Articles tagged with Immunosurveillance
Researchers have discovered that γδ T cells use adaptive immune receptors to drive rapid, innate-like responses to tissue stress, inflammation, and cancer. These cells rely on the receptor to maintain and mount rapid tissue surveillance responses, making them a promising candidate for next-generation cancer immunotherapies.
Researchers from the University of Osaka have found a rare type of immune cell that expands in supercentenarians, potentially helping protect against cancer and other age-related threats. The cells, known as CD4 CTLs, have been shown to be highly active and may help the body cope with persistent threats that increase with age.
Research at UT MD Anderson Cancer Center has identified biomarkers to identify patients with resectable NSCLC who benefit most from perioperative immunotherapy. The center also found that the composition of donor cord blood may influence CAR NK cell therapy outcomes.
A spatial map of muscle-invasive bladder cancer reveals organized tumor cell states, immune environments, and therapeutic vulnerabilities. Luminal-like cells are found in tumor cores with relevant therapeutic markers, while basal-like cells near margins show signs of aggressiveness. This study guides treatment strategies by accounting ...
Researchers at the Francis Crick Institute have developed a new method to enhance anti-cancer immunity by redirecting non-specialized immune cells to present a broader range of tumor antigens. This approach, leveraging understanding of dendritic cell biology, has shown promise in reducing tumour growth and amplifying responses in mice.
A new mRNA-based strategy amplifies the T-cell response to vaccines, enabling more powerful cancer vaccines and stronger protection against infectious diseases. The approach reprograms immune cells from within using mRNA instructions that expand cancer-fighting T cells.
Dr. Marcus Ruscetti receives the prize to study senescence and its impact on immune responses in cancer metastasis. The funding will help him develop novel treatments targeting senescent cells.
Researchers at MD Anderson have made significant discoveries in the treatment of rare bile duct cancers, with zanidatamab showing promising results. Additionally, a study identified RASH3D19 as a target to overcome treatment resistance in KRAS-mutant cancers.
Researchers at La Jolla Institute for Immunology examine how genetics, sex hormones, and environmental factors shape the immune system. Women have a stronger immune response due to their XX chromosomes and estrogen, but also face an increased risk of autoimmune diseases.
Researchers discover mitochondrial transfer between cancer cells and immune cells as a key immune evasion strategy. Cancer cells can reshape the tumor microenvironment to weaken tumor-infiltrating lymphocytes, and mitochondria play a significant role in this process.
A new mechanism has been found by which tumor cells escape the immune system, involving a protein called IRGQ. Studies have shown that suppressing IRGQ can trigger a stronger immune response against cancer cells, leading to improved survival rates in liver cancer patients.
A recent study has shed light on the vital role of the immune system in lung cancer risk, particularly among smokers. The research found that individuals with heterozygosity at HLA-II genes experienced a decreased risk of lung cancer.
Researchers analyzed 408 patients receiving immune checkpoint inhibitor therapy and found no increased risk of side effects from receiving both immunotherapy and the vaccine. The study supports NCCN's recommendations for COVID-19 vaccination in people with cancer, citing strong protection against severe COVID-19 for all variants.