Articles tagged with Tuberculosis
A SLU researcher suggests focusing on high-risk tuberculosis patients to improve treatment completion rates and accelerate the US goal of eliminating the disease. By identifying latent patients at highest risk of active infection, doctors can better communicate the importance of completing treatment regimens.
A new test method using lung lavage has been developed to improve tuberculosis diagnosis in rhinoceros, with minimal stress for the animals. The study found that lung fluids revealed only harmless mycobacteria, reducing the risk of false positives and improving animal welfare.
Researchers used PET scans to track TB drug levels in a rabbit model and human patients, revealing that current treatments may not be effective due to poor penetration of the drug into infected brain lesions. The study aims to optimize treatment by tailoring doses for individual patients based on imaging results.
Researchers have identified an essential role for the protein heme oxygenase-1 in host defense against tuberculosis, highlighting its potential as a therapeutic target. Studies using human lung tissue and mouse models showed that HO-1 production is critical in protecting against TB pathophysiology.
A genetic scan of 4,578 TB samples from China revealed just two dominant strains account for 99.4% of cases, with strain L2 spreading widely due to internal movement allowing its spread. The study also found that strain Lineage 4 was introduced via the silk trade between 1084 and 1336 A.D.
Researchers found that targeted therapies could be more effective in treating TB, which killed an estimated 1.3 million people worldwide last year. Patients with minimal disease showed high efficacy with four-month treatments, while those with moderate or severe disease required longer treatment durations.
A study reveals lymph nodes as reservoirs of persistent tuberculosis infection, where the bacteria can persist for extended periods. This finding has significant implications for tuberculosis treatment and patient outcomes.
Researchers developed a machine learning approach to identify and predict antibiotic resistance genes in Mycobacterium tuberculosis. The approach identified 33 known and 24 new resistance genes, which could aid in personalized treatment for different strains of the bacteria.
A study found that patients with HIV are more likely to experience tuberculosis drug-related adverse events and have longer treatment durations. The researchers emphasized the importance of having resources and expertise to treat coinfected patients in areas with high HIV prevalence.
A recent outbreak of multidrug-resistant tuberculosis (MDR-TB) in South Africa remains undetected for five years due to the failure of WHO-endorsed diagnostic tests. Researchers discovered two strains with a specific DNA mutation associated with resistance to Rifampicin, which were not detected by commercial tests.
A new study reveals that Lineage 4 TB emerged in Europe around 1,000 years ago and spread globally with European explorers and colonialists. The study found that drug-resistant strains of Lineage 4 TB have hardly spread beyond their country of origin, suggesting a regional challenge to control.
A study in South Africa found that certain strains of Mycobacterium tuberculosis are resistant to the two primary antibiotics prescribed for TB. The resistance is not detected by standard DNA tests, leading to unsuccessful treatments and increased mortality.
A recent study reveals that TB resistance mutations evolved independently in various regions multiple times, with little international dissemination. This finding has significant implications for tuberculosis management and treatment, suggesting localized efforts could be successful.
A study from University of California San Diego found that patients who recorded videos of themselves taking TB medications had better adherence to treatment than those observed in-person. VDOT (video directly observed therapy) was also cost-effective and preferred over traditional DOT.
Researchers found that certain gut bacteria in European badgers kill off M. bovis, potentially reducing TB spillover to cattle. The bacteria also stimulate the badger's immune system, improving vaccine effectiveness.
A large-scale genome analysis of over 10,000 TB pathogen strains has shown that genome sequencing can improve treatment and potentially replace traditional resistance testing. This method enables precise prediction of drug resistance and individualized treatment plans, saving resources and time.
The NIAID Strategic Plan for Tuberculosis Research prioritizes expanding fundamental knowledge of TB by using modern tools to better understand the disease. The plan also focuses on developing rapidly accurate inexpensive point-of-care tests for different forms of TB, as well as identifying host and microbial biomarkers.
The UN is calling for the establishment of prevention programs to reduce tuberculosis among miners and others exposed to silica dust. Implementing primary prevention in high-risk occupations can prevent 300,000 new cases annually with improved ventilation, water spray misting, and personal protective equipment.
Researchers found that private healthcare providers in urban India deliver inadequate TB care, with only 35% adhering to national and international standards. The study highlights the need for improved training and protocols to enhance TB management in the country's private sector.
Researchers at Newcastle University have identified a naturally occurring antibiotic called kanglemycin A that is effective against rifampicin-resistant Tuberculosis. The compound was found to bind to the same groove as rifampicin but with extended structures, allowing it to maintain its affinity and inhibit the bacteria.
Researchers have identified a naturally occurring antibiotic called kanglemycin A that is effective against Mycobacterium tuberculosis, including drug-resistant strains. The compound maintains its activity by binding to bacterial RNA polymerase and preventing RNA production.
