Developmental Disabilities

Drug reverses autism-like brain changes in adult mice within hours, study finds

Researchers found that a single dose of rapamycin rapidly improved symptoms in adult mice with autism-like changes, reversing abnormal brain signaling and behavior within two hours. The study suggests the adult brain's functional circuitry, not just its physical structure, as a target for future treatment approaches.

Can sports help improve motor skills in children with autism?

Research suggests that sports-based interventions may improve motor skills in children with autism spectrum disorder. Martial arts and aquatic training demonstrated the most consistent benefits, particularly in balance and total motor skills. Larger studies are needed to confirm these findings.

Review calls attention to brain development risks associated with certain medications during pregnancy

A review article highlights the potential risks of certain medications during pregnancy on brain development, including autism and neurodevelopmental disorders. Altering fundamental brain processes can have detrimental effects, emphasizing the need for reduced use or alternative treatments.

Brain signal linked to communication challenges in autism

Researchers found subtle patterns in brain activity while children listened to speech linked to verbal communication abilities in autistic youths. Altered brain signals suggested the brain may process speech less efficiently, with noisier signals associated with lower scores on everyday verbal communication.

Families report positive outcomes from fully virtual, BCBA-delivered, focused autism support program

A new study finds that fully virtual applied behavior analysis (ABA) services delivered by a Board Certified Behavior Analyst (BCBA) are a feasible alternative to traditional in-person therapy. Children with autism who received focused ABA services showed improvements in adaptive skills, behavior outcomes, and family quality of life.

Physical activity may help ease fatigue in children with developmental disabilities

A recent study by Virginia Tech researchers found that physically active children with cerebral palsy and Down syndrome experienced less fatigue. Parents reported similar results, highlighting the importance of physical activity for long-term health outcomes in children with developmental disabilities.

A review argues the family dog may become science’s unlikely ally against autism

A decade of canine research suggests that genetically engineered Beagles could be a complementary and welfare-conscious model for autism treatments. The study gathers findings on the behavior and traits of these dogs in relation to human autism, including signs of treatment with oxytocin and psychedelics.

Texas Children’s Hospital and Baylor College of Medicine researcher awarded up to $17.25 million to join an international autism research collaborative

Baylor College of Medicine researcher Dr. Jimmy Holder and his team will join the ARIA IMPACT Network to accelerate clinical trial readiness and implementation for promising therapies on autism. The collaboration aims to better understand how autism develops and changes over time in children with profound autism.

Boston Children’s Hospital awarded up to $17.25 million to join new autism research network

Boston Children's Hospital has been awarded up to $17.25 million to participate in the Innovative Medicine and Precision Approaches to Clinical Trials (IMPACT) Network, an international effort aimed at speeding up the development of urgently needed treatments for children with profound autism and related neurodevelopmental disabilities...

New therapy may reverse autism-related brain deficits

Researchers identified a promising new strategy for reversing autism-related brain deficits by targeting a specific glycine transporter. The therapy restored NMDA receptor function in mouse models and human brain organoids, improving behavioral abnormalities such as social interaction and repetitive behaviors.

Dr. Helen Willsey and Dr. David Kastner to investigate SYNGAP1’s role in cilia function and behavior with support from CURE SYNGAP1

Researchers will investigate the link between SYNGAP1 protein deficiency, cilia dysfunction, and clinical symptoms of SYNGAP1-Related Disorders. The study aims to inform rational drug design and provide new insights for targeted therapies.

Global SYNGAP1 organizations form CURE SYNGAP1 COLLECTIVE (CSC) to accelerate treatments and ensure patient access through coordinated global action

The CURE SYNGAP1 COLLECTIVE is a collaborative framework uniting independent SYNGAP1 charities worldwide to accelerate treatments for individuals with SYNGAP1-Related Disorders. The Collective focuses on three primary pillars: research, industry engagement, and patient advocacy.

Copper imbalance linked to white matter development and social behavior in autism

A research team at Niigata University has identified a copper-HIF1α-BNIP3-mTOR pathway connecting trace elements to glial cell development in autism spectrum disorder. Lower plasma copper levels were associated with higher ASD symptoms and reduced white matter volume, which was linked to social symptoms.

The LEGO Foundation launches new global research fellowship

The LEGO Foundation Fellowship will support up to 10 researchers pursuing ambitious work on how children thrive in crisis and conflict settings, neurodivergent children, and AI-enabled learning. The fellowship aims to deepen understanding of what helps children learn, grow, and thrive.

