Articles tagged with Melanoma
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Higher blood levels of interleukin-12 (IL-12) are associated with poor overall survival in Stage III melanoma patients. Age is also a significant risk factor for death, but only when combined with IL-12 levels.
A study found that melanomas can appear noticeably different from other moles, with 85% of participants identifying them as distinct. The 'ugly duckling' sign may prove a useful screening strategy for primary health care providers and skin self-examination.
Research found that patients traveling farther to reach their physician are more likely to have thicker skin cancer at diagnosis. Longer distances were associated with increased Breslow thickness, and rural locations and lack of dermatologists in the area also contributed to poorer outcomes.
Researchers found that early life sun exposure increases the risk of melanomas with BRAF gene mutations. Patients who reported high levels of sun exposure before age 20 were more likely to have this mutation. In contrast, patients with NRAS gene mutations had higher exposure between ages 50-60.
A Phase II study has shown that combining chemotherapy drugs with an antiangiogenic agent can significantly delay the spread of tumors in patients with metastatic melanoma. The treatment, which included paclitaxel and carboplatin with bevacizumab, prevented tumor growth for almost six months and improved survival rates.
Researchers found that patients with higher levels of protein S-100 in their serum samples had a greater likelihood of melanoma returning after treatment. The study identified S-100 as a potential biomarker for predicting disease recurrence and stratifying patients into those more or less likely to relapse.
A recent study by Frederick H. Davidorf, MD, found that uveal melanoma patients and their families are at higher risk for developing colon cancer. The study involved 130 patients who provided their extended family medical histories, revealing a significant number of patients and relatives with an increased risk for colon cancer.
Research found that individuals with melanoma diagnosed by a dermatologist tend to have thinner tumors, leading to improved five-year survival rates. The study analyzed data from Medicare and cancer databases, comparing outcomes between dermatologist- and non-dermatologist-diagnosed patients.
The online survey aims to learn how people of different nationalities behave while having fun in the sun, and their attitudes to tanning and skin cancer. Researchers have identified four high-risk melanoma genes that increase someone's risk of skin cancer.
A study found that learning skin self-examination with a partner enhances the perceived importance and performance of this critical cancer prevention behavior. Participants who learned together showed stronger intentions to examine their skin regularly, especially in hard-to-see areas like the scalp and back.
A mathematical model suggests that one-time screening of adults age 50 or older for malignant melanoma is very cost-effective, with costs totaling $10,100 per quality-adjusted life year gained. Screening every two years may also be cost-effective, depending on disease progression rates.
A study investigated melanoma growth rate in 404 patients and found that fast-growing melanomas are more likely to occur in elderly men and individuals with fewer moles and freckles. The study provides descriptive data on the spectrum of melanoma rates of growth, offering insights into subgroups associated with rapid growth.
A study found that children who received light therapy (phototherapy) for jaundice as infants had an increased risk of developing skin moles in childhood. The study, published in Archives of Dermatology, examined 58 French children and found a significant association between phototherapy and the number of moles
Researchers discovered a potential strategy for treating metastatic melanoma by combining an antibody with radiation, leveraging insights from studying a fungus that causes infection in people with AIDS. The treatment approach shows promise in inhibiting tumor growth and inducing regression in mice with small melanoma tumors.
A study of marathon runners found that those who ran longer distances and wore inadequate clothing during training were more likely to develop skin cancer. The authors advise runners to reduce UV exposure by choosing low-sun schedules, wearing adequate clothing, and regularly using water-resistant sunscreens.
Studies found that statins and fibrates have uncertain impact on melanoma prevention, while a new virus kills brain cancer cells in mice. An antibody combination shows efficacy in ovarian cancer, while immunohistochemical assays predict breast cancer treatment response better than older methods
Scientists have developed a method to predict whether melanoma of the eye will spread to the liver, where it quickly turns deadly. The molecular screening test can detect both whether a tumor is likely to spread and how fast.
A study has identified molecular markers in RNA and DNA that can detect small metastases from ocular melanoma, allowing for early intervention. Fine needle biopsy is a feasible method to accurately detect these markers, enabling clinicians to identify high-risk patients who may benefit from targeted treatments.
A new study reveals that targeted melanoma education of high-risk groups leads to sustained improvements in skin self-examination rates. The intervention, which included personalized educational materials and counseling sessions, significantly increased the number of siblings who performed regular skin self-examinations.
A community-based education campaign significantly increased skin cancer screening rates in men over 50, with a two-fold increase in self-screening and four-fold increase in physician-screening. Men who recognized personal risk factors or had previously removed skin lesions were more likely to undergo screening.
