Articles tagged with Sepsis
Research finds association between high air pollution and increased risk of post-surgical complications, including sepsis, pneumonia, and surgical wound infection. Higher levels of PM2.5 air pollution above EPA daily limits increase risk by 8%.
A new €2.5 million project aims to better understand why people with inherited mitochondrial disorders are more vulnerable to severe infections, which can cause profound neurological impairment and a range of other complications. The project will investigate how harmful mutations in mitochondrial DNA alter the behavior of immune cells.
A large clinical trial involving thousands of patients across the US and abroad found that balanced crystalloid fluid resuscitation was as effective as saline solution in preventing major adverse kidney events after pediatric sepsis treatment. The study also revealed biochemical differences between the two fluids, including elevated bl...
Researchers estimate sepsis occurs in 1.3% of pediatric hospitalizations, resulting in a 10% mortality rate, and urges the need for immediate recognition and treatment. The study's findings highlight the importance of awareness among families to improve child survival rates.
A major multi-country study found that WHO-recommended first-line antibiotics for neonatal sepsis are effective in only one quarter of infections in low- and middle-income countries. High levels of antimicrobial resistance were observed, making it challenging to identify consistently effective empirical antibiotic regimens.
Researchers evaluated the performance of the Phoenix Sepsis Score for predicting in-hospital mortality among pediatric ICU patients in China. They found that a modified version, PSS+, showed substantially improved discrimination without sacrificing clinical usability.
Researchers developed a machine learning model to predict 28-day mortality in patients with sepsis complicated by acute respiratory failure. The model demonstrated strong discrimination for predicting mortality, with key variables including oxygenation indices, serum albumin levels, and disease severity scores.
Researchers identified PCED1B as a key protective factor in sepsis, modulating metabolic pathways and influencing immune homeostasis. Elevated PCED1B expression reduced sepsis-related mortality risk by 36%.
A new study published in The Lancet Respiratory Medicine found that an early and rapid diagnostic test for sepsis significantly reduced mortality, especially among patients from the most deprived communities. However, the study also showed no difference in the speed of intravenous antibiotic initiation.
A new study estimates that more than 18,000 hospitalized children in the US have sepsis each year, including over 1,800 who die. The study also found that most pediatric sepsis cases were present on admission, but a smaller proportion developed during hospitalization and were associated with higher mortality.
A new study has estimated pediatric sepsis in the US, revealing a significant impact on pediatric hospitalizations. The study found that sepsis affects approximately 1.3% of hospitalizations, resulting in over 18,000 cases and more than 1,800 deaths annually.
Researchers found that disabling TRIM13 enhances survival in a mouse model of polymicrobial sepsis. The study suggests targeting TRIM13 or its associated ER quality control machinery as a potential strategy for reprogramming immune competence.
Researchers propose an integrative framework to explain sepsis-induced granulopoiesis shift. Immature neutrophils exacerbate tissue damage and contribute to immune paralysis. Precision interventions targeting metabolic pathways and biomarker-guided stratification are suggested.
Researchers at Adelaide University have discovered a naturally occurring protein that can protect against sepsis by reducing inflammation. The protein, corticosteroid-binding globulin (CBG), has been shown to reduce relative mortality in an animal model with septic shock by over 70 per cent.
The American College of Chest Physicians (CHEST) has certified its first class of critical care advanced practice providers with the CCAPP designation. This achievement recognizes their dedication to high-quality patient care and their role in supporting multidisciplinary critical care teams. The CCAPP certification is designed to vali...
The study validates the use of SOFA-2 in sepsis care and research, demonstrating its ability to identify clinically meaningful organ dysfunction. The findings suggest that incorporating immune markers may not improve predictive performance, highlighting the biological complexity of sepsis.
The American College of Chest Physicians' CHEST Critical Care journal has been added to the Web of Science Core Collection through the Emerging Sources Citation Index. This indexing marks a significant milestone for the journal, increasing access to high-quality research and supporting its commitment to advancing critical care medicine.
A sweeping new study has identified tuberculosis as the predominant cause of deadly sepsis among people with HIV in Africa. Immediate treatment for TB significantly increased survival rates, especially when treatment was started before diagnosis.
In sepsis, endothelial cells undergo programmed death-apoptosis, pyroptosis, ferroptosis, and excessive autophagy, leading to barrier collapse. Targeted therapeutic strategies include glycocalyx protectors, barrier stabilizers, anticoagulant approaches, which aim to repair or replace the damaged endothelial barrier.
Researchers at Griffith University have successfully conducted a Phase II clinical trial in China, showing promising results for a carbohydrate-based drug candidate called STC3141. The treatment aims to reduce organ damage and reverse biological responses associated with sepsis.
