Articles tagged with Lymphoma
Patients with celiac disease who have persistent intestine damage are at a higher risk of developing lymphoma compared to those whose intestines have healed, according to new research. The study found that the risk of lymphoma is significantly lower in patients with healed intestines, approaching that of the general population.
A new study found that regions near petroleum refineries and manufacturing plants releasing benzene have significantly higher non-Hodgkin lymphoma incidence rates. The risk of the disease decreases with increasing distance to these facilities.
Researchers developed a new treatment combining chemotherapy and radioimmunotherapy, which showed significant improvement in survival rates without recurrence. Patients who received this treatment had a 64% chance of survival and a 100% chance of survival at two-year follow-up.
Researchers at Johns Hopkins Medicine have developed a novel approach to sorting out cancer-causing genetic mutations in cancer cells. By testing proteins produced by genes with random mutations, they created a catalog of mutants with cancer-promoting potential. This could lead to more personalized treatment strategies for patients.
Researchers found that elevated galectin-1 levels correlate with tumor burden and adverse clinical characteristics in newly diagnosed Hodgkin lymphoma patients. The study suggests using galectin-1 as a biomarker to predict patient outcomes and inform treatment decisions.
Researchers have identified a key pathway called the Unfolded Protein Response (UPR) that helps tumor cells escape programmed cell death during lymphoma development. Inhibiting this pathway could lead to new blood cancer treatments.
Researchers discovered that inhibiting PDGFRB can prevent growth of this type of tumour, extending survival in mice and a human patient. The study found that imatinib treatment significantly improved the patient's prognosis.
Transplant recipients and lymphoma patients are at higher risk of developing melanoma, which can be fatal if not detected early. They should be aware of their skin changes and consult a dermatologist regularly.
A University of Rochester Medical Center study challenges traditional treatment guidelines for early-stage follicular lymphoma, concluding that six different therapies can bring remission. Careful patient staging is key to predicting prognosis and superior progression-free survival.
Researchers at MDC Berlin-Buch have identified a critical enzyme, PI3K, that enables c-MYC to transform B lymphocytes into malignant cells. This finding may lead to effective treatments by inhibiting the PI3K signaling pathway.
Researchers found tristetraprolin (TTP/ZFP36) to be a tumor suppressor that impairs lymphoma development and maintenance. The study's findings suggest TTP could be a key target for treating cancers with MYC involvement, including relapsed and refractory tumors.
Researchers at the University of York are launching a major study to improve survival rates for myeloma and lymphoma patients through earlier diagnosis. The study aims to develop an evidence base that could reduce time-to-diagnosis in patients with these cancers, ultimately saving thousands of lives.
A study by Dr. Andreas Engert and colleagues found that six cycles of BEACOPPescalated chemotherapy followed by radiotherapy are more effective in treating advanced Hodgkin's lymphoma with fewer treatment-related events. This approach also reduces toxicity compared to the standard eight-cycle regimen.
Researchers found that viral lytic replication impairs the effectiveness of Nutlin-3, a targeted therapy for KSHV-induced lymphomas. The study suggests reactivating p53 as a selective treatment modality.
Blood cancers in pregnancy can lead to increased risk of blood clots and health complications for the mother. Termination is recommended at early stages, while cancer therapy is possible later. Progesterone-only contraceptives are considered safe for patients in long-term remission.
A new PET technique using FLT-PET has shown highly sensitive imaging for patients with mantle cell lymphoma, a relatively rare and devastating blood cancer. The study found that all cancerous lesions were very highly visible using FLT-PET, providing a powerful biomarker for MCL.
A systematic review and meta-analysis of randomized control trials found no improvement in overall survival for adult patients with advanced follicular lymphoma who received high-dose chemotherapy and ASCT compared to conventional-dose chemotherapy alone. The study concluded that HDC-ASCT is not effective as a primary treatment option.
Researchers sequenced DNA from two sisters with follicular lymphoma and found identical BCL2/IGH rearrangements. The study identified 15 mutations that were present in both lymphomas, indicating a donor-recipient transmission of cancer-causing genetic material.
Researchers have discovered that cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide. This finding helps understand which patients may be more or less likely to respond to therapy, enabling the development of targeted treatments.
A randomized Phase III study found that repeated rituximab treatment at disease progression is just as effective as ongoing maintenance therapy in managing follicular lymphoma. The study suggests that an as-needed approach to treatment may be the preferred option for patients with low-tumor-burden FL, reducing healthcare costs and impr...
Researchers investigate how c-myc gene mutations interact with p53 and Bcl2 genes in Burkitt's lymphoma. The study shows that the nature of the second 'hit' determines immune response against developing tumours, with implications for cancer therapy.