A review of 1,690 melanoma cases in Miami-Dade County found that Hispanic and black patients were more likely to have advanced-stage melanomas than white patients. This disparity may contribute to lower survival rates among blacks and Hispanics.
Breakthroughs in melanoma research suggest optimism for future cures, with artificial skin models enabling the study of tumor interactions and immune system responses. A novel vaccine approach also shows promise in treating melanoma by stimulating killer T cells to attack cancerous cells.
Researchers found no link between a fatty diet and an increased risk of skin cancer. In fact, patients who had previously been diagnosed with a skin cancer other than melanoma even had a lower risk of getting a further non-melanoma skin cancer if they reported consuming more fat.
A new professorship in melanoma research has been established at the Cross Cancer Institute in Edmonton, Alberta. The endowment fund, valued at $1 million, will support long-term commitment to researching key pathways in melanoma development that could lead to potential targets for prevention and therapy.
A recent study published in Dermatologic Surgery reveals a significant link between summer sun exposure and the development of melanoma. Sun protective measures such as sunscreen and clothing are necessary to prevent skin cancer, despite controversy surrounding current guidelines.
Researchers found that 20% of participants developed additional melanoma within one year and 27% within two years after initial diagnosis. Those with atypical moles had a higher risk of developing additional melanomas, with those having three or more atypical moles being four times more likely to develop multiple tumors.
Researchers found that interferon treatment correlates with signaling proteins STAT1 and STAT3, which can be used as biomarkers to predict melanoma risk. The study suggests that these markers could help identify patients most likely to benefit from specific doses of interferon therapy.
A new mouse model has been developed to induce melanoma with a defined cancer antigen, closely mimicking human tumors. This model allows for detailed immunological analyses before and after vaccination, which may lead to a better understanding of spontaneous melanoma regressions and the optimization of cancer vaccine timing.
Counseling pediatricians on skin cancer prevention is crucial, as childhood sun exposure increases the risk of melanoma. UV light from natural sunlight and artificial sources like tanning beds also pose risks.
The incidence of invasive melanoma has significantly increased among Hispanic males in California between 1988 and 2001. The rate of invasive tumors greater than 0.75mm thick is particularly concerning, with a notable increase among Hispanic men compared to non-Hispanic whites.
A study found that nearly half of patients treated with the PC combination experienced a clinical benefit, including stable disease and tumor size reduction. Researchers believe this combination has a beneficial role, especially for patients with poor treatment outcomes.
A study by Northwestern University found that postmenopausal white women with a history of non-melanoma skin cancer are twice as likely to develop cutaneous melanoma. Regular skin checkups are crucial for these high-risk individuals to reduce the incidence of deadly melanoma.
A global skin cancer research consortium, Genomel, has won £7m in funding to investigate the genetics of melanoma and identify those at high risk. The project will also develop a website providing information on melanoma symptoms, diagnosis, and treatment.
A new study found that radiation therapy can effectively control primary tumors and spare vision in patients with uveal melanoma. The procedure involves plaque radiotherapy, which delivers radiation to the eye tumor via a small metal shield containing radioactive seeds.
Researchers found that individuals carrying CDKN2A mutations have a significantly higher risk of developing melanoma by age 50 (14%), 70 (24%), and 80 (28%). Genetic testing is unlikely to identify many mutation carriers due to the modest impact of these mutations on population incidence.
A research team at the University of Montreal has developed a cancer-curing therapy using T-lymphocytes, which recognize and destroy abnormal cells. The treatment targets specific antigens found on cancer cells, producing interferon gamma and perforine/granzyme to eradicate tumors without causing side effects.
A study published in JAMA found that patients with melanoma are at a higher risk of developing multiple primary melanomas. The study identified characteristics of patients at risk and estimated the five-year risk of MPM to be significantly higher for those with positive family history or dysplastic nevi.
A study of 4,484 patients with first primary melanomas found that 8.6% had multiple primary melanomas, with a higher risk for those with family history or dysplastic nevi. The estimated cumulative 5-year risk of a second primary tumor was 11.4%, with a significant increase in incidence for the development of third primary melanoma.
Renal transplant recipients are 3.6 times more likely to develop melanoma than the general population, with a mortality rate up to 6 percent in some regions. Men who have had a kidney transplant face the greatest risk, and risk increases rapidly with age.
Renal transplant recipients are at increased risk for melanoma due to immunosuppression, with a 3.6-fold increase in incidence compared to the general population. The risk increases five percent per year after transplantation and is greater in men, who also experience rapid age-related increases.
