Articles tagged with Neurological Disorders
Research presented at the European Academy of Neurology Congress 2026 found that women with Parkinson's disease had significantly greater amyloid plaque burden and neuritic plaque density compared to men. The study suggests that women may be more susceptible to Alzheimer's-related changes in the brain.
A simple bedside eye test may predict recovery of consciousness in patients with severe brain injuries, according to new research. The late light-off response (LOR) phase of the pupil response predicted improvements in consciousness seven days later.
A new study finds that multiple sclerosis has a substantial impact on social life and work, with 51% of people reporting an effect. The study highlights the need for comprehensive care addressing not only physical health but also daily functioning, employment, and overall wellbeing.
Salk Institute researchers discovered chronoferroptosis, a chronic stress pathway in cells that causes neurons to become less resilient over time and more susceptible to neurodegeneration. Iron accumulation was found to lower the cells' defenses, making them more vulnerable to stressors.
Researchers at Texas A&M University develop a laser technique called TRIP to directly measure quantum forces shaping proteins, enabling accurate prediction of how pharmaceutical drugs interact with them. This breakthrough could lead to the design of medicines tailored to specific diseases, revolutionizing precision medicine.
A new commission, launched at the Texas Brain Economy Summit, aims to define, measure, and operationalize brain capital, a concept encompassing both brain health and critical cognitive skills. The initiative seeks to address the gap in economic planning and promote brain health as a driver of economic resilience.
Researchers developed zebrafish model that reproduces key features of CADASIL, a hereditary disease causing brain damage and recurrent strokes. The study found progressive decline in cerebral blood flow and impaired learning ability, similar to human patients.
Researchers study blind Mexican cavefish to understand how evolution rewires the brain and shapes behavior. They found that cavefish become more active in light, a response believed to help them avoid predators.
The American Heart Association and International Federation for Emergency Medicine collaborate to strengthen training, research, and systems of care for emergency cardiovascular and resuscitative care. The three-year agreement aims to improve access to training, education, and emergency care resources in low- and middle-income countries.
Researchers discovered blood RNA biomarkers that could support earlier diagnosis of Alzheimer's disease, potentially reducing the need for invasive tests. They identified brain-specific markers in circulating blood nanoparticles, which may offer a minimally invasive approach for diagnosing the progressive neurodegenerative disease.
A USC study found subtle but widespread differences in the brain's communication networks in people with bipolar disorder, relating these differences to illness severity and treatment. The research team analyzed brain scans from 449 individuals with bipolar disorder and 510 healthy controls, revealing less densely connected networks an...
A new EPI-SLEEP study will investigate the impact of personalized in-ear sleep technology on sleep disturbances and circadian health in adults with epilepsy. The study aims to generate robust evidence for a low-risk approach to improving sleep without adding medication burden.
A new compound, compound 10, has shown promising effects in slowing the development of Alzheimer's disease by inhibiting GRK2 aggregation. This leads to improved mitochondrial function and reduced amyloid beta deposition, potentially breaking a vicious circle that contributes to dementia progression.
A study analyzing French and Swedish national health databases reveals a rise in Parkinson's disease, multiple sclerosis, and motor neuron diseases' prevalence worldwide. Improved life expectancy and therapies contribute to the increase in multiple sclerosis cases, while population aging is the primary driver of ALS rising incidence.
University of Delaware researchers are developing an AI-powered approach to diagnose epilepsy earlier by identifying subtle EEG patterns. The method, tested on mice with genetic forms of epilepsy, shows promise for detecting biomarkers that flag underlying changes in brain activity before seizures occur.
A pioneering pilot clinical trial showed that spinal cord stimulation improved arm strength by 32% in stroke survivors, with significant reductions in muscle spasticity. The intervention required minimal training time and was safe with no serious adverse events.
The new vaccine adjuvant induces a strong mucosal immune response in the GI tract, which is crucial for eradicating polio. The researchers achieved a 20-fold increase in antibodies needed for mucosal immunity compared to the existing injectable polio vaccine.
Researchers developed a new reference model for the human brain using diffusion MRI scans from over 54,000 people. The model provides growth charts for white matter neural pathways, helping identify subtle changes linked to aging, Alzheimer's, schizophrenia risk and other neurological conditions.
Researchers have identified an experimental molecule called OLE that helps restore microglia's protective function against Alzheimer's disease. The compound reduces beta-amyloid plaque size and toxicity, improving cognitive performance in memory tests.
A groundbreaking study created a world's first pure cerebral microbleed model by targeting brain vascular collagen IV using CRISPR/Cas9 gene editing. The research implicated dysfunctional collagen in tiny brain hemorrhages, which are strongly associated with dementia and cognitive decline.
A new brain imaging test can detect Alzheimer's disease pathology in twice as many people before symptoms appear. The test uses a new tau PET tracer that identifies more tau-positive cases than the current standard, leading to better decisions about who is on an Alzheimer's trajectory.
A major clinical trial found ocrelizumab significantly slows disability progression and preserves hand and upper-limb function in people with primary progressive multiple sclerosis. The study included over 1,000 patients across 22 countries and showed a 30% lower risk of disability progression.
A new approach combines MRI scans and AI tools to measure fluid flow in the brain, shedding light on the glymphatic system’s mechanics. The study reveals two main ways the system washes away particles, with one way moving faster than the other.
Researchers identified a potential new way to relieve chronic pain linked to neurofibromatosis type 1 (NF1). Blocking MAPK signaling with a MEK inhibitor lowered GDNF levels in Schwann cells and reduced pain-like responses in mice.
