Articles tagged with Vascular Diseases
A team of researchers has proposed a novel ultrathin flexible sensor inserted endovascularly to detect Type-I endoleaks with maximum rupture risk. The sensor is robust enough to withstand dynamic processes and exhibits long-term stability and functionality.
Research reveals DKK3's role in AAA progression through phenotypic switching of vascular smooth muscle cells, driven by the TGFβ3-Smad2/3 axis. This study identifies DKK3 as a potential therapeutic target for maintaining VSMC homeostasis in AAA.
Post-traumatic vasospasm (PTV) is a sudden narrowing of brain arteries that can lead to stroke and long-term neurological damage. Early diagnosis using tools like transcranial Doppler ultrasound and S100 protein blood tests is crucial to prevent secondary brain injury.
Researchers are testing whether low-concentrate atropine drops can delay the onset of myopia in children. The study aims to reduce the risk of sight-threatening complications later in life by decreasing how nearsighted someone becomes.
The Mount Sinai Health System has received an $8 million grant from DataPhilanthropy to fuel urgently needed research into CADASIL, a genetic disease associated with migraines, strokes, cognitive decline, and dementia. The center will focus on extending brain healthspan and preventing dementia in individuals with genetic risk for cereb...
The report makes recommendations for diagnosing, treating and preventing serious heart and blood vessel complications linked to the virus. Structured cardiac rehabilitation programmes are also recommended to prevent long-term problems after infection and aid recovery from long Covid.
A study published in Annals of Translational Medicine found that intense light therapy can lower troponin levels and increase ANGPTL4 protein, protecting heart tissue. The treatment may reduce the risk of myocardial injuries after non-cardiac surgery, which affects 20% of patients and increases one-year mortality rates.
The study found that detection rates of congenital heart disease have improved due to advances in ultrasound screening practices, with added specific views helping detect more defects before birth. However, detection rates still vary by region and type of defect, highlighting the need for continued improvements in prenatal care.
A study in mice found that high triglyceride levels directly cause abdominal aortic aneurysms, challenging the notion that they are merely biomarkers of vascular disease. Researchers identified specific proteins and lipoproteins as causal drivers of aneurysm development and growth.
Researchers at the University of Cambridge have found that common blood pressure readings are inaccurate, with as many as 30% of cases of high blood pressure being missed. The team developed an experimental model to explain the physics behind these inaccuracies and identified a previously unknown factor contributing to underestimation.
Folate and biopterin cofactors modulate disease mechanisms through shared enzymatic pathways and structural similarities. Key interactions include BH₄ salvage, enzyme substitution, and CNS folate-biopterin axis, highlighting the importance of their crosstalk in diseases such as depression, autism, and vascular disease.
Researchers at the University of Vermont have developed a more precise way to assess stroke risk in people with atrial fibrillation. The improved CHA 2 DS 2 -VASc-Biomarkers risk calculator accounts for additional risk factors and can help physicians better determine who needs anticoagulant medications.
A new study from the University of South Australia confirms that eggs are not high in cholesterol and do not contribute to cardiovascular disease. In contrast, saturated fat intake was found to increase LDL levels, highlighting the importance of dietary balance for heart health.
A recent study by Tarang Parekh reveals that 80% of US adults show signs of CKM syndrome, which increases the risk for cardiovascular disease. The condition progresses in stages, with stage 4 being the most dire, characterized by clinical CVD diagnoses such as heart failure and kidney failure.
A study from The University of Osaka reveals nearly half of patients with extracranial arteriovenous malformations carry mutations in the RAS/RAF/MAPK signaling pathway. These mutations were linked to abnormal vascular morphology and were frequently detected in younger female patients.
Researchers found that after accounting for known differences, implicit bias in physician and hospital levels persists among Black, Hispanic, and Native American people with vascular disease. The AI model helps identify unconscious biases in clinical decisions.
Patients with chronic limb-threatening ischaemia (CLTI) are at risk of serious complications, including major amputations and heart attacks. A new statement from the European Society of Cardiology recommends using dual pathway inhibition (DPI) to prevent blood clots in CLTI patients after leg artery procedures.
Four researchers have been awarded early-career grants from the ATS Research Program to study pulmonary vascular disease. The $100,000 grants will support investigations into pathways and pathophysiology of the disease.
A study found that brain age gap plays a key role in the connection between cognitive impairment risk factors and thinking memory skills. Researchers discovered that accelerated brain aging influences the relationship between cognitive decline and risk factors like high blood pressure and diabetes.
Researchers at Lund University discovered three gene variants associated with a significantly increased risk of blood clots in the leg. These genetic mutations can lead to a 10-30% higher risk of venous thrombosis and are found in various populations worldwide.
