Articles tagged with Metabolic Syndrome
A new study by King's College London reveals that proposed new obesity definitions give greater insight into the ill health of metabolic bariatric surgery candidates compared to BMI. The study found marked variation in disease burden among patients considered for surgery, despite similar BMI.
A study published in the Journal of Cachexia, Sarcopenia and Muscle reveals that deleting transforming growth factor-beta 1 (TGF-β1) from macrophages enhances muscle regeneration and mitochondrial function. The research found that this approach protected against obesity-related muscle wasting and improved exercise performance.
A European cohort study suggests that childhood exposure to air pollution at home and school increases the risk of metabolic syndrome. The study found stronger associations with metabolic syndrome risk at school than at home.
The study found associations between mitochondrial heteroplasmy and cardiometabolic parameters in patients with metabolic syndrome. Intermediate heteroplasmic mutations were associated with the degree of vascular stenosis and lipid metabolism parameters.
A CU Anschutz study reveals reduced mitochondrial efficiency in healthy yet sedentary individuals, which may precede the development of major diseases like cancer, diabetes, and Alzheimer's. Regular exercise acts as a literal shield for cellular health, helping mitochondria seamlessly switch between burning fat and carbohydrates.
The new clinical practice guideline provides recommendations for identifying cardiovascular-kidney-metabolic (CKM) syndrome risk earlier and taking action to protect long-term heart, metabolic, and kidney health. Lifestyle modification, including the American Heart Association's Life's Essential 8 measures, can help prevent a range of ...
The new clinical guideline identifies excess weight, especially in the abdomen, as a key driver for cardiovascular-kidney-metabolic syndrome. Nearly 9 in 10 adults in the US have at least one condition within this syndrome, which includes high blood pressure, abnormal cholesterol and metabolic conditions like diabetes and obesity.
The summit brought together endocrine leaders to identify opportunities to work closely together on increasing the visibility of endocrine health in policy decisions. Early findings from a workforce survey revealed challenges including long patient waiting times and retention concerns among early-career clinicians.
New data show that over 50% of patients with obesity and CKD experienced a significant reduction in kidney failure risk, as well as a nearly 75% drop in mortality rate after undergoing bariatric surgery. This study highlights the transformative impact of metabolic and bariatric surgery on chronic disease outcomes.
The European Society of Endocrinology organizes World Hormone Day to educate the public about hormone-related health issues. Global endocrine disorders affect millions worldwide, emphasizing the need for proper hormone balance.
A Salk Institute study identifies Fibroblast Growth Factor 1 (FGF1) as the molecular signal that tells the liver when to release fat into the bloodstream, following a precise rhythm timed to the body's internal clock.
Researchers found a clear connection between oral health and kidney health, with immune dysregulation and systemic inflammation driving the relationship. The study highlights the need for physicians to integrate oral and renal health into clinical care systems.
Elevated uric acid promotes liver damage and disease severity through inflammation, oxidative stress, and metabolic disturbances. Lifestyle interventions, medications, and potential biomarkers are being explored to improve diagnostic efficacy and treatment.
A $3.4 million NIH grant will fund a semi-automated feedback system to support people tracking diet, exercise, and weight in weight-management programs. The system aims to provide personalized feedback to increase tracking and weight loss success.
A new study has identified an altered expression of specific genes in individuals with obesity, metabolic dysfunction-associated steatotic liver disease (MASLD), and liver fibrosis. The research team found that inhibiting the gene expression can reduce liver fibrosis, offering a potential new treatment option.
The ESE and ESPE have launched a landmark Joint Clinical Practice Guidance to support structured and effective transition of young people with endocrine conditions. The Guidance provides practical, evidence-based recommendations to ensure continuity, safety and quality of care during this critical phase in a patient's life.
The American Heart Association reports that millions of US adults with diabetes are unaware they have it, while nine in ten with chronic kidney disease do not know they have it. Regular screening can catch problems early, with approximately 80% of heart attacks and strokes being preventable.
A new study finds salcaprozate sodium may have adverse biological effects on the gut and beyond, including shifts in potentially harmful gut bacteria and elevated inflammatory markers. The research highlights an important gap in understanding the long-term impact of repeated SNAC exposure.
A new study reveals that people with an unexpectedly high metabolic BMI have up to a five times higher risk level for diseases such as diabetes and fatty liver. Metabolic BMI is based on advanced metabolomic analyses and identifies obesity-linked changes in metabolism that can be present even at normal weight.
A Finnish study found that adults who remained physically active throughout adulthood had a lower prevalence of metabolic syndrome at age 61. Increasing physical activity later in life, especially muscle-strengthening exercises, also mitigated risks.
