Articles tagged with Uterine Cancer
The study found that epigenetic modification of the HAND2 gene plays a critical role in endometrial cancer development. Hand2 methylation is already increased in premalignant endometrial lesions and predicts a poor response to progesterone treatment.
Researchers at Yale University have defined the genetic landscape of uterine serous carcinoma (USC), a chemo-resistant form of endometrial cancer. The study identifies three previously unknown genes that play a role in tumor growth and development, offering new avenues for personalized therapy.
A new study from Henry Ford Hospital found that delaying radiation therapy after hysterectomy can increase the risk of uterine cancer recurrence. Patients who started treatment within nine weeks after surgery had a five-year relapse-free survival rate of 90%, compared to 43% for those treated later.
Researchers have identified three novel genes - CHD4, FBXW7 and SPOP - that are frequently altered in serous endometrial cancer, a rare and aggressive form of uterine cancer. These findings may lead to new therapeutic targets for this devastating disease.
A large international study found that women who give birth at age 30 or older have a reduced risk of endometrial cancer. The risk decreases by approximately 13 percentage points for each five-year delay in last births, with the greatest reduction seen among women who give birth between ages 35 and 39.
A new study found people with Lynch syndrome have an increased risk of developing several types of cancer, including bowel, uterus, ovarian, kidney, stomach, and bladder cancers. The study also revealed a moderately increased risk of breast and pancreatic cancer in those with the condition.
Experts Roger Short and Kara Britt argue that nuns should be given the contraceptive pill due to its link to reduced ovarian and uterine cancer risk. The pill's overall mortality benefits, particularly in nulliparous women, make it a viable health option for nuns.
Researchers at Henry Ford Hospital found that African American patients are more likely to have a recurrence of uterine cancer after undergoing a total hysterectomy or radiation therapy. The study, which analyzed 750 patients, also identified higher tumor grade and cancer stage as risk factors for recurrence.
Babies born to parents who underwent cancer treatment in childhood or adolescence show minimal risks, according to two new studies. Female cancer survivors had a higher risk of preterm and low birth weight infants compared to the general population, but no increased risk of birth defects or infant death.
A new study published in the American Cancer Society's journal finds that young women with early-stage ovarian cancer can preserve future fertility by conserving at least one ovary or the uterus. Researchers analyzed data from over 1,800 patients and found those who conserved an ovary had similar survival rates for up to five years.
A post-hysterectomy analysis found about half of women with pre-cancerous cell changes still had invasive endometrial cancer. Women diagnosed with complex atypical hyperplasia should be referred to a gynecologic oncologist for evaluation.
A new study published by the American Cancer Society found that black women with uterine cancer are more likely to die from the disease than their white counterparts. The researchers discovered that black patients were diagnosed at younger ages and had more advanced and aggressive tumors, which contributed to the survival disparity.
A subset of endometrial cancers has been found to have previously unrecognized alterations in the FGFR2 gene, resulting in uncontrolled cell division. This discovery could accelerate the development of new treatments for endometrial cancer by targeting drugs already in clinical trials.
African-American women with advanced/recurrent endometrial cancer had worse disease presentation and lower survival rates compared to Caucasian women. After controlling for clinical features and treatment, African-Americans survived significantly fewer months, suggesting socioeconomic and cultural factors may influence disease outcome.
Two new studies reveal laparoscopic surgery is as safe as traditional laparotomy for uterine cancer patients, with a significant reduction in hospital stay and improved quality of life. The studies also show that laparoscopy results in less pain, faster recovery, and better body image.
Researchers found no link between high soy consumption and increased uterine cancer risk in postmenopausal women. The studies suggest that dietary soy may even offer a protective effect against endometrial cancer, contradicting previous concerns about its safety.
A study by Yale researchers found that a combination of platinum-based chemotherapy and vaginal radiation significantly reduces the recurrence of uterine papillary serous carcinoma (UPSC). The procedure increases survival rates among women with this aggressive form of uterine cancer, which affects about seven percent of new cases at Yale.
A Phase II clinical trial suggests that RAD001, targeting mTOR, can decrease uterine tumor size in recurrent endometrial cancer. The treatment offers new hope for patients with advanced and recurrent cases, which account for about 7,000 deaths annually.
A study found that doctors' initial diagnoses of uterine cancer were incorrect in over 25% of cases, with a significant number being misclassified as benign. The findings highlight the need for improved classification guidelines to prevent unnecessary surgeries and ensure accurate diagnosis.
A new biomarker for ovarian and uterine carcinomas has been identified, associated with poor clinical outcome. L1 glycoprotein was found in 46 of 58 ovarian cancers and 20 of 72 uterine cancers, indicating a bad prognostic factor for patient survival.
Researchers discover that PTEN can be activated by phosphorylation, a process that counterbalances cell growth and suppresses tumor growth. This breakthrough could lead to a new therapy for cancers associated with PTEN gene mutations.
A study found that examining lymph nodes in women with early-stage uterine cancer can prevent unnecessary radiation therapy and improve treatment outcomes. The researchers analyzed data from 144 women diagnosed with grade 1 endometrial cancer, finding that lymph node removal saved patients from unneeded radiation therapy in 22 cases.
Mutations in the MSH6 gene occur in at least 1.6 percent of women with endometrial cancer, increasing their risk for developing certain cancers later in life. This study suggests that these mutations may be inherited and recommends genetic testing for family members.
Research suggests that nonsteroidal anti-inflammatory drugs like aspirin may be effective in treating uterine cancer by inhibiting the COX-2 enzyme. The study also found increased levels of COX-2 and prostaglandins in endometriosis, a painful condition where tissue from the uterus attaches to other organs.
Two studies found that common screening techniques for tamoxifen-induced endometrial cancer are ineffective. Tissue biopsies and transvaginal ultrasound screenings detected few abnormalities and led to unnecessary procedures. Patients should be reassured and monitored for abnormal vaginal bleeding instead.
A non-invasive ultrasound test can accurately detect up to 96% of uterine cancer and 92% of uterine disease in postmenopausal women experiencing abnormal vaginal bleeding. The endovaginal ultrasound (EVUS) eliminates the need for invasive biopsies, which are often uncomfortable or unsuccessful.
A new animal study suggests that female mice exposed to DES in utero are at higher risk of reproductive tract cancers, while their unexposed offspring show no such increase. This finding indicates a potential transmission of susceptibility to cancer across generations.
Researchers at the University of Maryland Greenebaum Cancer Center have linked the PTEN gene to endometrial cancer in a study published in Nature Genetics. The findings suggest that up to 50% of all endometrial cancers may contain a mutation in this gene, highlighting the potential for improved detection and treatment options.