Articles tagged with Vascular Diseases
Researchers at King's College London have been awarded £191,000 to enhance the prediction of aortic coarctation by adapting their established biomarker from MRI to ultrasound. The goal is to improve the accuracy of CoA diagnosis before birth using routine 2D scans.
Researchers at Kyoto University have discovered that targeting the CNP/GC-B signal pathway may provide a promising approach for treating Pulmonary Arterial Hypertension (PAH). The study reveals that CNP/GC-B signaling plays a protective role against PAH, and administration of CNP ameliorates experimental pulmonary hypertension.
This study reveals the regulatory role of BCAT2-mediated BCAA catabolism in VSMCs and its impact on intraplaque calcification in diabetic atherosclerosis. BCAT2 deficiency attenuates vascular calcification severity, decreases calcium salt deposition, and suppresses osteogenic phenotypic transition of VSMCs.
Researchers developed a high-speed photoacoustic microscope to track red blood cells in the mouse brain, allowing for single-cell resolution imaging of microvascular structures. This enables study of cerebral small vessel disease, cognitive impairment and dementia.
The Society of Interventional Radiology has published new practice guidance for treating chronic pelvic pain in women with venous-origin disorders, emphasizing interventional radiology's role in care. The guidance provides evidence-based recommendations on diagnosis, treatment options, and imaging.
A recent study found that higher IL6 levels are associated with increased mortality, while genetically higher IL6R levels reduce all-cause mortality through cardiovascular mechanisms. The researchers suggest that IL6R antagonism may be a potential strategy for preventing cardiovascular disease.
A new study found that adding one avocado and a cup of mango to daily meals and snacks for eight weeks improved vascular function among adults with prediabetes, while also reducing diastolic blood pressure. The Avocado-Mango diet showed significant increases in flow-mediated dilation and nutrient-dense nutrients without changes in calo...
A group of nerve cells in the brainstem has been identified as a stabilizing system for blood pressure, preventing fluctuations between daily activities. The study suggests that loss or dysfunction of these cells can lead to unstable blood pressure and is associated with conditions such as multiple system atrophy.
The review outlines how vascular-immune crosstalk affects various diseases, revealing novel therapeutic opportunities. It highlights the shared embryonic origin of blood vessel cells and immune cells, as well as coordinated immune cell trafficking mechanisms.
A study in Lesotho shows that trained laypeople can achieve better blood pressure control in their community compared to normal treatment in healthcare facilities. The layperson-assisted model was found to be safe and effective, reducing hospital admissions and improving access to healthcare for underserved rural communities.
Advanced 3D imaging reveals that vascular amyloid deposition follows a specific pattern, starting from surface vessels and spreading inward along connected pathways. The study provides new insights into the spatial organization of amyloid pathology in cerebral amyloid angiopathy.
A new randomized clinical trial found that training the less-impaired arm significantly improved movement coordination, speed and control in chronic stroke survivors. The study showed that motor skills in the less-affected arm can be improved even years after a stroke occurs.
Ascending aortic hemiarch replacement is comparable to extended arch reconstruction for patients over 65 with acute type A aortic dissection. The study found no significant difference in long-term survival or surgical reintervention rates between the two procedures.
Vinay Badhwar, MD, was elected President of The Society of Thoracic Surgeons with a three-part framework emphasizing daily practice excellence, data-driven science, and measurable impact. He aims to advance collaboration across surgical disciplines and integrate the specialty into the broader healthcare ecosystem.
Researchers analyzed cases in the STS Adult Cardiac Surgery Database to identify factors predicting postoperative risk. The study found that 16.7% of adults nationwide with CHD were considered high-risk for operative mortality and serious complications after redo cardiac surgery.
Researchers found that patients seen by cardiologists had lower mortality rates and fewer serious heart problems, including heart attack, sudden failure, or irregular heartbeat. The study suggests close teamwork between surgical and heart teams can improve outcomes after major surgery.
A new AI tool has been developed to predict the chances of death, major bleeding, or another cardiac event in cancer patients who have had a heart attack. The ONCO-ACS score combines cancer-related factors with standard clinical data to provide individualized treatment recommendations.
A late-breaking study at the STS Annual Meeting presents a new risk model for surgery after TAVR, showing declining operative mortality over time. The model demonstrated excellent accuracy for predicting surgical TAVR explant risk, providing valuable evidence for improving patient care and treatment strategies.
A new study from Lund University finds that modifiable risk factors like smoking and high blood pressure can damage brain blood vessels and increase dementia risk. Living a healthy lifestyle may help delay symptom onset in Alzheimer's disease.
