Articles tagged with Cervical Cancer
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A study found that an annual conventional Pap smear is a cost-effective strategy for follow-up after cervical lesion treatment. This approach reduced expected cervical cancer deaths by 73-77% compared to more frequent testing.
A study confirms that eight human papillomavirus (HPV) types, including HPV 16, 18, and 45, are responsible for over 90% of all cervical cancer cases worldwide. Current vaccines prevent infection by these high-risk HPV genotypes, but future type-specific screening is recommended to target the most common types.
A randomized trial found that HPV DNA-based screening and cryotherapy significantly reduced high-grade cervical cancer precursors in unscreened South African women. The study suggests that a 'screen-and-treat' approach can be an effective cervical cancer prevention strategy, especially in low-resource settings.
The survey found that interest in receiving the HPV vaccine increased if it was available free of charge, but decreased as out-of-pocket costs rose. Convenience also played a role, with many women preferring to receive the vaccine at a doctor's office rather than a local pharmacy.
Using an electronic medical record (EMR) tracking system can improve follow-up after an abnormal Pap test, leading to increased diagnostic resolution and faster treatment times. The study found that physicians who used this tracking system had significantly shorter times to diagnosis compared to traditional methods.
A new study has demonstrated that combining a specific drug with radiotherapy significantly improves treatment outcomes for cervical cancer patients. The research found that the addition of cisplatin to radiotherapy reduces the likelihood of death by 23%, leading to improved survival rates.
Scientists at the University of Cambridge have developed a vaccine to stop cancer-causing viruses that invade host cells, initiate cancer, and then disappear. The vaccine has been shown to protect against subsequent cancer development in mouse models, holding promise for preventing human cancers.
Researchers from A*STAR made three groundbreaking discoveries in fight against cancer: a mechanism to prevent metastasis, biomarkers for breast cancer, and improved detection of cervical cancer. Their work sheds light on key areas of cancer research, offering new strategies to combat this devastating disease.
The European Society for Medical Oncology (ESMO) has published updated clinical practice guidelines for cancer care, providing vital information on diagnosis, treatment plans, and follow-up. The new guidelines cover various tumor types and include expanded sections on cardiotoxicity and fertility considerations.
A community-based study found HPV DNA testing to be over 50% more sensitive than cytology testing for detecting precancers and cervical cancers. The study involved 50,000 women and revealed a significant reduction in precancer rates among HPV DNA-positive women.
Clinical guidelines recommend screening low-risk women every three years after age 30, but most primary care clinicians advocate for more frequent testing. Annual Pap testing has helped decrease cervical cancer burden, but cost-effectiveness models suggest overuse may increase costs with little improvement in outcomes.
According to a new report, only about one in three young women has received the human papillomavirus (HPV) vaccine to help prevent cervical cancer. The vaccination rate is increasing, but there is still a significant disparity in HPV vaccination rates among different racial and ethnic groups.
Research suggests extending HPV testing intervals to five years for women over 30 could significantly reduce cervical cancer cases. The study found HPV tests detect early signs of cervical cancer more accurately than current cytology screening.
Researchers at UAB found that Gardasil vaccine reduces the likelihood of HPV-related disease recurring after surgery by approximately 40 percent. This protection can provide crucial follow-up care and overall health planning for teens and women.
A new study in the Journal for Healthcare Quality reveals that P4P programs can improve quality of care, especially for selected measures like mammography and childhood immunization. Low performing physicians who used a P4P program improved significantly over time, highlighting the importance of sustaining these programs.
Researchers at UF's College of Veterinary Medicine have discovered that dolphins can harbor multiple infections of apillomaviruses, which are linked to cervical cancer in humans. The study suggests that dolphins may be an ideal model for studying human cervical cancer due to their genetic similarity to humans.
A new study published in the Journal of the National Cancer Institute found that HPV vaccination benefits decline with age and frequent screening for women over 41 is likely to be low. The study suggests that newly detected HPV infections do not progress to cervical intraepithelial neoplasia grade 2 or worse, regardless of age.
Triapine regimen provides significant reduction in cancer disease and cancer control, shows great promise for patients at high risk of relapse and death. The study's complete response rate was observed and no disease progression documented through 18 months of median follow-up.
Researchers developed a mathematical model to predict cervical cancer treatment outcomes, allowing for quicker identification of non-responding tumors. The model uses MRI scans and can provide a prediction accuracy of 90 percent for local tumor control and recurrence.
Researchers at the University of Texas Health Science Center at Houston are working on cutting-edge projects to protect girls from cervical cancer and develop new approaches for treating colon cancer. The center has received over half of the $61M awarded by CPRIT, with grants totaling $4.5M.