Salk Institute scientists found distinct disease courses and tolerance mechanisms in younger and older mice with sepsis, indicating a need for age-tailored therapies. The study suggests that future treatments may focus on controlling infection-generated damage rather than just targeting the pathogen.
Acute sepsis alters fluid kinetics and creates a 'third space' resistant to adrenergic modulation, leading to maldistribution of crystalloid fluid. Vasoactive drugs have limited effect on fluid distribution in septic sheep compared to healthy animals.
Researchers at the University of Minnesota Medical School identified a key protein called GDF3 that drives inflammatory responses in older adults. The study showed that GDF3 signals through SMAD2/3, inducing permanent changes in the genome and increasing inflammatory cytokines.
A new study from the University of Gothenburg has found that high teenage BMI and poor physical fitness are associated with a higher risk of developing severe bacterial infections in adulthood. The study, which followed over 44,000 men for three decades, shows that even at high normal weight, individuals are already at increased risk.
Precision immunotherapy targeting macrophage activation–like syndrome and sepsis-induced immunoparalysis improved organ dysfunction by day 9 compared to placebo. The study suggests that this approach can be a promising treatment option for sepsis patients.
A precision medicine-based approach tailors treatment to each patient's unique immune status, improving disease severity and reducing organ failure. The study reveals a significant improvement in clinical outcomes for patients with specific types of sepsis.
Researchers have discovered that a mitochondrial mutation can remodel immune cell function and inflammatory signalling, leading to whole-body issues in animal models. This finding offers a plausible hypothesis for why individuals with these disorders often experience problems with multiple organs and repeated infections.
Researchers found that hospital-acquired bacteria Pseudomonas aeruginosa often spread from the lungs to the gut in patients, heightening the risk of life-threatening sepsis. The study also identified frequent DNA changes associated with antimicrobial resistance, making treatment more difficult.
A landmark trial has shown that a structured approach to infection prevention and treatment can save women's lives. The programme reduced severe maternal infections and deaths by about one-third (32%) compared to usual care.
Researchers have discovered a new gene, ALOX15, that protects against sepsis-induced lung injury in mouse models. The findings suggest that mild lung thrombosis may actually reduce the severity of lung damage from sepsis, offering a potential novel therapeutic strategy.
In response to rising RSV cases, ECDC advises policymakers and public health authorities on effective ways to mitigate the impact of RSV disease in infants. Immunisation interventions, including long-acting monoclonal antibodies and maternal vaccines, can prevent severe illness and hospitalization.
A 47-year-old man from New Jersey died after consuming beef due to a tick-borne meat allergy caused by the Lone Star tick's alpha-gal sugar. Researchers identified the allergy and its link to fatal anaphylaxis, urging physicians to investigate severe abdominal pain after eating red meat in areas with high Lone Star tick populations.
Researchers found that early clindamycin administration significantly improved recovery rates in patients with invasive Group A Streptococcus (iGAS) infections. The study also showed that M1uk strain does not worsen prognosis in critically ill adults, but prompt treatment remains crucial.
A deep learning model developed by researchers identified subgroups of ICU patients with sepsis who could benefit from corticosteroid therapy. Patients with severe metabolic acidosis and circulatory dysfunction benefited the most from treatment.
Researchers focus on unraveling immunoregulatory mechanisms in sepsis, exploring the NF-κB and JAK/STAT signaling pathways. Emerging treatments aim to mitigate hyperinflammation and prevent organ failure through personalized, multi-target modulatory approaches.
Two landmark international studies published in The Lancet and Nature Medicine expose the need for faster recognition, better diagnostics, and personalized treatment pathways to combat pneumonia and sepsis. Irish ICUs face a shortage of beds, with implications for delayed care and increased mortality.
The editorial highlights how biological sex and gender inequities contribute to suboptimal sepsis treatment, potentially compromising outcomes for women. Hormonal fluctuations, body composition, and renal clearance all influence drug processing, yet these variables are rarely considered in dosing algorithms.
The article argues that a universal 30 mL/kg fluid bolus is no longer appropriate and instead calls for a balanced, individualized approach to fluid management in septic shock. This approach considers the patient's comorbidities, infection source, and estimated fluid losses, and guides management by frequent reassessment.
A study published in the Journal of Intensive Medicine found that moderate-dose corticosteroids improve sepsis patient recovery rates by stabilizing immune cells and reducing inflammation. The treatment also shows protective effects on the heart and vascular system, preventing cardiovascular failure and organ damage.
Researchers developed AI models to identify high-risk children for sepsis within 48 hours, enabling early preemptive care. The study used electronic health record data from the Emergency Department and showed robust balance in identifying at-risk children without overidentifying those who are not at risk.
