Neurological Disorders
Articles tagged with Neurological Disorders
Neuronal hyperacitivity triggers severe autoimmune brain disorder
Armed conflict and penetrating traumatic brain injury in children in the Gaza Strip
Chinese Medical Journal study examines rising neurological disease burden in China
UCLA to lead $9M study on pesticides’, air pollutants’ link to Parkinson’s disease risk
AI model predicts 10-year stroke risk based on routine cardiology test
Using real-time brain signals to predict and prevent attention lapses in kids
Precision DNA editing targets root cause of severe childhood epilepsy in preclinical study
Hereditary epilepsy successfully treated in mouse model
Pitt Team receives $9M grant for Parkinson’s research
The timing of trauma leaves a lasting mark on the brain and behavior
New Chinese Neurosurgical Journal study report novel surgical strategy for moyamoya disease
Researchers develop tailored revascularization approach for moyamoya disease, improving circulation while minimizing complications. The technique, called STAPC, uses vessel diameter, blood-flow dynamics, and recipient brain arteries to guide surgical decisions.
New study finds higher dementia risk in insulin-requiring diabetes
What factors might account for the increased risk of autism in children with epilepsy?
A large population-based study found that children with epilepsy have a significantly higher risk of also having autism spectrum disorder. The study highlighted key differences between children with co-occurring conditions, including intellectual disability and age of diagnosis.
New MRI technology provides a comprehensive view of the human brain
Researchers developed multiplexed MRI technology, enabling simultaneous imaging of signals from multiple molecules in the brain. The technology provides a comprehensive view of the brain's structure, physiology, and molecular processes, allowing for more precise diagnosis and individualized treatment planning.
FAU review: Obesity and Alzheimer’s linked by disease-driving metabolic pathways
A review from Florida Atlantic University links obesity to Alzheimer's disease through disruptions in metabolism, highlighting the importance of mitochondrial function and gut-brain axis balance. Early detection and whole-body prevention may become possible through monitoring metabolic health.
Researchers identify new ways to boost nervous system repair in MS
A doctoral thesis reveals two drug molecules that can initiate the regrowth of a protective layer surrounding neurons, enhancing remyelination and accelerating brain tissue repair. The study also identifies scar tissue as a physical barrier to neural regeneration and demonstrates effective treatment with a second drug molecule.
7 honorees nationwide are redefining what life after stroke can look like
The American Stroke Association honors seven Stroke Heroes for their efforts in supporting survivors and caregivers through connection, education, and shared experiences. The winners showcase how personal experience can become a source of strength for others, reducing isolation and helping fellow survivors find a path forward.
Knowing stroke signs can save a life when every minute counts
Knowing stroke signs can help protect the brain, reduce long-term disability, and save a life, according to the American Stroke Association. Approximately 2 million brain cells die every minute when stroke goes untreated, making early recognition critical.
Researchers discover a new link between brain sugar levels and myelin development
Researchers at CUNY ASRC have uncovered a metabolic switch that influences the formation of myelinating cells, helping shape brain development. The study reveals that glucose levels act as a signal directing behavior during development and can be harnessed to protect myelin in the developing brain and promote repair in disease states.
Epilepsy "brain blips" revealed by high-definition probes
Researchers discovered that interictal epileptiform discharges (IEDs) occur in a predictable pattern, unfolding sequentially in individual neurons. Nearly 80% of IED-involving neurons are also involved in language and perception, suggesting the brain blips can derail cognition.
Researchers discover a molecular switch that guides the movement of neurons during brain development
A protein called Teneurin 4 directs neuronal migration through mutually exclusive pathways, regulating adhesion to fibres and enabling faster movement. The discovery improves understanding of brain development and offers insights into neurodevelopmental disorders.
Re-conceptualizing Parkinson’s disease as a lifelong neurobiological trajectory: A framework for prevention
A new review proposes a prevention-focused framework for understanding Parkinson's disease risk, highlighting the role of early-life vulnerability, environmental exposures, and resilience factors. The study suggests that susceptibility to PD may begin earlier in life through interactions between biology and environment.
New experimental drug may restore movement after stroke
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
Hydraulic brain: Body motion linked to fluid movement in the brain
A study using mice and simulations found that abdominal contractions compress blood vessels connected to the spinal cord and brain, enabling gentle brain movement that facilitates cerebrospinal fluid flow and potentially removes neural waste. This mechanism may explain why exercise is thought to benefit brain health.
Epigenetic aging linked to MRI signatures of neurodegeneration but not general brain aging
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.
Severe strokes linked to 5 times higher dementia risk
A national study found that people with severe strokes have a five times higher odds of developing dementia. Stroke severity also affects thinking and memory after stroke, highlighting the need for close monitoring and treatment of dementia risk factors.
How do astrocytes contribute to fragile X syndrome?
Researchers from the Salk Institute found that astrocytes play a crucial role in fragile X syndrome symptoms. Correcting dysregulations in star-shaped brain cells improved some symptoms, including reduced seizures and restored molecular balances in a mouse model of FXS. The study validates the importance of studying astrocytes in FXS r...
