Of mice and men
Researchers discovered that inhibiting PDGFRB can prevent growth of this type of tumour, extending survival in mice and a human patient. The study found that imatinib treatment significantly improved the patient's prognosis.
Lymphoma
Articles tagged with Lymphoma
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Mayo Clinic: Melanoma up to 2.5 times likelier to strike transplant, lymphoma patients
Transplant recipients and lymphoma patients are at higher risk of developing melanoma, which can be fatal if not detected early. They should be aware of their skin changes and consult a dermatologist regularly.
Many options, good outcomes, for early-stage follicular lymphoma
A University of Rochester Medical Center study challenges traditional treatment guidelines for early-stage follicular lymphoma, concluding that six different therapies can bring remission. Careful patient staging is key to predicting prognosis and superior progression-free survival.
New key element discovered in pathogenesis of Burkitt lymphoma
Researchers at MDC Berlin-Buch have identified a critical enzyme, PI3K, that enables c-MYC to transform B lymphocytes into malignant cells. This finding may lead to effective treatments by inhibiting the PI3K signaling pathway.
Scripps Florida scientists identify a critical tumor suppressor for cancer
Researchers found tristetraprolin (TTP/ZFP36) to be a tumor suppressor that impairs lymphoma development and maintenance. The study's findings suggest TTP could be a key target for treating cancers with MYC involvement, including relapsed and refractory tumors.
New research seeks to improve survival for myeloma and lymphoma patients
Researchers at the University of York are launching a major study to improve survival rates for myeloma and lymphoma patients through earlier diagnosis. The study aims to develop an evidence base that could reduce time-to-diagnosis in patients with these cancers, ultimately saving thousands of lives.
Viral replication impedes the efficacy of a targeted therapy against virus-induced lymphomas
Researchers found that viral lytic replication impairs the effectiveness of Nutlin-3, a targeted therapy for KSHV-induced lymphomas. The study suggests reactivating p53 as a selective treatment modality.
Less intense chemotherapy more effective and less toxic for patients with advanced Hodgkin's lymphoma
A study by Dr. Andreas Engert and colleagues found that six cycles of BEACOPPescalated chemotherapy followed by radiotherapy are more effective in treating advanced Hodgkin's lymphoma with fewer treatment-related events. This approach also reduces toxicity compared to the standard eight-cycle regimen.
Complications of blood cancers make termination advisable at early stages of pregnancy; but cancer therapy is possible for later stage pregnancies
Blood cancers in pregnancy can lead to increased risk of blood clots and health complications for the mother. Termination is recommended at early stages, while cancer therapy is possible later. Progesterone-only contraceptives are considered safe for patients in long-term remission.
Autologous stem cell transplantation does not improve os in patients with follicular lymphoma
A systematic review and meta-analysis of randomized control trials found no improvement in overall survival for adult patients with advanced follicular lymphoma who received high-dose chemotherapy and ASCT compared to conventional-dose chemotherapy alone. The study concluded that HDC-ASCT is not effective as a primary treatment option.
PET technique promises better detection and response assessment for Non-Hodgkin's lymphoma
A new PET technique using FLT-PET has shown highly sensitive imaging for patients with mantle cell lymphoma, a relatively rare and devastating blood cancer. The study found that all cancerous lesions were very highly visible using FLT-PET, providing a powerful biomarker for MCL.
Study of 2 sisters sheds light on lymphoma evolution
Researchers sequenced DNA from two sisters with follicular lymphoma and found identical BCL2/IGH rearrangements. The study identified 15 mutations that were present in both lymphomas, indicating a donor-recipient transmission of cancer-causing genetic material.
Study favors as-needed treatment over maintenance therapy for patients with follicular lymphoma
A randomized Phase III study found that repeated rituximab treatment at disease progression is just as effective as ongoing maintenance therapy in managing follicular lymphoma. The study suggests that an as-needed approach to treatment may be the preferred option for patients with low-tumor-burden FL, reducing healthcare costs and impr...
Emerging lymphoma and myeloma treatments focus on improving individual patient response
Researchers have discovered that cereblon expression is required for the anti-myeloma activity of lenalidomide and pomalidomide. This finding helps understand which patients may be more or less likely to respond to therapy, enabling the development of targeted treatments.
'If Hamlet give the first or second hit': The development of Burkitt's lymphoma
Researchers investigate how c-myc gene mutations interact with p53 and Bcl2 genes in Burkitt's lymphoma. The study shows that the nature of the second 'hit' determines immune response against developing tumours, with implications for cancer therapy.
