Muscle Damage
Articles tagged with Muscle Damage
Giving stem cells room to breathe
Researchers developed hybrid spheroids with biodegradable nanogels to improve stem cell function and survival in injured swallowing muscles. The approach significantly improved muscle regeneration, cell retention, and functional recovery in a rat model.
Why some broken bones fail to heal: scientists reveal a critical molecular trigger
Researchers discovered that Apex1 plays a crucial role in initiating and progressing bone healing after injury. The protein is required for activating the master regulatory gene Bmp2, which initiates healing by stimulating periosteal expansion and callus formation.
Researchers develop biodegradable, self-powered electrical stimulator for muscle repair
A fully biodegradable, self-powered implantable electrical stimulation system was developed to address the challenge of effective muscle regeneration. The device combines degradable materials and in situ electrical stimulation intervention, overcoming key limitations of conventional electrical stimulators.
Age-related muscle wasting tied to cell recycling defect
Researchers found that a decline in chaperone-mediated autophagy activity is linked to age-related muscle wasting and can be boosted by exercise and fasting. The study suggests that enhancing this process may be a promising therapeutic strategy for preventing or treating sarcopenia in aging populations.
Study finds gender gap in knee injuries
The study found significant differences in injury patterns between men and women, with men experiencing more ACL tears and women more frequent meniscal and MCL tears. These findings can help radiologists tailor imaging protocols and risk assessments to optimize patient outcomes.
A surprising insight may put a charge into faster muscle injury repair
Researchers at Cincinnati Children's Hospital Medical Center have discovered a shared mechanism that may help improve healing across several types of muscle injury. Macrophages, immune cells known as microscopic garbage trucks, deliver ions to muscle fibers, facilitating rapid repair after an injury.
UTA study explores zinc’s power to heal blast injuries
Researchers at UTA are exploring the potential of zinc to protect and regenerate muscle tissue damaged by trauma, with a focus on reducing secondary damage. The study uses a zinc-infused gel to promote muscle regeneration following blast injuries and aims to identify a safe and convenient way to apply zinc directly to muscle tissue.
Making more supply to meet the demands of muscle cell therapy
Researchers at Sanford Burnham Prebys have developed a new method to generate more and potent skeletal muscle progenitor cells. The study found that blocking the activity of Janus kinase 2 (JAK2) yields a twofold increase in cell yield, while also delivering more mature and effective cells for regenerative medicine treatment.
Survey finds Americans choose short term relief for neck and back pain
A survey from the Orlando Health Spine Center found that Americans often opt for short-term relief methods such as rest (44%), over-the-counter pain relievers (42%), and hot/cold therapies (29%) when dealing with neck and back pain. In contrast, only 5% consider surgery as a top option for pain relief.
Overtraining: the cause of symptoms caused by excessive physical exercise has been discovered
Researchers found that hyperactivation of the PARP1 protein after exhaustive training is associated with decreased performance, fatigue, and behavioral symptoms of overtraining. A study published in Molecular Metabolism suggests that excessive protein expression may be the cause of the syndrome.
Research reveals how exercise helps prevent acute muscle pain from becoming chronic
Researchers at State University of Campinas found that physical exercise prevents the transition from acute to chronic muscle pain by activating an anti-inflammatory signaling pathway in immune cells. This can lead to the development of new treatments for muscle pain, potentially reducing opioid consumption.
Using AI to predict athletes' risk of lower-extremity injury after concussion
Researchers developed a machine learning model that analyzes over 100 variables to predict an athlete's risk of lower-extremity musculoskeletal injury after concussion. The model achieved 95% accuracy in identifying vulnerable athletes, highlighting the importance of tracking individual performance and medical histories.
Shouldering the burden of how to treat shoulder pain
A recent study published in the International Journal of Sports Physical Therapy identified five risk factors for athletes developing shoulder pain, including range of motion, strength, and training load. The research also examined treatment options for frozen shoulder, an inflammatory condition that causes unrelenting stiffness and pain.
Improving rehabilitation after spinal cord injury using a small compound oral drug
Researchers discover edonerpic maleate enhances neural plasticity, supporting cortical reorganization and improving motor control in non-human primates with SCI. The compound promotes AMPA receptor movement to areas responsible for motor control, strengthening existing neural connections.
When you get hurt matters: Circadian rhythms affect muscle repair
A new Northwestern Medicine study suggests that muscle injuries heal faster when they occur during the body’s natural waking hours. The findings could have implications for shift workers and may also prove useful in understanding the effects of aging and obesity.
