Articles tagged with Glaucoma
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A University of Georgia study found that medical marijuana leads to lower prescription drug use, particularly for conditions like glaucoma and pain. The study estimated savings of $468 million if all states had implemented medical marijuana laws.
A new clinical trial shows that modulating brain plasticity can partially restore vision in patients with glaucoma and optic nerve damage after 10 days of noninvasive stimulation. The treatment improved visual acuity, reading, mobility, and orientation, with benefits stable two months later.
Researchers have identified a genetic mutation in the TEK gene that causes primary congenital glaucoma, a devastating eye disease affecting children worldwide. The finding validates previous research in mice and suggests a new therapeutic pathway to repair damaged vessels in the eye.
Researchers have developed a medicated silicone ring that slowly releases medication over 6 months, potentially lowering the risk of vision loss among seniors with glaucoma. The device reduced eye pressure by about 20% in patients compared to traditional daily drops.
The BrightFocus Foundation has awarded nearly $5 million in vision research grants to five scientists studying macular degeneration and glaucoma. The grants, named after prominent leaders in the field, will support innovative research projects aimed at understanding and preventing these diseases.
Accurate IOP measurement is crucial for managing glaucoma and identifying high-risk patients. Newer methods like Dynamic Contour Tonometry offer alternative solutions for patients with abnormal corneas, but limitations remain.
Researchers developed a compound called KUSs that may help prevent nerve damage in glaucoma, allowing patients to maintain near-normal vision. Early tests in mice showed promising results, suggesting these compounds could slow down disease progression and potentially treat other neurodegenerative diseases.
Scientists create method to differentiate patient-derived stem cells into retinal ganglion cells, which can help combat neurodegeneration in glaucoma. This breakthrough enables personalized medicine prospects for patients with glaucoma.
Researchers at IUPUI have successfully identified cellular processes related to glaucoma using stem cells derived from human skin cells. The study found that skin cells from individuals with glaucoma became unhealthy and died off faster than those of healthy individuals when reprogrammed into retinal ganglion cells.
A study published in JAMA Ophthalmology found that higher dietary nitrate and green leafy vegetable intake is associated with a lower risk of primary open-angle glaucoma. Participants who consumed more nitrate-rich foods had a 20-30% reduced risk of developing the condition.
The study, funded by the National Eye Institute, identified FOXC1, TXNRD2, and ATXN2 as contributing genes to primary open-angle glaucoma. Variations in these genes may lead to reduced mitochondrial protection, increasing optic nerve cell death.
Researchers have identified three genetic associations that influence susceptibility to primary open angle glaucoma, a leading cause of irreversible blindness. The study found associations between TXNRD2, ATXN2, and FOXC1 genes, which may lead to the development of gene-based screening tests and therapy for glaucoma patients.
Researchers found that head-down yoga poses, such as downward-facing dog, can cause a rise in eye pressure in glaucoma patients. Glaucoma patients should inform their yoga instructors about their condition to modify poses and avoid potential damage to the optic nerve.
A survey of glaucoma patients in Washington, D.C. found that perceptions of marijuana legality and false beliefs about its value were associated with intentions to use it as a treatment. The study suggests a need for education on the topic to protect patients against increased acceptability based on misconceptions.
A study found that patients with glaucoma can adapt their visual scanning behavior to compensate for impaired vision and pass a standard driving test. By making more frequent head and eye movements, they can improve traffic safety and potentially be granted a driver's license in some countries.
Washington State University researchers created a sensing platform to measure and analyze gait patterns in people with glaucoma. This innovation aims to reduce falls and injuries by detecting early signs of the disease, such as slower walking pace and unequal step placement.
Bamosiran reduced IOP by similar magnitude across four doses, but failed to demonstrate non-inferiority to timolol in total population; showed excellent tolerability and non-inferiority at dose 1.125% in patients with baseline IOP >=25mmHg
Scientists at UC San Diego School of Medicine have elucidated a genetic interaction between SIX6 and p16INK4a that may prove key to the development and progression of glaucoma. Inhibiting p16INK4a expression could offer a new therapeutic approach for the disease, which is currently treated by lowering intraocular pressure.
Researchers have discovered the molecular culprits behind primary open-angle glaucoma, a leading cause of blindness, by identifying two key risk genes: SIX6 and P16. The study found that high eye pressure increases expression of P16, linking it to increased risk of vision loss.
Krishnakumar Kizhatil has been awarded the prestigious Lewis Rudin Glaucoma Prize for his research on Schlemm's canal, a unique vessel that plays a key role in glaucoma. The prize recognizes Kizhatil's work as a major breakthrough in understanding the molecular basis of intraocular pressure elevation and its link to glaucoma.