From genomic data to new cancer drug
Researchers have identified a new potential cancer drug targeting EPHA7, a tumor suppressor protein associated with follicular lymphoma. The discovery demonstrates the power of functional genomics in translating genetic insights into therapies.
IMRT improves outcomes in patients with extranodal lymphoma of the head and neck
Researchers at Fox Chase Cancer Center found that IMRT improved treatment outcomes for patients with extranodal lymphoma of the head and neck, with minimal side effects. The study showed high response rates and no severe dry mouth, relapses, or tissue abnormalities.
Protein may help diagnose and treat lymphoma in people and dogs
Researchers at the University of California, Davis have identified a protein that may play a key role in the development of lymphoma by inhibiting a tumor-suppressing gene. The study found that this protein, known as RNPC1, is frequently overactive in dog lymphomas and may contribute to the formation of cancerous cells.
Early transplants are no better than chemotherapy followed by transplant for NHL patients
Patients with aggressive non-Hodgkin lymphoma who receive early stem cell transplants have comparable survival rates to those who undergo chemotherapy alone. Researchers urge caution for patients with poor risk factors, recommending careful consultation with their physician.
Vaccine increases disease-free survival for follicular lymphoma patients
A personalized vaccine uniquely tailored for each patient extends disease-free survival by 14 months, with improved response in patients with a specific biological marker. The trial's findings have the potential to usher in a new age of cancer vaccines.
IPF lung disease numbers are rising quickly to become a significant cause of mortality in UK
The incidence of idiopathic pulmonary fibrosis (IPF) is increasing rapidly in the UK, with estimated annual diagnoses of 5,000 new cases. Researchers found a significant rise in IPF-related deaths, with more people dying from IPF than from certain types of cancer.
Study confirms link between breast implants and rare form of cancer
A recent study by the RAND Corporation has confirmed a link between breast implants and anaplastic large cell lymphoma (ALCL), a rare type of immune system cancer. The disease takes a slow course and can be controlled by surgical removal of the implant and surrounding tissue.
Sniffing out lymphoma by turning dogs into humans
Researchers at North Carolina State University used a genetic model of dogs to identify genes involved in human non-Hodgkin lymphoma. The study found that only a few genes were shared between dogs and humans, suggesting that the genetic changes associated with the cancer are much less complex in canines.
2 proteins play key roles in Burkitt's lymphoma
Researchers at Sbarro Health Research Organization have discovered a new mechanism for INK4/ARF protein inactivation in Burkitt's lymphoma. The study suggests that reactivating tumor suppressor genes p16 and p14 could lead to the inhibition of cell proliferation and induction of apoptosis, offering potential new treatment avenues.
Computer-assisted diagnosis tools to aid pathologists
Researchers developed computer-assisted diagnosis tools to grade Follicular Lymphoma samples more accurately and efficiently. The tools use high-resolution images and machine learning algorithms to identify malignant regions and classify disease grades, promising faster and more accurate diagnoses.
Rituximab maintenance significantly improves progression-free survival in patients with follicular lymphoma
The PRIMA study found that rituximab-maintenance therapy significantly improved progression-free survival and response rates compared to no treatment in patients with follicular lymphoma. After 2 years, 71.5% of patients in the rituximab group achieved complete or unconfirmed complete response compared to 52.2% in the observation group.
Personalized vaccine for lymphoma patients extends disease-free survival by nearly 2 years
The personalized vaccine is effective in preventing recurrence among certain follicular lymphoma patients with a specific protein on their tumor cells. The vaccine improves disease-free survival by nearly two years compared to placebo treatments.
New standards of care and novel treatment options for several forms of lymphoma unveiled
Researchers present promising new treatment options for advanced asymptomatic follicular lymphoma, mantle cell lymphoma, and early Hodgkin disease. The study shows that upfront rituximab therapy can significantly prolong the time until a patient may require chemotherapy.
New mutation linked to non-Hodgkin's lymphoma
A new mutation in the B cell activating factor receptor (BAFF-R) has been identified as a potential contributor to non-Hodgkin's lymphoma. The mutation amplifies BAFF signaling, leading to increased B cell function and cancer progression.
Newer, more intense chemotherapy with less radiation not more effective against Hodgkin's lymphoma
A randomized study found that standard chemotherapy and radiation therapy remain the most effective treatment for early, intermediate-stage Hodgkin's lymphoma patients. The study also showed that a more intensive chemotherapy regimen is not more effective than standard ABVD chemotherapy in treating this group of patients.
