Articles tagged with Obesity
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Researchers identified biomarkers like uric acid and bile acids as critical regulators of arterial stiffness and inflammation in adolescents with obesity. These findings provide new avenues for early intervention to prevent the progression of vascular stiffness and cardiovascular disease.
The Endocrine Society supports the bipartisan legislation to ensure people living with obesity have access to effective treatments. The bill will cover anti-obesity medications and intensive behavioral therapy, addressing the chronic disease's complications like cancer, type 2 diabetes, and heart disease.
A new study from the University of Surrey found that teenagers in affluent counties like Surrey struggle with access to healthy food and exercise due to systemic issues. The research highlights the need for structural changes to support young people's health and wellbeing.
Obesity can lead to coronary microvascular dysfunction, causing impaired blood flow to the heart and increased risk of heart problems. Studying pannexin-1 protein, a key player in this process, could help develop treatments to prevent heart issues before they start.
Research finds that following a low-calorie diet is associated with a heightened risk of depressive symptoms, especially in men who are overweight. The study analyzed data from over 28,500 adults and found that calorie-restrictive diets were linked to higher cognitive-affective symptom scores in men.
Children born to mothers with a BMI of 35 or higher are at heightened risk of being admitted to hospital for an infection. Maternal obesity is characterised by chronic inflammation, which increases the risk of a disordered immune system response and unfavourable changes to the gut microbiome.
A new study found that patients lean towards tirzepatide, while sleep medicine professionals favour continuous positive airway pressure therapy (CPAP) to treat comorbid obesity and obstructive sleep apnea. Results show a significant difference in treatment preferences between patients and providers.
Researchers found that obese mice displayed more anxiety-like behaviors and showed different signaling patterns in the hypothalamus, a region involved in regulating metabolism. The study also observed distinct differences in the makeup of gut bacteria in obese mice compared to lean mice.
The American Society for Nutrition released a clinical advisory outlining eight key nutritional priorities to support GLP-1 therapy, including personalized diets, micronutrient prevention, and adequate protein intake. Studies have shown that patients receiving combined pharmacologic and lifestyle interventions achieve greater weight lo...
Research suggests that self-employment among white women is associated with lower rates of obesity, physical inactivity, and poor sleep duration. This study uses biologic and physical measures to explore the relationship between self-employment and cardiovascular disease risk factors across sex and racial/ethnic minority status.
Researchers have discovered a unique group of nerve cells in the brain that regulates body weight and is linked to obesity. Removing specific receptors in these cells leads to increased food intake and weight gain in mice.
A Japanese study found that choosing the right type of meal can extend meal duration and encourage more mindful eating. Researchers discovered that traditional bento-style meals with individual components promoted longer meal times and more chewing compared to fast food.
Researchers at University of Gothenburg identified a group of nerve cells controlling semaglutide's appetite-suppressing effects without causing nausea. The discovery may lead to improved treatments for obesity and type 2 diabetes.
A new study reveals that the weight of fathers during adolescence can harm genes in future children, linked to asthma, obesity, and low lung function. The effect is more pronounced in female children, highlighting a potential vulnerability window for lifestyle influences.
Researchers found that central body fat, especially around the abdomen, is a stronger link to psoriasis risk than total body fat. This association remained consistent regardless of genetic predisposition, suggesting abdominal fat as an independent risk factor.
A new study reveals that boys who are overweight in their early teens risk damaging the genes of their future children, increasing the chances of developing asthma, obesity, and low lung function. The researchers identified epigenetic changes in over 2,000 sites in 1,962 genes linked to fat cell formation and lipid metabolism.
A cohort study found children on the path to obesity by age 3.5, highlighting modifiable risk factors that can be targeted in prevention programs. The Environmental influences on Child Health Outcomes (ECHO) cohort provided valuable insights into early-life factors and BMI trajectories.
A new NIH study found that early childhood weight patterns may signal future obesity risk. The study tracked children's body mass index (BMI) from infancy through age 9 and identified two distinct growth patterns, with a smaller group following a trajectory marked by a sharp rise in BMI.
The American Heart Association has awarded nearly $1.2 million in planning grants to 12 researchers testing the efficacy of food is medicine interventions, such as produce prescriptions and medically tailored groceries. The grants support clinical trial protocols to develop and test these approaches for treating chronic diseases like c...
Researchers found that residual inflammation in psoriasis patients is linked to obesity, metabolic dysfunction, and increased systemic inflammation. This study suggests that despite good skin response to biologics, patients may still exhibit broader health implications, such as cardiovascular disease and fatty liver disease.
