Articles tagged with Muscle Damage
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Researchers found that when FXR1 is absent, vascular smooth muscle cells proliferate more slowly, become senescent, and scar tissue development is reduced. This suggests that drugs targeting FXR1 may treat vascular proliferative diseases such as atherosclerosis, restenosis, hypertension, and abdominal aortic aneurysm.
Research highlights devastating impact of war injuries on civilians and soldiers, resulting in complex bone and soft-tissue infections. Doctors describe treating patients with highly complex musculoskeletal infections caused by multidrug-resistant pathogens.
Researchers found that statin users can engage in moderate-intensity exercise without exacerbating muscle injury or symptoms. The study's findings are reassuring for people experiencing muscle pain or fatigue from statins and provide important guidance for maintaining physical activity and heart health.
Researchers found that applying ice to minor muscle damage in rats enhances muscle repair and reduces inflammation. The study used an animal model of mild injuries and showed that icing attenuates the recruitment of pro-inflammatory macrophages, preventing injury expansion. This contradicts previous findings on the negative effects of ...
A WVU researcher is working on a biopsychosocial intervention to help people with chronic hip pain move and regain mobility. The intervention, called HIPS, combines mindfulness techniques like self-compassion and progressive relaxation with goal-setting and diaphragmatic breathing to reduce pain and increase physical activity.
Researchers discovered that mechanical loading can exacerbate inflammation in aged muscles, hindering healing. However, combining mechanotherapy with anti-inflammatory treatment significantly improves healing in aged muscles.
A new study found that eccentric contractions prove most effective in preventing muscle wasting and damage after immobilization. Strengthening the unaffected arm through weightlifting also counteracted muscle atrophy, with a stronger cross-education effect observed for eccentric contractions.
Researchers analyzed MRI images of Olympic athletes' injuries during the 2020 Tokyo Games and found that those with tendon tears were more likely to drop out. The study aims to improve injury management and prevention by understanding different types of muscle injuries and their outcomes.
A randomized controlled trial found that daily almond supplementation increased the beneficial fat molecule 12,13-DiHOME in blood plasma after intense exercise. This increase was associated with reduced muscle damage and fatigue, as well as improved recovery from exercise. The researchers suggest that polyphenols in almond skin may be ...
Researchers at Michigan Medicine have developed a new biomarker-based strategy to screen for immune checkpoint inhibitor-induced myocarditis, which can cause muscle damage and liver injury. Early detection of these biomarkers can lead to earlier treatment and improved survival rates.
The proportion of hamstring injuries and associated lay-off days among male professional European footballers has doubled over the past 20 years. Nearly one in five injuries were recurrences, occurring within two months of return to play, with most injuries being structural and resulting in more lay-off days.
A new study found that bioelectrical impedance analysis can accurately assess knee muscle function, offering a non-invasive alternative to traditional methods. The findings suggest that thigh PhA is a better predictor of knee extensor strength than whole-body PhA.
A major new study found that 24% of farmers reported mobility problems, while 31% experienced anxiety and depression. The research, published in BMC Public Health, highlights the need to tackle physical and mental health issues in the agricultural industry.
Researchers from Tokyo Medical and Dental University found a novel GLP-1R agonist, PF1801, that can suppress muscle inflammation and restore muscle strength in patients with polymyositis. The study suggests PF1801 could be used to treat patients with muscle wasting disease and improve symptoms associated with inflammatory myopathies.
A recent study published in Science reveals that hyaluronic acid plays a key role in controlling muscle repair. The natural compound awakens stem cells to start the repair process after a 40-hour cleanup job by immune cells is complete.
A new study by Edith Cowan University identified the most common injury types and body regions affected among police recruits, with knee injuries having the greatest impact. The study also found that men under 30 had a substantially reduced injury risk, highlighting the importance of tailored training programs to reduce injury rates.
A study in biomechanics measures the impact of head-first, hand-first, and feet-first diving to provide data-driven recommendations for safe diving. The researchers found that spinal cord and neck injury is likely above eight meters in a head-first dive, while knee injury is likely above 15 meters with feet-first diving.
The England Men's Cricket Team has become leaner and fitter over the past seven years, with a significant drop in body fat and substantial improvements in fitness levels. The study found players have 18% less body fat and increased cardiovascular capability.
Children using trampoline centers are at a higher risk of serious injuries and hospital admissions compared to those using trampolines at home. Mandatory safety standards for trampoline centers are urgently required, highlighting the need for public awareness and evidence-based safety measures.
A recent study reveals that 91% of athletes display dysfunctional breathing patterns, which can lead to increased risk of musculoskeletal injuries. The study emphasizes the importance of screening and addressing these patterns through targeted interventions and breathing training protocols.