Researchers found that the brain coordinates vision loss in glaucoma patients, with a 'Jigsaw Effect' where two puzzle pieces fit together. This suggests that the brain optimizes vision in the face of glaucoma's destruction of sight, opening up new areas of research for neuroprotective therapies.
A study published in JAMA Ophthalmology has found associations between lower blood manganese levels and higher blood mercury levels with a greater risk of glaucoma diagnosis. The research suggests that trace metals may play a role in the pathogenesis of glaucoma, and future investigations could explore potential neuroprotective effects.
BrightFocus Foundation has awarded $11 million in research grants to 58 scientists worldwide. The grants focus on treatments for age-related diseases such as Alzheimer's, glaucoma, and macular degeneration, with a emphasis on early detection, disease progression, and potential interventions.
A study published in JAMA Ophthalmology found that patients taking metformin hydrochloride had a 25% reduced risk of developing open-angle glaucoma compared to those who took no metformin. Higher doses of metformin were associated with greater reductions in OAG risk, suggesting potential benefits for eye health.
A study of 3,353 Chinese adults in Singapore found the prevalence of glaucoma to be 3.2%, with primary open-angle glaucoma affecting 1.7% and primary angle-closure glaucoma affecting 1.5%. The study also highlighted the need for increased public awareness of this potentially blinding condition.
A new virtual reality testing environment provides a more realistic assessment of balance control in glaucoma patients. The study found that patients with glaucoma made balance adjustments 30-40% more pronounced than healthy subjects, highlighting the need for preventative measures.
A researcher at IUPUI is studying how glaucoma develops in stem cells created from skin cells genetically predisposed to the disease. The goal is to identify the cause of damage and develop customized strategies to fix it, potentially leading to repairing existing cells and restoring vision.
Researchers identified structural features and cell types in the retina that may act as key factors in glaucoma progression. Within seven days of elevated eye pressure, some retinal ganglion cells underwent significant rearrangements, such as reductions in number and length of dendritic branches.
A new study finds that chronic hypertension increases a person's susceptibility to glaucoma by damaging blood vessels in the eye. This damage compromises the eye's capacity to cope with changes in blood flow, making hypertension a risk factor for the potentially blinding eye disorder.
A study published in The Lancet found that prostaglandin analogue eye drops can reduce the risk of vision loss in people with open angle glaucoma by over 50% over 2 years. The treatment showed significant benefits even after just 12 months, and more frequent testing can lead to faster data collection and improved drug development.
Glaucoma, affecting over 60 million worldwide, has been linked to mitochondrial gene mutations through DNA sequencing. The research aims to support personalized medicines targeting mutated mitochondria and prevent disease progression.
A new study from City University London found that eye movement analysis can detect diseases like glaucoma while watching TV. This method could help clinicians identify the disease earlier, enabling timely treatment before permanent damage occurs.
A study using a free peripheral vision assessment app on iPads screens approximately 200 patients in Nepal for glaucoma, showing promise for populations with limited access to traditional eye care. The results agree between 51-79% with the industry standard test and can be an effective initial screening tool for high-risk groups.
A study led by Queen's University professor Robert Campbell revealed that using anti-inflammatory medicines after common eye surgery isn't helpful or necessary. The research found that steroids and nonsteroidal anti-inflammatory drugs do not affect the ability of laser treatment to lower eye pressure.
Researchers found that endothelial cells in eyes with glaucoma are stiffer than healthy cells, leading to increased flow resistance and elevated pressure. This mechanical dysfunction may lead to a cure for the debilitating disease.
Researchers at Northwestern University identify a critical chemical signaling pathway for the healthy functioning of Schlemm's canal, a key factor in developing glaucoma. They are now developing an eye drop that activates regrowth of the clogged vessel to lower pressure and restore normal drainage.
The Stanford-developed eye implant is a tiny device that measures intraocular fluid flow and provides data on eye pressure. This information can help doctors tailor treatment plans, potentially improving outcomes for glaucoma patients. The device is currently designed to fit inside a standard intraocular lens prosthetic.
Schlemm's canal has been found to have lymphatic characteristics, including a growth factor that reduces eye pressure. This discovery challenges the current understanding of the eye's drainage system and opens up new avenues for glaucoma treatment and diagnosis.
A new study published in PLOS Biology reveals that Schlemm's canal forms from blood vessels through a novel process called canalogenesis. This discovery sheds light on the complex functions of Schlemm's canal, which plays a critical role in maintaining ocular health and preventing diseases like glaucoma.