Researchers have identified a new potential cancer drug targeting EPHA7, a tumor suppressor protein associated with follicular lymphoma. The discovery demonstrates the power of functional genomics in translating genetic insights into therapies.
Researchers at Fox Chase Cancer Center found that IMRT improved treatment outcomes for patients with extranodal lymphoma of the head and neck, with minimal side effects. The study showed high response rates and no severe dry mouth, relapses, or tissue abnormalities.
Researchers at the University of California, Davis have identified a protein that may play a key role in the development of lymphoma by inhibiting a tumor-suppressing gene. The study found that this protein, known as RNPC1, is frequently overactive in dog lymphomas and may contribute to the formation of cancerous cells.
Patients with aggressive non-Hodgkin lymphoma who receive early stem cell transplants have comparable survival rates to those who undergo chemotherapy alone. Researchers urge caution for patients with poor risk factors, recommending careful consultation with their physician.
A personalized vaccine uniquely tailored for each patient extends disease-free survival by 14 months, with improved response in patients with a specific biological marker. The trial's findings have the potential to usher in a new age of cancer vaccines.
The incidence of idiopathic pulmonary fibrosis (IPF) is increasing rapidly in the UK, with estimated annual diagnoses of 5,000 new cases. Researchers found a significant rise in IPF-related deaths, with more people dying from IPF than from certain types of cancer.
A recent study by the RAND Corporation has confirmed a link between breast implants and anaplastic large cell lymphoma (ALCL), a rare type of immune system cancer. The disease takes a slow course and can be controlled by surgical removal of the implant and surrounding tissue.
Researchers at North Carolina State University used a genetic model of dogs to identify genes involved in human non-Hodgkin lymphoma. The study found that only a few genes were shared between dogs and humans, suggesting that the genetic changes associated with the cancer are much less complex in canines.
Researchers at Sbarro Health Research Organization have discovered a new mechanism for INK4/ARF protein inactivation in Burkitt's lymphoma. The study suggests that reactivating tumor suppressor genes p16 and p14 could lead to the inhibition of cell proliferation and induction of apoptosis, offering potential new treatment avenues.
Researchers developed computer-assisted diagnosis tools to grade Follicular Lymphoma samples more accurately and efficiently. The tools use high-resolution images and machine learning algorithms to identify malignant regions and classify disease grades, promising faster and more accurate diagnoses.
The PRIMA study found that rituximab-maintenance therapy significantly improved progression-free survival and response rates compared to no treatment in patients with follicular lymphoma. After 2 years, 71.5% of patients in the rituximab group achieved complete or unconfirmed complete response compared to 52.2% in the observation group.
The personalized vaccine is effective in preventing recurrence among certain follicular lymphoma patients with a specific protein on their tumor cells. The vaccine improves disease-free survival by nearly two years compared to placebo treatments.
Researchers present promising new treatment options for advanced asymptomatic follicular lymphoma, mantle cell lymphoma, and early Hodgkin disease. The study shows that upfront rituximab therapy can significantly prolong the time until a patient may require chemotherapy.
A new mutation in the B cell activating factor receptor (BAFF-R) has been identified as a potential contributor to non-Hodgkin's lymphoma. The mutation amplifies BAFF signaling, leading to increased B cell function and cancer progression.
A randomized study found that standard chemotherapy and radiation therapy remain the most effective treatment for early, intermediate-stage Hodgkin's lymphoma patients. The study also showed that a more intensive chemotherapy regimen is not more effective than standard ABVD chemotherapy in treating this group of patients.
Researchers at the University of Illinois have identified a new target for cancer therapy in dogs and tested a compound that arrested tumor growth and induced partial remission. The study suggests that the treatment could be effective and safe, potentially adding to existing lymphoma treatments.
The American Society of Hematology will honor six scientists with significant contributions to the understanding and treatment of hematologic diseases. Volker Diehl, Sanford Shattil, David T. Scadden, Leonard I. Zon, Barry S. Coller, and Joel S. Bennett will receive awards for their pioneering research in Hodgkin lymphoma, platelet cel...
Researchers developed multicolor quantum dot staining to identify Reed-Sternberg cells, characteristic of Hodgkin's lymphoma. This method allows for rapid detection and identification of rare malignant cells from heterogeneous tissue specimens.
A study published in the American Society of Clinical Oncology annual meeting showed that lenalidomide significantly improved response rates and complete remission in patients with transformed lymphoma. Patients treated with lenalidomide had a remarkable response rate, with some experiencing complete remission for over a year.