Funding for “Validating Remote Developmental Assessments in SYNGAP1-Related Disorders” grant awarded to co-PIs Julie Orlando DPT, PhD of ENDD at U Penn and Dr. Jill McKee of CHOP from CURE SYNGAP1

CURE SYNGAP1 invests in remote assessment tools to broaden access to clinical care and trials for patients with SYNGAP1-Related Disorders. The study aims to evaluate the validity of a standardized remote developmental assessment to reduce travel burden.

Brain scans reveal two distinct subtypes of autism with different underlying biology

Researchers identified two reproducible autism subtypes characterized by reduced brain connectivity (hypoconnectivity) or increased connectivity (hyperconnectivity), linked to synaptic pathways and immune-related systems, respectively. The study provides a biological foundation for precision medicine approaches.

New urine test provides simple way to screen for autism in children

A new screening tool tests for microbial metabolites in urine to identify children at risk for autism, with 90% sensitivity and 100% specificity. The test may guide more targeted interventions, including approaches to restore a healthy gut microbiome.

Adults with intellectual and developmental disabilities or cerebral palsy experience higher fall-injury risk at younger ages

Research analyzed over 35.8 million emergency department visits to compare fall-related injury risks among adults with and without intellectual and/or developmental disabilities or cerebral palsy. Adults with these conditions were more likely to visit the emergency department due to falls, especially at younger ages.

CURE SYNGAP1, fka SynGAP Research Fund (SRF), announces the release of their 2025 impact report – unlock their tomorrow

The 2025 Impact Report showcases tangible progress made by CURE SYNGAP1, including almost $1.8M in grants and the most successful SYNGAP1 Science Conference ever. The report highlights the organization's focus on Collaboration, Transparency, and Urgency, driving momentum for clinical trials and treatments.

CURE SYNGAP1 announces $111,960 investment in RARE-X partnership to advance ProMMIS patient-reported outcome measure data collection – PR46

CURE SYNGAP1 partners with RARE-X to accelerate ProMMiS study's Patient-Reported Outcome measure data collection. This investment enables the centralized collection of high-quality PROs, essential for regulatory approval and therapy development.

Strong genetic mutation overrides female protective effects in autism

Researchers developed a viable homozygous CHD8 mouse model, showing that stronger mutations can dramatically alter male–female autism patterns. The study revealed pronounced autism-related abnormalities in both sexes with severe mutations.

Severe asthma patients often battle multiple health conditions, study finds

A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.

Non-coding gene linked to core social and behavioral traits in Autism, major SickKids-led study finds

New AI tool developed by Stowers Institute and Helmholtz Munich scientists predicts how cells choose their future — helping uncover hidden drivers of development

Researchers developed RegVelo, an AI framework that models cellular dynamics and gene regulation to predict cellular fate decisions. The model traces developmental trajectories and simulates regulatory interactions, providing insights into hidden drivers of development and potential therapeutic targets.

What factors might account for the increased risk of autism in children with epilepsy?

A large population-based study found that children with epilepsy have a significantly higher risk of also having autism spectrum disorder. The study highlighted key differences between children with co-occurring conditions, including intellectual disability and age of diagnosis.

Stereotypes of autism in TV and film may be linked to delayed diagnosis, Stirling study finds

Researchers found that portrayals in media lacked diversity, often focusing on white, socially awkward male characters. Autistic participants felt that such portrayals were exaggerated and simplified, limiting public understanding and self-understanding.

The boy on the balcony who never came outside

Dr. Dilek Colak's journey began with a childhood observation of a boy with mental illness, which inspired her to pursue a career in neuroscience. Her current work focuses on understanding autism and schizophrenia through the study of human brain organoids.

Toxic PCBs, sex-biased genes, and the developing brain

Researchers at the UC Davis MIND Institute found that polychlorinated biphenyls (PCBs) alter genes more in females than males, with a key gene called XIST playing a protective role. Folic acid also shows promise in mitigating harmful effects of PCB exposure, particularly in women.

Can wearable technology detect the earliest signs of autism in infants? New study seeks to find out

Researchers are developing a new wearable technology to monitor babies' movements and detect early signs of autism. The study aims to improve early identification and intervention, which is crucial for optimal developmental outcomes in autistic individuals.

