Articles tagged with Hepatocellular Carcinoma
Researchers examined the effectiveness of intra-arterial combination chemotherapy in treating advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). The treatment led to a median survival time of 457.2 days and a one-year survival rate of 70%.
A Chinese medicine compound, delisheng, has shown satisfactory anti-cancer effects on hepatocellular carcinoma cells in a three-dimensional cell culture model. The compound's ginseng component is believed to be responsible for its anti-tumor activity, which may lead to new treatment options for HCC patients.
Researchers discovered that nerve growth factor (NGF) is positively related with liver cancer, the No.2 killer among all kinds of cancers. NGF and its receptor trkANGF were expressed in liver cells of patients with liver cirrhosis and/or hepatocellular carcinoma.
Researchers have developed a new blood screening technique that can detect early-stage liver cancer and predict treatment outcomes. They detected an altered version of RASSF1A, a tumor-suppressing gene, in the blood of HCC patients and HBV-infected test subjects, with promising results.
Researchers discovered that nerve growth factor (NGF) is positively related to liver cancer and may be expressed by liver cells to affect themselves or adjacent cells. Targeting NGF could suppress or prevent the development of liver cirrhosis and hepatocellular carcinoma.
Researchers developed a new blood test to detect liver cancer in an early stage, improving detection accuracy by 70%. The test uses the ratio of two sugar groups on blood proteins to identify liver cancer in patients with cirrhosis.
A meta-analysis of 11 studies on coffee consumption and hepatocellular carcinoma (HCC) found a 41% reduction in HCC risk among coffee drinkers. The study suggests that compounds in coffee may act as blocking agents, reducing carcinogenic detoxification and liver disease risk.
Research at University of California, San Diego reveals that male mice produce more IL-6 in response to liver injury, leading to a higher incidence of liver cancer. The study suggests therapies targeting IL-6 production or estrogen-like compounds may reduce liver cancer risk in males.
The Sorafenib HCC Assessment Randomized Protocol (SHARP) Trial demonstrated Nexavar's effectiveness in extending overall survival by 44% compared to placebo. Hepatocellular carcinoma is the most common form of liver cancer, responsible for about 90% of primary malignant liver tumors in adults.
Patients with liver cancer undergoing chemotherapy who have high serum levels of hepatitis B virus (HBV) DNA are at risk of developing severe hepatitis, which is associated with poor survival. Researchers found that a pre-chemotherapy HBV viral load above 10^5.65 copies per milliliter was linked to poorer outcomes.
Researchers at Columbia University's Mailman School of Public Health discovered a means for early detection of liver cancer using DNA isolated from serum samples. The study found changes associated with cancer in serum DNA one to nine years before actual clinical diagnosis, leading to an overall predictive accuracy of 89%.
The study found that survival rates for patients with hepatitis B who need liver transplants are similar between those with and without hepatocellular carcinoma (HCC). Despite the higher likelihood of transplantation, 5-year survival rates were comparable between the two groups. The findings suggest that antiviral therapy may have bene...
A recent double-blind study found that long-acting octreotide did not improve outcomes for patients with liver cancer compared to a placebo. The study enrolled 119 patients and followed them for over 30 months, but showed no significant difference in survival rates between the two groups.
A study found that higher levels of specialized blood cells from bone marrow are associated with liver cancer prognosis. Elevated endothelial progenitor cells were linked to poorer outcomes in patients with inoperable hepatocellular carcinoma.
A recent study found that colchicine significantly reduces the risk of developing hepatocellular carcinoma (HCC) in patients with hepatitis virus-related end-stage liver disease. Colchicine treatment delays HCC diagnosis by an average of 72 months and improves survival rates.
A new study found that liver cancer metastasis is influenced by the local tissue's microenvironment, with a unique gene expression signature predicting metastatic potential. The researchers identified a key role for colony-stimulating factor 1 in promoting anti-inflammatory conditions supporting tumor growth and metastasis.
Researchers found that patients with hepatocellular carcinoma who responded well to transarterial chemoembolization (TACE) prior to liver transplantation had a higher survival rate. The study's findings challenge the traditional use of Milan criteria, which rely on tumor size and number, as a reliable predictor of recurrence.
Researchers identified 254 gene sequences in melanomas that may inhibit metastasis and found high retinol levels reduce risk of hepatocellular carcinoma. Grb7 peptide inhibitor targets pancreatic cancer cells, showing promise as a new therapy.
Researchers have found that combining the monoclonal antibody C225 with photodynamic therapy in a mouse model of ovarian cancer resulted in substantial tumor reduction and improved survival rates compared to single-agent treatments. This innovative approach may provide new hope for women diagnosed with this aggressive form of cancer.
Scientists have found that the hepatitis B virus primes liver cells to turn cancerous by 'turning off' an enzyme called GSK-3ß, which normally suppresses tumor formation. This discovery has potential relevance for other cancers and could lead to novel therapeutic approaches, including gene therapy and small molecules.
Studies show that smoking, red meat intake, and alcohol use increase the risk of serious gastrointestinal cancers. Patients who used tobacco and/or alcohol were diagnosed three to five years earlier on average than those who never smoked or drank.
A nested case-control study found that higher HBV viral loads were associated with increased liver cancer risk in Taiwanese men. Genotype C was also linked to a five-fold increased risk of HCC, with effects exacerbated by high viral load levels.
A study has identified two distinct subclasses of liver cancer with differing survival rates, providing new molecular insight into the pathogenesis of hepatocellular carcinoma. The findings suggest that gene expression profiles can accurately predict patient survival and may lead to the development of more targeted therapies.
A US study found that liver transplantation significantly improves five-year survival rates for patients with hepatocellular carcinoma (HCC), from 25.3% in the late 1980s to 61.1% in the early 2000s. The study suggests that careful patient selection based on improved criteria may be a key factor in these improvements.
Researchers identified a specific gene required for liver cancer metastasis, which may serve as a diagnostic marker and therapeutic target. The study found that the activity of genes in tumors with metastatic potential differed from those without, enabling early detection and potentially improving treatment outcomes.
A new treatment option called TheraSphere appears safe and effective in reducing liver tumors and improving quality of life for patients with advanced stage hepatocellular carcinoma. The novel treatment emits beta rays via microscopic glass beads, delivering a higher dose to the liver than standard radiotherapy.
A study by University of Pittsburgh surgeons found that liver cancer patients wait nearly a year for transplants, allowing tumors to grow too large to be cured. Modifying the policy could improve survival rates for Stage IV patients with four or more nodules less than 3 cm.
Mutations in the beta-catenin gene are frequent in hepatocellular carcinoma, a type of liver cancer. The study found that about 50% of tumors in transgenic mice contained these mutations, and 26% of human liver cancer samples also had similar genetic alterations.