A new study published in The Lancet Oncology suggests that HPV DNA testing is more effective than conventional cytology screening in preventing invasive cervical cancer. The study found that HPV-based screening is more effective in detecting precancerous lesions and reducing the incidence of invasive cervical cancer, particularly in de...
The HPV-16/18 AS04-adjuvanted vaccine (Cervarix) induces a strong and sustained antibody response and has a favourable safety profile. Vaccine efficacy against incident infection with HPV-16/18 was 95% and against 12-month persistent infection was 100%.
Researchers identified specific genetic changes associated with an increased risk of relapse in cervical cancer patients. These changes are crucial steps in the progression of the disease towards an aggressive and treatment-resistant state.
Researchers at University of Wisconsin-Madison used two FDA-approved drugs to eliminate and prevent cervical cancer in mice. The drugs, which block estrogen's ability to bind to cells, cleared precancerous growths and prevented cancer onset in mice with HPV-positive lesions.
Primary HPV DNA screening with cytology triage is more sensitive than conventional screening for detecting cervical lesions, especially among older women. This approach can lead to fewer colposcopy referrals and follow-up tests.
A Dutch study of nearly 90,000 women found that liquid-based cytology is not superior to the conventional Pap test for detecting cervical cancer precursors or cancer. The study's findings provide strong evidence that liquid-based cytology performs similarly to the traditional Pap smear in a well-organized screening program.
The American College of Physicians (ACP) has issued clinical practice guidelines for treating erectile dysfunction (ED), recommending the use of phosphodiesterase type 5 (PDE-5) inhibitors and individualizing decisions on hormonal tests. For patients with stable ischemic heart disease, adding ACE inhibitors to standard care improves ou...
Common human papillomavirus (HPV) genotypes in northern India are primarily HP-16 and HP-18. These types cause 75 percent of cervical cancers in the region, according to researchers.
Researchers found that vaccinating boys would be less cost-effective than vaccinating pre-adolescent girls, with a higher cost-effectiveness ratio of $290,290 per QALY. The study suggests prioritizing HPV vaccination of girls and continued cervical cancer screening in adulthood.
A study published in The Lancet Oncology found that immunodeficiency increases the risk of multiple cancers in HIV patients. Lower CD4 counts were linked to higher risks of certain cancers, while antiretroviral therapy reduced this risk. Effective cancer screening programs are recommended for HIV-positive individuals.
The University of Alabama at Birmingham Comprehensive Cancer Center has won an $11.5 million grant from the National Cancer Institute to explore groundbreaking cervical cancer research, prevention, and treatment. The grant will focus on next-generation human papillomavirus (HPV) vaccines for cervical cancer prevention and test therapeu...
Vaccination against HPV, combined with national screening programmes, could lead to the eradication of cervical cancer in countries that implement such measures. HPV screening is more effective than Pap smear tests and can detect the virus in smears rather than relying on visual examination.
Cancer experts are developing a tool to work out the percentage risk a woman has of developing cervical cancer. The tool uses cervical precancer, defined as histological cervical intraepithelial neoplasia grade 3 (CIN3) or more severe, as a surrogate for cervical cancer.
The study analyzed reports of adverse events following HPV vaccination and found a higher proportion of reports of fainting and blood clots. However, the rates were still consistent with pre-licensing data and background rates of other vaccines.
People living with AIDS are at a higher risk of developing HPV-associated cancers, particularly those with lower CD4 T-cell counts. The study estimates that incidence rates increased across three periods, with the greatest risk observed in invasive anal cancer among men after the introduction of highly active antiretroviral therapy.
The Latino/a population is projected to triple by 2050, leading to a significant increase in cancer diagnoses. Improvements are needed in knowledge and access to services, particularly for breast and cervical cancers among Latinas.
A team of scientists developed a computer model that predicts cancer recurrence in an individual based on how their tumor changes size in response to the first rounds of radiation therapy. The study found that tumors with higher resistance to radiotherapy had a lower chance of reappearing years later.
The HPV-16/18 AS04-adjuvanted vaccine shows high efficacy against precancerous cervical lesions, with cross-protective efficacy against other oncogenic HPV types. The vaccine also demonstrates efficacy in universal mass vaccination and catch-up programmes, potentially reducing cervical cancer incidence.
A study published in JNCI found HPV vaccination to be non-cost-effective in the Netherlands due to low cervical cancer cases and deaths. The authors suggest vaccine price reduction could make it more cost-effective, but only if the vaccine's effectiveness increases.
A study published in The Lancet Oncology found that combining HPV testing with routine liquid-based cytology (LBC) screening in the UK did not increase the detection of cervical cancer. However, HPV testing detected cases of precancerous cervical cells in the first round of screening, but this effect was not sustained over two rounds.