Researchers identified biomarkers like uric acid and bile acids as critical regulators of arterial stiffness and inflammation in adolescents with obesity. These findings provide new avenues for early intervention to prevent the progression of vascular stiffness and cardiovascular disease.
A novel screening approach called VEST uses virtual echocardiography to identify patients at high risk of pulmonary arterial hypertension, a life-threatening form of heart failure. The tool has been shown to generate accurate PAH risk scores without manual calculations and can guide timely referrals for expert care.
Researchers have discovered a crucial molecular basis for aortic dissection by linking endothelial dysfunction with immune infiltration. The study reveals that abnormalities in vascular endothelial cells facilitate the accumulation of inflammatory cells, leading to fatal rupture.
Researchers from Mass General Brigham have identified a key predictor of stroke risk among women: brain health scores. Women with higher McCance Brain Care Scores (BCS) had a reduced risk of experiencing a cerebrovascular event, with those with a five-point higher baseline score being 37% less likely to experience an event.
Researchers found that Marfan syndrome increases vulnerability to brain damage from reduced oxygen supply and raises the risk of subsequent neurological disorders. The study highlights the importance of recognizing and managing neurological risks in Marfan patients to prevent complications.
A new study from Uppsala University investigates how sleep deprivation affects biomarkers associated with cardiovascular disease. Researchers found that chronic lack of sleep increases the risk of heart problems by promoting inflammatory proteins.
A new study reveals a significant increase in ischemic heart disease prevalence across Southeast Asia, East Asia, and Oceania between 1990-2021. The regions experience distinct risk factors, including air pollution, dietary patterns, and high blood pressure.
Researchers at University of East Anglia developed 4D flow MRI scan to diagnose aortic stenosis more accurately and reliably than current ultrasound techniques. The technology offers more accurate measurements of blood flow through heart valves, leading to better prediction of when patients need surgery.
A study of 273,770 individuals with cardiovascular disease found that increasing lipoprotein(a) levels significantly increases the risk of subsequent cardiovascular events. Treatment with high-impact LDL-C lowering therapies may help reduce this risk.
Dr. Kenneth Rosenfield is a distinguished interventional cardiologist recognized for his seminal work in endovascular therapy and pioneering innovative techniques. He has made significant contributions to the field of vascular medicine, including the development of self-expanding stents and drug-coated balloons.
A study from The University of Osaka found that specific white blood cells and an inflammation protein can predict relapse of autoimmune blood vessel disease. Researchers analyzed neutrophils in patients' blood to identify a subpopulation involved in disease progression.
Juvenile-onset recurrent respiratory papillomatosis (JORRP) is a rare disease causing chronic hoarseness and breathing difficulties in children. New clinical guidelines provide actionable recommendations for early recognition, diagnosis, and treatment to improve long-term outcomes.
Castleman disease is a rare lymphoproliferative disorder with overlapping features with reactive and neoplastic diseases. The condition is characterized by vascularized regressed follicles and fibrotic stroma, and diagnosis relies on a combination of clinical, laboratory, and histological findings.
A new USC-led study using fMRI reveals the neural mechanisms that contribute to urinary incontinence in stroke survivors. The research found significant differences in brain activity during voluntary versus involuntary bladder contractions, presenting potential pathways for targeted therapies.
Researchers created a thromboinflammation-on-a-chip model that can sustain blood clots for several months and track treatment options. This model reveals critical information on clot resolution and suggests new drug combinations to protect endothelial function in patients with sickle cell disease.
The device uses AI technology to detect potential heart problems and provides real-time health insights. It has multiple points touching the skin near the heart, allowing for more accurate tracking even during movement.
Research published in JAMA Network Open found that college graduates experienced faster cognitive decline after a stroke compared to those with less education. The study highlights the importance of identifying patients at high risk for post-stroke cognitive decline to target future interventions.
TCT 2025 will take place October 25-28, 2025, at the Moscone Center in San Francisco, California. The event will feature acute interventions, breakthrough technologies, and cutting-edge research driving the next era of cardiovascular care.
Josep Rodés-Cabau takes over as Editor-in-Chief of Structural Heart: The Journal of the Heart Team, following Anthony N. DeMaria's retirement. Dr. Rodés-Cabau is a world-renowned expert in structural heart disease with extensive research and academic experience.
A POSTECH research team developed a photoacoustic computed tomography (PACT) system that non-invasively monitors cerebrovascular changes in small animals with early stages of an ischemic stroke. The technology also measures oxygen saturation in blood vessels, allowing precise tracking of vascular recovery after stroke.