A study from Edith Cowan University reveals that electrical stimulation on specific nerves and relaxation techniques can reduce neural amplification in the spinal cord, which may help alleviate involuntary muscle spasms. These methods could provide a non-pharmacological alternative to current treatment options.
A team from the Terasaki Institute for Biomedical Innovation has created a method to repair tendons using silk fibroin scaffolds, which showed improved healing and regeneration of injured tendons. The scaffold combines silk fibroin with GelMA to promote cell attachment, growth, and differentiation.
Researchers have developed a new method to recover muscle mass in aged mice by injecting pericyte-derived extracellular vesicles into the muscles after disuse. This approach has shown promise in recovering skeletal muscle fiber size and remodeling the extracellular matrix, which supports muscle structure and growth.
A recent clinical trial has shown that sodium thiosulfate does not reduce injury to damaged areas of heart muscle following a heart attack. Despite promising results in animal studies, the trial did not meet its primary endpoint or show significant differences in secondary endpoints.
A retrospective cohort study found that shoulder injuries occurred in fewer than 1 in 10,000 patients who received intramuscular vaccinations administered in the deltoid muscle. Researchers also identified risk factors for developing shoulder conditions, including advanced age, female sex, and receiving pneumococcal conjugate vaccine.
Dr. Zhiqiang Lin has been awarded a $3.2 million NIH grant to investigate the roles of YAP and IRF2BP2 in the cardiac innate immune response, with the goal of reducing cardiac inflammation and promoting heart recovery after a heart attack.
The National Athletic Trainers' Association has updated its position statement to reduce intentional head-first contact behavior in American football players. The new recommendations address education and administration, skill development and behavior modification, rules and regulations, and technology and scientific research.
A recent study by researchers from Ritsumeikan University found that athletes with a history of sprained ankle showed reduced gut bacteria diversity compared to those without such a history. This suggests that musculoskeletal injury may have a negative impact on the gut microbiota, potentially leading to long-term health consequences.
A new study published in NEJM Evidence reveals that exercise and patient education can provide similar results as surgery for young people with meniscal tears. The research compared surgical and non-surgical treatment options among 121 young individuals and found no significant difference in outcomes between the two groups.
A molecule of RNA called CARMN has been found to play a crucial role in maintaining healthy smooth muscle cells in the blood vessel wall, which can help prevent atherosclerosis and angioplasty-induced restenosis. Restoring healthy CARMN levels may lead to new approaches for treating heart disease.
A new study reveals that extracellular vesicles deliver genetic instructions for the longevity protein Klotho to muscle cells, which declines with age. This finding suggests that EVs could be developed into novel therapies for healing damaged muscle tissue and improving functional recovery in older individuals.
Researchers at Johns Hopkins Medicine have discovered that manipulating certain nerve cells may trigger the formation of new heart muscle cells, restoring heart function after heart attacks. The study found that removing specific genes associated with circadian rhythms increased neonatal heart size and cardiomyocyte numbers by up to 10%.
Researchers discover changes in muscle torque recovery can predict maximum voluntary strength gains but not delayed-onset muscle soreness. The study's findings offer a promising approach to assessing muscle damage symptoms after exercise.
A recent study reveals that muscle regeneration after physiological damage relies on the rearrangement of nuclei, accelerating repair of contractile units. Nuclei are attracted to injury sites and deliver mRNA molecules to initiate protein synthesis for muscle repair, offering a new insight into muscle biology.
A study using a mouse model of eccentric contraction revealed that icing injured muscles delays muscle regeneration. The phenomenon is linked to pro-inflammatory macrophages' ability to infiltrate damaged cells, delaying the healing process.
The American College of Physicians and the American Academy of Family Physicians recommend treating acute pain from non-low back musculoskeletal injuries with topical NSAIDs, with or without menthol gel, as the first line of treatment. Topical NSAIDs were shown to be effective for pain reduction, physical function, treatment satisfacti...
A new clinical guideline recommends treating acute pain from non-low back musculoskeletal injuries with topical NSAIDs, suggesting against opioid use. The guideline focuses on effective treatments and suggests oral NSAIDs, acetaminophen, acupressure, or transcutaneous nerve stimulation for patients.
Two new evidence reviews from McMaster University suggest that alternative treatments are as effective as opioids in managing acute musculoskeletal injuries like strains and sprains. The studies found that opioids have a higher risk of harms to patients, particularly those with past or current substance use disorders.
People with ACL injuries can lose up to 40% of muscle strength due to muscle atrophy. A new University of Michigan study found that adding eccentric exercises to physical therapy can increase muscle volume and improve outcomes.
A new experimental model of severe Duchenne muscular dystrophy (DMD) reveals that high TGFβ activity suppresses muscle regeneration and promotes fibroadipogenic progenitors, leading to muscle degeneration. The study identifies correcting the muscle micro-environment caused by high TGFβ as a therapeutic target.