Simple, quick test can predict fall risk in older adults six months in advance
A study of 153 people between the ages of 60 and 89 suggests a modification to the well-established clinical test for assessing balance in the elderly to make it more efficient, accessible, and predictive. The assessment can predict the risk of falling over a six-month period with accuracy.
The big chill: is cold-water immersion good for our health?
A systematic review and meta-analysis found that cold-water immersion can reduce stress levels within 12 hours, improve sleep quality, and boost quality of life. However, these benefits may fade after three months. Cold showers also showed promise in reducing sickness absence and improving mood.
ISarcoPRM algorithm: advancing global sarcopenia diagnosis
A new algorithm proposes measuring quadriceps muscle mass for more accurate sarcopenia diagnosis, potentially leading to earlier detection and better treatment options. Ultrasound imaging is recommended as a cost-effective and practical solution for diagnosing sarcopenia in clinical settings.
Study examines differences in strength by position among football players
A new study from the University of Kansas found significant differences in muscular power and strength among different football positions, with linemen having more body mass and quarterbacks having higher peak force. The research suggests position-specific training could optimize athletic performance.
Revidia Therapeutics expands leadership team
Revidia Therapeutics has expanded its leadership team to prepare for an FDA IND application and clinical trials. The company's lead drug candidate, MSI-1436, is being developed as a treatment for heart injury in Duchenne muscular dystrophy patients.
New drug shows promise against Duchenne muscular dystrophy
A preclinical study suggests the experimental compound K884 can restore lost muscle function in Duchenne muscular dystrophy (DMD) patients by strengthening muscle repair. The drug targets specific enzymes, allowing muscle stem cells to develop into functional tissue.
New study details why aging cells struggle to heal
A new study published in Nature Aging details the changes in muscle regeneration over time, finding that immune cells exhibit differences in abundance and reaction time between age groups. The research also identifies altered stem cell states, leading to discoordination in the process of muscle repair in older mice.
Pitchers rejoice? Plasma irradiation might prevent tendon re-tears
Researchers at Osaka Metropolitan University have found that plasma irradiation can enhance tendon-to-bone junction repair, leading to faster healing rates and stronger repairs. The study used rabbit models to test the effects of plasma on rotator cuff injuries, showing promising results.
Gene named for mythical Irish land could aid muscle function after traumatic nerve injuries
Researchers have discovered a gene called NANOG that can improve nerve regrowth and re-establish innervation in damaged muscles after traumatic nerve injuries. This discovery has significant potential to help mitigate long-term disability for people with debilitating nerve injuries.
Study: Backward hopping may be better indication of recovery from ACL reconstruction
A University of Kansas researcher has found that single leg backward hopping can accurately measure knee strength and recovery in patients after ACL reconstruction. This method shows significant changes in knee mechanics compared to forward hopping, making it a potentially superior indicator of quadriceps strength deficiency.
Scientists discover how starfish get ‘legless’
Researchers at Queen Mary University of London have identified a neurohormone responsible for triggering arm detachment in starfish. The team's discovery sheds light on the complex interplay of neurohormones and tissues involved in autotomy, a well-known survival strategy in the animal kingdom.
New bacteria-derived hydrogel heals tissue
Researchers at Technical University of Denmark developed a new biopolymer, PAMA, derived from bacteria to heal tissue. The PAMA bactogel shows significant muscle regeneration properties and nearly 100% mechanical recovery in rats.
New brain-computer interface allows man with ALS to ‘speak’ again
Researchers developed a new brain-computer interface that translates brain signals into speech with up to 97% accuracy, enabling a man with amyotrophic lateral sclerosis (ALS) to communicate with friends and family. The system was tested in real-time conversations with continuous updates, achieving high word accuracy rates.
“Extraordinary levels” of ice use at summer Olympics not always evidence based and bad for the planet
Researchers question the high levels of ice used at summer Olympics, citing potential stress on local resources and lack of evidence-based practices. They advocate for more sustainable approaches and better data on ice consumption.
Female Australian football players are taking more hits
Sub-elite female Australian football players experience different injury patterns compared to males, highlighting the need for targeted training and injury prevention strategies. Ankle sprains, concussions, and anterior cruciate ligament injuries are the most common and burdensome, resulting in the most missed matches.