Researchers identified metabolite patterns in blood and urine related to ultra-processed food intake. A poly-metabolite score was developed, showing potential to objectively measure diet and reduce reliance on self-reported data.
A study published in Cell Metabolism finds that a combination of gut bacteria and acetate reduces obesity in mice. The researchers discovered that the specific combination of Bacteroides species and acetate leads to increased fat burning and reduced sugar storage, resulting in weight loss.
Girls who enter puberty early have a higher BMI before, during, and after puberty, increasing the risk of overweight later in life. The study found that biological differences between sexes make girls more vulnerable to this impact.
Bariatric surgery, a critical tool for combating obesity, is under threat in Australia due to skyrocketing indemnity insurance premiums. The study found that surgeons are being penalized by rising premiums, forcing some to reconsider their future in the field.
GLP1-RA treatment is associated with improvements in quality of life, restrained eating, and emotional eating behavior. The treatment also provides reassurance regarding its psychiatric safety profile.
A new study found that adults diagnosed with type 1 diabetes after age 40 have a higher risk of cardiovascular disease and death compared to those diagnosed earlier. Poor glucose control, obesity, and smoking are the main risk factors identified in the study.
A new study by York University suggests that the broad ethnic categories used in clinical settings may mask differences in sub-ethnic groups. The findings indicate that socio-economic factors play a significant role in weight loss disparities among Black, Middle Eastern, Latin, and South Asian communities.
Limited effectiveness and high prevalence of adverse events are the key limitations of semaglutide. Plant-based dietary interventions have led to long-term, significant weight loss and improvements in cardiometabolic risk factors.
A new study from the University of Bath found that regular, moderate-intensity exercise preserves vitamin D levels in overweight and obese individuals. The study showed that exercise completely maintained the body's active form of vitamin D, which plays a key role in supporting bone health and the immune system.
A new study published in Aging (Aging-US) Volume 17, Issue 4 has found that the drug buthionine sulfoximine (BSO) produces similar reductions in fat mass and weight gain as the sulfur amino acid-restricted diet. BSO may offer a practical alternative to difficult-to-maintain diets for treating obesity.
SYNT-101 successfully redirects nutrient absorption to the lower intestine, promoting satiety and metabolic balance. The study demonstrated strong safety and tolerability profiles, as well as control of hunger and weight loss.
A global survey found a significant disconnect between physicians' and patients' perceptions of obesity causes and treatment goals. Physicians tend to attribute obesity to behavioral causes, while patients cite biological factors as the primary cause.
Research found that GLP-1 receptor agonists significantly reduced the risk of heart attacks, strokes, and other cardiovascular events. Treatment with these medications after bariatric surgery was associated with a 67% lower risk of major adverse cardiovascular events or death.
Researchers found that individuals who consumed collagen-enriched protein bars lost twice as much weight as a control group. The supplement also improved blood pressure, waist circumference, and liver health. Participants reported feeling less hungry and more full.
A new analysis of the SELECT trial shows semaglutide reduces major cardiovascular events by 40% within 3-6 months, even before significant weight loss and full target dose. The study found that semaglutide's effects on reducing inflammation, blood sugar, and blood pressure may contribute to its early clinical benefits.
A new head-to-head study has shown that tirzepatide results in around 50% more weight loss than semaglutide in adults with obesity. The study found that tirzepatide led to an average weight loss of 20.2%, significantly higher than the 13.7% achieved with semaglutide.
Patients in an online obesity clinic achieved average weight loss of 16.7% after 64 weeks, similar to clinical trials of semaglutide, but using less than half the medication. The study found that personalized doses of semaglutide combined with behavioral therapy and support led to successful weight loss.
Researchers found that GLP-1 receptor agonists have a direct effect on reducing obesity-related cancer beyond weight-loss, with a 41% lower relative risk compared to bariatric surgery. The study also suggests that these medications work through multiple mechanisms, including reducing inflammation.
Researchers found that a 3-month program of time-restricted eating at any time of the day can result in significant weight loss for at least a year, regardless of eating window timing. The study suggests that restricting the eating window to 8 hours may be an effective long-term approach for sustaining weight loss.
A systematic review of available evidence found GLP-1 RAs lead to significant weight loss and improved blood sugar control in adults with severe mental illness. The analysis also showed that these medications were not associated with a worsening of mental state or suicidal behaviour.
Professor Sadaf Farooqi has been awarded the inaugural Joint ‘Endocrinology Across the Life Course Award’ for her groundbreaking research on human eating behaviour and severe childhood obesity. Her work has changed attitudes towards people with severe obesity by demonstrating its biological basis.