New genetic insights into developmental dysplasia of the hip

A large multiethnic study identifies genetic factors associated with developmental dysplasia of the hip (DDH) and its progression to osteoarthritis of the hip. Variations in COL11A2, CALN1, and TRPM7 genes were found to be common to both DDH and hip OA.

Study suggests link between prenatal exposure to certain medications and increased autism risk

A landmark study found a significant association between prenatal prescription of sterol biosynthesis-inhibiting medications and the risk of autism spectrum disorder (ASD) in children. The research identified commonly prescribed medications as potential contributors to neurodevelopmental vulnerability.

AI models lean on autism stereotypes when giving social advice, new study finds

Artificial intelligence models provide personalized advice, but may perpetuate negative stereotypes about people with autism. Researchers found that up to 70% of the time, AI discourages those with autism from socializing.

Scientists engineer a tool to “edit” brain circuits and enhance memory

Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.

Survey: Americans strongly support autism research — but most don’t know brain donation is needed to advance it

A new survey by Autism BrainNet reveals a significant disconnect between Americans' strong support for autism research and their limited understanding of postmortem brain donation. The survey found that 70% of respondents had never heard of brain donation, despite 92% agreeing its importance in advancing research.

Researchers identify the most common recessive neurodevelopmental disorder ever discovered

The study identified a previously unknown recessive neurodevelopmental disorder caused by changes in the RNU2-2 gene, affecting thousands of individuals in the US. Symptoms vary widely, including developmental delays, limited speech, and seizures, and may be more common than previously thought.

Video training helps young adults with disabilities navigate romance

Researchers developed a video modeling program to enhance romantic relationship skills in young adults with intellectual and developmental disabilities. The study found that participants significantly improved their decision-making skills across four relationship domains, averaging 76% accuracy after the intervention. The findings high...

SynGAP Research Fund (SRF) announces formal transition to CURE SYNGAP1, reinforcing commitment to treatment development

CURE SYNGAP1 accelerates treatment development for SYNGAP1-Related Disorders through rigorous research and family-led leadership. The organization has funded over $8 million in grants and identified over 1,707 patients to date.

TikTok’s mental health ‘minefield’

A systematic review of social media platforms reveals that TikTok contains a substantial proportion of misleading information about mental health and neurodivergence, with higher rates of misinformation than other platforms. The study emphasizes the importance of credible sources and evidence-based content to combat spreading false ide...

Augmented reality job coaching boosts performance by 79% for people with disabilities

A new study found that augmented reality job coaching significantly improves job performance for individuals with intellectual and developmental disabilities. The AR-based application delivered real-time guidance, enabling participants to complete complex tasks with minimal external support. This innovative approach has the potential t...

Online spaces can provide bodily comfort, relief and inclusion for some autistic people, study says

Online spaces provide bodily comfort, relief, and inclusion for some autistic adults, allowing them to express themselves and connect genuinely without scrutiny. This challenges the assumption that in-person interaction is always more valuable.

Teachers report limited or no training to support neurodivergent pupils, new study finds

A new study found that nearly 25% of UK teachers received no training on supporting neurodivergent pupils, with most reporting brief and limited sessions. The researchers highlight a mismatch between the complexity of pupils' needs and the training teachers are currently receiving.

Georgia State experts to help lead landmark study of profound autism

Researchers from Georgia State University, Marcus Autism Center and Emory University are collaborating to investigate the causes of profound autism in children. The 7,500 child study will explore patterns in development, behavior, brain activity and genetics to find more effective therapies.

Study: Anxiety, gloom often accompany intellectual deficits

A study analyzing data from 44,000 adults found that those with intellectual and developmental disabilities experience substantially higher rates of anxiety and depression. The study also highlights significant healthcare treatment and access barriers facing this population.

Anxiety, depression, and care barriers in adults with intellectual and developmental disabilities

This cross-sectional study highlights critical gaps in accessible mental health services for adults with intellectual and developmental disabilities. The findings underscore the need for policy reforms to address systemic inequities and provide disability-informed care.

Babies with an increased likelihood of autism may struggle to settle into deep, restorative sleep, according to a new study from the University of East Anglia.

A new study from the University of East Anglia found that babies with an increased likelihood of autism may struggle to settle into deep, restorative sleep. Those with high sensory sensitivity slept more lightly even in quiet environments.

Does the motion of our DNA influence its activity?