Researchers use microchips with human tissue to study brain damage caused by sepsis and neurodegenerative diseases, finding that the blood-brain barrier breaks down under stress. The technology also reveals how pericytes support the barrier and may lead to new treatments for preserving or introducing these cells.
Researchers developed a collection of blood tests that assess genetic activity patterns in immune cells to reveal patient immune states. These tests could help physicians determine diagnosis and care protocols for patients with suspected infections or critical conditions, providing more accurate diagnoses and treatment guidance.
A study published in The Lancet Regional Health – Western Pacific found that most newborn infections in Southeast Asia are caused by bacteria unlikely to respond to current treatments, highlighting the need for updated diagnostic and treatment guidelines. Locally relevant data is crucial for guiding routine medical decisions, and new a...
The Improving Pediatric Sepsis Outcomes Collaborative has received the prestigious John M. Eisenberg Award, recognizing outstanding leadership and innovation in reducing pediatric sepsis mortality. The award highlights programs demonstrating impact, innovation, sustainability, replicability, and data-driven success.
A large community-based study has found that individuals with type 2 diabetes are at a doubled risk of developing sepsis, particularly among younger adults and men. The study identified several modifiable risk factors, including smoking, high blood sugar, and complications of diabetes.
Scientists have developed a monoclonal antibody to combat life-threatening inflammatory diseases like sepsis and ARDS. The antibody shows promise in blocking the immune system's hyperactive response and restoring healthy function without unwanted side effects.
Researchers discover vitamin B1 restores mitochondrial energy metabolism, drastically reducing lactate production and increasing survival rates in sepsis. The combination of vitamin B1 and glucose proves to be an effective treatment, promising hope for patients affected by this deadly condition.
The article highlights the need for improved sepsis diagnosis, personalized treatment, and innovative trial designs. It advocates for a multifaceted approach integrating timely diagnosis, tailored therapy, and equitable implementation to tackle the global burden of sepsis.
Researchers investigate the role of NUFIP1 in modulating dendritic cell activation during sepsis. They found that NUFIP1 facilitates dendritic cell function by mitigating excessive ER stress, leading to improved immune responses and survival outcomes in septic models.
The American College of Chest Physicians (CHEST) has launched a critical care APP education and certification program, covering 11 topic areas including patient-centered care and pharmacology. The CCAPP Certification Exam is now available, with an August 5 deadline to apply for the 2025 exam.
A new study has identified specific proteins in umbilical cord blood that signal acute systemic inflammation, providing a non-invasive means to diagnose early onset sepsis in preterm newborns. This discovery could lead to the development of a diagnostic test to avoid prolonged antibiotic exposure for infants at risk.
A large cohort study has shown that supplementary treatment with statins can boost survival chances for critically ill patients with sepsis. The results indicate a 39% lower death rate over 28 days after hospital admission.
A new study presents evidence that the Area Deprivation Index (ADI) is not an accurate measure of neighborhood health, particularly in areas with high costs of living. The Healthy Places Index (HPI), on the other hand, was found to be a better predictor of mortality risk for patients hospitalized with sepsis.
Researchers have reexamined the Ashwell-Morell receptor's functions using innovative glycoengineering techniques, clarifying its roles in sepsis and inflammation control. The study reveals that the receptor can bind to a specific type of protein glycan chain, which was previously thought to be incompatible with binding.
Researchers develop a novel self-assembling prodrug, LDO, that targets glycolysis and STING signaling to alleviate inflammation and improve survival in sepsis animal models. LDO reprograms macrophage polarization, reducing cytokine storms and acute lung injury.
Researchers from Radboud University Medical Center found that an existing drug can revive immune cells paralyzed by sepsis, a leading cause of death in ICUs. The study provides new perspectives for the treatment of sepsis and may lead to potential treatments for patients with immune paralysis.
The American College of Chest Physicians' CHEST Critical Care and CHEST Pulmonary journals have been indexed in Elsevier's Scopus database. This achievement is a testament to the high-quality research published in these journals, which provide open access content in pulmonary and critical care medicine.
Preet Chaudhary and Michael Selsted, USC innovators, recognized by the National Academy of Inventors for their work on harnessing the power of the immune system. Their research aims to develop new treatments for diseases such as cancer, rheumatoid arthritis, and sepsis.
Researchers developed an AI-driven model to predict mortality risk in sepsis patients, outperforming traditional scoring systems. The model provides real-time risk alerts and enhances personalized interventions, leading to improved patient outcomes.
Researchers found that patients who received non-compliant care had more complex medical conditions and were more likely to present with unusual symptoms. The study's findings challenge the assumption that SEP-1 compliant care is associated with better survival, highlighting the need for risk-adjusted outcome measures.