Articles tagged with Leukemia
A newly discovered protease enzyme, Taspase1, plays a crucial role in the MLL protein's dual-function. Blocking Taspase1 may provide a novel way to halt runaway cell proliferation in leukemia. Enzyme inhibitors with few side effects could be effective against various cancers.
A new study by St. Jude Children's Research Hospital found that black children with acute lymphoblastic leukemia (ALL) can achieve high cure rates comparable to those of white children, contradicting previous clinical studies. The research suggests that personalized risk-directed therapy played a key role in overcoming disparities in t...
Researchers used DNA microarray technology to identify seven major subtypes of pediatric acute lymphoblastic leukemia, including six known prognostic subtypes. This discovery enables more accurate diagnoses and personalized treatment plans based on a patient's unique expression profile.
A study found that using aggressive chemotherapy with high doses of methotrexate, asparaginase, and doxorubicin improves survival rates for children with T-cell acute lymphoblastic leukemia by 15 percentage points. The new approach also showed minimal long-term effects beyond those seen in lower-dose treatment regimens.
Dr. Rawal has developed a rapid and straightforward reaction that can assemble pieces of complex molecules with high accuracy. This innovation is expected to improve the performance of anticancer drugs like vincristine, which has been used successfully in treating childhood leukemia.
A new monoclonal antibody combination therapy has been found to be highly effective in treating chronic lymphocytic leukemia, with a remarkable 69% complete remission rate. The treatment, which combines two chemotherapy drugs with Rituximab, shows promising results across all age groups and stages of the disease.
Researchers have developed a new tool to study mankind's diseases by using bacteria as 'copy machines' for DNA taken from other organisms. The tool, called Red/ET recombination, allows scientists to engineer large DNA molecules and insert artificial versions of genes into living systems.
A study led by UT Southwestern Medical Center found that Gleevec, a drug used to treat chronic myelogenous leukemia (CML), does not effectively target CNS leukemia in the brain or spinal fluid. The research revealed that Gleevec poorly penetrates the blood-brain barrier, allowing leukemia cells to avoid eradication.
Researchers have created a zebrafish model that can help pinpoint genes accelerating or delaying the spread of T cell acute lymphoblastic leukemia. The model will enable testing of novel drugs against the disease, potentially leading to new treatments for cancer patients at risk.
Scientists have discovered that BID protein plays a crucial role in regulating apoptosis of myeloid cells, which are prone to developing CMML. In mice genetically engineered to lack BID, researchers found an overexpansion of myeloid cells leading to leukemia, highlighting potential tumor suppression roles for other BH3-only proteins.
The MLL protein edits the histone code at specific sites, regulating Hox gene expression and contributing to leukemia. This study highlights the importance of the histone code in developmental biology and disease.
The Leukemia & Lymphoma Society has awarded a $7 million grant to Fred Hutchinson Cancer Center researchers to develop new, more tolerable and effective therapies for blood cancers. The project aims to harness the immune system to selectively target cancer cells using immune cells or antibodies armed with toxic agents.
Researchers have identified organosulfur compounds, such as ADT, as effective in preventing lung cancer progression. Vitamin B12 analogues also showed promise in targeting chemotherapy drugs to tumor cells, while aminopeptidase inhibitors may help restore apoptosis in leukemia cells
Abnormalities in the mouth, like swollen gums and oral sores, can signal serious medical conditions. Regular oral exams can detect signs of nutritional deficiencies and systemic diseases.
Researchers at Thomas Jefferson University developed an animal model of chronic lymphocytic leukemia (CLL), a disease characterized by uncontrolled proliferation of white blood cells. The model enables scientists to investigate biochemical and molecular mechanisms underlying the disease and test potential new drugs.
Researchers found that mitoxantrone induction therapy significantly reduced disease activity in MS patients, with a 76% relapse-free rate at one year and 64% at four years. The annual relapse rate decreased by nearly 90% following treatment.
Researchers identified a genetic anomaly in mice resistant to the ecotropic murine leukemia virus, a major cancer-causing virus. By analyzing proteins, they found a defective protein that blocks viral entry, potentially leading to new gene therapies for humans.
Researchers are using spatial statistics to analyze cases of renal failure and leukemia in Texas. They found that the distribution of renal failure cases is consistent with random phenomena, but may have underlying hotspots for cancer cases.
