Articles tagged with Immune Disorders
A team of researchers developed a multi-organ chip on-a-chip that applies 3D cell printing technology to closely replicate the pathological environment of type 2 diabetes. The chip shows a correlation between visceral fat and T2D, as well as impaired retina cell function, indicating potential complications.
A protein called PI3K plays a crucial role in immune cell function, and genetic variations disrupting its signalling have been identified as the root cause of two immunodeficiency disorders. The study reveals how minor disruptions in immune cell signalling can lead to immune deficiency or dysfunction.
Researchers at UCLA successfully used base editing to correct a mutation causing rare immune deficiency CD3 delta SCID. The treatment corrected an average of 71% of patient stem cells and allowed them to produce fully functional T cells, suggesting long-term persistence of corrected blood stem cells.
A new cutaquig study found that increasing infusion volume per site resulted in a reduction of injection sites, while increasing infusion rates decreased infusion duration. The research also showed that dosing every other week demonstrated equivalency to trough levels with weekly dosing.
A large Dutch study found that the BCG vaccine does not protect elderly people with co-morbidities against COVID-19 symptoms. The study analyzed 6,112 participants and showed no difference in disease manifestations or hospitalizations between those who received the vaccine and those who received a placebo.
Researchers have identified serine as a key contributor to peripheral neuropathy in diabetes, a condition that affects approximately half of people with type 1 or type 2 diabetes. Supplementing diabetic mice with serine alleviated neuropathy symptoms, suggesting a potential treatment option.
A recent study of over 42,000 patients found low adherence to COVID-19 booster dose recommendations among immunocompromised individuals. This vulnerable population faces increased risk of severe COVID-19, underscoring the importance of tailored efforts to ensure they remain up-to-date with booster doses.
Researchers have isolated two new bacterial species from patients with inflammatory bowel disease (IBD), which break down the protective mucus layer of the gut. The bacteria, Allobaculum mucilyticum and Allobaculum fili, are highly efficient at degrading intestinal mucus, leading to potent immune responses.
Researchers have discovered a way to predict the course of ALS by measuring immune cells in cerebrospinal fluid. A high proportion of effector T cells is associated with low survival rates, while activated regulatory T cells indicate a protective role against rapid disease progression.
Researchers from the University of Zurich have discovered why a stem cell transplant is effective in treating multiple sclerosis. The study found that memory T cells reappear immediately after the transplant and do not trigger an autoimmune reaction due to pre-damage caused by chemotherapy. This knowledge enables the body to gradually ...
A large randomized clinical trial demonstrated Octagam 10% as an efficacious and well-tolerated treatment option for adult dermatomyositis patients. The study showed improved outcomes in patients with this rare disease, providing a much-needed treatment alternative.
Osaka University researchers identified medullary thymic epithelial cells (mTECs) expressing neuromuscular molecules in myasthenia gravis-thymoma samples. These findings suggest a new connection between the two diseases and may lead to novel therapeutic methods.
A rise in severe acute hepatitis of unknown causes (SAHUC) in children has been reported worldwide, with symptoms including jaundice, vomiting, and diarrhea. Diagnostic tests such as liver enzymes and biopsy reports can help identify the disease, but its etiology remains unclear.
Researchers developed topological membrane metadevices for on-chip terahertz wave manipulations, showcasing robust single-mode manipulation and valley-locked edge states. This breakthrough enables the development of a robust platform for terahertz on-chip communication, sensing, and multiplexing systems.
Studies by UC Davis MIND Institute found predictive protein patterns in expecting mothers' blood and links between maternal autoantibodies and higher autistic traits. MAR ASD patterns were associated with autism before birth, with certain patterns predicting autism in previously diagnosed children.
A Brazilian patient with a rare genetic disease was treated with breast milk donated by a vaccinated woman, boosting her IgA levels and eliminating the virus. The treatment was successful after a week, with the patient testing negative twice at ten-day intervals.
A study analyzing 17 million patient GP records in England found that people with certain inflammatory immune conditions were at higher risk of dying or needing hospital care from COVID-19. The analysis suggests that targeting prevention strategies and early interventions towards those most at risk can help inform evidence-based policy.
Researchers developed a genetic test that diagnoses primary immunodeficiency disorders (PID), revealing inherited genetic defects in nearly half of patients. The test uses next-generation sequencing technology to identify specific gene variants associated with PID, enabling targeted treatment and earlier intervention for family members.
Researchers at Gwangju Institute of Science and Technology have developed a new bioinformatics pipeline, CRESSP, to investigate the mechanism underlying autoimmune diseases following SARS-CoV-2 infection. The tool identified potential epitopes responsible for COVID-related autoimmune diseases and predicted cross-reactive epitopes of di...