Researchers discovered a key step in the hepatic ERK pathway that triggers insulin production in response to colonic inflammation caused by obesity. The study reveals a novel role of the gastrointestinal tract in regulating glucose homeostasis.
A new study published in Diabetes, Obesity and Metabolism found that weight loss medications liraglutide or semaglutide can cut alcohol intake by nearly two-thirds in just four months. Patients reported a significant reduction in their drinking habits, with some describing the effects as 'effortless'. The study's findings offer promisi...
A Swedish study discovered that lipolysis is more effective in women than in men, potentially explaining why women are less likely to develop metabolic complications despite having more body fat. The study suggests that understanding this difference could aid in the development of drugs that lower the risk of type 2 diabetes in men.
A new Australian study highlights the need to support women and their families with overweight or obesity before pregnancy. The research found that a woman's BMI in early pregnancy is linked to her child's weight from birth to age 10, with every 5kg/m² increase in maternal BMI associated with an increase in child BMI.
Women who experience menopause before age 50 are at higher risk of developing fatty liver disease and its related metabolic risk factors. The study found that early menopause is associated with increased risks of pre-diabetes, obesity, hypertension, and dyslipidemia.
A cohort study of 12,480 mother-offspring pairs found that pre-pregnancy obesity, gestational diabetes, and hypertensive disorders of pregnancy are associated with increased offspring blood pressure. These risk factors may also promote a faster rate of blood pressure change from age 2 to 18 years.
A new NIH study found that maternal cardiometabolic health before and during pregnancy is associated with higher blood pressure in children. The study analyzed data from 12,480 mother-child pairs and identified three key risk factors: pre-pregnancy obesity, gestational diabetes, and high blood pressure during pregnancy.
A new study from the Keck School of Medicine of USC found that children born to mothers with obesity, gestational diabetes, and hypertensive disorders have higher systolic and diastolic blood pressure. The study's findings suggest that early blood pressure interventions could start as early as pregnancy.
A recent study published in Osteoarthritis and Cartilage reveals that obesity is a leading cause of knee osteoarthritis. The research also found that certain lifestyle changes, such as following a Mediterranean diet and engaging in regular physical activity, can significantly reduce the risk of developing the condition.
A University of California, Riverside-led research team adapted an intervention for childhood obesity prevention to better serve Latina mothers, non-maternal caregivers, and families of low-income backgrounds. The study emphasizes the importance of involving non-maternal caregivers in the adaptation process.
A recent study by Edith Cowan University has found a significant association between excess weight and long-term neurological and mental health symptoms after COVID-19. The researchers suggest that this link could be due to an exaggerated inflammatory response linked to fat tissue, which may store the virus and increase its spread.
A study published in Human Reproduction found that healthy childhood diets are associated with delayed onset of menstruation, independent of body mass index (BMI) or height. The research suggests that a diet high in fruits, vegetables, and whole grains may help reduce the risk of chronic diseases such as diabetes and breast cancer.
Researchers at Pennington Biomedical found that mitochondrial fragmentation can bypass defects in mitophagy to sustain skeletal muscle quality control in patients with Type 2 Diabetes. This adaptation helps maintain mitochondrial function despite impaired mitophagy.
A new MRI technique measures a person's 'functional age' of their heart, revealing how unhealthy lifestyles add years to their heart's aging process. This method has the potential to transform heart disease diagnosis and offer a lifeline to millions by catching problems early.
A recent study published in the Journal of Hepatology has shown that simultaneous bariatric surgery and liver transplant is safe and improves long-term health outcomes for severely obese patients. The combined approach resulted in sustained weight loss, reduced risk of type 2 diabetes, and lower risk of fatty liver disease recurrence.
A study by Helmholtz Munich researchers found that GIPR agonism and antagonism decrease body weight and food intake via different mechanisms. GIPR agonists use GABAergic neurons to exert their effect, while antagonists rely on the GLP-1 receptor signal.
The American Heart Association has awarded $1M to research the link between cardiovascular risk reduction and GLP-1 use. The studies aim to identify predictors of cardiovascular risk reduction among individuals with obesity and cardiovascular disease taking GLP-1 medications, enabling more precise and effective care.
Despite slight increase in prescriptions between 2021 and 2024, only 3% of eligible patients received a prescription. Disparities were found based on race, ethnicity, social vulnerability, and urbanicity, with small but significant differences compared to overall underutilization.
A combination of bazedoxifene and conjugated estrogens reduces obesity-related changes in rats, including fat cell accumulation and insulin resistance. The treatment also increases beneficial gut microbes and improves metabolic health, making it a promising alternative to tamoxifen for women at high breast cancer risk.