The Mount Sinai Health System has received an $8 million grant from DataPhilanthropy to fuel urgently needed research into CADASIL, a genetic disease associated with migraines, strokes, cognitive decline, and dementia. The center will focus on extending brain healthspan and preventing dementia in individuals with genetic risk for cereb...
Research found higher fetal movement frequencies correlate with greater maternal attachment; paying attention to these signals may strengthen prenatal attachment and postnatal caregiving. Fetal movements contribute to emotional attachment formed during pregnancy.
Armida Labs will use the funding to advance preclinical studies of Targefrin, a potential clinical candidate for pancreatic and other cancers. The grant aims to develop an anti-metastatic agent that targets the EphA2 protein, which drives cancer cell invasion and metastasis.
Scientists have developed new anti-Cryptococcus compounds using molecular networking and SMART strategies. Three phenolic bisabolane sesquiterpenoids exhibited moderate to high antifungal activity, with compound 9 showing an additive effect when combined with fluconazole.
The Whole Person Physiome Research and Coordination Center aims to create a comprehensive digital map of the healthy human body, combining physiology, precision medicine, and computational biology. The initiative will empower researchers and clinicians to better understand health and disease using AI-ready models.
Researchers developed an AI-driven algorithm that can predict nearly 70% of hot flashes before they're felt. The Embr Wave wearable device will incorporate this technology to mitigate symptoms and provide meaningful relief.
A new study published in Autism found that autistic children are more likely to experience ongoing gastrointestinal problems than their typically developing peers. These symptoms can affect sleep, communication, sensory processing and behavior, and often don't have an identified medical cause.
Dr. Alan Sager presents a guide to thorough healthcare reform in the US, citing high costs and inadequate insurance coverage as major issues. He proposes solutions such as containing costs safely, insuring all Americans, and securing adequate pay for doctors and hospitals.
Research finds fish diversity declining in arid regions of US and Australia due to reduced water availability. Climate change is also affecting these ecosystems, but the study's findings suggest multiple stressors are at play.
A new study found that cocoa extract supplements rich in flavanols decreased hsCRP levels, an inflammatory marker associated with cardiovascular disease. The results suggest cocoa extract's anti-inflammatory potential may help explain its heart-protective effects.
A cohort study suggests nicotinamide reduces skin cancer risk, with greatest effect seen after initial skin cancer diagnosis, indicating potential chemopreventive properties of the vitamin B3 derivative
A new study shows that remote perioperative monitoring significantly improves recovery for cancer surgery patients, with a 6% greater functional recovery rate by day 14 after surgery. The study also found fewer major complications and improved symptom management.
Researchers at University of Maryland Baltimore County harness quantum computing to address train delays, achieving promising results on hybrid tram-rail networks. Current NISQ quantum devices can solve large-scale transportation scheduling problems but require more advanced hardware.
Researchers found that a high-fat diet impairs memory formation in fruit flies by reducing autophagy, a crucial cellular recycling process. This suggests that lifestyle interventions promoting autophagy, such as exercise or intermittent fasting, may improve cognitive decline associated with HFD.
Researchers at DTU have discovered a way to combat antibiotic-resistant bacteria by nourishing special bifidobacteria that is naturally occurring in the gut. Special lactic acids produced by bifidobacteria play a key role in keeping antibiotic-resistant bacteria at bay.
Researchers developed computational tools to analyze ecological data, identifying functionally equivalent species across different ecosystems. These tools use optimal transport distances to compare network structures, allowing for large-scale monitoring of ecosystem health and guiding conservation efforts.
The book provides an overview of agent-based modeling and multi-agent systems, highlighting their application in understanding economic crises. It integrates machine learning to enhance adaptation and behavior of agents in dynamic environments.
A new review from the University of Victoria suggests that psilocybin and 5-MeO-DMT may help treat concussions and traumatic brain injuries by increasing neuroplasticity and reducing inflammation. The compounds have shown promise in treating depression, anxiety, and other conditions in clinical research.
A study published in Neurology found that amateur soccer players who frequently head the ball experience changes within the folds of their brain, including disruptions in a specific layer of white matter. This association was linked to poorer performance on thinking and memory tests.