A review of nearly 6,000 women found that lack of information and misconceptions about breast and cervical cancer significantly contribute to screening fear. The study recommends promoting education and targeting specific fears to increase uptake rates.
A recent Florida State University study found that informing men about the HPV vaccine's benefit for their female partners did not increase their interest in getting the vaccine. The researchers suggest that men may need more direct information on the vaccine's benefits for their own health to consider vaccination.
A new surgical technique, total mesometrial resection (TMMR), has been shown to reduce complications and improve survival rates in patients with early-stage cervical cancer. The study found a 94% recurrence-free survival rate and a 96% 5-year survival rate, significantly better than traditional radical hysterectomy methods.
A new multimeric-L2 protein vaccine shows robust antibody responses and protection against human papillomavirus (HPV) infection in mice and rabbits. The vaccine has the potential to address the limited protection of current HPV vaccines against other HPV types, which cause cancer.
A large retrospective cohort study found that women with precancerous Cervical Intraepithelial Neoplasia (CIN) are at higher risk of developing invasive cervical cancer and recurrent severe CIN, especially after treatment. The study suggests the need for long-term follow-up of these patients.
A large population-based study found that women who have been treated for abnormal cervical cell growth are at higher risk for a recurrence of the disease or invasive cervical cancer. The study's findings should help guide physicians in making recommendations about follow-up treatment guidelines.
New data from Ugandan scientists find that adult male circumcision decreases rates of herpes and human papillomavirus (HPV), two most common sexually transmitted infections. Circumcision is linked to a 25% reduction in HPV risk and a third reduction in HPV risk, according to researchers at the University of Washington.
A population-based study found that HPV16 and HPV18 genotypes were present in the majority of invasive cervical cancers in New Mexico. The mean age of women diagnosed with HPV16- or HPV18-positive cancer was 5 years younger than that of women diagnosed with other HPV types, suggesting implications for future cancer screening.
A new Norwegian study suggests that HPV vaccination can prevent up to 35-128 preterm births per 100,000 births by reducing the risk of surgical treatment after cervical cell changes. The vaccine may have an important impact on preventing extremely preterm births.
Researchers at Albert Einstein College of Medicine found that genetic differences in a gene called TAP can provide protection against high-grade Cervical Neoplasia, which is a premalignant condition caused by HPV.
A study by Massachusetts General Hospital found that both Latino and non-Latino women are more likely to accept HPV vaccination for themselves and their children than previously reported. The main motivator for these women is the prevention of cancer, with no association between vaccine acceptance and income or education level.
A study found that pretreatment MRI and PET/CT can direct women with stage IB cervical cancer to optimal therapy choices, avoiding trimodality therapy. The imaging modalities resulted in the highest percentage of correct primary treatment (89%) and saved the most patients from trimodality therapy (95%).
A new study published in BMC Public Health found that cervical cancer incidence varies among geographical areas in Southeast England, with higher rates in more deprived areas. The research analyzed data on 2,231 cases of cervical cancer diagnosed between 2001 and 2005, revealing dramatic variations within regions.
A study published in the Journal of the National Cancer Institute found that HPV18 DNA levels are not associated with the likelihood of progressing to advanced precancerous lesions of the cervix. The study suggests that testing for high levels of HPV18 DNA is not clinically useful.
Denise Galloway, a microbiologist, was honored for her work on human papillomaviruses causing anogenital malignancies. Her studies established that nearly all cervical cancers are caused by HPVs, leading to breakthroughs in Gardasil vaccine development. Gerald Smith, a geneticist and microbiologist, was recognized for his research on h...
New studies suggest that male circumcision can lower the risk of human papillomavirus (HPV) infection, particularly high-risk subtypes associated with cervical, penile, and other cancers. Circumcised men are about half as likely to have HPV as uncircumcised men, according to research published in The Journal of Infectious Diseases.
Arbor Vita Corporation presented new data on its rapid, point-of-care prototype HPV test with a high positive predictive value for cervical cancer and pre-cancer detection. The test detects the E6 oncoprotein produced by human papillomavirus (HPV), which is a diagnostic marker of high positive predictive value.
A comprehensive assessment of HPV-associated cancers found significant racial disparities, with higher rates among African American women and Hispanic men. The study also identified the most common types of HPV-related cancers, including cervical, anal, and oral cancers.
The HPV-positive cancer cells adapted to the hypoxic environment by expressing a protein that activates a cell signaling pathway, helping them survive, grow and spread. The study may lead to new therapies targeting this pathway to interrupt cancer cell proliferation.
Researchers have developed a new MRI technique that can identify cervical cancer in its early stages by measuring the movement of water within tissue. The technique offers better imaging of smaller tumors and may improve surgical options for fertility-sparing procedures.