Articles tagged with Persistent Infections
A new study published in PLoS Pathogens reveals that Staphylococcus aureus can develop resistance to the last-line antibiotic vancomycin by acquiring a single mutation in its DNA. This discovery highlights the high adaptability of Staph and emphasizes the need to improve antibiotic treatment strategies for serious bacterial infections.
Researchers have discovered a transient protective effect of herpesvirus infections in mice, suggesting possible benefits against bacterial pathogens. The findings, confirmed by Dr. Marcia Blackman's team, contradict previous suggestions that vaccinated individuals may experience unintended negative consequences.
Researchers at the University of Illinois have discovered a new two-component lantibiotic called haloduracin, which has shown promising therapeutic potential in treating nasty infections. The discovery could provide new sources of antibiotics to combat drug-resistant bacterial strains.
A vaccine against cervical cancer has shown sustained high levels of antibodies for up to 4.5 years, providing substantial long-term protection against cancerous cell changes associated with high-risk HPV types. The vaccine was also found to be effective against persistent and new infections, setting the stage for its widescale adoption.
A Stanford scientist argues that persistent bacterial infections may provide beneficial effects on the host, such as protection against certain cancers. The researcher notes that many organisms cause disease but often remain asymptomatic, and that messing with microbes can lead to unforeseen consequences.
HIV-infected women are 3.9 times more likely to have HPV infection at the outset of the study, and smoking significantly increases this risk. Smoking and HIV infection may each alter the natural history of HPV infection to heighten tumor risk.
Researchers identified a mechanism preventing immune system destruction of chronic viral infections like herpes and HIV. Regulatory CD4+ T cells suppress normal function of CD8+ T cells in persistently infected mice, allowing virus to evade the immune system.
Scientists found that herpes virus uses regulators of complement activation (RCA) to evade the immune system. The study reveals that complement plays a crucial role in controlling persistent and latent infection, contradicting previous assumptions.
Researchers found that humans can acquire immunity to hepatitis C virus, reducing the risk of persistent infection and its complications like liver cirrhosis and cancer. The study's findings add to growing evidence that vaccines could be used to protect against hepatitis C.
A recent study found that people previously infected with HCV are 12 times less likely to develop persistent infection than those infected for the first time. This suggests that immunity can be acquired to protect against viral persistence, making vaccines a potential solution to reduce medical consequences of HCV infection.
Cystic fibrosis (CF) patients are more susceptible to Pseudomonas aeruginosa infections due to hypoxic mucus. Hypoxia disrupts the natural antimicrobial properties of mucus, creating an ideal environment for bacterial growth.
A longitudinal study of 1791 Brazilian women found that persistent HPV infections increased the risk of squamous intraepithelial lesions (SIL) by 10.2 times compared to those without infection. Women with persistent type 16 or 18 HPV infections had a strong correlation with SIL incidence.