Researchers developed a scalable method for creating complex ceramic structures using binder jet additive manufacturing and advanced post-processing techniques. This innovation enables the production of high-quality, leak-proof components for critical applications like pharmaceutical or chemical processing.
A new study by Anneke van Heteren found that early bears like the Auvergne bear were likely typical omnivores, not insect-eaters as previously thought. The research used 3D jaw analyses and geometric morphometrics to compare jaw biomechanics with different diets.
Researchers at Stanford University created an algorithm that efficiently manufactures products with a team of robots, directing them to work alone or in teams and laying out the assembly floor to prevent collisions. The ability to generate assembly plans quickly could provide flexibility in manufacturing, allowing factories to pivot mo...
A new RNA-based drug, RES-010, is designed to block an RNA molecule called miR-22, which plays a key role in obesity. The treatment has shown promising results in preclinical studies, inducing significant weight loss without regaining weight after treatment stops.
A study of 92 individuals with type 2 diabetes found that those who overeat due to emotional reasons are less likely to lose clinically significant weight while taking GLP-1 receptor agonists. In contrast, individuals who eat in response to external stimuli tend to respond well to the therapy.
Researchers at the Max Delbrück Center have successfully used base editing to correct mutations that cause autosomal dominant polycystic kidney disease (ADPKD) in human and mouse cells. The technique shows promise in reducing liver cysts, a key symptom of the disease.
Scientists at UCSF successfully used CRISPRa to increase SCN2A levels in mice with the genetic disorder, resulting in reduced seizures and improved brain function. The therapy offers hope for treating neurodevelopmental issues related to SCN2A haploinsufficiency.
A recent study has found that people with psoriasis are at a significantly higher risk of developing AMD, including both exudative and non-exudative forms. The study suggests that biologic therapies may offer protective benefits for individuals with psoriasis.
Most coral reefs in the western Atlantic are projected to stop growing and begin eroding due to global warming, with more than 70% expected to decline by 2040. The study also found that reefs will lag behind sea-level rise, resulting in increased flooding risks along vulnerable coasts.
Researchers have identified CNNM4 as overexpressed in cholangiocarcinoma and found that inhibiting it, combined with GalNAc siRNA technology, can slow tumor growth and increase sensitivity to treatment. This approach could lead to personalized therapies for patients with limited treatment options.
A study by Stanford Medicine researchers reveals that creeping fat, a type of abnormal adipose tissue, forms scars in the intestines of people with Crohn's disease. This triggers debilitating scarring, which worsens symptoms and treatment options for patients.
Researchers analyzed aeroelastic coupling characteristics of TEF/NTBT rotor in forward flight and proposed a functional control strategy to suppress hub vibration intensity. The study revealed the influence mechanisms on aeroelastic characteristics and demonstrated a 45.72% reduction in vibratory hub loads using optimal TEF control.
A team at the University of Kansas will develop intelligent spectrum management frameworks to enable reliable communication for drones. They aim to study how to use a proposed 5030-5091 MHz frequency band efficiently, with potential benefits including quicker deliveries and improved emergency response.
Researchers will evaluate a patent-pending electrolyzer in simulated partial gravity environments aboard parabolic flights. The technology is designed to produce fuel, oxygen, and other life support compounds on the Moon or Mars for long-term human habitation.
DDX17 promotes HCC metastasis via the β-catenin/TCF4 pathway, inducing EMT and enhancing migration/invasion. The β-catenin/TCF4/DDX17 feedback loop is essential for HCC dissemination.
Mass General Brigham has identified key areas of innovation in medicine, including gene editing, immune system modulation, AI-powered care, and organ transplantation. The 'Big Ideas in Medicine' aim to transform diagnosis, treatment, and prevention of disease with next-generation technologies.
A new study from Karolinska Institutet found that music training strengthens the brain's ability to focus under distracting conditions. Musical people were better at using top-down attention while being less sensitive to bottom-up distractions.
A new AI model trained on routine ECG data accurately predicts patients at risk for life-threatening complications after surgery, outperforming current risk scores. The model achieves 85% accuracy and has the potential to transform decision-making and risk calculation for both patients and surgeons.