New lymphoma treatment shows promise in dogs
Researchers at the University of Illinois have identified a new target for cancer therapy in dogs and tested a compound that arrested tumor growth and induced partial remission. The study suggests that the treatment could be effective and safe, potentially adding to existing lymphoma treatments.
6 researchers to receive prestigious awards from the American Society of Hematology
The American Society of Hematology will honor six scientists with significant contributions to the understanding and treatment of hematologic diseases. Volker Diehl, Sanford Shattil, David T. Scadden, Leonard I. Zon, Barry S. Coller, and Joel S. Bennett will receive awards for their pioneering research in Hodgkin lymphoma, platelet cel...
Multicolor quantum dots aid in cancer biopsy diagnosis
Researchers developed multicolor quantum dot staining to identify Reed-Sternberg cells, characteristic of Hodgkin's lymphoma. This method allows for rapid detection and identification of rare malignant cells from heterogeneous tissue specimens.
Study identifies promising treatment for aggressive lymphoma
A study published in the American Society of Clinical Oncology annual meeting showed that lenalidomide significantly improved response rates and complete remission in patients with transformed lymphoma. Patients treated with lenalidomide had a remarkable response rate, with some experiencing complete remission for over a year.
Treatment of Helicobacter pylori-negative gastric MALT lymphoma
Researchers found that H. pylori eradication therapy may be an initial treatment option for localized, H. pylori-negative gastric MALT lymphoma. The study adds information to establish strategies for patients with localized H. pylori-negative gastric MALT lymphoma.
'Junk DNA' drives cancer growth
Researchers at University of Leeds and Charité University Medical School have discovered that 'junk' DNA promotes cancer cell growth in patients with Hodgkin's lymphoma. Long terminal repeats (LTRs) are a form of genetic material that can activate cancer genes, leading to the growth of cancer cells.
Vitamin K may protect against developing non-Hodgkin's lymphoma, say Mayo Clinic researchers
Researchers at the Mayo Clinic found that people with higher vitamin K intakes from their diet had a lower risk of developing Non-Hodgkin lymphoma. Vitamin K intake was estimated from a food questionnaire and was associated with a significant protective effect against the disease.
Lymphoma Research Foundation announces publication of Mantle Cell report
The Lymphoma Research Foundation has published a report on Mantle Cell Lymphoma, highlighting the disease's rarity and the need for further research. The report, based on the 2009 MCL Scientific Workshop, aims to accelerate advances in MCL treatment and improve patient outcomes.
New research demonstrates advances in optimizing treatments and quality of life
A new study demonstrates advances in optimizing treatments and quality of life for patients with multiple myeloma. The research explores optimal induction therapies, advance care planning, and a potential new first-line therapy for non-Hodgkin lymphoma.
Immunotherapy demonstrates long-term success in treating lymphoma
A new study demonstrates the effectiveness of immunotherapy using specialized white blood cells to prevent or treat EBV-lymphoma in patients who have received a hematopoietic stem cell transplant. The therapy achieved sustained complete remission in 85% of treated patients and long-term protection for up to nine years.
Lymphoma Research Foundation announces recipients of CLL/SLL Research Initiative grants
The Lymphoma Research Foundation has awarded grants of $300,000 and $200,000 to Drs. David Frank and Thomas Kipps for their research on Chronic Lymphocytic Leukemia (CLL) and Small Lymphocytic Lymphoma (SLL). The grants aim to develop new treatments for patients with refractory disease.
Exercise is good medicine for lymphoma patients
A three-year study by University of Alberta researchers found that aerobic exercise training significantly improved physical functioning and overall quality of life in patients with lymphoma. The study showed a 46.4% complete response rate in the exercise group, compared to 30.8% in the usual care group.
Using RNAi-based technique, CSHL scientists find new tumor suppressor genes in lymphoma
Cold Spring Harbor Laboratory scientists uncover a large cache of genes that act as built-in barriers against cancer, including over 10 new tumor suppressor genes. The study reveals that even partial loss of function in these genes can accelerate tumor growth.
Experimental drug lets B cells live and lymphoma cells die
Researchers have discovered an experimental compound that selectively kills cancerous B lymphocytes while allowing normal B cells to survive. The study found that K252a disrupts a key signaling pathway involved in the growth of lymphoma cells, offering new hope for treating non-Hodgkin lymphoma.
Combining 2 anti-cancer drugs improves remission rates in patients with primary central nervous system lymphoma
Researchers found that adding high-dose cytarabine to methotrexate therapy improved complete remission rates (46%) and overall response rates (69%) in patients with primary central nervous system lymphoma. The combination also resulted in a lower risk of relapse and improved progression-free survival.
