Articles tagged with Epilepsy
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A groundbreaking study led by NYU Langone Medical Center has identified nine specific genes with four completely new mutations associated with two severe forms of epilepsy: infantile spasms and Lennox-Gastaut syndrome. These genetic risk factors may lead to personalized therapy and drug development.
A new guide created by researchers at Case Western Reserve University and Cleveland Clinic provides valuable information for parents of children with epilepsy and mental health problems. The guide covers topics such as child development, treatment options, and navigating the school system for support.
A global study using exome sequencing identified new genetic mutations causing severe childhood epilepsies, revealing common pathways to target the condition with drugs and therapies. The findings could lead to fast-tracking discoveries of genetic causes and improving treatment options for devastating childhood epilepsies.
A genetic study of childhood epilepsies has discovered two new genes associated with severe forms of the disease. The study used exome sequencing to identify disease-causing gene mutations and found an unusually large number of mutations, providing a wealth of information for epilepsy research.
University of Washington researchers have made significant progress in linking a rare form of epilepsy called epilepsy aphasia to genetic mutations in the GRIN2A gene. This breakthrough finding may lead to new diagnostic tools and treatments for patients with this condition, which is characterized by seizures and speech abnormalities.
A large-scale international study has identified 25 new mutations on nine key genes behind severe childhood epilepsy, including two new genes never before associated with the disorder. The findings suggest a new direction for developing genome-wide diagnostic screens and precise therapies for the condition.
Researchers developed a real-time system for detecting and identifying epilepsy using a nonlinear dynamics index and support vector machine. The system effectively identifies epileptic electroencephalogram signals with good generalization ability, making it suitable for clinical applications.
A new brain mapping technique using magnetoencephalography (MEG) has been developed to help surgeons plan for surgical treatment in epilepsy. The study, published in Human Brain Mapping, produced detailed spatial maps of critical language functions to improve surgical outcomes.
Researchers created a 'dish' of patient-specific neurons from skin cells, discovering abnormal sodium current activity that could set off seizures in Dravet syndrome patients. The study holds promise for modeling seizure disorders and screening medications.
Researchers found that intracerebroventricular injection of neuropeptide Y gene suppressed mossy fiber sprouting, inhibited abnormal synaptophysin expression, and reduced epileptic seizures. This study suggests a recombinant adeno-associated virus expression vector carrying the neuropeptide Y gene as a potential therapeutic approach.
Researchers at UC Riverside aim to develop more effective treatments for brain disorders like epilepsy by studying neuronal hyperexcitability and astrocytic swelling. They will investigate the relationship between astrocytic swelling and seizure thresholds using mouse models and modern imaging techniques.
A study published in The Lancet found that people with epilepsy are ten times more likely to die prematurely than the general population, with mental illness being a major contributor. The research revealed a strong correlation between psychiatric diagnoses and increased risk of accidents and suicide.
A 41-year study of 70,000 patients with epilepsy found that three-quarters of those who died had also been diagnosed with a psychiatric condition. The study suggests that carefully assessing and treating psychiatric disorders could help reduce the risk of premature death in these patients.
Children exposed to antiepileptic drugs in utero are at risk for motor development issues, language skills difficulties, and autistic traits. The study also found no increased risk of developmental delays in children born to mothers with epilepsy who did not use AEDs during pregnancy.
Scientists at Bonn University Hospital and MPI Cologne developed a method to predict temporal lobe epilepsy surgery success rates, achieving 96% accuracy for female patients and 94% for males. The algorithm assesses brain images to differentiate between seizure-free and non-seizure-free patients.
A new study shows that everolimus dramatically reduces seizures in patients with tuberous sclerosis complex (TSC), a genetic disease characterized by benign tumors on multiple organ systems. The drug also improves overall quality of life, with significant reductions in seizure frequency and duration.
Patients with epilepsy and mild cognitive impairment (aMCI) showed earlier cognitive decline than those without epilepsy. Epilepsy increases the risk of seizures and accelerates symptoms in Alzheimer's disease (AD). Identifying and treating epilepsy could improve clinical outcomes for patients.
Dr. Gary Mathern, a pediatric neurosurgeon at UCLA, was honored with the Ambassador for Epilepsy Award for his significant work in improving clinical care for children with medically refractory epilepsy. His research has led to breakthrough discoveries on mechanisms of the disease process and how seizures develop in the brain.
Researchers develop mathematical approach to understand synchrony in medical and ecological conditions, with potential applications in epilepsy and predator-prey systems. The formula analyzes indirect coupling in complex systems, enabling predictions and tests through experiments.
Researchers found DBI calms key brain rhythms and could be valuable for developing novel therapies for epilepsy, anxiety, and sleep disorders. DBI binds to GABA receptors, enhancing inhibition, and its actions are tightly controlled to occur only in specific brain areas.