A UK Biobank study suggests that people with type 2 diabetes progress to additional chronic conditions at a faster rate than those without the condition. The study found that individuals with T2D experience a 60% higher risk of new disease diagnosis compared to those without T2D.
Researchers develop flexible batteries with internal voltage regulation using liquid metal microfluidic perfusion and plasma-based reversible bonding techniques. This technology addresses limitations of traditional rigid batteries.
A study of Black and Latina women in South Los Angeles found that choosing safer personal care products can significantly lower exposures to risky chemicals. Women who avoided fragrance, parabens, and oxybenzone had lower levels of these chemicals in their urine compared to those who did not avoid them.
A study by University of Cambridge researchers found that ChatGPT, an AI chatbot, improvised solutions to a 2,400-year-old mathematical challenge. The bot made mistakes and adapted its approach based on user input, demonstrating a 'learner-like' behavior.
Researchers developed a powder based on morin, extracted from plants like guava leaves, apple peels, and figs, to combat periodontal disease. The study found that the substance can be slowly released through polymers, providing an alternative to antibiotics for controlling microorganisms.
Researchers at MIT have developed a new approach to gene editing that reduces errors by up to 90%, making it a safer alternative for treating genetic diseases. The technique uses modified versions of the Cas9 enzyme to target specific DNA sequences, reducing off-target effects and increasing precision.
Astronomers have discovered a frozen, water-rich planetary fragment being consumed by a white dwarf star outside our Solar System. The object is thought to be an icy planetesimal, possibly similar to Halley's Comet or Pluto, and has a high nitrogen abundance, making it a rare finding in the field.
Researchers have developed an implantable system to stabilize blood pressure in people with spinal cord injuries. The therapy, which involves delivering finely tuned electrical stimulation, has been shown to restore blood pressure stability and prevent life-threatening spikes.
A study by the BMJ Group found that one in three GPs with a license to practise in England are not working in NHS general practice. The number of patients for each full time equivalent GP has risen by 15% since 2015, while the number of patients for each full time equivalent NHS consultant fell by 18%. This imbalance threatens governme...
Children born with an accelerated growth trajectory are more than 4 times likely to be overweight or obese as two-year-olds. Maternal metabolic factors significantly contribute to this increased risk of childhood obesity.
Mayo Clinic researchers developed a genetic test that can predict how people will respond to weight loss medications. The test estimates an individual's calories to satiation, linking it to treatment success and providing personalized estimates of expected satiation threshold.
Researchers from Dalian Institute of Chemical Physics have created the first rechargeable hydride ion battery with fast conductivity at room temperature and high stability. The novel core-shell composite electrolyte enables efficient energy storage and conversion.
The XRISM mission reveals an unexpected difference between winds launching from a disc around a neutron star and those from material circling supermassive black holes. The surprisingly dense wind blowing from the stellar system challenges our understanding of how such winds form and drive change in their surroundings.
A Lund University AI model analyzed mammograms to identify breast cancer patients at high risk of armpit metastasis, suggesting that 41.7% of axillary surgeries could be avoided. The study's findings have the potential to revolutionize breast cancer treatment by enabling more personalized care and reducing unnecessary surgeries.
Researchers found that offshore migration over Atlantic coast and Gulf of Mexico occurs in more concentrated pulses for a shorter time compared to terrestrial migration. The study identified critical window of time when millions of birds migrate offshore each year, offering wind energy managers opportunity to reduce collisions.
The SAGEST Predictive Simulation Center will develop simulation tools to give scientists confidence in exploring extreme physical conditions. The center, led by UVA's Xinfeng Gao, will use high-fidelity and low-fidelity solvers to balance accuracy and efficiency in predictions.
Quaise Energy has successfully demonstrated its groundbreaking geothermal drilling technology, achieving record-breaking depths and speeds. The company aims to revolutionize the energy sector by providing a reliable and sustainable source of clean energy.
HPV integration in high-risk types like HPV18, 31, and 45 approaches 100% in malignant lesions, driving clonal expansion and genomic instability. Integration-based biomarkers are being evaluated to enhance diagnostic accuracy and patient management.
Researchers will generate maps showing the intensity and extent of an earthquake, helping to identify regions with a higher probability of infrastructure damage. The simulation will recreate a hypothetical scenario of an 8.1 magnitude earthquake in Mexico's Michoacán state.
