Articles tagged with Epilepsy
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Researchers discovered that quercetin in pickled capers regulates proteins controlling bodily processes like heartbeat, thought, and muscular contraction. The study may lead to future therapies for epilepsy and abnormal heart rhythms.
A study published in Neurology suggests that at least one million Chinese people with epilepsy could be candidates for a standard operation to leave them seizure-free. The study found 108 patients with lesions that could potentially be cured by surgery, with a high success rate of around 70-80%.
Researchers at the Medical University of South Carolina have developed a vitamin K-based compound that eliminates medication-resistant epileptic seizures in mice. The compound works by increasing brain cells' ability to produce energy and protects mitochondrial health, making it a promising new treatment option for those with epilepsy.
Researchers discovered a novel potassium channel activator, GiGA1, that selectively opens GIRK channels and reduces neuronal excitability. Systemic administration of GiGA1 exhibits anti-seizure properties in an acute epilepsy animal model.
Researchers have identified a critical step in how brain cells function in people with one of the most common forms of epilepsy, which could lead to new treatment approaches. Changes in gene activity and polyadenylation processes were found to be dramatically altered in people with epilepsy, changing protein production in the brain.
Researchers identified microRNAs associated with epilepsy and designed drug-like molecules to target them, finding three that stopped seizures in preclinical tests. The study aims to develop novel treatments for people whose seizures cannot be controlled by current medications.
A new study identified a significant common genetic component in BECTS, suggesting potential new treatments, and found maternal smoking in pregnancy quadrupled the risk of BECTS. The association with CHRNA5 gene opens up research possibilities into how epilepsy is caused.
Researchers have made significant breakthroughs in understanding chandelier cells, which are key regulators of brain signaling. Abnormalities in these cells have been linked to neurodevelopmental disorders, and studying them may provide insights into disease mechanisms.
A recent clinical research study found that listening to Mozart's Sonata for Two Pianos in D Major, K. 448 daily reduced seizure frequency in adult individuals with epilepsy. The study suggests this as a supplemental therapeutic option for those who do not respond well to anti-seizure medications.
A new animal study suggests that exposure to beneficial microorganisms during pregnancy may prevent an autism-like disorder in offspring. The study found that rats given a heat-killed preparation of Mycobacterium vaccae showed no signs of autism-like behavior, unlike those who were stressed and administered terbutaline.
A new study found that mortality rates for epilepsy-related deaths did not decrease between 2009 and 2015, with a six-fold increased risk of death among young adults aged 16-24. The majority of epilepsy-related deaths (78%) were classified as potentially avoidable.
Researchers developed a noninvasive ultrasound neuromodulation technique that inhibits epileptiform activities with an efficiency exceeding 65% in biopsy specimens from epileptic patients. The study demonstrates the potential clinical use of low-intensity pulsed ultrasound stimulation for epilepsy treatment.
A new wearable device aims to prevent SUDEP, a deadly complication of refractory epilepsy. The device monitors key biomarkers and sends alerts to caregivers when abnormalities are detected.
Researchers found that a genetic mutation in the KCC2 protein causes a glitch in brain activity suppression, leading to panic responses and seizures. The R952H variant has been linked to individuals with autism spectrum disorder, epilepsy, and schizophrenia.
Researchers at Carnegie Mellon University have developed a novel source imaging technology using high-density EEG to map underlying brain networks. This breakthrough can accurately estimate the size and scope of active areas within the brain, as well as interactions between functionally related regions.
A study by the University of Bonn has identified an autoantibody that triggers epilepsy in some patients. The autoantibody targets the protein Drebrin, disrupting nerve cell transmission and leading to inflammation and seizures.
A new neurodegenerative disorder has been discovered in children, characterized by developmental regression and severe epilepsy. The disorder is caused by a variation in the NRROS gene and appears to require two copies of the defective gene.
Researchers have discovered a potential new treatment for drug-resistant epilepsy using compounds derived from magnolia trees. The study found that extracts from the bark of Magnolia officinalis reduced seizure-like behavior in both zebrafish and mice, providing a promising lead for the development of new treatments.
Researchers at the Gladstone Institutes report that reducing levels of tau protein prevents core autism symptoms, seizures, and other abnormalities in mouse models. The findings suggest promise as a potential treatment for some forms of autism.
Researchers discovered a key molecular mechanism mediating GABAergic synaptic development and function, with somatostatin peptide found to regulate synaptic transmission between nerve cells.