Approximately one-third of US adults met criteria for metabolic syndrome in 2023, with no significant change in prevalence between 2013 and 2023. Triglyceride levels demonstrated a modest increase over the past decade.
Pennington Biomedical Research Center launched its first international scientific symposium in Riyadh, Saudi Arabia, exceeding expectations with distinguished audience engagement and new institutional contacts.
A study conducted at the University of California, Riverside, has uncovered a link between soybean oil consumption and obesity in mice. The research found that a genetically engineered group of mice on a high-fat diet rich in soybean oil did not gain weight, suggesting that the liver protein HNF4α plays a crucial role in fat metabolism.
Researchers identified a group of metabolites produced in the intestine that travel to the liver and heart, influencing metabolic pathways and insulin sensitivity. The study found that environmental factors can regulate these metabolites, which play a crucial role in obesity and type 2 diabetes.
The European Society of Endocrinology is launching a new campaign to raise awareness about the importance of hormone health. The #BecauseHormonesMatter initiative aims to improve public understanding of hormones and promote practical steps for better hormone health, following the success of last year's campaign.
The European Society of Endocrinology has released the EndoCompass Research Roadmap, a major new initiative to align research efforts and improve funding strategies for hormone-related health challenges. The roadmap identifies specific research needs across eight endocrine specialties and five cross-cutting areas.
A new study found that high blood pressure, pre-diabetes or Type 2 diabetes, and low HDL cholesterol are the three deadliest cardiometabolic risk factors for MASLD patients, with risks of death increasing by 40%, 25%, and 15% respectively. The study used data from the National Health and Nutrition Examination Survey to reach its conclu...
A large Spanish multicenter clinical trial found that a calorie-reduced Mediterranean diet combined with moderate exercise reduces type 2 diabetes risk by 31%. The intervention group also lost weight and reduced waist circumference, preventing approximately three in every 100 participants from developing the disease.
Researchers at the Salk Institute have identified dozens of microproteins that play a crucial role in regulating fat cell proliferation and lipid accumulation. This breakthrough discovery offers new potential drug targets for treating obesity and metabolic disorders, building on recent advances in CRISPR gene editing technologies.
This review synthesizes evidence highlighting immune aging as a critical accelerator of type 2 diabetes pathogenesis. Chronic low-grade inflammation, organelle stress pathways, and the ominous octet framework contribute to metabolic-inflammatory vortex, disrupting β-cell function and insulin signaling.
This review systematically maps miRNA-mediated dysregulation of the AGE/RAGE pathway in MetS, revealing widespread but understudied miRNA dysregulation across adipose tissue, liver, and immune cells. Prioritizing poorly studied receptors and multi-pathology miRNAs could accelerate targeted therapies for MetS.
Researchers from FAU's Schmidt College of Medicine recommend using high-potency statins as the primary pharmacologic approach in treating and preventing cardiovascular disease. Lifestyle changes, such as regular physical activity and a healthy diet, are also crucial in reducing cardiovascular risk.
A new study identified neurobeachin as a genetic predictor of weight loss response to GLP-1RAs. The findings have the potential to advance obesity care and provide more effective, personalized treatment options.
Michael Karin, renowned for his work on chronic inflammation and cancer, will lead the Center for Metabolic and Liver Diseases at Sanford Burnham Prebys. He aims to develop new treatments for metabolic and liver diseases, which affect millions of patients worldwide.
A new potential drug treatment has shown promising results in reducing blood sugar levels and increasing fat burning in people with type 2 diabetes and obesity. The treatment activates metabolism in skeletal muscle, promoting healthy weight loss and preserving muscle mass, a key factor in metabolic health.
The University of Gothenburg, AstraZeneca, Knut and Alice Wallenberg Foundation, and Region Västra Götaland are partnering to tackle metabolic disorders. The SEK 200 million initiative aims to deepen understanding of obesity's mechanisms and develop effective treatments.
A Japanese study found that choosing the right type of meal can extend meal duration and encourage more mindful eating. Researchers discovered that traditional bento-style meals with individual components promoted longer meal times and more chewing compared to fast food.
Researchers identified six risk groups for cardiometabolic complications in older people without type 2 diabetes, with a special high-risk group characterized by inflammation and insulin resistance. The study emphasizes the need for precise early detection and prevention strategies.
A study published in Neurology found that metabolic syndrome is associated with a higher risk of young-onset dementia. Researchers identified nearly two million people between the ages of 40 and 60 who had a health check-up, and found that those with metabolic syndrome were more likely to develop dementia, including Alzheimer's disease...
The American Heart Association funds research teams to investigate how risk factors for cardiovascular and kidney diseases impact women differently. The project aims to understand the biological significance of certain life cycles and societal factors on disease development.