Researchers conducted a survey of published studies on the transmission risk of 39 pathogens and diseases, finding that only 7.4% consider hazard, exposure, and vulnerability. The study recommends integrating these components for reliable models and guiding public policies.
Researchers found that magnetic fields can regulate iron metabolism to improve Monascus pigment synthesis and reduce citrinin production. This approach may enhance the safety of fermented food products.
A study analyzing four decades of Italian cetacean strandings reveals that bottlenose and striped dolphins are most commonly impacted by fishery interactions. The research, published in PLOS One, highlights the need for conservation efforts to mitigate these effects.
Research from Huntsman Cancer Institute found that people with two or more tattoo sessions had a decreased risk of both invasive and in situ melanoma. However, participants with only one tattoo session were more likely to develop melanoma, especially in situ.
A team of researchers found that a regulatory region of the genome, which controls the development of digits in mice and fish, was co-opted by evolution to guide digit formation. This discovery reveals a major evolutionary strategy of reusing existing genetic mechanisms.
Researchers at UC Berkeley find that chimpanzees consume about 14 grams of pure ethanol per day, equivalent to one standard American drink. This chronic exposure suggests a dietary heritage of alcohol from our common ancestor with chimpanzees.
A newly discovered pachycephalosaur fossil from Mongolia's Gobi Desert provides crucial insights into the dinosaur group's growth and development. The 15-million-year-old specimen, called Zavacephale rinpoche, is the oldest and most complete skeleton of this iconic dinosaur group found to date.
A University of Houston researcher found that recording brain activity while listening to a story can help diagnose primary progressive aphasia, a rare neurodegenerative syndrome. The method was up to 75% effective in classifying the disorder's subtypes using machine-learning algorithms and electroencephalography data.
A randomized clinical trial shows that low-dose aspirin reduces the risk of recurrence by 55% in patients with colon and rectal cancer harboring a specific genetic mutation. Aspirin's anti-inflammatory and anti-tumor effects may be responsible for its therapeutic benefits.
iRECODE reduces technical and batch noise in single-cell data, revealing cellular patterns hidden by noise. The method outperforms existing techniques with high accuracy and low computational cost, enabling researchers to detect rare cell types and subtle biological changes.
The researchers developed a new microscopy method that enables imaging of vibrations in specific directions at the atomic scale. This allows engineers to tailor materials for use in electronics, semiconductors, optics and quantum computing.
In Gaza's 'Medical Points,' temporary medical centers, an average of 117 people are treated daily with only about 7 staff members per center. Despite severe shortages, these facilities play a critical role in providing care to those in need.
A new study by NUS-MOH reveals Singapore's healthcare system is more sustainable than previously estimated, with world-class healthcare at 20% lower carbon intensity. The report provides crucial evidence on where healthcare emissions lie, enabling leaders to target reductions and safeguard patient care.
This study analyzed adverse events following HPV vaccination in male recipients of Gardasil 9 and Gardasil. The results showed that most AEFI reports occurred within 30 days post-vaccination, with a lower cumulative incidence for Gardasil 9, suggesting a potentially more favourable safety profile.
A blood test using microbial DNA analysis can distinguish primary liver cancer from colorectal cancer that has spread to the liver, according to a new study. The test reveals distinct bacterial 'fingerprints' for each cancer type, making it a powerful tool for non-invasive diagnosis and potential future therapy guidance.
A study led by Syracuse University researchers found that simple resistance training can improve nerve function in older adults, potentially leading to greater independence and quality of life. The training reactivated fast neurons in the muscles, which deteriorate with age, allowing for faster muscle activation and improved strength.
The UK's new weather-health alert system has been deemed successful in supporting vulnerable groups, but minor confusion remains around its color-coded warnings. Researchers identified areas for improvement, including clearer yellow alert scales and simplified alerts for rapid use on the ground.
Researchers at Queensland University of Technology have created a prototype electronic device using chitosan, a naturally derived biopolymer from seafood waste. The material is used to create flexible and wearable health sensors that can monitor vital signs without compromising comfort or the environment.
