Researchers have developed a wireless, battery-free device that can illuminate neuron activity in the brain without penetrating the skull or tissue. This breakthrough technology has the potential to revolutionize treatments for conditions like epilepsy, chronic pain, and depression by enabling less invasive optogenetics experiments.
SourceUniversity of Arizona College of Engineering·JournalProceedings of the National Academy of Sciences·TypeExperimental study·DateJul 29, 2021
Apple iPhone 17 Pro
Apple iPhone 17 Pro delivers top performance and advanced cameras for field documentation, data collection, and secure research communications.
Researchers at Ruhr-University Bochum have developed a new reverse optogenetic tool that can be controlled by light, suitable for studying changes in the brain responsible for epilepsy.
SourceRuhr-University Bochum·JournalNature Communications·DateJul 23, 2021
A new dietary supplement, K.Vita, has been shown to reduce seizures in children and adults with drug-resistant epilepsy, with a mean 50% reduction in seizures or paroxysmal events. The study found that the supplement was well-tolerated and palatable, with fewer than 10% of participants producing significant ketones.
SourceUniversity College London·JournalBrain Communications·DateJul 22, 2021
Researchers at UC Riverside's Brain Injury Lab have received significant federal funding to investigate the molecular mechanisms underlying traumatic brain injury and post-traumatic epilepsy. Two graduate students, Laura Dovek and Susan Nguyen, have each won prestigious fellowships to study the role of immune receptors in the developme...
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Researchers at the University of Queensland have discovered a rare genetic mutation that can cause epilepsy. The study found that a specific receptor in brain cells behaves differently, leading to an imbalance in communication - a key factor in the development of disorders.
SourceUniversity of Queensland·JournalCell Reports·DateJul 8, 2021
Researchers have developed a new, noninvasive brain stimulation technique using magnetoelectric nanoparticles to stimulate deep brain function. The method is more efficient than traditional methods without invasive procedures, showing promise for treating various neurological conditions.
SourceIndiana University School of Medicine·JournalNeurotherapeutics·DateJul 1, 2021
Researchers are exploring the mechanisms of CASK loss-of-function mutation associated epileptic encephalopathy. A new mouse model suggests that deleting the CASK gene impairs mitochondrial function and energy supply to the brain, potentially causing seizures.
A study led by Professor Ivan Rektor found that listening to Mozart's Sonata for Two Pianos K448 reduced epileptiform discharges in epilepsy patients by 32%, while Haydn's music had the opposite effect. The acoustic properties of music were responsible for this anti-epileptic effect.
SourceSpink Health·JournalEuropean Journal of Neurology·DateJun 18, 2021
Researchers at Vanderbilt University Medical Center identified a common mechanism underlying a spectrum of brain disorders caused by variations in the SLC6A1 gene. Boosting transporter function via genetic or pharmacological means may be beneficial in treating these disorders.
SourceVanderbilt University Medical Center·JournalBrain·DateJun 9, 2021
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A multidisciplinary team has developed a genomic single-cell map that identifies cell-type specific transcriptional signatures of hyper-excitability and neurodegeneration. The study provides grounds for improved diagnosis of temporal lobe epilepsy and may also shed light on Alzheimer's disease.
SourceSpanish National Research Council (CSIC)·JournalCell Biology·DateJun 8, 2021
Researchers at Linköping University have developed new resin acid molecules with antiseizure effects, opening a potassium ion channel that can prevent epileptic seizures. The molecules also show less effect on smooth muscle, reducing undesired side effects.
SourceLinköping University·JournalEpilepsia·DateJun 8, 2021
A large research project found that children of women with epilepsy who took antiseizure medication during pregnancy have similar cognitive outcomes at age 2 as those born to healthy women. However, higher levels of medication were linked to lower scores on motor and general adaptive tests related to self-care.
SourceNIH/National Institute of Neurological Disorders and Stroke·JournalJAMA Neurology·DateJun 7, 2021
Researchers used standardized reporting of clinical data to determine the most effective methods for controlling seizures in pediatric epilepsy patients. The study found that using telemedicine had no impact on seizure frequencies and that certain patient demographics were more likely to experience worsening seizures.
SourceChildren's Hospital of Philadelphia·JournalEpilepsia·DateJun 3, 2021
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A new $2.3 million grant will support a five-year research project at UC Riverside, led by Viji Santhakumar, exploring the relationship between inflammation and abnormal neuron connections after brain injury. The study aims to identify potential early therapies to prevent epilepsy and memory issues following traumatic brain injury.
Researchers developed a neuromorphic chip that can detect high-frequency oscillations and recognize complex biosignals in real time. The technology has the potential to improve neurosurgical interventions and monitor epilepsy outside of hospitals.