Researchers found that a single mutation in TB bacteria makes them resistant to antibiotics and elicits a weaker immune response, leading to higher mortality rates. The study suggests that the same approach may not work for drug-resistant TB strains.
Researchers at the University of Manchester have developed a groundbreaking new treatment for tuberculosis (TB), targeting the bacteria's defenses rather than killing it directly. The compound shows promise in animal studies, offering hope for a more effective and less toxic treatment option.
A new international collaborative study led by Dr. Dick Menzies found that new TB drugs achieve excellent results in treating MDR-TB, demonstrating consistently better cure rates and reduced mortality compared to currently used treatments. The study prompted a complete overhaul of worldwide guidelines for MDR-TB treatment.
A new analysis reveals that poor-quality care is responsible for an estimated 5 million deaths per year, surpassing deaths due to insufficient access to care. Global efforts to improve health systems will be futile if quality does not improve.
Researchers found that immune cells in lung tissue accumulate triglycerides, a type of fat, rather than cholesterol, and form through distinct mechanisms depending on the disease. This discovery may lead to new biomarkers and therapeutic strategies against tuberculosis.
The Lancet study estimates that one in three people drink alcohol, with 2.2% of women and 6.8% of men dying from alcohol-related health problems each year. The risk of death increases rapidly with higher levels of consumption, offsetting any potential protective effects against cancer, injuries, and infectious diseases.
A large international systematic review found that 78% of children with multidrug-resistant tuberculosis had successful treatment outcomes when treated with second-line MDR-TB drugs. The study highlights the need for HIV treatment in these children and the importance of aggressive solutions to address malnutrition.
Researchers at Boston Medical Center have developed a method to identify high-burden communities for drug-resistant tuberculosis in South Africa, tracking changes over five years. The study found that Cape Town townships and informal settlements saw the highest rates of drug-resistant TB.
A new technique links samples to individuals and locations, providing continuous national surveillance for eradicating tuberculosis and drug-resistant tuberculosis. The Western Cape Province in South Africa was used as a testing ground for this method, revealing spatially heterogeneous rifampicin-resistant tuberculosis rates.
Scientists have identified nearly 200 potential drug targets for tuberculosis, a complex disease caused by bacteria made up of 4,000 genes. The research found that specific human proteins, such as CBL, can limit bacterial infections and potentially provide a new approach to combat the disease.
Scientists have created a fluorescent probe that can tag single specimens of tuberculosis bacteria, which could lead to faster diagnosis and more effective treatments. The probe works by detecting the presence of an enzyme called BlaC, allowing for the identification of live versus dead bacteria.
A recent study published in Molecular & Cellular Proteomics has uncovered changes in TB strains that make them vulnerable to other antibiotics. The research also reveals a potential target for developing new drugs against isoniazid-resistant tuberculosis.
Chronic alcohol consumption modulates host immune defense mechanisms, increasing susceptibility to Mtb and other infections. Young alcoholic individuals with latent TB infection are at a higher risk of developing active TB, according to the study published in PLOS Pathogens.
A new international collaborative research study has found that a four-month daily regimen of antibiotic rifampicin is as effective as a nine-month daily regimen of another antibiotic, isoniazid, in preventing people with latent tuberculosis infection from developing the full-blown disease. The study, published in the New England Journ...
A new study from McGill University Health Centre reveals that a four-month rifampin treatment is as effective as nine months of isoniazid in preventing tuberculosis, with significantly fewer side effects. The treatment was also more acceptable to patients, particularly those with liver toxicity.
A study by ISGlobal reveals significant discrepancies in global tuberculosis death estimates between the World Health Organisation (WHO) and the Institute for Health Metrics and Evaluation (IHME), primarily due to differences in methodology and data sources. The researchers identify a dozen countries with notable variations, emphasizin...
Scientists have discovered a key structural motif in the tuberculosis NagA enzyme, providing a promising drug target. The research aims to design specific molecules to block its function and inhibit the critical pathway, potentially leading to new TB therapeutics.
A Phase 2 study published in the NEJM found that vaccination can reduce the rate of sustained TB infections, with a 45.4% vaccine efficacy against BCG revaccination. The trial also showed promise for an investigational subunit vaccine candidate, H4:IC31, which reduced sustained infections by 30.5%.
Researchers discovered that Mycobacterium tuberculosis uses a toxin to deplete NAD+ in macrophages, leading to necrotic cell death. Adding NAD+ replenishment or mitochondrial function protectants restricted bacterial growth and increased macrophage viability. These findings suggest patient-targeted therapies to treat tuberculosis.