Researchers developed a dynamic soft electrode called NeuroWorm that enables wireless steering of implanted devices via external magnetic fields. This allows for noninvasive repositioning of implants, potentially eliminating surgeries due to drift or misplacement.
A study published in The New England Journal of Medicine found that nearly 4 million children and adolescents were at higher risk of developing blood cancers due to radiation exposure from medical imaging. The researchers estimated that up to 10% of pediatric blood and bone marrow cancers may be attributable to radiation exposure.
The SwRI-built Solar Wind Plasma Sensor (SWiPS) and Space Weather Follow-On Magnetometer (SWFO-MAG) will capture real-time data on solar wind and magnetic field changes to monitor space weather phenomena. This data will support NOAA's Space Weather Prediction Center and help predict potential impacts on Earth's magnetic field.
Saiful Chowdhury's five-year project aims to create a blueprint of how immune proteins work, which could lead to new medical treatments for cancer and inflammatory diseases. The team will use advanced proteomics technologies to map protein interactions and modifications.
Dr. Barbara Riegel will be honored for her pioneering research on self-care in patients with chronic illnesses, particularly heart failure. Her work has led to the development of the internationally recognized Self-Care of Heart Failure Index.
Researchers at DTU Energy and DTU Construct developed a new fuel cell design using 3D printing and gyroid geometry for improved surface area and weight. The Monolithic Gyroidal Solid Oxide Cell delivers over one watt per gram, making it suitable for aerospace applications.
A new study reveals that puppy ownership can bring joy to parents and children, but also presents mental health challenges, including child-puppy interactions and caregiver responsibilities. To mitigate these risks, researchers recommend discussing dog-care responsibilities with children and attending safety training classes.
The SNU–APCTP joint research team experimentally demonstrated multiscale coupling in plasma, a phenomenon that explains how microscopic instabilities drive macroscopic structural changes. Their findings have significant implications for fusion energy development and astrophysical plasma study.
Researchers at QUT developed a material that achieves record-high thermoelectric performance, converting waste heat into clean electricity with over 13% efficiency. The material also has environmental benefits, being stable and simple to produce without toxic elements.
Researchers develop a new approach for treating inflammatory bowel diseases by delivering locked nucleic acids (LNAs) to the relevant organ using lipid nanoparticles. The study shows improvement in inflammation markers with no side effects, paving the way for potential treatments of rare genetic disorders and other diseases.
Rates of alcohol-induced deaths in the US nearly doubled between 1999 and 2024, reaching a record high in 2021. The largest increase was among females aged 25-34, with mortality rates rising by 255%.
Research suggests that young girls may be socialized to pay attention to external cues when deciding how much to eat, while boys focus on their bodies' hunger and fullness signals. The study found that boys adjusted the total number of calories they consumed during a meal after eating fruit, whereas girls did not.
Indian adolescents are starting their periods at an average age of 12.8 years, 1.3 years earlier than 25 years ago. Improved education and potential climate change are likely contributing factors.
UC San Diego Health has been ranked as a top performer in the Vizient Quality Leadership Ranking, demonstrating excellence in patient-centeredness and quality of care. The recognition reflects the institution's dedication to delivering safe, effective, and compassionate care.
FigureYa is a modular visualization framework that eliminates technical barriers to scientific visualization. It offers pre-configured code templates, sample datasets, and bilingual annotations, enabling users with minimal programming background to generate professional-grade visualizations.
A Chinese Medical Journal study reviews the association between lipid metabolism and Parkinson’s disease. The research highlights how lipid disruptions contribute to α-Syn aggregation, mitochondrial dysfunction, and neuroinflammation, suggesting lipids as a promising therapeutic target for PD.
A USC Stem Cell-led team has successfully generated lab-grown kidney structures, or organoids, that exhibit kidney-like functions such as blood filtration and urine production. The 'assembloids' achieved maturity levels comparable to newborn mouse kidneys, paving the way for developing new therapies for patients awaiting transplant.
Dr. Carl Nathan's groundbreaking research has advanced our understanding of innate immunity, tuberculosis, and cancer. His discovery of macrophage-activating factor (MAF) and its role in driving immune responses has led to the development of new treatments for previously intractable diseases.