Researchers have discovered that acute glaucoma is an inflammatory disease caused by high eye pressure, leading to vision loss. The study found that a rapid increase in eye pressure triggers an immune response that damages retinal cells.
Researchers at the University of Washington have designed a low-power sensor to track eye pressure changes and monitor for glaucoma. The sensor would be embedded with an artificial lens during cataract surgery and transmit data wirelessly, allowing for real-time tracking and potentially preventing vision loss.
A new study published in TVST found that glaucoma is controlled by the brain, not the eye. The research shows that as previously disabled optic nerve axons recover, the remaining areas of permanent visual loss coincide with the areas that can still see in the other eye, forming a jigsaw puzzle-like pattern.
Two studies in JAMA Ophthalmology investigated glaucoma medication adherence, finding that a sizable number of patients struggle to use prescribed eye drops. Electronic monitoring revealed that 82.8% of patients took their medication correctly on at least 75% of days, highlighting the need for risk calculators to identify nonadherent p...
A study published in Journal of Agricultural and Food Chemistry found that chlorogenic acid in coffee may prevent retinal degeneration due to oxidative stress. Regular coffee consumption could potentially protect against eye diseases like glaucoma, age-related macular degeneration, and diabetic retinopathy.
The BrightFocus Foundation has honored five outstanding scientists in the fields of macular degeneration and glaucoma. Researchers from California, Florida, Maryland, Michigan, and Texas received $3.5 million in grant awards to study new treatments for these eye diseases.
Researchers explore new approaches to managing intraocular fluid buildup in the trabecular meshwork, a key structure controlling eye pressure. The development of next-generation glaucoma therapies aims to improve treatment options for those at risk of glaucoma.
A prospective cohort study found that higher total folate intake was associated with a lower risk for exfoliation glaucoma (EG)/suspected exfoliation glaucoma (SEG). The results showed a trend of reduced EG/SEG risk with higher folate intake, particularly from supplements. This supports a possible causal role of homocysteine in EG/SEG.
New research reveals a melanoma-specific biomarker for predicting immune dysfunction. A murine model of glucocorticoid-induced glaucoma has also been developed, highlighting the role of ER stress in disease progression.
Researchers from UCLA have developed a drug delivery system that may improve glaucoma management by reducing side effects and increasing patient compliance. The nanodiamond-drug compound was released into the eye through contact lenses, showing great promise for sustained treatment.
Researchers discovered a new layer in the human cornea that plays a vital role in fluid flow from the eye. This finding could shed light on glaucoma, a devastating disease caused by defective drainage of fluid.
Scientists have discovered molecules that may block the accumulation of a toxic eye protein leading to early onset glaucoma. The researchers identified two compounds with potential for future drug development to treat this condition, which affects several million people from childhood to age 35.
Glaucoma blindness risk has dropped by half in the last generation, according to Mayo Clinic research. The study found a significant decrease in the probability of going blind in at least one eye due to glaucoma.
The probability of blindness from glaucoma has decreased by nearly half since 1980, with advances in diagnosis and therapy likely contributing to the reduction. However, a significant proportion of patients still progress to blindness, emphasizing the need for continued research and vigilant eye exams.
Researchers found that vision restoration training can strengthen partially surviving neurons and promote visual recovery 'hot spots'. The study analyzed data from 32 stroke patients with hemianopia and found that average absolute improvement was 6%.
Research found that women who used oral contraceptives for three or more years are 2.05 times more likely to have glaucoma, a leading cause of blindness. The study suggests long-term use of birth control may be a risk factor for glaucoma, particularly in combination with other factors such as ethnicity and family history.
African-American individuals are disproportionately affected by glaucoma, with a four to five times higher risk of occurrence and up to 15 times greater likelihood of significant visual impairment compared to European descent.
Researchers found that people with sleep apnea are at a significantly higher risk of developing open-angle glaucoma compared to those without the condition. The study recommends clinicians alert patients about this association to encourage treatment.
The BrightFocus Foundation has awarded $7.2 million in grants to 53 scientists conducting research on Alzheimer's, glaucoma, and macular degeneration. The funded projects focus on imaging technology, gene therapy, and cell regeneration to better understand disease development and potential new therapies.
Researchers developed a new open-source platform to analyze and visualize visual fields, enabling transparent collaboration among independent labs. The platform contains analytical and visualization tools, including methods for glaucoma detection, and can be used for experimentation and research.
The US Preventive Services Task Force found insufficient evidence to recommend for or against screening for primary open-angle glaucoma. Two commentaries explore the physician's role in preventing gun violence, including the importance of discussing guns with elderly patients and advocating for mental health treatment.