Articles tagged with Ovarian Cancer
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A study at Memorial Sloan Kettering Cancer Center found that BRCA mutation carriers are more likely to be diagnosed with early-stage breast and ovarian cancers. The research showed that intensive screening and preventive surgery can lead to the detection of these cancers, but also highlights the limitations of screening.
A new computer-based algorithm identifies a distinct proteomic pattern that distinguishes malignant from benign tumours within the ovary with 100% sensitivity and 95% specificity. This technique may help screen for ovarian cancer in high-risk and general populations.
A new study analyzing oral contraceptive use among women with epithelial ovarian cancer found a significant association between progestin levels and reduced risk. Women using low-progestin/high-estrogen contraceptives were more likely to develop ovarian cancer compared to those using high-progestin/high-estrogen contraceptives.
A study led by Joellen Schildkraut at Duke University Medical Center found that oral contraceptives with higher levels of progestin may be more protective against ovarian cancer than those with lower progestin potency. Higher progestin levels were associated with a significant reduction in risk, even for short periods of use.
Researchers have identified matrix metalloproteinases as a key player in the spread of prostate cancer to the bone, offering a new target for treatment. Additionally, a genetic marker may be useful in predicting survival rates for patients with diffuse large B-cell lymphoma, while oral contraceptive use has been found to reduce ovarian...
Researchers found that raloxifene stimulates cell growth in ovarian adenocarcinoma cells with estrogen receptors, increasing the risk of recurrence. The study suggests caution for women with a history of breast cancer and estrogen receptor-positive ovarian cancer.
Researchers found that Raloxifene stimulated the growth of ovarian cancer cell lines, raising concerns about its use in ER+ patients. The study advises caution when prescribing Raloxifene to women with a history of breast cancer and ovarian cancer.
A new study reveals that the BRCA2 gene, linked to breast and ovarian cancers, plays a previously unsuspected role in human cell division. Inactivating the BRCA2 protein delays cells' progress through mitosis, suggesting a potential new target for cancer treatment.
A new platinum-based cancer drug, BBR3464, has shown promising activity against ovarian cancer that is resistant to cisplatin. The drug, developed by Nicholas Farrell and his team, has been found to be significantly more potent than cisplatin and may offer new hope for the treatment of this devastating disease.
Researchers found that women at high risk for breast and ovarian cancer scored very low on measures of psychological distress and disorders. Despite having a high-risk profile, these women had little or no worries about developing the disease.
Researchers at the University of Pittsburgh Medical Center found that low-dose oral contraceptives offer a 40% reduced risk of ovarian cancer, similar to high-dose pills. The protection begins soon after use and continues for at least 30 years after stopping.
Introgen presents Phase I trial results on RPR/INGN 201, showing safety and expression in ovarian cancer, lung carcinoma, and glioblastoma patients. The therapy has demonstrated significant potential in treating these life-threatening conditions.
The company presented Phase II data of tgDCC-E1A, a lead cancer therapy, which showed a 45% objective response rate in patients with recurrent head and neck squamous cell carcinoma. Preclinical studies also demonstrated the ability of E1A to sensitize tumors to radiation and chemotherapy.
The data from an ongoing Phase 1/2 trial of O-Vax in patients with advanced ovarian cancer indicates that the vaccine induces a positive immunological response, as measured by a delayed type hypersensitivity test. Favorable clinical responses were also observed, including complete regression of tumors and normalization of CA-125 levels.
Researchers have reported promising results from a Phase I-II trial of an ovarian cancer vaccine made from patient's own cancer cells. Eight of 10 patients showed immunological response, with one experiencing complete tumor disappearance and CA125 levels normalization.
Three Cedars-Sinai physicians are leading a fight against women's cancers through innovative research, clinical care, and genetic screenings. Beth Karlan focuses on curing and preventing ovarian cancer, while Maren Scheuner develops personalized prevention plans for breast, endometrial, and ovarian cancers.
A Northwestern University researcher is leading a five-year, $5 million National Cancer Institute-sponsored study to improve current methods and evaluate new tests for detecting early-stage ovarian cancer. The study aims to identify novel biomarkers that can detect ovarian cancer in its early stages.
Researchers at Fox Chase Cancer Center are conducting a clinical trial to investigate the efficacy of fenretinide, a vitamin A-related medicine, in preventing ovarian cancer. Women with high-risk factors for breast and ovarian cancer will take part in this study to examine the molecular effects of fenretinide on ovarian tissue.
Women at high risk for ovarian cancer experience depression when concerned about passing the disease to their daughters. A study found that 33% of participants were depressed during initial assessments and 38% during follow-ups, with concern for daughters being a leading source of distress.
The Pacific Ovarian Cancer Research Consortium aims to discover genes, develop a cancer vaccine, and improve treatment outcomes for ovarian cancer. The five-year study will involve researchers from several institutions and involve at least 3,500 women in its various studies.
A clinical trial at UNC is testing the effectiveness of LY353381, a selective estrogen receptor modulator (SERM), for treating ovarian and endometrial cancers. The drug has minimal side effects compared to traditional chemotherapy.
A study suggests that an imbalance in genes expressed on the X chromosome may lead to ovarian cancer development. The research found nonrandom X-chromosome inactivation in over 50% of women with invasive ovarian cancer, particularly those with BRCA1 mutations.
Researchers found that progestin activates apoptosis in the ovarian lining, preventing precancerous cells from becoming malignant. The study suggests that periodically administering progestin could be a highly effective preventive treatment for ovarian cancer.
A multi-center study provides clear guidelines for genetic testing in women with breast cancer, identifying those at high risk of ovarian cancer. The study found that nearly 40% of participants had abnormalities in BRCA1 and BRCA2 genes, associated with a 10-fold increase in ovarian cancer risk.
Researchers successfully delivered and expressed an E1A gene in both diseased and normal human cells using a proprietary non-viral liposomal delivery mechanism. The study showed decreased levels of surrogate tumor markers in three patients with breast and ovarian cancers, indicating potential as a treatment for various types of cancer.
Researchers at Thomas Jefferson University have created an autologous ovarian cancer vaccine that stimulates an immune response in patients, showing promise for treatment. The vaccine is custom-made for each patient and has been safe with no significant side effects, paving the way for further clinical trials.
Researchers found a strong link between increased ovulatory cycles and p53 genetic mutations in ovarian cancer. Women at high risk can protect themselves by reducing their ovulation through birth control, pregnancy, or breast-feeding.
A new study found that prophylactic surgery can prolong life expectancy by approximately 8.5 years, but at a significant impact on quality of life. The study also concluded that prophylactic surgery is cost-effective compared to cancer treatments.