The AACR Cancer Progress Report highlights the impact of federal investments on cancer research, with FDA approval of 20 new cancer drugs and improved survival rates. However, challenges such as early-onset cancers and instability at NIH threaten ongoing progress.
Scientists found that stretching the skin stimulates immune cells and increases its ability to absorb large molecules, including vaccines. This approach resulted in higher antibody levels against the H1N1 flu antigen compared to traditional needle-free delivery methods.
Researchers are exploring bioelectrical impedance technology to monitor neurological diseases like stroke, epilepsy, and brain tumors. The technology captures subtle changes linked to cellular metabolism and pathological processes, enabling clinicians to track disease progression with minimal risk.
A new study challenges conventional assumptions about urban healthcare advantages by revealing that larger cities have proportionally fewer specialists per resident than smaller ones. Smaller cities often serve more patients per specialist, with some specialties like addiction medicine showing significant disparities in availability.
A new study by Boston University School of Medicine reveals a cascade of brain injuries in young former contact sport athletes, leading to neuron loss, inflammation, and vascular damage. Many changes were seen in athletes before the onset of CTE.
Ancient farmers in the Middle East used advanced cultivation techniques to balance crop stress and moisture availability, adapting to climate fluctuations. This study reveals a stronger commitment to viticulture compared to other crops like olives.
Researchers developed a fusion protein that blocks the 'do not attack' signal and selectively activates tumor-fighting immune cells. The molecule, combining an IL-2 variant with a PD-1 antibody, induces a multifaceted anti-tumoral T cell response in human lung cancer patients.
A new study from the University of Oulu, Finland, found that reindeer grazing can buffer ecosystem functions, such as carbon exchange, under changing climate conditions. The results provide perspective on the role of reindeer in sustaining biodiversity in northern ecosystems.
Scientists have identified two dozen types of minerals that reveal a dynamic history of volcanic rocks altered by liquid water on Mars. The findings support multiple episodes of habitability, with three distinct categories of minerals indicating different conditions favorable or unfavorable for life.
The report makes recommendations for diagnosing, treating and preventing serious heart and blood vessel complications linked to the virus. Structured cardiac rehabilitation programmes are also recommended to prevent long-term problems after infection and aid recovery from long Covid.
A new study by Shedd Aquarium found that at least 24 species of fish have been documented to breed in the Chicago River, showcasing a remarkable comeback for a once severely polluted river. The research also revealed differences between sites, suggesting opportunities to augment spawning habitats for fishes.
A new study reveals that Gulf of Aqaba corals have endured four consecutive and intensifying marine heatwaves without mass bleaching. The findings raise hopes for the future of this globally-significant coral reef amid worsening climate change, but highlight the urgent need for regional conservation policies.
Researchers developed a new strategy to modify zinc oxide interlayers with polymer zwitterions, effectively passivating defects and enhancing solar cell device performance and stability. The conjugated units in the polymer zwitterions improved UV light absorption and facilitated more efficient charge extraction.
The use of atomic magnetometers in electromagnetic induction imaging (EMI) has greatly improved its low-frequency sensitivity. This technology enables the exploration of challenging applications such as through-barrier imaging and organ imaging, expanding EMI's potential in medicine and other fields.
Researchers have developed a soft, thread-like implantable biosensor/stimulator called NeuroString that can host hundreds to thousands of independent electronic channels. This breakthrough enables the tracking of various biological events, such as intestinal contractions, neuron activity, and biochemical secretion.
A new study from the University of Georgia found that both mothers and fathers influence their children's social confidence, but in different ways. More warmth and affection from both parents were linked to fewer social anxiety symptoms, while rejection and coldness increased anxiety levels. Parents should balance setting age-appropria...
A team led by Joe Ripberger from the University of Oklahoma aims to create a unified national approach to wildfire warnings. The project will focus on understanding fire and atmospheric interactions, social and behavioral science questions, and building a transdisciplinary network with practitioners and researchers.
Farmers in Middle East prioritized viticulture over olive growing due to irrigation, which maintained grape cultivation. This suggests that grapes and wine held cultural and economic value.
A study published in Science Advances reveals that an autism-linked mutation disrupts brain circuits responsible for erasing fear memories, leading to PTSD-like symptoms. By reactivating specific neurons, researchers were able to reverse the behavioral and physiological abnormalities.