Researchers developed a Herceptin-DM1 conjugate that targets HER2-positive breast cancer and shows complete regression in mice. Additionally, a new Bcr-Abl inhibitor called PD173955 demonstrates greater potency than Gleevec against leukemia cells, providing new hope for treatment-resistant cancers.
Researchers found that brief cycles of high-dose chemotherapy produced long-term disease-free survival in more than half of adults treated for Burkitt's small non-cleaved lymphoma and leukemia. The regimen achieved an 80% complete response rate, with 52% of patients remaining in continuous remission after five years.
A study published in JCI Journals reveals that an excess of healthy cells may hold leukemia in check. The researchers found that these healthy cells could be used as a therapeutic target to develop new treatments for the disease.
Researchers at UCSD Cancer Center develop a two-drug combination that tricks leukemia-causing gene Bcr-Abl into committing suicide, achieving complete eradication of CML cells. The treatment uses STI571 and Leptomycin B to mobilize and trap the oncogene in the nucleus.
Researchers have found that leukemia cells resist apoptosis due to constitutive activation of STAT3 and/or STAT1. AG-490, a JAK inhibitor, promotes apoptosis in these cells by blocking STAT3 function.
Researchers found that 10 out of 20 bioflavonoids tested caused breaks in the MLL gene, which is a key player in about 80% of infant leukemias. The study suggests that high dietary intake of bioflavonoids could cause DNA damage and potentially trigger leukemia.
A study using polymerase chain reaction detects MRD in long-term CML survivors, finding that approximately 25% of patients had evidence of disease at some time after transplant. The team aims to identify patients who appear cured but may still harbor disease and benefit from early therapeutic intervention.
Researchers at the University of Toronto found a strong association between magnetic field exposures in residences and the risk of developing childhood leukemia. Children exposed to higher levels of magnetic fields were two to four times more likely to develop leukemia, with risks highest for those diagnosed before age six.
Dr. Lee Hartwell, president of the Fred Hutchinson Cancer Research Center, will join four biotechnology leaders in discussing the future of biotechnology. They will address topics such as new methods for diagnosing diseases like lupus and leukemia, and the potential impact on drug development.
Researchers at Oregon Health Science University have uncovered a mechanism used by certain leukemia viruses to attach themselves to cell surfaces and sneak into cells. They've also developed a rapid cloning method for human genes encoding viral receptors, which could lead to new treatments for viral diseases.
Researchers at Brandeis University have induced a form of chronic myelogenous leukemia (CML) in mice, allowing them to study its molecular mechanisms and potential treatments. The breakthrough could lead to the development of new therapies for CML, which affects one-fifth of all leukemia patients.
Researchers aim to prevent leukemia relapse by educating the immune system using immunotherapy and genetically modified cells. The new technology could eliminate second rounds of chemotherapy, reducing toxicity and hospital stays.
Oregon Health & Science University scientists begin human trials of a targeted drug therapy for chronic myelogenous leukemia, aiming to eliminate leukemia cells with a faulty gene. The investigational drug has shown success in destroying BCR-ABL cells in mice and animal trials.
Researchers at Memorial Sloan-Kettering Cancer Center have identified a combination of drugs that can induce leukemia cells to mature and behave like normal blood cells. By targeting genetic changes underlying acute promyelocytic leukemia, the team developed a novel 'transcription therapy' approach that may improve treatment for other ...
Top researchers gathered at St. Jude Children's Research Hospital to discuss breakthroughs in acute lymphoblastic leukemia (ALL) treatment, aiming for improved cure rates and reduced side effects. Rearrangement of the ETV6/TEL gene is associated with favorable treatment outcomes, enabling safer alternatives to radiation therapy.
Researchers at St. Jude Children's Research Hospital have discovered a novel leukemia-producing transcription factor called E2A-HLF, which transforms immature lymphocytes by preventing normal destruction programs. This finding provides a potential window into understanding leukemias that result from altered survival signals.
Researchers identify a molecular 'safety key' that normally regulates cell growth, and discovering how it can be disrupted to trigger cancer. The team found a protein called Abi-2 that fits into the normal enzyme cABL, keeping it turned off, and proposes a new way to treat cancers by targeting this molecular pathway.