Dr. Gragoudas is being recognized for his groundbreaking work on protein beam irradiation and photodynamic therapy for intraocular melanoma and neovascular age-related macular degeneration. He has made significant contributions to the clinical practice of ophthalmology, particularly in the study of retinal vascular diseases.
A study by researchers at the University of Michigan Health System found that patients learned more facts from educational videos than from their doctors during a clinic visit. However, the video was less effective in reducing anxiety and stress levels compared to face-to-face interactions with their doctors.
Researchers at the University of Texas M. D. Anderson Cancer Center discovered that curcumin stops laboratory strains of melanoma from proliferating by shutting down nuclear factor-kappa B (NF-kB). The spice also induces apoptosis, or programmed death, in cancer cells.
The Sydney Melanoma Unit has been awarded a National Health and Medical Research Council Program Grant, providing $7.8 million to support its vital research. The grant aims to identify molecular factors that determine an individual's risk of melanoma and develop more effective treatments.
A new study found long-duration regular use of aspirin or NSAIDs may lower prostate cancer risk by 18%. Gene variants associated with melanoma risk were also identified in a Mediterranean population study, while another study found no link between gene mutations and response to bevacizumab
The number of new melanoma cases in the US increased 60% from 1988-1991 to 1996-1999, with thick melanomas primarily composed of nodular subtype. The study suggests that current early-detection educational programs may not be effective for detecting this aggressive type of melanoma.
Patients with a personal or family history of melanoma exhibit similar sunbathing patterns and protective measures to low-risk populations, highlighting the need for improved education and awareness campaigns.
A study assessed dermatologists' perception of 4,036 skin lesions and found that irregularity, ugly duckling sign, and recent change are key factors. These findings suggest that teaching the public to recognize these patterns could improve early detection of melanoma.
Archaeological findings reveal extensive ancient Maya salt workshops beyond royal control, while researchers investigate the role of Toll-like receptor 4 in inducing neuropathic pain. Atmospheric pollution is linked to wheat disease prevalence, and microarray technology helps diagnose skin cancer stages. Serotonin levels may regulate e...
Researchers discovered that targeting mutant B-Raf protein can prevent the spread of melanoma and halt tumor growth. Lowering mutant B-Raf activity reduced melanoma development in human cells, providing a potential breakthrough for treating this aggressive form of skin cancer.
Researchers genetically engineered zebrafish to develop black-pigmented moles with mutated human BRAF and p53 genes. The study shows that BRAF mutations are necessary for mole development, but insufficient for cancer. The model provides insights into how gene mutations contribute to melanoma
Researchers have developed a zebrafish model that shows human BRAF mutations can induce dramatic black pigmentation and aggressive melanomas. The study also found that p53 deficiency is crucial for melanoma development, providing new insights into melanoma genetics and drug development.
Research findings indicate that increased sun exposure is associated with improved melanoma survival, while decreased UV radiation exposure may lower non-Hodgkin lymphoma risk. These studies provide new evidence for the potential beneficial effects of sunlight on cancer incidence and outcome.
Researchers expand the ABCD rule to recognize changing characteristics of early melanomas, especially nodular melanomas. The new guideline aims to improve detection and diagnosis of this aggressive form of skin cancer.
PET scans improved detecting distant metastases with an accuracy of 85%, compared to 55% for current standard diagnostics. The technique also showed high accuracy in diagnosing locoregional disease, surpassing current practice by 24 percentage points.
The combination of BAY 43-9006 and standard chemotherapy showed durable partial responses in 40% of patients with advanced metastatic melanoma. The study demonstrated anti-tumor activity that was not solely dependent on a BRAF gene mutation, offering new hope for treatment options.
Researchers found tumor disappearance and shrinking in four out of nine patients with advanced melanoma treated with CP-675,206. The antibody works by blocking a negative regulator of the immune system, allowing it to attack cancer cells. A Phase II study is now underway to further investigate the treatment.
A phase II multicenter study evaluated a multiepitope CD8 T-cell vaccine for metastatic melanoma patients, demonstrating an immune response associated with longer survival. The vaccine showed promising results in stimulating an immune response, but no correlation was found with clinical tumor responses.
Researchers discovered feasible chemotherapy combinations that include trastuzumab for HER2-positive advanced breast cancer, with higher overall response rates and lower cardiac dysfunction. Two phase II clinical trials showed promising results, paving the way for future randomized phase III trials.
Researchers found that digital photographs improved detection of new or changed moles, increasing accuracy by over 10% compared to skin self-examinations alone. Baseline photography may effectively improve diagnostic accuracy in patients performing skin self-examinations.