A Monell Center study found that GLP-1 receptor agonists can effectively manage metabolic complications associated with Bardet-Biedl Syndrome, a rare genetic disorder characterized by early-onset obesity and cognitive impairments. The therapy significantly reduced food intake, caused weight loss, improved glucose tolerance, and normali...
A new study published in The Journal of Internal Medicine found that having an unhealthy metabolic profile increases the risk of breast cancer recurrence by 69% and subsequent breast cancer mortality by 83% among survivors. This association was consistent across Europe, North America, and Asia.
Chronic kidney disease rates increased by 24% globally from 1990 to 2021, linked to higher cardiovascular disease risk. Collaborative care and screening for cardiovascular-kidney-metabolic syndrome can reduce mortality and improve patient lives.
A new study from the University of Colorado Anschutz Medical Campus identified significant mitochondrial dysfunction in lymphoblast cell lines from children with Dravet syndrome, a severe form of epilepsy. The findings suggest that mitochondrial defects play a role in the metabolic dysfunction observed in Dravet syndrome.
The review explores the pathophysiological mechanisms linking obstructive sleep apnea syndrome and metabolic syndrome, highlighting recent advancements in therapeutic strategies. Treatment approaches aim to break the harmful cycle between OSA and MetS, which affects approximately 14% of the global population.
A study of over 6,000 Brazilians found that consuming polyphenols from foods like fruits, coffee, chocolate, and wine can reduce the risk of metabolic syndrome by up to 23%. The study also found that flavan-3-ols in red wine were associated with a lower risk of developing the condition.
A study found that pro-inflammatory molecules contribute to benign prostatic hyperplasia (BPH) in aging men, especially those with metabolic syndrome. Men with BPH had higher levels of pro-inflammatory markers and lower anti-inflammatory substances, suggesting a link between inflammation and prostate conditions.
This study found a U-shaped association between waist circumference and all-cause mortality in women, and a J-shaped trend in men. The optimal waist sizes for minimizing mortality risk were 107 cm for women and 89 cm for men.
Researchers identified early cellular changes associated with Mandibular Hypoplasia, Deafness, Progeroid Features, and Lipodystrophy (MDPL) syndrome, a rare genetic aging disorder. MDPL syndrome is characterized by premature aging of mesenchymal stem cells, which can form tissues like bone and fat.
Additional research is required to explore the relationship between COPD and metabolic syndrome, focusing on outcomes, intervention trials, and health services research. This will help shift from a COPD-focused approach to an integrated care approach considering all comorbidities.
A new study proves a suspected link between poor sleep and MASLD, a liver disorder that affects 30% of adults. Patients with MASLD experience significant sleep fragmentation, waking up 55% more often at night.
The review explores the pathophysiological relationship between OSA and MetS, revealing a complex cycle of increased cardiovascular risks. Treatment options, including CPAP, weight management, and metabolic surgery, are discussed for improving patient outcomes.
Christian Wolfrum will serve as NTU's chief academic officer, overseeing educational and research excellence, while strengthening talent development. He brings experience in translating research into real-world applications, having co-founded biotechnology firm Glycemicon AG.
More than 70 hematology researchers from the University of Miami Miller School of Medicine will showcase their work at the 66th ASH Annual Meeting & Exposition. Researchers from Sylvester Comprehensive Cancer Center are authors or co-authors on a significant number of posters presented during the event.
A new review reveals how leptin resistance, a key feature of obesity, exacerbates metabolic syndrome by triggering pro-inflammatory pathways and mitochondrial dysfunction. The study identifies potential therapeutic targets for restoring leptin sensitivity and mitigating its metabolic effects.
Researchers found that individuals with chronic kidney disease, Type 2 diabetes, or both are at increased risk of cardiovascular disease, with the risk predicted to occur up to 28 years earlier than in those without these conditions. The study aimed to better understand the effects of cardiovascular-kidney-metabolic syndrome on CVD risk.
The American Heart Association has announced five health technology start-up companies as finalists in its 7th annual Health Tech Competition. The competition aims to drive technological advancements with the potential to transform heart and brain health patient outcomes.
This review highlights bilirubin's diagnostic value, antioxidant properties, and immunomodulatory effects in liver diseases. It also discusses the metabolic and clinical implications of disrupted bilirubin metabolism and its therapeutic potential.
A randomized controlled trial found that time-restricted eating (TRE) led to greater improvements in glucose control, weight loss, and fat reduction compared to standard nutrition counseling in adults with metabolic syndrome. TRE resulted in a lower risk of muscle mass loss during weight loss.
A clinical trial found time-restricted eating improved blood sugar regulation and reduced markers of metabolic dysfunction in adults with metabolic syndrome. Participants who followed a customized eight-to-ten-hour eating window saw significant improvements compared to standard treatments.