Young leukemia and lymphoma patients live longer today than in years past
A new analysis reveals that adolescents and young adults with blood-related cancers have better long-term survival rates than those diagnosed in the 1980s. However, survival rates in this age group are still lower than those seen in younger children and some older adults.
Millennium Pharmaceuticals Inc./Lymphoma Research Foundation funds lymphoma research
Dr. Kai Fu receives $300K Clinical Investigator Career Development Award for mantle cell lymphoma research, focusing on miR-17~92 expression and its correlation with patient survival. The funding aims to support a pre-clinical study to determine the effectiveness of suppressing miR-17~92 in improving chemotherapy outcomes.
Gene linked to increasingly common type of blood cancer
Researchers at UC Berkeley and TGen found a gene variant, rs6457327, associated with nearly twice the risk of developing follicular lymphoma, a cancer of the body's disease-fighting network. The presence of the G allele was protective against the disease, while the A allele increased risk.
Hodgkin lymphoma survivors have increased risk of stroke and transient ischemic attack
Patients treated for Hodgkin lymphoma with radiation therapy have a substantially higher risk of stroke. After a median follow-up of almost 18 years, 96 patients developed cerebrovascular disease, with the incidence rate for stroke being 2.2 times that in the general population. Risk factors include radiation to the neck and mediastinum.
New alternative to biopsy detects subtle changes in cancer cells, Stanford study shows
Researchers at Stanford University School of Medicine developed a machine that can analyze tiny blood samples for cancer-associated proteins, detecting subtle changes in protein modifications. The technique may provide a faster and less invasive way to track solid tumors and monitor treatment response.
Study shows that maintenance rituximab is useful for advanced indolent lymphoma
A new study has found that maintenance rituximab therapy improves progression-free survival in patients with stage III-IV indolent lymphoma. The treatment showed significant benefits, including a 22% improvement in disease response and a 68% three-year progression-free survival rate.
Rituximab maintenance therapy improves survival in patients with relapsed follicular lymphoma
Patients with relapsed follicular lymphoma who continue on maintenance rituximab therapy after chemotherapy have better overall survival than those without treatment. Rituximab maintenance therapy was associated with a 40% improvement in overall survival relative to observation or retreatment.
An enzyme that mutates antibodies also targets a cancer-causing oncogene
Researchers find AID causes genetic malfunctions leading to Burkitt's lymphoma and potentially other cancers. The enzyme, responsible for immune system adaptation, also targets a cancer-promoting gene.
USC researchers identify key mechanism that occurs at the inception point of many human lymphomas
Researchers at USC have identified a key mechanism that occurs in the inception point of many human lymphomas, a process previously unknown. The study found that chromosomal translocations occur at CpG sites in early B-cells, driven by enzymes AID and RAG complex.
Intense chemotherapy wards off recurrence in half of mantle cell lymphoma patients after seven years
A study published by researchers at M.D. Anderson Cancer Center revealed that intense chemotherapy significantly reduces the risk of recurrence in young mantle cell lymphoma patients. In a median follow-up of seven years, 52% of patients aged 65 or younger achieved disease-free survival.
Researchers aim to over-stress already taxed mantle cell lymphoma cells
Mantle cell lymphoma cells rely on heat shock protein 90 to maintain their rapid growth. Researchers are using inhibitors to block this process, causing stress in the cells' machinery. The goal is to trigger apoptosis in cancer cells.
Socioeconomic and treatment factors affect non-Hodgkin lymphoma patients' survival
A new study reveals that poorer socioeconomic status increases mortality risk in non-Hodgkin lymphoma patients, while chemotherapy reduces the risk. Ethnic disparities are also observed, with African-Americans less likely to receive chemotherapy and living in poorer communities.
How to differentiate abdominal tuberculosis from lymphomas?
A research article compares CT findings in mesenteric tuberculosis and non-Hodgkin's lymphoma (NHL), revealing specific enhancement patterns and anatomic lymph node distribution. The 'sandwich sign' is more often found in NHL, aiding in differential diagnosis between tuberculosis and untreated NHL involving the small bowel mesentery.
Rheb's role in cancer
Researchers found Rheb overexpression is sufficient to induce low-grade prostate neoplasias and contributes to lymphoma formation. Targeted inhibition of Rheb shows promise in counteracting tumor progression in both cancers.
News from Cancer: Risk factors for deadly form of lymphoma
A new study reveals that mantle cell lymphoma incidence is increasing, especially among men and Caucasians, with advanced stages detected in nearly 75% of patients. The research also highlights the need for better understanding of the disease's epidemiology and development of novel treatment agents.