Research links long-term exposure to wildfire smoke with increased risk of stroke in US adults, estimating around 17,000 annual cases. The study suggests wildfire smoke may be more harmful than pollution from other sources, and highlights the need for preventative measures.
A quarter of pregnant patients suffering stroke symptoms were misdiagnosed due to overlooked warning signs, according to a new study. The researchers highlight the need for better clinician education and decision-support tools to improve maternal health outcomes.
Researchers at the University of Vermont discovered that adding a missing phospholipid back into the circulatory system could restore normal brain blood flow and reduce symptoms of dementia. Boosting PIP2 levels may become a new treatment strategy to enhance brain function and prevent neurovascular diseases.
The Baveno VII consensus guidelines have reshaped portal hypertension management, focusing on early intervention and noninvasive diagnostics. Nonselective beta-blockers and transjugular intrahepatic portosystemic shunt (TIPS) are recommended for clinically significant portal hypertension diagnosis.
Researchers developed an AI model that can detect coronary microvascular dysfunction using a common electrocardiogram, outperforming previous models in diagnostic tasks. The model can accurately identify a condition often missed in emergency department visits, providing a cost-effective and non-invasive way to diagnose serious heart co...
Researchers found that glycation stress, caused by methylglyoxal, promotes aortic stiffening and cellular senescence. Natural compound Gly-Low, containing nicotinamide and alpha-lipoic acid, reversed these effects and reduced stiffness in aging mice.
Researchers identified a way to suppress daily fluctuations in immune cells' activity, which may prevent tissue damage during daylight hours. A drug that targets neutrophils was found to alleviate inflammation and protect against infections.
A new study found that calcium accumulation in breast arteries and its progression on mammograms can predict future cardiovascular disease. Women with more severe calcification and those whose calcification worsened over time had a higher risk of heart-related events, such as heart attack, stroke, and death.
A new Danish study reveals that social inequities in survival after atrial fibrillation have remained unchanged over the past 20 years. Individuals with low income, education, and social relationships live significantly shorter lives than those with high-income backgrounds.
A mouse study by University of California, Riverside scientists suggests microplastic exposure may accelerate the development of atherosclerosis in males. The study found microplastics dramatically worsened plaque buildup in male mice, but not females.
A new study reveals that sons born to mothers with type 1 diabetes show early signs of vascular dysfunction in their blood vessels, even before metabolic health is affected. The research suggests that this sex-specific effect could help clinicians assess risk and prevent cardiovascular disease earlier in life.
A new international study confirms that drug-coated balloons can effectively treat larger narrowed blood vessels, offering a safer alternative to stents. The findings validate the method developed by Professor Bruno Scheller and demonstrate its efficacy in treating arteries with diameters larger than 2.75 mm.
MIT engineers have developed a programmable drug-delivery patch that can reduce damaged heart tissue by 50 percent and improve cardiac function. The patch is designed to release different drugs at specific times, promoting healing and regeneration of cardiac tissue.
A new resource identifies genetic variants associated with elevated 'bad' cholesterol, a major contributor to heart disease. Clinicians can now predict patient risk for heart attacks and strokes, allowing for prevention and early treatment.
The merger strengthens CRF's leadership in medtech, integrating Fogarty's expertise in early-stage innovation. The unified platform will accelerate breakthroughs into patient care, driving global progress in cardiovascular medicine.
A team of researchers has proposed a novel ultrathin flexible sensor inserted endovascularly to detect Type-I endoleaks with maximum rupture risk. The sensor is robust enough to withstand dynamic processes and exhibits long-term stability and functionality.
Research reveals DKK3's role in AAA progression through phenotypic switching of vascular smooth muscle cells, driven by the TGFβ3-Smad2/3 axis. This study identifies DKK3 as a potential therapeutic target for maintaining VSMC homeostasis in AAA.
Post-traumatic vasospasm (PTV) is a sudden narrowing of brain arteries that can lead to stroke and long-term neurological damage. Early diagnosis using tools like transcranial Doppler ultrasound and S100 protein blood tests is crucial to prevent secondary brain injury.
Researchers are testing whether low-concentrate atropine drops can delay the onset of myopia in children. The study aims to reduce the risk of sight-threatening complications later in life by decreasing how nearsighted someone becomes.
The Mount Sinai Health System has received an $8 million grant from DataPhilanthropy to fuel urgently needed research into CADASIL, a genetic disease associated with migraines, strokes, cognitive decline, and dementia. The center will focus on extending brain healthspan and preventing dementia in individuals with genetic risk for cereb...