A large scientific study has discovered two new genes associated with severe seizure disorders in infants and children. The finding will lead to new tests to diagnose these conditions and promises to improve outcomes for affected families.
A new study found that children and adolescents with seizures involving the temporal lobe are at risk for clinically significant behavioral problems and psychiatric illness, especially depression. Routine psychiatric evaluation is crucial before epilepsy surgery to improve quality of life.
A new imaging technique developed by Jean Gotman and his colleagues combines electroencephalogram (EEG) and functional magnetic resonance imaging (fMRI) to more precisely localize the areas generating epileptic seizures. This allows neurosurgeons to better understand the optimal ways of intervention for patients with epilepsy.
Researchers at the University of Arizona used a state-of-the-art DNA sequencing technique to determine the genetic mutations causing severe epilepsies in seven out of ten previously undiagnosed children. The study found 15 mutations in nine children, seven of which are known or likely to cause epilepsy.
Researchers at the University of California at San Francisco have made a breakthrough in treating epilepsy by transplanting new inhibitory nerve cells into the brains of adult mice. This innovative approach has shown promising results in reducing seizure occurrence and reversing associated learning and memory problems.
Researchers at UCSF controlled seizures in epileptic mice with a one-time transplantation of MGE cells, which inhibit signaling in overactive nerve circuits. The treatment showed promising results, eliminating seizures in half of the treated mice and reducing spontaneous seizures in the rest.
A world-first study led by Professor Mark Cook has accurately predicted epilepsy seizures in humans using a device implanted between the skull and brain surface. The system correctly predicted seizures with a high warning rate of 65% of the time, offering new management strategies for epilepsy.
Researchers developed an implantable device that detects abnormal brain activity and predicts seizures with a high accuracy rate. The technology has the potential to improve management strategies and potentially allow patients to avoid dangerous situations.
A study published in JAMA found that maternal use of valproate during pregnancy significantly increases the risk of autism spectrum disorder and childhood autism in offspring. The absolute risk is estimated at 4.42% for autism spectrum disorder and 2.50% for childhood autism.
A study by W. Curt LaFrance Jr., M.D., M.P.H. found that TBI significantly increases the odds of major depression, personality impulsivity, and PTSD in patients with psychogenic nonepileptic seizures (PNES). Patients with PNES and TBI had higher rates of disability, unemployment, and poorer functioning.
Researchers have discovered that epileptic seizures in temporal-lobe epilepsy patients can propagate through anatomically and functionally connected brain networks. The study found reduced gray-matter concentrations in certain brain regions, which correlated with changes in functional connectivity and communication between brain areas.
Researchers characterized SUDEP in a mouse model of DS, finding that treatment with drugs reducing parasympathetic activity reduced incidence. Lymphatic vasculature also plays crucial role in cholesterol removal from arteries, with impaired lymphatic growth leading to increased cholesterol retention. A new therapeutic target is identif...
Researchers characterized SUDEP in a mouse model of Dravet Syndrome and found that a prolonged slowing of the heart beat preceded SUDEP. Treatment with certain drugs reduced the incidence of SUDEP, suggesting mortality results from seizure-related parasympathetic hyperactivity.
The Max Planck Florida Institute for Neuroscience received $1.257 million in grant funding to study Parkinson's and epilepsy. Researchers aim to develop new molecular tools to analyze the human brain, with potential breakthroughs in treatments and cures.
The updated SEEG technique combines sophisticated imaging data reconstructions and robot-assisted surgery to provide essential information in complex cases of drug-resistant epilepsy. The new workflow reduces procedural error risks and improves accuracy in localizing the epileptogenic zone.
A new study by Michigan State University found that young people with epilepsy experienced significant reductions in stigmatization after participating in regular peer support groups. The research, published in Epilepsy and Behavior, suggests a potential solution to the debilitating stigma surrounding epilepsy in developing countries.
Researchers at Tel Aviv University discovered that astrocytes play a key role in brain communications, integrating messages and connecting neuronal circuits. This new framework offers insight into brain disease and disorders, such as epilepsy and Alzheimer's, which are linked to malfunctions in brain connectivity.
A new study in rats indicates that gentle brain cooling after injury may prevent seizures in humans, a finding that could lead to a safe and relatively simple way to treat patients with head injuries.
A Michigan State University research team begins a groundbreaking clinical drug trial to control seizures caused by cerebral malaria, which affects brain function in three million children. The trial aims to improve seizure control and potentially prevent epilepsy.
Researchers tracked 73 subjects with intracerebral hemorrhage (ICH) to find that about 60% of newborns had visible seizures at the time of stroke, while 43% of older children did. Within two years, 13% of study subjects developed epilepsy, and patients with elevated brain pressure were more likely to experience later seizures.