Researchers found that H. pylori eradication therapy may be an initial treatment option for localized, H. pylori-negative gastric MALT lymphoma. The study adds information to establish strategies for patients with localized H. pylori-negative gastric MALT lymphoma.
Researchers at University of Leeds and Charité University Medical School have discovered that 'junk' DNA promotes cancer cell growth in patients with Hodgkin's lymphoma. Long terminal repeats (LTRs) are a form of genetic material that can activate cancer genes, leading to the growth of cancer cells.
Researchers at the Mayo Clinic found that people with higher vitamin K intakes from their diet had a lower risk of developing Non-Hodgkin lymphoma. Vitamin K intake was estimated from a food questionnaire and was associated with a significant protective effect against the disease.
The Lymphoma Research Foundation has published a report on Mantle Cell Lymphoma, highlighting the disease's rarity and the need for further research. The report, based on the 2009 MCL Scientific Workshop, aims to accelerate advances in MCL treatment and improve patient outcomes.
A new study demonstrates advances in optimizing treatments and quality of life for patients with multiple myeloma. The research explores optimal induction therapies, advance care planning, and a potential new first-line therapy for non-Hodgkin lymphoma.
A new study demonstrates the effectiveness of immunotherapy using specialized white blood cells to prevent or treat EBV-lymphoma in patients who have received a hematopoietic stem cell transplant. The therapy achieved sustained complete remission in 85% of treated patients and long-term protection for up to nine years.
The Lymphoma Research Foundation has awarded grants of $300,000 and $200,000 to Drs. David Frank and Thomas Kipps for their research on Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL). The grants aim to develop new treatments for patients with refractory disease.
A three-year study by University of Alberta researchers found that aerobic exercise training significantly improved physical functioning and overall quality of life in patients with lymphoma. The study showed a 46.4% complete response rate in the exercise group, compared to 30.8% in the usual care group.
Cold Spring Harbor Laboratory scientists uncover a large cache of genes that act as built-in barriers against cancer, including over 10 new tumor suppressor genes. The study reveals that even partial loss of function in these genes can accelerate tumor growth.
Researchers have discovered an experimental compound that selectively kills cancerous B lymphocytes while allowing normal B cells to survive. The study found that K252a disrupts a key signaling pathway involved in the growth of lymphoma cells, offering new hope for treating non-Hodgkin lymphoma.
Researchers found that adding high-dose cytarabine to methotrexate therapy improved complete remission rates (46%) and overall response rates (69%) in patients with primary central nervous system lymphoma. The combination also resulted in a lower risk of relapse and improved progression-free survival.
A new analysis reveals that adolescents and young adults with blood-related cancers have better long-term survival rates than those diagnosed in the 1980s. However, survival rates in this age group are still lower than those seen in younger children and some older adults.
Dr. Kai Fu receives $300K Clinical Investigator Career Development Award for mantle cell lymphoma research, focusing on miR-17~92 expression and its correlation with patient survival. The funding aims to support a pre-clinical study to determine the effectiveness of suppressing miR-17~92 in improving chemotherapy outcomes.
Researchers at UC Berkeley and TGen found a gene variant, rs6457327, associated with nearly twice the risk of developing follicular lymphoma, a cancer of the body's disease-fighting network. The presence of the G allele was protective against the disease, while the A allele increased risk.
Patients treated for Hodgkin lymphoma with radiation therapy have a substantially higher risk of stroke. After a median follow-up of almost 18 years, 96 patients developed cerebrovascular disease, with the incidence rate for stroke being 2.2 times that in the general population. Risk factors include radiation to the neck and mediastinum.
Researchers at Stanford University School of Medicine developed a machine that can analyze tiny blood samples for cancer-associated proteins, detecting subtle changes in protein modifications. The technique may provide a faster and less invasive way to track solid tumors and monitor treatment response.
A new study has found that maintenance rituximab therapy improves progression-free survival in patients with stage III-IV indolent lymphoma. The treatment showed significant benefits, including a 22% improvement in disease response and a 68% three-year progression-free survival rate.
Patients with relapsed follicular lymphoma who continue on maintenance rituximab therapy after chemotherapy have better overall survival than those without treatment. Rituximab maintenance therapy was associated with a 40% improvement in overall survival relative to observation or retreatment.
Researchers at USC have identified a key mechanism that occurs in the inception point of many human lymphomas, a process previously unknown. The study found that chromosomal translocations occur at CpG sites in early B-cells, driven by enzymes AID and RAG complex.
Researchers find AID causes genetic malfunctions leading to Burkitt's lymphoma and potentially other cancers. The enzyme, responsible for immune system adaptation, also targets a cancer-promoting gene.