USC-led team receives funding to build next-generation medical device that uses tears to monitor health
A USC-led team is working on a medical device that uses tears to monitor health, starting with dry eye disease. The device aims to provide continuous monitoring and automated medication delivery, improving patient comfort and treatment efficacy.
Transcranial alternating current stimulation (tACS): Mechanisms and clinical applications in neuropsychiatric disorders
tACS modulates brain oscillations, induces synaptic plasticity, and regulates neurotransmitter release to alleviate symptoms of various neuropsychiatric conditions. Personalized approaches are essential for treatment efficacy.
Study reveals dynamic interactions between brain tumors and immune cells
Researchers at DZNE discovered complex, situation-dependent interactions between glioblastoma cells and microglia in the brain. The study found that microglial activity changes as tumors spread, influencing containment and spread of the disease.
Gut microbiome changes may signal Parkinson's disease risk
A new study reveals that people with Parkinson's disease have a distinct gut microbiome, as do those at genetic risk but without symptoms. This could lead to early detection and potential prevention strategies.
Study uncovers hidden factor shaping dementia caregiving stress
A study from Rice University reveals that caregivers' relationships play a crucial role in their mental and physical health. Caregivers who are more self-reliant or emotionally distant experience worse health outcomes, but those with higher relationship satisfaction have stronger buffering effects.
Lab-grown mini-brains shed light on childhood epilepsy
Researchers developed mosaic mini-brains to study focal cortical dysplasia type II, a condition causing seizures in children. The findings support the two-hit model, suggesting that complete loss of DEPDC5 is necessary and sufficient to initiate the disease, with mosaicism determining lesion extent.
Scientists engineer a tool to “edit” brain circuits and enhance memory
Researchers develop molecular tool called SynTrogo, which enables selective dismantling of synaptic connections in brain circuits. By harnessing astrocytes, the system reduces synapse number while strengthening remaining connections, leading to enhanced long-term potentiation and improved memory.
“MitoCatch” delivers healthy mitochondria to diseased cells
Researchers developed MitoCatch, a system that targets disease-affected cells with healthy mitochondria. The innovation enables efficient cell type-specific mitochondrial delivery, improving survival of damaged neurons in vitro and retinal ganglion cells in vivo.
Rett syndrome study highlights potential for personalized treatments
A new study by MIT researchers uses advanced human cell cultures to model Rett syndrome, revealing distinct abnormalities caused by two different mutations of the MECP2 gene. The findings suggest that correcting key differences made by each mutation requires different treatments, paving the way for personalized therapies.
High-salt diet linked to faster memory decline in men, ECU study finds
A new study from Edith Cowan University found that higher sodium intake is associated with a faster decline in episodic memory in men. The study of over 1,200 participants suggests that diets high in salt may have broader cognitive impacts than previously understood.
Scientists reverse brain aging, with a nasal spray
Researchers developed a nasal spray that reversibly reduces brain inflammation, restores cellular power plants, and improves memory. The treatment bypasses the brain's protective shield through intranasal delivery, suppressing chronic inflammation and promoting successful brain aging.
Blast exposure linked to brain aneurysms in U.S. Special Operations Forces
A large sample of US Special Operations Forces personnel were found to have a higher prevalence of intracranial aneurysms with greater repeated blast exposure. The study suggests that repeated low-level blast exposure during years of service may leave a measurable vascular signature in the brain.
Role of environmental enrichment in poststroke functional recovery
A new study shows that poststroke environmental enrichment reduces chronic inflammation and promotes sustained sensorimotor recovery in mice. The study found that enriched environment mice had better neurological scores and stronger recovery compared to standard environment mice.
Composition of neuronal motor proteins regulates their cargo-specificity
Researchers discovered multiple molecular subtypes of kinesin-2 with distinct compositions and functions, including a KIF3B/B/KAP3 complex that preferentially associates with TRIM46 and facilitates its transport to the AIS. This study provides insights into how neurons regulate cargo delivery with specificity.
Barrow Neuro Analytics Center doubles footprint to support growing neurological research programs
The Barrow Neuro Analytics Center has nearly doubled its dedicated research space to 18,000 square feet, supporting growing neurological research programs. Researchers at the center are globally renowned for their work on Parkinson's disease, Alzheimer's, and other neurological disorders using data-focused methods.
Salk Institute to lead ARPA-H project with up to $41.3M to advance sonogenetics as a noninvasive therapeutic
The Salk Institute will lead an ARPA-H-funded project to develop ultrasound-sensitive protein tools, wearable ultrasound delivery technology, and a translational path to the clinic for major unmet medical needs. The team aims to create a noninvasive therapy for conditions such as peripheral neuropathy.
Scientists reverse severe epilepsy in lab mice in promising step toward a cure
Researchers used base editing to correct the SCN8A gene mutation responsible for severe inherited epilepsy. The approach successfully eliminated or reduced seizures and improved brain function in lab mice, offering new hope for treating genetic epilepsies.