Cats and humans share a similar form of epilepsy caused by an autoimmune response targeting nerve cell proteins. Researchers have discovered antibodies reacting to these proteins in the blood of affected cats, which is consistent with a similar human condition.
Scientists at Johns Hopkins University and Tel Aviv University found that mutations in the NHE9 gene lead to a profound loss of function in an ion transporter, which may trigger seizures. This discovery could lead to new diagnosis or treatment options for autism patients.
A large-scale study reveals that parasites and inadequate prenatal care contribute significantly to epilepsy prevalence in sub-Saharan Africa. The research found that adults with parasitic infections were 1.5-3 times more likely to have epilepsy than those without exposure.
Researchers have found that the human papillomavirus 16 (HPV16) is present in the brains of individuals with a common form of childhood epilepsy. The discovery suggests that the virus may play a role in the development of the condition, and could lead to new therapeutic options related to HPV.
Researchers created an EEG-based computer system that activates optical fibers in the brain to arrest seizure activity and reduce severe 'tonic-clonic' events. The approach shows promise for treating severe manifestations of epilepsy with minimal side effects.
A new study from MIT researchers suggests that some epileptic seizures may originate in non-neuronal glial cells. Mutations in a gene called zydeco, which influences glial-cell communication with neurons, appear to make neurons more excitable and prone to seizures.
A recent study found that individuals with a strong family history of seizure disorders are more likely to experience migraines with aura. The research, published in Epilepsia, analyzed data from over 730 participants with epilepsy and demonstrated a significant genetic link between the two conditions.
Scientists have identified a gene expression that initiates a protective electrical response after seizures, which could prevent recurrent seizures and the onset of devastating epilepsy. This discovery also has implications for relief from chronic pains, cardiovascular disease, and recovery from mood disorders.
A study by neurologists at Henry Ford Hospital found that brain surgery for refractory localization-related epilepsy can lead to significant long-term benefits, with 73% achieving favorable seizure outcomes and 28% experiencing seizure freedom. The researchers tracked 470 patients over 15 years after surgery.
Researchers at Duke University discovered that carbon nanotubes can accelerate the growth of neuronal cells and lower nerve-damaging chloride levels. This finding has potential applications in developing new neural engineering devices using carbon nanotubes to treat neural injuries.
A small Johns Hopkins Children's Center study found that children on the ketogenic diet experienced reduced seizures after incorporating periodic fasting. The results suggest that fasting does not intensify but rather changes the metabolism of children with epilepsy.
A new study by Emory researchers has proven successful in preventing depression in people with epilepsy, reducing seizures and improving quality of life. The web-based method, called Project UPLIFT, provides patients with depression prevention and stress management skills, increasing knowledge and skills to replace negative feelings.
A Loyola University Medical Center neurologist reports a higher-than-expected rate of patients with non-epileptic seizures who also experience epileptic seizures during the same hospital stay. This finding is significant because it highlights the need for more accurate diagnosis and treatment of these conditions.
Scientists have discovered several toxins in sea anemones that could be used as new generation of insecticides. These toxins disable ion channels, potentially leading to the development of pain and cardiac disorder treatments.
Researchers identified potent antiepileptic fatty acids in the ketogenic diet, which could lead to a new pill for controlling seizures. The discovery aims to replace the high-fat, low-carbohydrate diet with a safer treatment option.
Researchers created a new fruit fly model of inherited epilepsy that shows the link between temperature-dependent seizures and flawed sodium channels. The study establishes a platform to develop therapies for febrile seizure disorders, such as GEFS+, which can persist beyond childhood and often develop seizures in the absence of fever.
Researchers identified a new drug target for epilepsy in human brain tissue, which also shows promise for treating behavioral disorders. The study found that specific brain layers are activated during seizures and linked to increased synapses, leading to abnormal neuronal synchrony.
Scientists developed a genetically engineered fruit fly model to study temperature-dependent seizures. The model reveals that disease-causing mutations lead to breakdowns in brain regulation, causing excessive electrical activity. Researchers hope this discovery will lead to the development of new treatments for febrile seizures.
A study by Rhode Island Hospital researcher W. Curt LaFrance Jr. compared diagnosis and treatment practices for PNES in the US and Chile. Increasing access to video-EEG is crucial for accurate diagnosis and effective treatment of PNES, which are often misdiagnosed as epilepsy.
A study by UC Irvine neurologist Dr. Jack Lin suggests that screening for comorbidities can enhance the care and quality of life for children and adults with epilepsy. The study highlights the importance of early detection, treatment, and prevention of psychiatric, cognitive, and social issues in conjunction with epilepsy.