity. This breakthrough could provide new tools for investigating the role of HSCs in NASH-associated liver cancer progression.
Scientists have discovered a link between air pollution and lung cancer in people who have never smoked. Exposure to particulate matter (PM2.5) has been shown to promote cancerous changes in airway cells with EGFR and KRAS gene mutations, driving them towards a cancer stem cell-like state.
The DeFi trial shows targeting the Notch pathway with nirogacestat improves progression-free survival and reduces symptoms in patients with desmoid tumours. Patients reported a statistically significant benefit in reduced pain, symptom burden, and improved quality of life.
Late-breaking results at ESMO Congress 2022 reveal a strong association between air pollution and non-small cell lung cancer, with exposure to particulate matter linked to increased risk. The research underscores the need for environmental sustainability in oncology, particularly in cancer prevention and early detection.
Researchers have developed a new safety system for CAR-T cells, called VIPER CAR-T cells, that can be turned on or off. This allows doctors to target cancer more aggressively while minimizing side effects. The new system uses an FDA-approved antiviral drug to control the cell's activity.
A new study has successfully predicted ovarian cancer in patients with a pelvic mass using a simple blood test. The liquid biopsy technology captures circulating tumor cells, allowing for genetic analysis in just a couple of hours, which can help diagnose the disease earlier.
Researchers at Dana-Farber Cancer Institute have made significant breakthroughs in treating breast and kidney cancers, with data from pivotal studies showing encouraging results for new treatments. Phase 3 trials are underway to evaluate a three-drug regimen for advanced kidney cancer, while a combination therapy is being tested for HR...
A team of researchers at the University of Minnesota has developed an accessible application called MVsim that can simulate complex molecular interactions. By using this tool, scientists can design more specific drugs for diseases like cancer and COVID-19 by optimizing multivalent interactions.
Researchers have developed a new method for 3D cell culture that accurately quantifies how breast cancer cells generate forces to spread within tissue. This study provides more accurate computational data on cellular forces during invasion by breast cancer cells, which may lead to more efficient and personalized drug development.
Researchers at the University of Gothenburg have identified a protein called HnRNPK that controls tumor growth by binding to messenger RNA, potentially enabling the development of new cancer drugs with fewer side effects.
A UTHSC-led team has received a $3.16 million National Cancer Institute grant to develop a cancer immunotherapy drug that boosts the immune system response to destroy tumor cells.
Researchers identified five new hepatoblastoma tumor signatures that could help predict responses to chemotherapy treatments. The study used single-cell transcriptomic techniques to analyze tumors from infants and children, providing a window into normal development and cancer.
A pilot study from UCLA researchers found that neurofeedback training significantly normalized brain wave frequencies and improved cognitive function in cancer patients with chemo brain. The study's results support further research into the effectiveness of neurofeedback as a treatment approach.
The center aims to develop and test advanced telehealth methods for cancer care, focusing on promoting health equity and addressing digital divides. Three principal investigators will lead the center, aiming to improve patient outcomes, communication, and healthcare use through telehealth strategies.
Cancer patients in rural areas experience higher mortality rates and are more likely to miss radiation appointments, leading to poorer overall survival. The study suggests that targeted support programs like patient navigation can help reduce disparities in cancer care.
A new study by Berkeley Lab scientists reveals that thirdhand smoke can exceed health risk guidelines, putting whole households at risk. The study found that concentrations of toxic chemicals in indoor environments where cigarettes have been smoked can lead to exposure through inhalation, dust ingestion, and dermal absorption.
A new AI model has improved the efficiency of cancer diagnosis by reducing costs and time while increasing accuracy. The model uses pathological image compression technology to effectively extract features from images, enabling it to accurately detect cancer sites.
A Swedish study of over 4,000 adults found that those with high prostasin blood levels were 76% more likely to develop diabetes and 43% more likely to die from cancer. Prostasin may be an indicator of disease occurrence or causally relevant, raising the possibility of targeting this protein for future treatments.
Researchers at the Centre for Genomic Regulation have identified PDIA6 as a key protein involved in driving melanoma malignancy. The study found that PDIA6 promotes melanoma cell growth by binding to RNA molecules inside tumor cells, making it a promising therapeutic target.