Movement sensors show promise in identifying horses at injury risk
Researchers used movement sensors to track thoroughbreds' stride patterns and identified miniscule changes associated with increased injury risk. The technology has been shown to prevent catastrophic injuries by alerting trainers and veterinarians to intervene before a major injury occurs, resulting in longer careers for affected horses.
Work should focus on safety and wellbeing for everyone, experts say
A special issue of WORK Journal explores the importance of designing healthy workplaces that address musculoskeletal conditions, burnout, and chronic pain. The issue highlights the need for an interdisciplinary approach integrating medical, psychological, and occupational therapies to prevent work-related illness and injury.
Perineal cut reduces the risk of serious birth injury
A randomized clinical study found that a lateral episiotomy reduced the risk of obstetric anal sphincter injury (OASI) by 53% in first-time mothers. The procedure also did not increase the risk of other complications, but may lead to wound complications.
Heart regeneration: The key role of a growth factor has been discovered
A growth factor called BMP7 has been found to promote cardiomyocyte proliferation and regeneration in both zebrafish and adult mice. This discovery offers a promising new approach to treating heart disease by stimulating cardiac muscle cell regrowth even in later stages of life.
Ascorbic acid supplementation and immune response in healthy women during high-intensity exercise
A recent study published in The Open Sports Sciences Journal found that Ascorbic acid supplementation reduced exercise-induced oxidative stress and inflammation in healthy women. The supplement also increased plasma ascorbic acid levels and reduced post-exercise MDA levels, suggesting a potential protective effect against muscle injury.
Healing faster: Unveiling the future of tissue & organ repair
A team of scientists at the University of Ottawa has developed a novel peptide-based hydrogel that can be used for on-the-spot repair to damaged organs and tissues. The material shows great potential for closing skin wounds, delivering therapeutics to damaged heart muscle, and reshaping and healing injured corneas.
First effective treatment found for spitting cobra snakebite
Scientists have found an effective treatment for spitting cobra snakebites by blocking one of the major dermonecrosis-causing toxins with varespladib. The study suggests that this repurposed drug can prevent tissue damage and may become a valuable treatment against black-necked and red spitting cobra venoms.
Chronic pain linked to socioeconomic background – new study
A new study found that people from lower socioeconomic backgrounds are twice as likely to develop chronic musculoskeletal pain following an injury. The researchers identified several factors, including smoking, fear of movement, and poorer support networks, that contribute to the development of chronic pain.
New strategy to facilitate muscle regeneration after injury
A study published in the Journal of Physiology reveals a new approach to accelerate recovery from muscle injuries, utilizing hypoxia and hypobaric chambers. This strategy has potential applications for athletes and the general population, offering a faster and more effective recovery process.
Ginseng speeds up recovery and reduces muscle fatigue after exercise
The study found that ginseng can significantly reduce post-exercise muscle damage in healthy adults and improve muscle regeneration. Taking ginseng systematically for a long time can also mitigate the response of biological markers responsible for exercise-induced muscle damage and inflammation.
Wound-homing molecule accelerates tissue repair
A study published in Nature Communications reports the discovery of a wound-homing molecule called CAR peptide, which accelerates tissue repair by activating natural healing pathways. The treatment shows promise for treating various injuries, including muscle ruptures and bone fractures, without forming less functional scar tissue.
Insights from a phase II clinical trial with CL2020 Muse cell-based therapeutic for Amyotrophic lateral sclerosis
A phase II clinical trial found Muse cell-based product CL2020 to be highly tolerated and improved ALS symptoms, but may not halt disease progression. The treatment's efficacy depends on combining it with other drugs for future treatments.
Pusan National University's breakthrough in muscle regeneration: Nanotech scaffolding supports tissue growth
Researchers develop nanofibrous matrices containing MXene nanoparticles to aid in muscle regeneration. The study reveals molecular mechanisms behind the effects of MXene nanoparticles on muscle growth, suggesting a promising avenue for treating volumetric muscle loss and muscle-related ailments.
Supports help keep Aussie firefighters safe
Research from University of South Australia shows professional firefighters have lower movement quality as they age, which could put them at greater risk of injury. Functional strength training can help maintain a fit and healthy workforce.
Same-level workplace falls set to rise amid surge in older female workforce numbers
Australian research predicts a surge in same-level workplace falls among older women due to the growing number of females in the workforce. The study analyzed hospital admission records and found that women aged 45 and older account for 21% of these falls.