Exposure to intense wildfire smoke during pregnancy may be linked to increased likelihood of autism

Researchers found strongest associations on very smoky days and in areas with cleaner air overall. The study of over 8.6 million births in California suggests that intense wildfire smoke exposure may increase the likelihood of autism in children.

As nights warm, study flags possible prenatal link to autism risk

A new study found that warmer nighttime temperatures during pregnancy may be associated with a higher risk of autism diagnosis in children. Exposure to extreme heat during early and late pregnancy increased the risk by 15% and 13%, respectively.

New study calls for faster autism diagnosis to prevent suicides

A new study by Bournemouth University calls for faster autism diagnosis and tailored mental health support to reduce autistic people's suicidal thoughts and attempts. The research identified key priorities, including improving autism diagnostic services, tackling societal inequalities, and providing autism-specific support in crisis.

No association between mRNA COVID-19 vaccination during pregnancy and autism in children, new research shows

Researchers studied 434 children for signs of autism or neurodevelopmental problems, finding no link between mRNA vaccine and autism. The study suggests that COVID-19 vaccines are safe to receive during pregnancy to protect maternal and infant health.

Dr. Paul Donlin-Asp of the University of Edinburgh to dissect the molecular functions and regulation of local SYNGAP1 protein synthesis with support from CURE SYNGAP1 (fka SynGAP Research Fund)

Dr. Paul Donlin-Asp will investigate the molecular functions and regulation of local SYNGAP1 protein synthesis, aiming to advance therapies for SYNGAP1-related Disorders. The project seeks to map mechanisms controlling SYNGAP1 protein production in neurons.

University of Houston study offers potential new targets to identify, remediate dyslexia

A University of Houston study challenges traditional views on dyslexia, suggesting it stems from an overall brain network vulnerability. The research identified two developmental origins: one related to brain architecture and another to synaptic signaling, which may be uniquely human.

Federation of European Neuroscience Societies Forum 2026, 6-10 July, Barcelona, Spain

The FENS Forum 2026 will be Europe's largest neuroscience congress, covering areas of basic to translational research. Journalists can register for free and attend symposia and poster sessions.

Study maps how varied genetic forms of autism lead to common features

Researchers created a comprehensive map showing how eight different genetic mutations associated with autism spectrum disorder affect early brain development. They found that despite initial differences, these mutations increasingly impact overlapping molecular pathways as development progresses.

Exposure to wildfire smoke late in pregnancy may raise autism risk in children

A new study published in Environmental Science & Technology found that exposure to wildfire smoke during the third trimester may raise the risk of autism diagnoses in children. Mothers who were exposed to more than 10 days of wildfire smoke had a 23% higher risk of their child being diagnosed with autism by age 5.

Autistic and non-autistic faces may “speak a different language” when expressing emotion

Researchers found that autistic and non-autistic individuals produce distinct emotional facial expressions, with autistic adults exhibiting more unique and complex expressions. The study suggests that these differences in facial expressions may contribute to difficulties in recognizing each other's emotions.

Taking paracetamol during pregnancy does not increase risk of autism, ADHD or intellectual disabilities

A systematic review and meta-analysis of 43 studies found no link between paracetamol use during pregnancy and increased risks of autism, ADHD, or intellectual disabilities. Researchers concluded that previously reported links may be due to genetic predisposition or maternal factors rather than the medication itself.

Autism research reframed: Why heterogeneity is the data, not the noise

Dr. Noritaka Ichinohe challenges the long-held assumption that averaging away individual differences is necessary in psychiatric research. Instead, biological heterogeneity is seen as a phenomenon demanding explanation. The author's work on primate brain mapping and molecular subtyping has identified convergence points between species ...

January 2026 issues of APA journals feature new research on autism, pediatric anxiety, psychedelic therapy, suicide prevention and more

The January 2026 issues of four American Psychiatric Association journals feature groundbreaking research on externalizing disorders, pediatric anxiety, autism, and inflammation-related depression. The studies also explore the potential benefits of psychedelic therapy in suicide prevention.

Why neurodiversity might be the hidden engine of entrepreneurial success

Researchers found that ADHD enables high entrepreneurial alertness and risk-taking, while dyslexia fosters advanced delegation strategies. Bipolar traits correlate with creativity and a willingness to pursue bold ventures. The study advocates for business environments that value neurodiverse strengths, rather than seeking normalcy.