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Vaccine for rare but deadly mosquito-borne viruses shows promise in clinical trial

A vaccine candidate for eastern equine encephalitis virus, western equine encephalitis virus, and Venezuelan equine encephalitis virus has been found safe and well-tolerated in a clinical trial. The vaccine induced a neutralizing antibody response against all three viruses.

SourceNIH/National Institute of Allergy and Infectious Diseases·JournalThe Lancet Infectious Diseases·DateMay 12, 2022

Researchers identify a set of cellular receptors in humans and other species for the eastern equine encephalitis virus, other members of the alphavirus family

A new study identifies a set of cellular receptors for eastern equine encephalitis virus and other alphaviruses shared across mosquitoes, humans, and animals. The researchers tested a decoy molecule that successfully prevented infection and slowed disease progression in cell and animal models.

SourceHarvard Medical School·JournalNature·TypeExperimental study·DateJan 14, 2022

Eastern equine encephalitis virus poses emergent threat, say NIAID officials

Eastern equine encephalitis virus is a deadly mosquito-borne illness that has existed for centuries, with a particularly deadly year in the US in 2019. Current research efforts focus on developing vaccines and treatments, but challenges include limited funding and difficulties in reaching target populations.

SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNew England Journal of Medicine·DateNov 21, 2019
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A virus changes its stripes

A significant outbreak of eastern equine encephalitis occurred in Panama in 2010, marking a change in the virus's behavior in Latin America. The outbreak confirmed 13 human cases and one dual infection case, with a low case-fatality rate compared to US standards.

SourceUniversity of Texas Medical Branch at Galveston·JournalNew England Journal of Medicine·DateAug 21, 2013