A team of researchers led by the University of Pittsburgh is developing a smart device that uses AI, bioelectronics, and regenerative medicine to regrow muscle tissue. The device aims to prevent stiff scars from forming in wounds over 20% damaged, which often leads to significant disability.
Researchers developed a handheld 3D bioprinter to treat volumetric muscle loss, allowing for direct scaffold deposition into defect sites. The bioprinter prints gelatin-based hydrogels that mimic native tissue properties and adhere precisely to surrounding tissues.
A new study found that road injury deaths have decreased worldwide, but the risk of death from a road accident remains high in some countries. In 2017, 54 million people were injured in road accidents, resulting in 1.2 million deaths globally.
Scientists develop DNA nanodevice that uses near-infrared light to guide stem cells to wounds, promoting muscle tissue regrowth in mice. The system successfully activated receptors, causing cells to move and grow, with treated mice showing increased signs of regeneration.
A study by James Cook University found that sports compression stockings positively influenced agility and lower limb muscular endurance in female soccer players. The findings confirmed a protective effect with compression stockings, which may be crucial for performance in soccer matches.
Research from the University of Pittsburgh suggests that Klotho protein can rejuvenate muscle healing in old mice. By raising Klotho levels or mitigating its deficiency, researchers were able to restore functional levels of muscle regeneration in aged skeletal muscle.
Researchers develop a system using IL-4 nanoparticles to target macrophages, reducing inflammation and promoting muscle fiber regeneration. Mice with injured muscles treated with IL-4 nanoparticles showed improved muscle structure and strength.
Two US programs, Sportsmetrics and PEP, have been shown to significantly decrease non-contact ACL injury rates and alter dangerous neuromuscular movement patterns in female athletes. These programs improve muscle strength, reduce muscular imbalances, and decrease landing forces.
A new study by researchers at Sanford Burnham Prebys Medical Discovery Institute describes the biology behind why muscle stem cells respond differently to aging or injury. Adult muscle stem cells are essential for repairing and regenerating muscle throughout life, but their ability to cope with different stimuli varies depending on the...
A team of researchers has received a $1.8M grant to develop an implantable muscle stimulator that mimics regular weight-shifting to improve muscle health and prevent pressure ulcers and deep tissue injuries in patients with spinal cord injuries.
A new study discovered how our body clocks impact wound healing, with wounds sustained at night taking up to 60% longer to heal compared to daytime injuries. The research found that skin cells move to the wound site faster during daylight hours, leading to increased collagen deposition and improved healing.
A new method of measuring sports-related muscle injury uses localised bioimpedance measurement (L-BIA) to quantify damage and provide accurate return-to-play time. The study found L-BIA enables clinicians to differentiate between two types of partial muscle tears that cannot be distinguished using MRI.
A study estimates the national incidence of facial fractures in adults 55 and older due to recreational activity, with a 45.3% increase between 2011 and 2015. The most common causes were bicycling, team sports, outdoor activities, and gardening, with men being more prone to injuries from these activities.
SLU researchers have made a breakthrough in understanding muscle regeneration, identifying the nuclear receptor REV-ERB as a key player. By targeting this receptor, scientists may be able to develop new drugs to treat a range of muscle disorders and injuries, including muscular dystrophy and sarcopenia.
Researchers at Stanford University School of Medicine discovered a lipid metabolite called prostaglandin E2 that activates muscle stem cells responsible for repairing damage after injury or exercise. Treating mice with PGE2 accelerates muscle repair and strength regain, while nonsteroidal anti-inflammatory drugs inhibit this process.
A Stanford study has identified a protein called hepatocyte growth factor (HGF) that can prime mouse stem cells to quickly respond to injury. The researchers found that HGF helps activate a critical signaling pathway in the cells, stimulating the production of proteins important for alerting stem cells and promoting tissue repair.
Paramedics using powered stretchers experience a significant reduction in musculoskeletal injuries, with injury rates dropping from 20 to 4.3 per 100 workers. The study suggests that the added cost of powered stretchers can be recovered within seven years due to reduced injury-related costs.
A pooled analysis of available data reveals that shock-absorbing insoles do not prevent injuries or stress fractures. In contrast, foot orthotics have been shown to reduce the risk of overall injury and certain types of leg and foot pain by up to 41%. However, the quality of the evidence varies, and further rigorous research is needed.
Researchers at McMaster University found that physical activity can retain, repair, and regenerate damaged muscle in the elderly. After eight weeks of exercise, old mice were able to repair and rebuild muscle more quickly following injury compared to non-exercise groups.
A new study published in The FASEB Journal suggests that regular exercise can improve muscle repair in older adults, allowing them to regain lost muscle mass and recover from injury more quickly. After just eight weeks of exercise, old mice experienced faster muscle repair and regrowth compared to non-exercised controls.