A study published in Cell reveals that individuals with gum disease are more susceptible to developing arthritis due to alterations in immune cell precursors in the bone marrow. The researchers also found that this association may prompt a reconsideration of how bone marrow donors are selected.
A UCLA-led team has created a roadmap tracing each step in human blood stem cell development, providing a blueprint for producing fully functional blood stem cells. The map could help expand treatment options for blood cancers and inherited disorders.
Researchers found that seven patients with inflammatory skin conditions experienced anaphylaxis after using goat's milk or cheese products. The study highlights the potential risks of using foodstuffs as therapy for inflammatory skin conditions, leading to new allergies.
A recent analysis found that hospital admissions for children with lupus showed a decrease in severe kidney problems over time. However, racial disparities persist, with Black and Asian children at higher risk of developing new kidney problems.
A new study found that common variable immunodeficiency (CVID) affects only one identical twin due to alterations in immune cell-cell communication and epigenome. Researchers identified defects in B cells and other immune cell types, as well as massive epigenetic problems with DNA methylation.
Researchers have identified formononetin as a potential therapeutic for treating food allergies, which affect nearly 10% of the world population. The plant compound has been shown to decrease IgE production and influence gene and protein targets regulated in food allergy and mast cell diseases.
A Johns Hopkins-led study published in New England Journal of Medicine found that convalescent plasma from recovered COVID-19 patients can effectively treat outpatients, with a 54% reduced need for hospitalization. The therapy's effectiveness increases with earlier administration within five days after diagnosis.
Human immune cells occupy certain tissues and remain there for years, contrary to previous belief. T cells found to be optimally adapted to their local environment, potentially supporting barrier function.
Researchers found an association between a specific HLA-DPB1 gene variant and poor response to sublingual immunotherapy (SLIT) for Japanese cedar pollinosis. The study suggests that genotyping the HLA-DPB1 gene could help predict patient responsiveness to SLIT.
A study suggests that targeting necroptosis in muscle fibers using an inhibitor can lessen myositis-induced muscle weakness and cell death, promoting muscle regeneration. This approach shows promise for treating polymyositis with potentially fewer infectious complications than current immunosuppressive therapies.
Scientists create a hybrid technology called heteroduplex oligonucleotide (HDO) that can safely and effectively silence disease-causing genes in certain immune cells. The HDO delivery method has shown promise in improving symptoms of autoimmune disorders and cancers by regulating the function of T and B lymphocytes.
Scientists at Washington State University have discovered a novel theory that the innate immune system can respond differently to specific pathogens. This quality, known as immunological specificity, is driven by the nervous system and could provide a basis for finetuning an experimental treatment to fight infection.
Researchers have developed a method to assess drug potential for rare disorders by profiling FDA-approved drugs. The study identified NMD modulators that could potentially treat hundreds of disorders associated with nonsense-mediated RNA decay.
A large-scale review of anti-inflammatory drugs used for autoimmune disorders suggests that current treatments can worsen lipid metabolism, leading to increased cardiovascular disease risk. Researchers propose the development of combination therapies targeting lipid metabolism to reduce immune complications and CVD risk in patients.
The Sanford Children's Genomic Medicine Consortium has initiated a whole genome sequencing research project to investigate undiagnosed illnesses in children with suspected inborn errors of immunity. The study aims to sequence the genomes of up to 25 patient genomes and learn information that can benefit patients and others.
A study published in Allergy reveals the importance of PU.1 transcription factor in regulating CCL17 gene expression, which contributes to allergic diseases. The research found that suppressing PU.1 can reduce inflammation in asthmatic mice, paving the way for novel treatments.
A new study suggests that Black children are more likely to be affected by a rare immune disease that causes scar tissue to form on skin and internal organs. The research found that one in five cases of the disease involve children under 16 years old, with over 90% of these being Black.
A study of HIV-positive black and Latino men found that methamphetamine use combined with intimate partner violence boosts inflammatory and antiviral genes, leading to immune system exhaustion. This combination may increase the risk of developing cardiovascular disease and other disorders.
The German Research Foundation has approved a new Collaborative Research Center (CRC) focused on developing sustainable iron alternatives to replace toxic or rare elements. The CRC will investigate iron's potential as a building block for the future, aiming to enhance its properties and make it more affordable and resource-efficient.
A study by Tokyo University of Science researchers identifies a novel regulatory axis targeting dendritic cell activity, suppressing autoimmune disease symptoms and bone loss. They discovered DCIR binds to glycoproteins on macrophages and osteoclasts, reducing inflammation and immune responses.
A new UCL-led study found that people who survived childhood cancer have a higher risk of cardiovascular disease, infections, and disorders of the immune system by age 45. The study also suggests that cancer survivors treated with chemotherapy and radiotherapy face greater long-term health effects.
