Articles tagged with Obesity
A new study found that over 40% of specialty clinics in the US turn away patients weighing 465 pounds or more due to lack of accessibility features. The study highlights a need for staff training on inclusive care and accommodations for patients with severe obesity.
A large-scale study of over 17,000 pupils and 2,300 teachers found dramatic differences in physical activity levels across England, with some schools achieving double or triple the levels of others. The research highlights growing evidence that children in deprived areas face bigger barriers to physical activity, even during school hours.
Researchers have identified a new population of hypothalamic neurons, Crabp1 neurons, that play a critical role in regulating energy expenditure. Silencing these neurons leads to reduced energy expenditure and obesity, while activating them enhances locomotor activity and protects against high-fat diet-induced weight gain.
A new study found that fat distribution appears to influence cancer risk, but the relationship varies by cancer type. The study used Mendelian randomization to investigate the role of adiposity distribution in 12 obesity-related cancers.
This study found a significant association between arsenic exposure and MASLD in humans, with higher urinary arsenic levels increasing the risk ofMASLD. The analysis also showed that arsenic exposure persisted across key subgroups, suggesting its contribution to hepatic steatosis even at moderate exposure levels.
A new study published in JAMA Network Open shows that regular phone support after losing weight is crucial for maintaining weight loss. Participants who received monthly phone calls maintained an average of 8% weight loss from their starting weight, with about 60% keeping off at least 5% of their initial weight.
A Georgia State University researcher has received a $25,000 grant to develop mechanisms for treating obesity and related metabolic dysfunctions. The goal is to identify therapeutic candidates with strong clinical translation capabilities.
A review of hundreds of studies found a link between childhood plastic exposure and long-term health concerns like heart disease, obesity, and asthma. Parents can take simple steps to limit their children's plastic exposure, such as replacing plastic containers with glass or stainless steel.
Researchers have designed a novel quintuple agonist combining GLP-1R, GIPR, and PPAR agonism to treat obesity and type 2 diabetes. The molecule, lanifibranor, shows potent effects in reducing body weight and improving hyperglycaemia in mice with obesity and insulin resistance.
Researchers at the University of Copenhagen discovered two new ciliary proteins that regulate cell communication and may lead to the development of new treatments for chronic diseases. The study found that defective cilia can disrupt signaling in almost all tissues and organs, leading to various diseases.
A recent study analyzing data from the Mexican National Health and Nutrition Surveys (2016-2023) found that cardiovascular disease risk increased in Mexico between 2016 and 2023. The average 10-year CVD risk was estimated at 9.5% using region-specific tools, highlighting the need for accurate models to predict local disease burden.
A new study uses three wearable sensors to track eating behavior and identifies five distinct patterns, including late-night snacking and stress binging. The findings lay the groundwork for personalized interventions to help individuals overcome unconscious habits that drive overeating.
Metabolic bariatric surgery shows promise as a cost-effective weight loss option for class II and III obesity patients. The study found bariatric surgery resulted in greater weight loss compared to GLP-1 receptor agonists.
A new RNA-based drug, RES-010, is designed to block an RNA molecule called miR-22, which plays a key role in obesity. The treatment has shown promising results in preclinical studies, inducing significant weight loss without regaining weight after treatment stops.
Researchers found that a high-fat diet impairs memory formation in fruit flies by reducing autophagy, a crucial cellular recycling process. This suggests that lifestyle interventions promoting autophagy, such as exercise or intermittent fasting, may improve cognitive decline associated with HFD.
A Cleveland Clinic study found that bariatric surgery offers greater long-term benefits compared to GLP-1 medicines, including lower risks of death, heart disease, and kidney failure. Patients who underwent weight-loss surgery experienced better blood sugar control and relied less on diabetes medications over 10 years.
A phase 3 trial of once-daily orforglipron found substantial weight loss in people with obesity but not type 2 diabetes. The medication improved cardiometabolic levels and was associated with significant reductions in body weight, waist circumference, systolic blood pressure, triglyceride levels, and non-HDL cholesterol.
A large-scale U.S-based randomized trial shows that intensive lifestyle changes can significantly improve global cognition in older adults at high risk of cognitive decline. The intervention emphasized regular physical activity, healthy diet, cognitive stimulation, and social engagement, leading to clinically meaningful improvements. T...
A recent Mount Sinai study analyzed genetic data from over 452,000 individuals to identify genetic differences linked to higher body fat but better metabolic health. The researchers discovered eight distinct obesity subtypes, each associated with unique health risks, and developed a genetic risk score to predict individual outcomes.
A systematic review and meta-analysis of 18 trials found GLP-1 RAs significantly improved glycemic and weight outcomes in children and adolescents with type 2 diabetes or obesity. However, gastrointestinal adverse effects warrant attention in long-term management.