Dr. Sarah Du, an associate professor at Florida Atlantic University's College of Engineering and Computer Science, has been selected as a Senior Member of the National Academy of Inventors for her significant contributions to advancing medical technology. Her research focuses on developing point-of-care diagnostic tools and monitoring ...
A study at Lund University found that brain trauma triggers Alzheimer's disease through vascular changes, challenging existing paradigms. The research team identified increased aggregation of amyloid-beta and vascular alterations in patients with traumatic brain injury.
A team of researchers has developed a novel model of the Blood-Brain Barrier, which mimics the complex structure of cerebral blood vessels. This breakthrough enables scientists to study neuroinflammation and develop new therapeutic strategies for Alzheimer's disease and other neurodegenerative disorders.
Researchers at Lancaster University have developed a new method to detect Alzheimer's disease by analyzing changes in brain oxygenation dynamics and neuronal function. The study found that individuals with Alzheimer's disease exhibit altered respiratory frequency, which may be an early indicator of the condition.
The project aims to improve the design of clinical trials for neurological conditions like stroke, Parkinson's disease, and vascular cognitive impairment and dementia. Community partners will facilitate academic and community partnerships for clinical trial development.
The Neuron special issue sheds light on the science of aging, focusing on how age-related changes impact the brain's ability to clear waste and transport energy. The collection also explores the link between the immune system and brain health.
Researchers at Karolinska Institutet used AI to analyze brain images from 70-year-olds and found that factors like inflammation and high glucose levels are associated with an older-looking brain. A healthy lifestyle, on the other hand, was linked to brains with a younger appearance.
Researchers used STOC-T to visualize retinal microcirculation in real-time, providing insights into the mechanisms of retinal function. The study offers a groundbreaking opportunity for precise monitoring of hemodynamic changes in the retina, enabling early detection and treatment of diseases such as Alzheimer's and Parkinson's.
Ken Perry, a UTA senior, has been recognized for his research on the connection between high-fat meals and cardiovascular health. He won two awards from the American Physiological Society for his work analyzing data collected from previous studies, which showed a correlation between high-fat consumption and changes in brain blood flow.
Researchers developed a platform to produce mature, uniform organoids using a three-dimensional engineered membrane. This breakthrough enables consistent quality and improved efficiency for practical applications in clinical trials and drug development.
Researchers have discovered two human antibodies that can recognize and target proteins causing severe malaria. These broadly reactive antibodies may represent a common mechanism of acquired immunity to severe malaria, offering insights for the design of a PfEMP1-based vaccine or treatment targeting severe malaria. The breakthrough cou...
A new finger prick test for Alzheimer's disease has shown strong performance in a European study, measuring biomarkers in blood from superficial vessels. The test could soon be implemented globally, increasing accessibility to Alzheimer's testing without the need for high-sensitivity analyses.
A diet rich in soybean protein β-conglycinin has been shown to increase short-chain fatty acid production, which plays a role in protecting the heart. Analysis of gut bacteria identified an increase in specific SCFA-producing bacteria, further supporting the potential benefits of soy on heart health.
A recent study published in the Journal of Vascular Surgery found that non-white patients have twice the risk of dying within 30 days of carotid endarterectomy compared to white patients. The study analyzed data from over half a million patients and highlights persistent racial disparities in medical outcomes.
A randomized trial found early TAVR to be safe and effective for patients with asymptomatic severe AS, reducing the risk of composite endpoints and favorable health status outcomes. Patients who received early TAVR had better left-ventricular and left-atrial health compared to those on clinical surveillance.
A new study suggests that immunotherapy may be an effective treatment strategy for heart failure by blocking scar tissue formation and improving heart function. Researchers identified a type of fibroblast cell responsible for scar tissue and used a monoclonal antibody to reduce its formation, showing promising results in mouse models.
Researchers created a single cell atlas of prenatal human skin, providing a molecular recipe for building skin. The study also led to the creation of a mini organ model that grows hair, offering insights into scarless skin repair and potential clinical applications in regenerative medicine.
Research suggests standing for long periods does not improve cardiovascular health and may increase circulatory issues. Sitting for over 10 hours a day was found to increase cardiovascular disease risk, highlighting the need for regular movement throughout the day.
Researchers validate a new blood test platform that can measure multiple biomarkers of Alzheimer's disease, potentially improving early diagnostics and treatment. The platform captures changes in proteins related to neurodegenerative diseases and may help track disease progression over time.
Researchers at Åbo Akademi University have discovered a crucial protein, TLNRD1, that helps maintain blood vessel stability in the brain. The study highlights the potential for targeted molecular therapies to improve patient outcomes in CCM disease.