The report makes recommendations for diagnosing, treating and preventing serious heart and blood vessel complications linked to the virus. Structured cardiac rehabilitation programmes are also recommended to prevent long-term problems after infection and aid recovery from long Covid.
A study published in Annals of Translational Medicine found that intense light therapy can lower troponin levels and increase ANGPTL4 protein, protecting heart tissue. The treatment may reduce the risk of myocardial injuries after non-cardiac surgery, which affects 20% of patients and increases one-year mortality rates.
The study found that detection rates of congenital heart disease have improved due to advances in ultrasound screening practices, with added specific views helping detect more defects before birth. However, detection rates still vary by region and type of defect, highlighting the need for continued improvements in prenatal care.
A study in mice found that high triglyceride levels directly cause abdominal aortic aneurysms, challenging the notion that they are merely biomarkers of vascular disease. Researchers identified specific proteins and lipoproteins as causal drivers of aneurysm development and growth.
Researchers at the University of Cambridge have found that common blood pressure readings are inaccurate, with as many as 30% of cases of high blood pressure being missed. The team developed an experimental model to explain the physics behind these inaccuracies and identified a previously unknown factor contributing to underestimation.
Folate and biopterin cofactors modulate disease mechanisms through shared enzymatic pathways and structural similarities. Key interactions include BH₄ salvage, enzyme substitution, and CNS folate-biopterin axis, highlighting the importance of their crosstalk in diseases such as depression, autism, and vascular disease.
Researchers at the University of Vermont have developed a more precise way to assess stroke risk in people with atrial fibrillation. The improved CHA 2 DS 2 -VASc-Biomarkers risk calculator accounts for additional risk factors and can help physicians better determine who needs anticoagulant medications.
A new study from the University of South Australia confirms that eggs are not high in cholesterol and do not contribute to cardiovascular disease. In contrast, saturated fat intake was found to increase LDL levels, highlighting the importance of dietary balance for heart health.
A recent study by Tarang Parekh reveals that 80% of US adults show signs of CKM syndrome, which increases the risk for cardiovascular disease. The condition progresses in stages, with stage 4 being the most dire, characterized by clinical CVD diagnoses such as heart failure and kidney failure.
A study from The University of Osaka reveals nearly half of patients with extracranial arteriovenous malformations carry mutations in the RAS/RAF/MAPK signaling pathway. These mutations were linked to abnormal vascular morphology and were frequently detected in younger female patients.
Researchers found that after accounting for known differences, implicit bias in physician and hospital levels persists among Black, Hispanic, and Native American people with vascular disease. The AI model helps identify unconscious biases in clinical decisions.
Patients with chronic limb-threatening ischaemia (CLTI) are at risk of serious complications, including major amputations and heart attacks. A new statement from the European Society of Cardiology recommends using dual pathway inhibition (DPI) to prevent blood clots in CLTI patients after leg artery procedures.
A study found that brain age gap plays a key role in the connection between cognitive impairment risk factors and thinking memory skills. Researchers discovered that accelerated brain aging influences the relationship between cognitive decline and risk factors like high blood pressure and diabetes.
Four researchers have been awarded early-career grants from the ATS Research Program to study pulmonary vascular disease. The $100,000 grants will support investigations into pathways and pathophysiology of the disease.
Researchers at Lund University discovered three gene variants associated with a significantly increased risk of blood clots in the leg. These genetic mutations can lead to a 10-30% higher risk of venous thrombosis and are found in various populations worldwide.
Researchers identified biomarkers like uric acid and bile acids as critical regulators of arterial stiffness and inflammation in adolescents with obesity. These findings provide new avenues for early intervention to prevent the progression of vascular stiffness and cardiovascular disease.
A novel screening approach called VEST uses virtual echocardiography to identify patients at high risk of pulmonary arterial hypertension, a life-threatening form of heart failure. The tool has been shown to generate accurate PAH risk scores without manual calculations and can guide timely referrals for expert care.
Researchers have discovered a crucial molecular basis for aortic dissection by linking endothelial dysfunction with immune infiltration. The study reveals that abnormalities in vascular endothelial cells facilitate the accumulation of inflammatory cells, leading to fatal rupture.
Researchers from Mass General Brigham have identified a key predictor of stroke risk among women: brain health scores. Women with higher McCance Brain Care Scores (BCS) had a reduced risk of experiencing a cerebrovascular event, with those with a five-point higher baseline score being 37% less likely to experience an event.
Researchers found that Marfan syndrome increases vulnerability to brain damage from reduced oxygen supply and raises the risk of subsequent neurological disorders. The study highlights the importance of recognizing and managing neurological risks in Marfan patients to prevent complications.