A study by Mass General Brigham researchers found that tirzepatide offers greater value than semaglutide for most patients with knee osteoarthritis and obesity. Bariatric surgery provides the best option from a clinical and economic perspective for eligible and willing patients.
Research suggests that semaglutide, a weight loss medication, decreases intrusive thoughts about food and improves mental health in individuals with obesity. The study found that 81% of participants experienced less food noise after taking semaglutide for at least four months.
A study found that tirzepatide is more cost-effective than semaglutide for treating knee osteoarthritis and obesity. Tirzepatide offered a more favorable return on investment, making it the better choice for patients.
A Danish study found that individuals with a normal weight range (22.5-25 kg/m2) had the lowest mortality rate, followed by those in the overweight category. However, being underweight was associated with a significantly higher risk of death, while severe obesity was linked to a slightly increased risk. The study suggests that BMI may ...
Two large-scale clinical trials found that a higher dose of semaglutide significantly improves weight loss and related health outcomes in adults with obesity. The study revealed an average weight loss of nearly 19% in those receiving the higher dose, compared to 10% with the standard dose or placebo.
A study reveals how PGC-1α protein and estrogen work together to boost thermogenesis in females, outperforming males. This finding highlights a sex-specific mechanism of energy metabolism and suggests new therapeutic targets for obesity and diabetes prevention.
The 2025 Childhood Obesity Conference, hosted by Pennington Biomedical's Greaux Health initiative, aims to educate healthcare providers and promote healthier futures for Louisiana's children through cutting-edge research and evidence-based strategies. Participants can earn up to 7.5 CMEs and gain practical tools to support healthier fu...
A recent study found that green tea extract improved glucose sensitivity and insulin resistance in obese mice, preserving muscle morphology. The treatment reduced body weight by up to 30% and increased the expression of genes related to glucose metabolism, suggesting a selective effect on excess body fat.
Researchers found genetic peptides called alpha-defensins that shape gut bacteria, producing healthier microbiomes and reducing insulin resistance. This discovery suggests personalized treatments can be tailored to individual genes, offering new hope for addressing chronic diseases like obesity and diabetes.
A landmark study by the University of Sydney found that family-based early obesity prevention programs did not improve BMI in young children. The researchers analyzed data from 17 international studies and concluded that environmental and structural drivers are key to addressing childhood obesity. Governments, health officials, and loc...
High consumption of ultra-processed foods is associated with higher levels of systemic inflammation and a greater risk of cardiovascular disease. The study found that individuals who consumed the most ultra-processed foods had significantly higher levels of high-sensitivity C-reactive protein, a key marker of inflammation.
A cohort study shows bariatric surgery significantly lowers major metabolic comorbidity risk compared to medical weight management. The procedure is deemed a durable approach for obesity-related risk mitigation.
Researchers at the University of Gothenburg found that semaglutide reduced both cocaine use and relapse in rats, with motivation to keep taking cocaine decreasing by 52%. The study suggests that semaglutide may blunt cocaine's ability to raise dopamine levels in the brain.
Dr. Steven B. Heymsfield joins an elite group of scholars recognized for advancing knowledge and transforming their fields. He has authored over 1,300 scientific publications with nearly 79,000 citations, placing him among the top 500 most-cited researchers globally.
IRB Barcelona researchers discovered a new strategy to combat obesity by activating brown fat, boosting energy expenditure and improving metabolic health. The approach, driven by Neuritin 1 protein, increased energy burning without affecting food intake or physical activity.
A new scientific review reveals that stress, hardship, and social challenges reshape a person's gut bacteria and brain performance, making it harder to keep weight off. Social determinants of health play a key role in obesity risk, and addressing these conditions is crucial for long-term solutions.
A new hypothesis proposes that transformation of adipokine molecules in excess internal fat tissue is the primary cause of heart failure with preserved ejection fraction (HFpEF). Drugs targeting fat tissue, not the heart, can alleviate HFpEF symptoms.
Researchers at Salk Institute discover a new microprotein, SLC35A4-MP, that regulates mitochondrial structure and function in brown fat tissue. The study reveals the microprotein's role in maintaining healthy cellular metabolism and regulating body temperature.
A new study found that 14% of bariatric surgery patients use GLP-1 weight loss drugs, with higher rates among those who underwent sleeve gastrectomy and experienced lower post-operative weight loss. The rate of GLP-1 use increased as more powerful drugs became available.
A new study found that treatment of heart failure patients with GLP-1 receptor agonists reduces hospitalizations, calorie intake, and greenhouse gas emissions. The study estimates a potential annual CO2-equivalent saving of over 2 billion kilograms, equivalent to 20,000 Boeing 747 flights.