A UC Riverside-led study found that brains treated with certain drugs within days of an injury have a reduced risk of developing epilepsy later in life. The development of epilepsy is linked to an immune system receptor, TLR4, which increases excitability in the hippocampus.
A preliminary study by the American Academy of Neurology found that children and teens with epilepsy who were treated with pharmaceutical cannabidiol (CBD) had better seizure control compared to those treated with artisanal CBD. Pharmaceutical CBD was found to have a 39% reduction in seizures, while artisanal CBD resulted in a 70% incr...
A new therapy called antisense oligonucleotide (ASOs) has shown dramatic effects in a mouse model of SCN8A-related encephalopathy, reducing mRNA expression by half and increasing lifespan by four-fold.
Researchers found that developing seizures after a severe ischemic stroke increases the risk of death and disability. The study identified several risk factors for post-stroke seizures, including age, severity of stroke, and previous heart conditions.
Researchers have developed sensitive and specific potassium nanosensors that can monitor dynamic changes of potassium ions in the brain during epileptic seizures. These nanosensors enable the accurate sensing of potassium levels in different parts of the brain, facilitating the diagnosis and therapy of epilepsy.
Researchers developed an algorithm using deep convolutional neural networks to analyze myoclonus severity from video footage. The method successfully quantified myoclonic jerks in EPM1 patients, correlating well with clinical evaluations and detecting small-amplitude and high-frequency jerks.
A new study reveals that people with neurological disorders have a 75% higher suicide rate than those without such disorders. The study found that severe neurological diseases like ALS and Huntington's disease are associated with particularly high risks of suicide.
A Danish registry study found a significant association between neurological disorders, including dementia and Parkinson's disease, and increased risk of suicide. The study analyzed nearly 40 years of data for 7.3 million people, revealing that those with neurological conditions were more likely to die by suicide.
Researchers at Cold Spring Harbor Laboratory have developed a chemical compound, UBP1700, that inhibits certain NMDARs while allowing others to function. This allows for the precise investigation of NMDAR activity in both healthy and diseased brains.
Researchers found that cells from children with NGLY1 deficiency lack sufficient water channel proteins called aquaporins, leading to inability to produce tears and other wide-ranging symptoms. The discovery opens new avenues for finding therapies to treat the disorder.
Researchers at Duke-NUS Medical School and NNI discovered that misregulated potassium ion channel activity causes seizures in AS patients. Suppressing this activity could potentially resolve seizures, benefiting people with autism as well.
A new study by Cedars-Sinai researchers found that abnormal electrical pulses from specific brain cells cause temporary memory disruptions in epilepsy patients. The study's findings could lead to better treatments for cognitive impairment in epilepsy patients, with the potential to improve their quality of life.
Researchers found that implanted neurostimulators can record brain data during anxiety attacks, guiding therapy changes to reduce negative symptoms caused by seizures. Five patients with epilepsy showed improvements in treating neuropsychiatric comorbidities through data analysis and counseling.
A randomized controlled trial found that fenfluramine reduced convulsive seizures by 62% in patients with Dravet Syndrome. Low-dose fenfluramine also showed significant reductions in seizure frequency, while side effects were manageable.
Scientists at Georgetown University Medical Center have discovered that a specific set of neurons in the brain can be targeted to stop seizure activity. The study's findings provide new hope for treating epilepsy, an incurable condition affecting millions worldwide.
A new statistical tool has been validated for assessing epilepsy seizure risk, allowing for more accurate treatment decisions. The Epilepsy Seizure Assessment Tool (EpiSAT) correctly identified changes in seizure risk in over 87% of cases.
Cenobamate reduces seizures by 55% in patients with treatment-resistant epilepsy, offering new hope for those who have limited success with traditional medications. The study, led by Johns Hopkins lead investigator Gregory Krauss, involved 437 participants across 16 countries and found significant improvements in seizure control.
A new study published in the British Journal of Clinical Pharmacology found that cannabidiol may not have a significant antiepileptic effect on seizure frequency in patients with Lennox-Gastaut syndrome. However, the interaction between cannabidiol and clobazam could be responsible for the reduction in seizures.
A new gene therapy has shown promise in suppressing epileptic seizures in animal models and human tissue samples. The treatment delivers a specific gene that produces dynorphin, modulating neural activity and dampening seizure spread.
Researchers discover DEPDC5, a chromosome 22q-targeting tumor suppressor, silenced by mutations in GISTs. The gene's inactivation promotes GIST cell proliferation and reduces sensitivity to KIT inhibitors.