A new study by Tokyo University of Science researchers reveals that dendritic cell immunoreceptor (DCIR) plays a crucial role in the development of colorectal tumors. Blocking DCIR may prevent ulcerative colitis and colon cancer, offering a potential therapeutic target for treating these diseases.
Researchers investigated the effects of neoadjuvant chemoradiotherapy on CD8+ tumor-infiltrating lymphocytes, PD-L1, and mucin expression in rectal cancer patients. The study found that nCRT exposure was associated with higher mucin expression and a non-significant difference in PD-L1 expression, suggesting an immunosuppressive phenotype.
A researcher studied the 'black box' phenomenon in breast cancer survivorship care, revealing communication gaps between women and their providers. She found that black boxing can hide service access complexities, emphasizing the need for improved information pathways to address post-treatment needs.
Researchers created a novel tumor organoid system to examine the impact of bacterial metabolites on immune checkpoint blockage, a promising cancer treatment. The system showed that certain bacterial-released factors improved immune cell viability and increased treatment efficacy.
A new class of glioma drugs exploits tumors lacking the DNA repair enzyme MGMT, generating cytotoxic DNA and selectively killing tumor cells without resistance. The approach may lead to new glioma treatments for highly aggressive brain tumors like glioblastoma.
A study found that a majority of online pharmacies selling imatinib, a chronic myeloid leukemia therapy, are uncertified and operate unsafely. Patients may face risks of nonadherence, treatment failures, and adverse events if they use these pharmacies.
A study of 3,028 patients with COVID-19 reveals that race, ethnicity, and severity of infection are key factors contributing to delayed cancer treatment. Researchers found that these patient demographic factors are strongly associated with delays in receiving timely medical care.
A new study found that over half of adult cancer survivors experience significant hearing problems after chemotherapy treatment. The researchers also discovered that platinum and taxane drugs, commonly used to treat the majority of cancers, are linked to high rates of hearing loss and tinnitus.
A new study published in Diabetologia finds that limiting food intake to a 10-hour window during the day improves metabolic health in adults with type 2 diabetes. The research, conducted by Prof Patrick Schrauwen and colleagues, shows a decrease in 24-hour glucose levels and an increase in time spent with normal blood glucose levels.
Artificial neural networks use white matter cracks and cerebral cortex furrows to estimate biological age, which can indicate possible disease or injury. The 'black box' problem has been solved, revealing the algorithm's decision-making process.
A recent PLOS Biology study examines the limitations of current anti-amyloid therapies for Alzheimer's disease, suggesting abnormal microglial function and tau tangles as key mechanisms. The authors review clinical trial results and propose new strategies for treating the disease, bringing hope for a cure.
A new study from MIT and Broad Institute researchers analyzed interactions between nanoparticles and nearly 500 types of cancer cells, revealing thousands of biological traits that influence cell response. The findings could help tailor drug-delivery particles to specific types of cancer.
A survey study of 1,240 adults with cancer found racial and ethnic disparities in cancer care during the pandemic. Black and Latinx adults reported more delayed cancer care and adverse social and economic effects compared to their white counterparts.
The new grant aims to address structural racism and discrimination affecting Asian-Americans with chronic hepatitis B virus infection and liver cancer. Researchers will examine factors such as socio-historical hardship, segregation, and mistrust of the health system to improve quality of care.
Researchers found that cancer cells can move faster and in a specific direction when placed in an environment with optimal stiffness, which challenges previous assumptions. This discovery could lead to new treatments by understanding how cancer cells invade tissues.
A large-scale study analyzing 29 studies and 139,624 participants found that people who viewed tobacco content on social media are more likely to report using tobacco. The study also identified susceptible individuals who may be influenced by pro-tobacco content.
Researchers at Osaka University identified Src as a key molecule in the process of epithelial cells becoming invasive and cancerous. The study found that CDCP1 forms a molecular scaffold that activates Src, promoting cancer cell invasion.
A study of 720 patients with thoracic cancer found increased odds of unsuccessful telemedicine visits among Black and disadvantaged patients. Unsuccessful telemedicine visits were associated with worse clinical outcomes, highlighting the need for improved access to healthcare.