SourceUniversity of Zurich·JournalNature Communications·DateMay 27, 2021
Researchers found that analyzing local networks within brain regions provides superior results to traditional fiber tract connectivity approaches for predicting disease progression and surgery outcomes in epilepsy patients.
SourceUniversity of Nottingham·JournalHuman Brain Mapping·DateMay 20, 2021
Case Western Reserve researchers have identified a potential new approach to controlling epileptic seizures by stabilizing the sodium channel through neddylation. This finding, published in The Journal of Clinical Investigation, offers hope for future research and potential drug development to prevent epilepsy.
SourceCase Western Reserve University·JournalJournal of Clinical Investigation·DateMay 19, 2021
Researchers at UCSF have discovered that brain waves travel both up and down the hippocampus, integrating messages from different areas of the brain. The finding suggests that brain waves can predict direction and may be a biomarker for cognitive activity.
SourceUniversity of California - San Francisco·JournalNature Communications·DateMay 14, 2021
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A Columbia University team designed a high-performance implantable system that can read and modify brain signals, suppressing pathological coupling in epileptic animal models. The multiplex-then-amplify (MTA) system enables simultaneous stimulation of arbitrary waveforms on multiple independent channels.
SourceColumbia University School of Engineering and Applied Science·JournalProceedings of the National Academy of Sciences·DateMay 10, 2021
New research from the University of Virginia School of Medicine reveals that sleep can increase the risk of sudden death in people with epilepsy. Seizures disrupt the body's natural regulation of sleep-related changes, leading to a slower heart rate and potentially deadly consequences.
SourceUniversity of Virginia Health System·JournalEpilepsia·DateMay 6, 2021
New research from the University of Virginia School of Medicine has identified a sequence of events during seizures that can progress to death. The researchers found that breathing disruption, or apnea, occurs during seizures and that artificially stimulating breathing can prevent sudden death after a seizure.
SourceUniversity of Virginia Health System·JournalAnnals of Neurology·DateApr 28, 2021
Researchers have discovered that fast brainwave oscillations can pinpoint brain tissues responsible for epileptic seizures. The collaborative research leverages noninvasive EEG technology to automatically identify high-frequency oscillations and epileptiform spikes, which are key links related to epilepsy.
SourceCollege of Engineering, Carnegie Mellon University·JournalProceedings of the National Academy of Sciences·DateApr 20, 2021
Researchers developed a method to localize epileptic tissue using EEG fast oscillations, differentiating pathological from nonepileptiform signals. High-frequency oscillations riding spikes provide a potential tool for presurgical diagnosis and postsurgical evaluation.
SourceProceedings of the National Academy of Sciences·JournalProceedings of the National Academy of Sciences·DateApr 19, 2021
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A case report warns of a potential link between medical cannabis and early puberty in children with severe childhood epilepsy. The 2-year-old boy's testosterone levels were abnormally high after using cannabis oil, raising concerns about the hormonal consequences of cannabis use.
Researchers at NYU Langone Health identified hundreds of potential new treatment targets for epilepsy by analyzing adult human brain tissue. Altered levels of brain proteins were found predominantly in the hippocampus and frontal cortex, suggesting that these regions may play a role in the development of the disorder.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalBrain Communications·DateMar 25, 2021
Researchers mapped over 400 patients with SCN2A-related disorders, linking genetic abnormalities to clinical features. The study provided a framework for precision medicine approaches to help individuals with these conditions.
SourceChildren's Hospital of Philadelphia·JournalGenetics in Medicine·DateMar 17, 2021
A new study found that children born to women taking epilepsy medications during pregnancy have no developmental delays at age three. The study involved 275 women with epilepsy and 77 without the disease, and found no differences in developmental scores between the two groups.
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Researchers at USC have developed a powerful mathematical model that can predict seizures with high accuracy, providing epilepsy patients with an early warning of up to five minutes. This breakthrough could revolutionize epilepsy management and treatment, allowing patients to take necessary interventions to prevent seizure onset.
SourceUniversity of Southern California·JournalJournal of Neural Engineering·DateFeb 25, 2021
Children with epilepsy experience poorer sleep quality, disruptions, and parasomnias compared to healthy peers. Integrating sleep assessments into diagnosis and management could reduce seizures' impact on sleep and overall quality of life.
SourceUniversity of Birmingham·JournalSleep Medicine Reviews·DateFeb 10, 2021
A rare genetic syndrome caused by mutations in the gene SATB1 has been identified, characterized by neurodevelopmental delay, intellectual disability, and muscle tone abnormalities. Variations in the gene lead to different levels of protein activity, resulting in varying symptoms and severity.