A Stanford University School of Medicine study found that even people with well-controlled epilepsy often experience cognitive deficits due to abnormal brain electrical activity called high-frequency oscillations. The research suggests that certain medications or implantable devices could be improved to alleviate these deficits.
A comprehensive register-based study from Aarhus University, Denmark, found a significant association between repeated febrile convulsions and the risk of developing epilepsy and psychiatric disorders. Children who suffered three or more febrile convulsions had a 15% risk of developing epilepsy within thirty years.
A new study developed genetic-based epilepsy risk scores that can accurately distinguish between healthy patients and those with epilepsy, as well as between patients with generalized and focal epilepsies. These scores have the potential to identify high-risk patients earlier and guide precision treatment.
A study published in Annals of Neurology found that the spread of seizures through the brain can be suppressed by a
Researchers found that CBD substantially lessened seizure severity in mice and restored normal brain rhythms in Angelman syndrome models. The study suggests CBD could benefit kids and adults with this serious condition, characterized by intellectual disability and epilepsy.
A systematic review and meta-analysis suggests that people with drug-resistant epilepsy have better prospects of being seizure-free if they undergo surgical treatment at an earlier stage. The study found a 15-21% higher probability of attack freedom for those who underwent surgery early compared to later stages.
A collaborative project between the University of Washington and UCB will explore ways to enhance community pharmacist engagement in epilepsy care. The effort seeks to address fragmented healthcare services and medication adherence issues affecting the 3.4 million people living with epilepsy.
Researchers have developed a new machine learning algorithm that can detect the seizure onset zone in just 10-20 minutes, eliminating the need for prolonged monitoring and reducing risks. This breakthrough could lead to a new treatment approach for epilepsy patients, particularly those with drug-resistant forms of the disease.
A review of 10-year experience at Ann & Robert H. Lurie Children's Hospital of Chicago found that ketogenic diet was safe and effective in treating drug-resistant epilepsy in infants under 3 years old. Nearly half of children with genetic causes of epilepsy experienced significant seizure reduction after three months on the diet.
Researchers developed an advanced method to detect low-level somatic mutations in intractable epilepsy with 100% accuracy, surpassing conventional sequencing analysis which stands at 30%. The study used deep sequencing replicates of major focal epilepsy genes and identified mutations in approximately 5% of patients.
FutureNeuro researchers integrated genomics data into the Irish National Epilepsy Electronic Patient Record system, enabling personalized treatment plans for individuals with unknown cause epilepsy. The new system facilitates multidisciplinary meetings and review of genomic test results to determine genetic causes, leading to better di...
A massive study involving 17,606 participants has identified rare genetic variations associated with a higher risk of epilepsy. The research found that both severe and less severe forms of the disease share similar genetic features, paving the way for more targeted treatments.
A novel antibody-enzyme fusion has virtually eliminated Lafora bodies in LD mouse brains, restoring normal brain metabolism. The therapy has potential treatment applications beyond Lafora Disease, including other glycogen storage diseases.
A new study found that social isolation in mice and rats causes higher stress and anxiety levels, leading to more severe seizures in epileptic rodents. This highlights the importance of housing conditions in experimental design and data analysis.
Researchers at UTSA have successfully removed new neurons that developed after a brain injury to reduce seizures in mice. The study found a 65% reduction in seizures, but the effect was not permanent and may be due to underlying factors such as chronic inflammation or reactive astrocytes.
Researchers at UT Health San Antonio have discovered a novel therapy that reduces brain damage after traumatic brain injury (TBI) in mice, preventing seizures and reducing inflammation. The study aims to develop a simple and effective treatment for TBI patients.
Researchers found that removing new neurons born after a brain injury reduced seizures in mice, with a 65% decrease observed. This approach may potentially prevent post-injury epilepsy if implemented within a specific time frame.
A study by the University of Saskatchewan found that medicinal cannabis oil containing CBD and THC can reduce or end seizures in children with severe, drug-resistant epilepsy. The research team tested a dosage regimen that showed significant improvements in quality of life for the children, with some experiencing complete seizure freedom.
A new guide from the American College of Physicians provides clinicians with a detailed framework for caring for transgender patients, highlighting specific medical issues and ways to improve practice. The guide also addresses broader concerns about healthcare access and disparities in marginalized populations.
The UAB clinic has achieved rapid accessibility and improved seizure control for patients with drug-resistant epilepsy. Vagal nerve stimulation (VNS) and responsive neurostimulation (RNS) therapies have shown promise, with 12-11 out of 27-16 patients experiencing a 60% reduction in seizures.