Chinese Medical Journal article white matter lesions modifying endovascular therapy outcomes in large ischemic core stroke: A secondary analysis of the ANGEL-ASPECT trial
A secondary analysis of the ANGEL-ASPECT trial found EVT to be beneficial for patients with anterior-circulation LVO and a large ischemic core and absent-to-moderate white matter lesions. In contrast, those with severe WMLs showed less pronounced benefits, suggesting uncertainty about EVT's efficacy in this subgroup.
Scientists discover how multiple sclerosis kills neurons
A team of researchers discovered that inflammation in multiple sclerosis causes DNA damage to neurons essential for higher thinking and cognition. This finding provides a new direction for the field and highlights the importance of protecting grey matter neurons from damage.
Chinese Medical Journal review illuminates the multifaceted role of LRRK2 in health and disease
The review highlights LRRK2's diverse cellular functions and pathogenic mechanisms in various diseases, including Parkinson's disease and inflammatory disorders. Therapeutic strategies targeting LRRK2, such as kinase inhibitors and emerging approaches like PROTACs and gene therapy, show promise for correcting cellular imbalances and re...
Survey: Americans strongly support autism research — but most don’t know brain donation is needed to advance it
A new survey by Autism BrainNet reveals a significant disconnect between Americans' strong support for autism research and their limited understanding of postmortem brain donation. The survey found that 70% of respondents had never heard of brain donation, despite 92% agreeing its importance in advancing research.
Large clinical RCT trial finds no clear added benefit of catheter ablation for preventing recurrent stroke in patients with atrial fibrillation
A nationwide Japanese trial found that catheter ablation did not reduce the risk of recurrent stroke or major cardiovascular events in patients with atrial fibrillation who had recently experienced a stroke. The study, which enrolled 251 patients and followed them for over three years, suggests that routine addition of catheter ablatio...
‘More therapy, earlier’ didn’t boost recovery in NZ stroke rehabilitation trial
A clinical trial by University of Auckland researchers found that high-intensity therapy for patients begun within two weeks of a stroke did not improve hand and arm recovery. Despite the extra therapy, neither group did better than a cohort who received standard care alone.
Researchers identify new drug target to prevent development of dangerous blood vessel defects in brain
Researchers have identified TIE2 as a crucial link between two signaling pathways that drive the growth of blood vessel abnormalities in the brain. Inhibiting TIE2 with a small drug called rebastinib may provide an endothelial cell-centered approach to prevent CCMs, which can cause brain hemorrhages and seizures.
Gut ‘Primes’ Pathogenic T Cells Responsible for Neuroinflammation in Multiple Sclerosis
Researchers identify gut-derived cells as key initiators of autoimmune neuroinflammation in Multiple Sclerosis. The study reveals that intestinal epithelial cells upregulate antigen presentation pathways, leading to the expansion of pathogenic Th17 cells that migrate to the CNS.
‘More therapy, earlier’ didn’t boost recovery in NZ stroke rehabilitation trail
A clinical trial found that high-intensity therapy for patients begun within two weeks of a stroke did not improve hand and arm recovery beyond standard care. Despite having access to extra therapy, neither group did better than a cohort who received standard care alone.
Largest clinical trial using brain training to reduce dementia receives $2.8 million in federal funding for USF
The Preventing Alzheimer’s with Cognitive Training (PACT) study, led by USF researchers, aims to delay the onset of dementia through computerized brain training exercises. With over $50 million in federal grant funding, the trial has enrolled 7,600 older adults and is expected to conclude in January 2028.
Regulatory B cells: Neuroprotective potential in neurological disorders
Regulatory B cells produce anti-inflammatory cytokines like IL-10, which dampens inflammatory responses and guides T cells toward regulatory phenotypes. This immune modulation can counteract damaging inflammation and promote neuroprotection.
Rethinking dementia: New book argues attention — not memory — may be the earliest warning sign
A new book by Swansea University researchers argues that attention impairments, rather than memory dysfunction, are a key aspect of dementia. The authors suggest that recognizing these changes could lead to earlier identification, improved diagnosis, and better care for those affected.
Severe infections may raise dementia risk, study finds
A Finnish registry study found that severe infections, such as cystitis and bacterial disease, are associated with an increased risk of dementia. The study examined nationwide health registry data and identified 29 diseases linked to dementia risk, including mental disorders, Parkinson's disease, and alcohol-related mental disorders.
An international team led by the Universitat Politècnica de València has developed one of the most detailed brain atlases in the world
An international team led by Universitat Politècnica de València has developed HoliAtlas, a highly detailed structural atlas of the human brain. This comprehensive map will aid in studying neurological diseases, including Alzheimer's and Parkinson's, and enable more accurate diagnoses.
Scientists discover new genetic disease that causes premature aging and cognitive deficits
Researchers define a new genetic disease marked by premature aging and brain function deficits, tracing the cause to a mutated IVNS1ABP gene. The study uses genome sequencing and cellular reprogramming to identify potential treatment targets.