SourceOxford Brookes University·JournalThe American Journal of Human Genetics·DateJan 28, 2021
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Researchers develop prototype to automate processing of brain data, allowing for accurate identification of epileptic focus; potentially saving up to 90% of time spent reviewing data. The tool has been validated by physicians and is expected to have a clinical impact.
Researchers use mathematical modeling to study synchronization changes during seizure onset, identifying key factors that influence the transition from desynchronization to high levels of synchronization. The study reveals a new phenomenon where amplitude coupling can accelerate or decelerate the domino effect.
SourceSociety for Industrial and Applied Mathematics·JournalSIAM Journal on Applied Dynamical Systems·DateJan 25, 2021
A large-scale electronic health record study found that functional seizures are prevalent and often misdiagnosed as epileptic seizures. The study also discovered novel associations between functional seizures and cerebrovascular disease, including stroke, as well as psychiatric disorders such as PTSD and depression.
SourceVanderbilt University Medical Center·JournalJAMA Network Open·DateJan 7, 2021
Researchers used a special backpack to monitor brain waves while participants walked around an empty room, finding hidden spots. The study found that brain waves flowed in a distinct pattern suggesting the brain mapped out physical space and boundaries.
SourceNIH/National Institute of Neurological Disorders and Stroke·JournalNature·DateDec 23, 2020
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Researchers at Université de Genève have developed a technique that can predict epileptic seizure periods between one and several days in advance. By recording neuronal activity over six months, they can detect individual cycles of epileptic activity and provide information about the probability of a future seizure.
SourceUniversité de Genève·JournalThe Lancet Neurology·DateDec 18, 2020
Researchers have made breakthroughs in predicting epilepsy seizures using brain implant data, identifying weekly-to-monthly cycles of 'brain irritability' that predict higher likelihood of seizures. The study's findings could enable patients to plan their lives around high or low seizure risk, avoiding potentially dangerous situations.
SourceUniversity of California - San Francisco·JournalThe Lancet Neurology·DateDec 17, 2020
A new study published in EPJ B reveals how complex dynamics in branching networks of neurons can be predicted to trigger episodes of epilepsy. The team's findings could lead to the development of better early warning systems for patients.
SourceSpringer·JournalThe European Physical Journal B·DateDec 8, 2020
Epileptic spasms originate from pyramidal cells in the deep layers of the neocortex, generating rhythmic slow oscillations similar to NREM sleep states. This discovery opens up new avenues for developing desperately-needed interventional therapies.
SourceBaylor College of Medicine·JournalAnnals of Neurology·DateDec 8, 2020
A large multi-site study has found a link between brain connectivity and grey matter atrophy caused by certain types of epilepsy. The study used big data analysis to accurately predict damage to grey matter over time.
SourceMcGill University·JournalJournal of Mathematical Sciences Advances and Applications·DateDec 2, 2020
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A highly unusual case of a right-handed patient performing unconscious 'mirror-writing' with her left hand while in the midst of having epileptic seizures was reported by doctors. The study, published at Euroanaesthesia, suggests that mirror writing may occur in patients with epilepsy affecting one limb.
SourceThe European Society of Anaesthesiology and Intensive Care (ESAIC)·DateNov 27, 2020
A study published by the American Academy of Neurology found that women with epilepsy who take valproic acid during pregnancy are at double the risk of having children with autism spectrum disorder and nearly double the risk of ADHD. The research used data from over 14,000 children born to mothers with epilepsy between 1996 and 2011.
SourceAmerican Academy of Neurology·JournalNeurology·DateOct 28, 2020
A new study finds that focal epilepsy, affecting one in 26 American adults, is often overlooked due to subtle symptoms. Early diagnosis can lead to fewer car accidents, with the researchers estimating 1,816 preventable accidents annually worldwide.
SourceNYU Langone Health / NYU Grossman School of Medicine·JournalEpilepsia·DateOct 20, 2020
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Davis Instruments Vantage Pro2 Weather Station offers research-grade local weather data for networked stations, campuses, and community observatories.
Researchers have found that an amino acid called D-serine could prevent a type of epileptic seizure by blocking receptors in the brain. The study, published in Nature Communications, suggests that D-serine levels are depleted in patients with temporal lobe epilepsy, leading to neuronal death and loss of function.
SourceFlorida State University·JournalNature Communications·DateOct 13, 2020
Researchers at the University of Illinois Chicago discovered a protein called DUSP4 that may help prevent or treat epilepsy. Boosting levels of DUSP4 could potentially block the spread of epileptic centers in the brain and reduce seizure activity.
SourceUniversity of Illinois Chicago·JournalNeurobiology of Disease·DateOct 8, 2020
A Rutgers University study found that patients with generalized epilepsy are at a higher risk of developing obstructive sleep apnea compared to those with focal epilepsy. Treatment of OSA may improve seizure control and overall health for these patients.