Scientists have reversed new-onset type 1 diabetes in mice by injecting pyramid-like DNA molecules called tFNAs, which increased regulatory T cells and protected pancreatic β-cells. The treatment is one of the most promising candidates for type 1 diabetes immunotherapy.
Researchers report that 90% of patients who received gene therapy between 2009 and 2012 remain disease-free, with significant immune system differences observed among those treated. The therapy is most effective in younger children, but further work is needed to achieve high levels of gene correction in all patients.
Research at Florida Atlantic University found that green sea turtles in polluted environments have impaired immune systems, leading to increased disease susceptibility. The study suggests a positive feedback loop where pollution compromises immunity, making turtles more prone to Green Turtle Fibropapillomatosis.
Researchers at UToledo have developed a protein-based vaccine that promotes a strong immune response, effectively treating rheumatoid arthritis and improving bone quality. The findings suggest long-term benefits following immunization.
A team of researchers from FAU has investigated the timing of treatment in autoimmune diseases and found that early intervention can have a major impact on disease progression. By targeting B cells, which produce autoantibodies and influence other immune cells, researchers were able to prevent or delay severe organ damage.
The FDA has granted orphan drug status to Octagam 10%, the first and only IVIg treatment for adult dermatomyositis. The therapy is expected to become the first treatment option for adults with this rare disease, which affects approximately 10 out of every million U.S. residents.
A new study examining the association between type 2 diabetes mellitus and skin diseases reveals a strong link between the two conditions. The research, published in Chinese Medical Journal, found that 93.5% of individuals with T2DM had skin problems, including over 47 types of comorbid skin diseases.
A new biomarker, HBcrAg, has been found to accurately predict viral load in patients with chronic hepatitis B and reflect response to anti-viral treatments. This discovery may lead to improved monitoring methods for CHB, enabling clinical decisions and potentially improving patient outcomes.
Researchers identified a rare case where COVID-19 triggered a recurrence of Guillain-Barré Syndrome in a 54-year-old man with prior episodes, highlighting the need for closer observation in patients with autoimmune disorders. The study provides new insights into treating COVID-19 patients with nerve-targeting autoimmune disorders.
Researchers found that elkhorn coral has a consistent immune response to diseases, indicating it actively fights off disease. The study suggests corals may have tougher epithelia and symbiotic dinoflagellates that develop differences in gene expression over time.
Research by University of Bergen scientists has found that patients with critical COVID-19 often have antibodies blocking interferons, a crucial part of the body's defense system. This finding may explain gender differences in severe COVID-19 cases and offer potential treatment options.
Researchers at UTA found a strong immune response in diseased corals leads to lower expression of genes associated with growth and reproduction. This trade-off may impact coral resilience and ecosystem recovery under climate change pressure.
A team of researchers from the University of Toronto has developed a portable, reconfigurable lab-on-a-chip diagnostic platform that can gauge immunity to vaccine-preventable diseases among vulnerable populations. The platform was validated at a refugee camp in Kenya and showed promising results in detecting measles and rubella.
Severe combined immunodeficiency disease (SCID) is a rare, deadly condition that can be cured with early diagnosis and treatment. A new review provides guidance for pediatricians and doctors on identifying and treating SCID, aiming to save lives and prevent suffering.
Researchers developed a new technique to study the gene shuffling process that creates diverse immune cell receptors. By analyzing the frequency of use of different V segment genes, they uncovered complex regulatory mechanisms involved in receptor diversity.
Researchers discovered a new class of common variable immunodeficiency disorder (CVID) caused by IKAROS gene mutations, enabling definitive genetic diagnosis and potential personalized treatment. The study found six unrelated families sharing similar symptoms and changes in the same gene, highlighting the need for early intervention.
A new type of vaccine is being developed that can trick the body into developing immunity against polio, with no risk of causing or spreading the disease. The replica virus particle will be designed to look and behave like the real virus but contain no genetic material.
Researchers have discovered a new genetic cause of familial hemophagocytic lymphohistiocytosis (FHL) type 5, a fatal immune disorder. The condition is caused by mutations in the Munc18-2 gene, leading to impaired release of death-inducing molecules from immune cells.
Researchers found a significant decline in Guillain-Barré syndrome (GBS) reports following influenza vaccination, with annual rates decreasing by 4-fold between 1993-1994 and 2002-2003. A GBS diagnosis was confirmed in 82% of reports, and preceding illness within 4 weeks of vaccination was identified in 24% of cases.
Researchers found that patients with moderate to severe Crohn's disease improved significantly after receiving GM-CSF, with 12 out of 15 patients in clinical remission. The treatment targets the innate immune response and has shown promise as an alternative approach to traditional therapies.