A new study suggests that being overweight (BMI 25–29.9) may actually be protective in the short term after surgery for older adults, with a 0.8% 30-day all-cause mortality rate compared to 18.8% for those with normal BMI.
A large Spanish multicenter clinical trial found that a calorie-reduced Mediterranean diet combined with moderate exercise reduces type 2 diabetes risk by 31%. The intervention group also lost weight and reduced waist circumference, preventing approximately three in every 100 participants from developing the disease.
Researchers designed an ideal primary care visit scenario that emphasizes patient-centered communication, respect, and inclusivity. A survey of 250 adults with obesity found that most preferred this approach, citing doctors who listen attentively and treat weight issues sensitively.
A recent study found that large portions of obesity-related conditions in US adolescents and young adults are attributable to obesity. Treating and preventing obesity may reduce these conditions and associated costs. The researchers emphasize the importance of addressing childhood obesity to prevent future health issues.
A new study found that excessive visceral fat is linked to faster ageing of the heart, with a genetic predisposition to female-type fat in women potentially slowing heart ageing. Researchers also discovered that artificial intelligence analysis of images revealed signs of organ ageing, including tissue stiffness and inflammation.
A retrospective cohort study found that GLP-1 receptor agonists may reduce overall cancer risk, including lower risks of endometrial and ovarian cancers, among patients with obesity or overweight. However, these medications may also increase the risk of kidney cancer, highlighting the need for longer-term follow-up.
A new imaging approach allows researchers to visualize how dual-acting diabetes and obesity drugs like tirzepatide interact with cells in the pancreas and brain. The tool, called daLUXendins, provides insight into the metabolic effects triggered by these drugs, which stimulate both GLP-1R and GIPR receptors.
Researchers at the University of Oklahoma have made a significant breakthrough in understanding the amylin hormone, which controls appetite and blood sugar. Their findings provide new tools for drug development, enabling pharmaceutical companies to target specific receptors with greater precision.
A new study found that adolescents with higher blood levels of per- and polyfluoroalkyl substances (PFAS) prior to bariatric surgery regained more weight and had greater increases in waist circumference up to five years after surgery. Researchers believe PFAS exposure disrupts endocrine and metabolic processes, leading to weight regain.
A University of Houston study found that positive childhood experiences, such as supportive relationships and regular household routines, can protect against disordered eating behaviors in college students. Adverse childhood experiences, including abuse and neglect, were also linked to increased risk factors for disordered eating.
A new study suggests that using glucagon-like peptide-1 receptor agonists (GLP-1 RAs) before surgery can help control blood sugar and support weight loss, potentially improving surgical outcomes. The medication was not associated with increased risk in 12 studies reporting postoperative outcomes.
The updated Canadian Adult Obesity Clinical Practice Guideline recommends a personalized approach to treating obesity, focusing on waist circumference, waist-to-hip ratio, and waist-to-height ratio. Two new medications, tirzepatide and setmelanotide, are included in the guideline for managing obesity-related complications.
Researchers at the University of Graz and the University of California, San Diego have developed a novel method to determine omega positions of lipids in complex biological samples. This breakthrough enables the study of biological mechanisms in unprecedented detail, particularly for inflammation-related diseases.
Researchers found that individuals with a mutation in the TTN gene are 21 times more likely to develop dilated cardiomyopathy than those without. Lifestyle factors such as being overweight or having high alcohol consumption contribute to an earlier diagnosis, and men with the mutation are more likely to develop DCM at a younger age.
Researchers found that maternal obesity prior to pregnancy can program long-term neurodevelopmental trajectories in children through epigenetic alterations. This led to autistic-like behaviors in male mice, correlating with altered gene regulation in the cortex and hippocampus.
Researchers at the Salk Institute have identified dozens of microproteins that play a crucial role in regulating fat cell proliferation and lipid accumulation. This breakthrough discovery offers new potential drug targets for treating obesity and metabolic disorders, building on recent advances in CRISPR gene editing technologies.
A study of over 452,000 adults found that metformin users had significantly lower risks of dementia and all-cause death compared to non-users. The benefits were seen across all categories of overweight and obesity, with reduced risks of up to 26% for death.
According to a RAND report, nearly 12% of Americans have used GLP-1 weight loss medications, with women between 50-64 years old making up about one-fifth of this group. The survey also found that half of those who have used the drugs experience nausea as a side effect, while one-third experience diarrhea.
A Korean survey of over 50,000 middle and high school students found that adolescent girls with weight concerns are at higher risk for depression and suicidality. The study highlights the importance of addressing body image issues in young females to prevent mental health problems.
A new study found that mothers' genetics may have a greater impact on their children's weight than previously thought. Researchers analyzed genetic and health data from over 2,600 UK families to examine the association between parental BMI and child birthweight, BMI, and diet.