Research analyzed over 35.8 million emergency department visits to compare fall-related injury risks among adults with and without intellectual and/or developmental disabilities or cerebral palsy. Adults with these conditions were more likely to visit the emergency department due to falls, especially at younger ages.
Guldner will investigate cellular communication mechanisms that regulate brain aging and disease, targeting those interactions to preserve brain health. His research aims to build the scientific foundation for future strategies to protect cognitive health by revealing early cellular shifts that precede disease.
A study published in Neurology found that quitting smoking is associated with a lower risk of dementia, especially for those who maintain a stable weight. The research followed 32,802 middle-aged and older individuals without dementia at the start of the study, finding a sustained lower risk of dementia with time since quitting.
Migraine with aura is linked to a 73% increased risk of ischemic stroke in middle-aged and older adults. The study found no association between migraine without aura and an increased risk of stroke. Men under age 72 with migraine also face a significantly higher risk of stroke, contradicting previous research in younger individuals.
A major new study has found that severe asthma patients are often battling other health conditions, with nearly all suffering from at least one major issue. The study identified three distinct profiles linked to how well asthma is controlled and the treatments needed, offering potential breakthroughs for improving care.
Researchers mapped HuD-bound mRNAs across embryonic and adult mouse brains, finding shared biological pathways. The study suggests that adult neurons use an embryonic
Researchers analyzed brain tissue from MSA patients and found that the immune cells known as microglia appear to be exhausted or dysfunctional in later stages of the disease. The study suggests that an overactive immune system may contribute to the development of MSA, providing a potential target for future treatment.
A case-control study found that amateur-level soccer heading is associated with increased blood biomarkers of neural damage, including dose-response relationships. The findings suggest that even low-impact heading may acutely affect neural integrity.
The study found that visual occlusion triggers brain compensation characterized by enhanced functional connectivity between the right precentral and middle frontal gyri. Walking activates multiple sensorimotor pathways to support basic locomotion, and visual occlusion further strengthens this connection as a compensatory mechanism.
A long-term study of patients treated with flow diversion devices (FDDs) for intracranial aneurysms revealed excellent safety profiles, with no significant differences in outcomes between various FDD platforms. The study found that multiple FDDs were associated with a higher risk of insufficient closure and delayed complications.
Researchers develop tailored revascularization approach for moyamoya disease, improving circulation while minimizing complications. The technique, called STAPC, uses vessel diameter, blood-flow dynamics, and recipient brain arteries to guide surgical decisions.
A large population-based study found that children with epilepsy have a significantly higher risk of also having autism spectrum disorder. The study highlighted key differences between children with co-occurring conditions, including intellectual disability and age of diagnosis.
Researchers developed multiplexed MRI technology, enabling simultaneous imaging of signals from multiple molecules in the brain. The technology provides a comprehensive view of the brain's structure, physiology, and molecular processes, allowing for more precise diagnosis and individualized treatment planning.
A review from Florida Atlantic University links obesity to Alzheimer's disease through disruptions in metabolism, highlighting the importance of mitochondrial function and gut-brain axis balance. Early detection and whole-body prevention may become possible through monitoring metabolic health.
A doctoral thesis reveals two drug molecules that can initiate the regrowth of a protective layer surrounding neurons, enhancing remyelination and accelerating brain tissue repair. The study also identifies scar tissue as a physical barrier to neural regeneration and demonstrates effective treatment with a second drug molecule.
The American Stroke Association honors seven Stroke Heroes for their efforts in supporting survivors and caregivers through connection, education, and shared experiences. The winners showcase how personal experience can become a source of strength for others, reducing isolation and helping fellow survivors find a path forward.
Knowing stroke signs can help protect the brain, reduce long-term disability, and save a life, according to the American Stroke Association. Approximately 2 million brain cells die every minute when stroke goes untreated, making early recognition critical.
Researchers at CUNY ASRC have uncovered a metabolic switch that influences the formation of myelinating cells, helping shape brain development. The study reveals that glucose levels act as a signal directing behavior during development and can be harnessed to protect myelin in the developing brain and promote repair in disease states.
Researchers discovered that interictal epileptiform discharges (IEDs) occur in a predictable pattern, unfolding sequentially in individual neurons. Nearly 80% of IED-involving neurons are also involved in language and perception, suggesting the brain blips can derail cognition.
A protein called Teneurin 4 directs neuronal migration through mutually exclusive pathways, regulating adhesion to fibres and enabling faster movement. The discovery improves understanding of brain development and offers insights into neurodevelopmental disorders.
A new review proposes a prevention-focused framework for understanding Parkinson's disease risk, highlighting the role of early-life vulnerability, environmental exposures, and resilience factors. The study suggests that susceptibility to PD may begin earlier in life through interactions between biology and environment.
Researchers discovered that strokes cause a chain reaction within the brain, leading to neuronal cell death. They found that blocking collagen production can prevent this damage and even restore motor function in paralyzed monkeys. The new drug KDS12025 reduces hydrogen peroxide levels and prevents the entire process from being triggered.
A study using mice and simulations found that abdominal contractions compress blood vessels connected to the spinal cord and brain, enabling gentle brain movement that facilitates cerebrospinal fluid flow and potentially removes neural waste. This mechanism may explain why exercise is thought to benefit brain health.
A recent study has found that epigenetic clocks are associated with cognitive impairment and dementia, but only specific epigenetic markers related to smoking exposure are linked to neurodegenerative changes. The study suggests that measures of epigenetic age acceleration capture different aspects of biological aging.