SourceRutgers University·JournalEpilepsy & Behavior·DateSep 29, 2020
A new analysis confirms that listening to Mozart's piano music can significantly reduce the frequency of epileptic seizures. The study, which evaluated 147 research articles, found that daily Mozart listening sessions resulted in a 31-66% reduction in epilepsy attacks.
SourceEuropean College of Neuropsychopharmacology·DateSep 11, 2020
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Researchers used magnetic resonance elastography to detect changes in the hippocampus of patients with mesial temporal lobe epilepsy, which is resistant to medication. The study found that MRE can improve early detection and characterization of the disease.
SourceBeckman Institute for Advanced Science and Technology·DateSep 2, 2020
A new generation of long-term brain monitoring technologies records neural activity to provide a reliable alternative to subjective seizure diaries. These devices, such as the Wyss Center's Epios system, offer flexible configurations and could enable optimized and personalized treatment for each patient.
SourceWyss Center for Bio and Neuroengineering·JournalEpilepsia·DateAug 27, 2020
Women with catamenial epilepsy experience nearly four times more frequent seizures during menstrual cycle and are more likely to have drug-resistant epilepsy. The study may lead to tailored treatments for this group.
A new investigational therapy has shown to prevent the onset of Dravet syndrome symptoms in a mouse model, increasing gene expression up to 100 percent in neurons. The treatment uses an antisense oligonucleotide (ASO) that is reversible and non-invasive.
SourceMichigan Medicine - University of Michigan·JournalScience Translational Medicine·DateAug 26, 2020
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A team of researchers at Children's Hospital of Philadelphia used new computational methods to link characteristic presentations of childhood epilepsies with specific genetic variants. They analyzed clinical information and large-scale genomic data, finding associations between 11 genetic causes and specific symptoms.
SourceChildren's Hospital of Philadelphia·JournalAmerican Journal of Human Genetics·DateAug 26, 2020
A new study finds the COVID-19 pandemic is driving the adoption of electronic patient portals for epilepsy, enabling better care and resource management. The PiSCES portal provides secure access to medical records and care tools, empowering patients to track their condition.
Research identifies two functionally distinct sub-circuits in the sensory thalamus that process distinct classes of information. These circuits enable powerful new optogenetic and chemogenetic strategies to probe behavioral and perceptual functions, potentially shedding light on conscious awareness and epilepsy.
SourceUniversity of Alabama at Birmingham·JournalNature·DateJul 23, 2020
Researchers discovered that quercetin in pickled capers regulates proteins controlling bodily processes like heartbeat, thought, and muscular contraction. The study may lead to future therapies for epilepsy and abnormal heart rhythms.
SourceUniversity of California - Irvine·JournalCommunications Biology·DateJul 13, 2020
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A study published in Neurology suggests that at least one million Chinese people with epilepsy could be candidates for a standard operation to leave them seizure-free. The study found 108 patients with lesions that could potentially be cured by surgery, with a high success rate of around 70-80%.
SourceMonash University·JournalNeurology·DateJul 6, 2020
Researchers at the Medical University of South Carolina have developed a vitamin K-based compound that eliminates medication-resistant epileptic seizures in mice. The compound works by increasing brain cells' ability to produce energy and protects mitochondrial health, making it a promising new treatment option for those with epilepsy.
SourceMedical University of South Carolina·JournalJournal of Medicinal Chemistry·DateJul 6, 2020
Researchers discovered a novel potassium channel activator, GiGA1, that selectively opens GIRK channels and reduces neuronal excitability. Systemic administration of GiGA1 exhibits anti-seizure properties in an acute epilepsy animal model.
SourceThe Mount Sinai Hospital / Mount Sinai School of Medicine·JournalCell Reports·DateJun 30, 2020
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Researchers have identified a critical step in how brain cells function in people with one of the most common forms of epilepsy, which could lead to new treatment approaches. Changes in gene activity and polyadenylation processes were found to be dramatically altered in people with epilepsy, changing protein production in the brain.
Researchers identified microRNAs associated with epilepsy and designed drug-like molecules to target them, finding three that stopped seizures in preclinical tests. The study aims to develop novel treatments for people whose seizures cannot be controlled by current medications.
SourceRCSI·JournalProceedings of the National Academy of Sciences·DateJun 25, 2020
A new study identified a significant common genetic component in BECTS, suggesting potential new treatments, and found maternal smoking in pregnancy quadrupled the risk of BECTS. The association with CHRNA5 gene opens up research possibilities into how epilepsy is caused.
SourceKing's College London·JournalEBioMedicine·DateJun 24, 2020