A randomized controlled trial found that higher daily doses of rifampin killed more TB bacteria in sputum cultures without increasing adverse effects. The study also showed that higher doses resulted in increased elimination rates of TB bacteria from sputum.
Researchers at Texas Biomedical Research Institute have repurposed promising cancer chemotherapy drugs to target tuberculosis (TB), a deadly disease that kills four people every minute. The study found that these experimental drugs can reduce TB growth by 80% and also decrease inflammation and damage to the lungs.
A gene signature in the bloodstream could reveal whether someone is going to develop active tuberculosis disease months before symptoms begin. Researchers developed a new 20-gene signature that distinguishes between TB and viral infections, showing promise for early detection and treatment.
Scientists at Trinity College Dublin have discovered how vitamin A supports the lung immune system in controlling tuberculosis (TB) by promoting autophagy and waste disposal. This finding has potential for developing more effective lung-targeted treatments using vitamin A to boost patient immunity.
Active case finding is recommended for hepatitis B and C, HIV, and tuberculosis in prison settings. The approach aims to diagnose infectious diseases early and interrupt transmission. Key findings include a high burden of communicable diseases among prisoners, leading to increased risk of transmission upon release.
Researchers at Martin-Luther-University Halle-Wittenberg found a way to increase the effectiveness of common TB antibiotics while reducing resistance. The new compound blocks the bacteria's pumping mechanism, improving drug efficacy. Tuberculosis is a major global health threat, with 490,000 cases of multi-resistant TB reported in 2016.
A virulent strain of TB has been linked to 60% of cases in younger people in Ho Chi Minh City. The Beijing lineage bacteria shows positive selection for a gene that enhances its survival and may be responsible for increased virulence.
Researchers have discovered a potential link between tuberculosis and Parkinson's disease, suggesting that drugs designed to treat Parkinson's may also work for TB. The study found that LRRK2 protein prevents immune cells from clearing bacteria, leading to build-up of protein in neurons that disrupts their function.
Researchers at McGill University Health Centre discovered that having excessive T cells can cause harm and imbalance disease tolerance, leading to tissue damage. The study found that a protein called cyclophilin D acts as a key checkpoint for T cell activation, controlling the body's ability to tolerate Mtb infection.
Researchers found that matrix metalloproteinase (MMP) inhibitors improve blood vessel health at the sites of tuberculosis infection, enhancing delivery and retention of standard drugs. This synergy revitalize current TB treatment and reduce the risk of multi-drug resistant strains.
A smartphone video-based app substitutes for in-person daily visits required for tuberculosis treatment, with patients showing similar adherence rates as traditional DOT. The app offers a more private and cost-effective option for monitoring medication intake, but further research is needed to assess its full impact.
Researchers at Duke University have discovered that a cancer drug, Marimastat, can help treat tuberculosis by improving the structural integrity of leaky blood vessels in granulomas. This allows antibiotics to penetrate and attack the disease-causing bacteria more effectively, leading to improved treatment outcomes.
Researchers have trained rats to sniff out tuberculosis in children, detecting cases 68% more accurately than traditional smear tests. The new method has the potential to save up to 70% of untreated patients in low-income countries.
A new blood test has been developed to predict tuberculosis (TB) development in high-risk individuals, such as those living with active TB, up to two years before its onset. The 'RISK4' signature measures the expression levels of four genes associated with inflammatory responses and shows improved accuracy compared to existing tests.
A new study reveals that diarrheal diseases are becoming a major public health concern in the US, with rates increasing substantially between 1980 and 2014. Diarrheal disease deaths were ranked as the second-leading cause of all infectious disease mortality, behind lower respiratory infections such as pneumonia and bronchitis.
Researchers found that tuberculosis patients with lower blood concentrations of key medications are more likely to be contagious. This discovery highlights the need for routine checks and potentially increased dosages to control the spread of the disease.
Researchers at Rockefeller University discover a molecular doorstop antibiotic that kills Mycobacterium tuberculosis, but not suitable for clinical use. By understanding its mechanism of action, medicinal chemists can design new antibiotics that target specific enzymes, offering hope for a more targeted treatment against the disease.
TB, a bacterial infection that infects the lungs, is a leading cause of death worldwide. The NIH calls for modernized TB research using new diagnostic and vaccine approaches to cure people infected with any strain of Mtb.
A one-month antibiotic regimen was at least as safe and effective as the standard nine-month therapy for preventing active tuberculosis disease in people living with HIV. The study found that treatment adherence was significantly better for the shorter regimen, with nearly all participants completing the full course.
The STATIS trial found that intensive tuberculosis screening was as effective as systemic antituberculosis therapy in reducing mortality among severely immunosuppressed HIV-infected adults. The study's results suggest that both strategies can be used to improve outcomes in resource-limited settings.