Researchers report detailed analysis of heart injury caused by yellow fever virus
A recent study published in EBioMedicine found that yellow fever virus causes myocardial fibrosis, cardiomyocyte hypertrophy, and vascular endothelium alterations, leading to cardiac conduction system disruption. The research provides new insights into the pathogenesis of YF-associated heart injury.
Fascicle gearing dynamics: Unveiling 3D rotation effects in muscle elongation
Researchers at Waseda University used diffusion tensor imaging to reconstruct fascicles in three dimensions, finding that a gearing mechanism reduces individual fascicle elongation during stretching. This mechanism allows muscles to extend without significant fiber length changes, preventing overstretching and injury.
Longer training sessions less likely to cause injury to military recruits
A new study by Edith Cowan University found that military recruits who undergo longer training programs are less likely to suffer injuries compared to those with shorter training periods. The research also showed that female recruits and those with a high body mass index (BMI) were at higher risk of injury.
Children who play baseball risk elbow injury
A study at the Radiological Society of North America annual meeting found that 20-40% of youth baseball players (ages 9-12) experience elbow pain. Skeletally immature children are more prone to injuries, including growth plate fractures and osteochondritis dissecans.
Understanding rapid tendon regeneration in newts may one day help human athletes
Researchers at Nagoya University have discovered a unique healing mechanism in newts that could aid humans in recovering faster from tendon injuries. By understanding how newts regenerate damaged tendons without scar tissue, scientists hope to develop more effective treatments for human athletes.
A novel lightweight wearable device to perform balance exercises at home
Researchers developed a lightweight wearable balance exercise device to improve reactive postural control in older adults, reducing the risk of falls. The device uses pneumatic artificial muscles to generate unexpected perturbations, resulting in improved peak displacement and velocity.
UC Irvine researchers discover how to better support lab grown muscle cells after transplantation.
Researchers at UC Irvine have identified a critical gene for muscle repair and regeneration, enabling the creation of muscle in the lab that can support human stem cells. The discovery has immense implications for treating various chronic muscle disorders and injuries, including rotator cuff tears and Duchenne Muscular Dystrophy.
New “injectable tissue prosthesis coupled with closed-loop bioelectronic system” to aid in damaged muscle/nerve regeneration and robot-assisted rehabilitation
Researchers from the Institute for Basic Science developed a novel approach to healing muscle injury using conductive hydrogels and robot-assisted rehabilitation. The injectable tissue prosthesis enhances gait in rodent models without nerve stimulation, while improving long-term muscle tissue regeneration.
First classification of four stages of heart attack based on heart muscle damage is released
A new classification system for heart attacks based on heart muscle damage is released, offering a more differentiated definition and improving understanding of acute atherothrombotic MI. This system has the potential to stratify risk more accurately and lay the groundwork for development of injury-stage-specific therapies.
New and improved bioink to enhance 3D bioprinted skeletal muscle constructs
Scientists at the Terasaki Institute for Biomedical Innovation have developed a new bioink that enhances the formation of mature skeletal muscle tissue from muscle precursor cells, increasing efficiency and potential therapies for muscle loss or injury. The bioink's sustained delivery of IGF-1 promotes muscle regeneration and repair.
NEW STUDY: Discovery of chemical means to reverse aging and restore cellular function
A team of scientists at Harvard Medical School has identified six chemical cocktails that can restore cellular aging and rejuvenate human cells. The study builds upon the discovery of Yamanaka factors, which can convert adult cells into induced pluripotent stem cells, raising hopes for treating age-related diseases and injuries. The im...
New saddle-mapping tech can reduce back pain for horses
A new method scans moving horses to produce an enhanced saddle-map, highlighting ideal areas for saddle placement to reduce pain and injury. The research identifies the most mobile areas of a horse's back as the least suitable for distributing pressure.
This patch uses nanomagnets to detect muscle movement through the skin
Scientists have invented a smart textile that can sense and measure body movements using nanomagnets. The device is self-powered, stretchy, durable, waterproof, and can be made with a sewing machine for under $3. It converts muscle activities into quantifiable electrical signals sent wirelessly to phone apps.
New research shows promising results for the development of a nonsurgical treatment for degenerative rotator cuff injury in the elderly
A novel study found that honokiol promotes healing of rotator cuff injury and may be an effective treatment for humans. The study suggests that SIRT3 activation plays a protective role in alleviating aging-induced fibrocartilage degeneration and promoting rotator cuff healing.