Researchers from Southeast University explore recent advances in catalytic hydrodeoxygenation (HDO) for converting lignin-derived compounds into biofuels and high-value chemicals. Key findings include metal sulfides, noble metal catalysts, and non-noble metal catalysts showing high activity and aromatic selectivity.
Researchers developed a scandium doping technique that improves the stability and cycle life of sodium-ion battery cathodes. The study found that Sc doping modulates the structure, preserving cooperative Jahn-Teller distortion and superstructure, and prevents side reactions with liquid electrolytes.
Scientists used long-read whole-genome sequencing to analyze methylation patterns in urine DNA, identifying bladder cancer. The approach outperformed existing tests in detecting cancer even at low tumour DNA levels.
Researchers at CDI Lab have identified two protein transcription factors, Tcf1 and Lef1, as critical modulators of T cell fate in the thymus. This discovery could lead to novel approaches in treating immune deficiencies, autoimmune diseases, and optimizing immunotherapies in cancer treatment.
A new surveillance study from UNC Greensboro found a dramatic increase in Lyme disease cases in North Carolina, with blacklegged ticks expanding their range into the state. Ticks from the Blue Ridge Mountains were more likely to carry Borrelia burgdorferi, the bacteria responsible for most Lyme disease cases.
A new study by University of Cincinnati researchers finds that foster caregivers across the US need more accessible, ongoing and community-driven training. They want sustainable learning, consistent support and meaningful connection with peers and experts to help them care for vulnerable children.
A new AI model can estimate the long-term risk of over 1,000 diseases and forecast human health changes over a decade. The model was trained on anonymised patient data from 400,000 participants and tested on data from 1.9 million patients in the Danish National Patient Registry.
Researchers reprogrammed the epigenetic code to affect tumour growth and survival in multiple myeloma. This study presents a comprehensive map of epigenetic alterations in multiple myeloma, highlighting site-specific increases in DNA and protein methylation that control gene activity.
A UCLA research team led by Dr. Donald Kohn has developed a one-time stem cell gene therapy treatment for alpha thalassemia major that could be curative. The therapy involves adding the missing alpha-globin gene to patient cells using a viral vector, enabling them to produce functional hemoglobin.
Researchers at the University Hospital Bonn have identified a neurobiological mechanism that could be responsible for post-ictal symptoms after an epileptic seizure. They found that spreading depolarization waves, or SD, are more common in people with temporal lobe epilepsy and may cause disorientation and wandering after seizures.
A new Canadian evidence-based framework has identified pathogens driving antimicrobial resistance risks in both healthcare and community settings. The framework highlights the growing threat of sexually transmitted infections as a significant risk factor.
A McGill University study reveals that mothers who experienced sexual violence during the Rwandan genocide often struggled with feelings of guilt, while their children displayed remarkable compassion and empathy. The research also found that these children formed peer support networks to cope with stigma and discrimination.
New research suggests that technological alien life may be rare on planets without plate tectonics and too little carbon dioxide. The study found that a planet with 10% carbon dioxide could maintain a biosphere for up to 4.2 billion years, while one with 1% carbon dioxide would last only 3.1 billion years.
Dr. Matthew Walker brings a multi-disciplinary approach to sleep research, focusing on the impact of sleep on human health and disease, and developing new tools and technologies to measure and improve sleep quality. The Sleep Innovation Laboratories will serve as a vital hub for discovery, innovation and public education.
A new study reveals how Moso bamboo degrades under fluctuating hygrothermal conditions, causing dramatic fluctuations in mass, dimensions, and appearance. Machine learning was integrated to predict changes in compressive strength and color difference with high accuracy.
Researchers developed Ovatools, a tool combining blood test results and age to identify women at higher risk of ovarian cancer. The approach is accurate for women over 50 and represents good value for the NHS, detecting more cancers earlier while remaining within affordability thresholds.
A large meta-study of over 12,000 participants reveals that APOE ε4 genotype, female gender and advanced age are significant risk factors for Alzheimer’s disease. The study confirms previous research and provides highly reliable prevalence estimates.
Researchers developed a fully automated finite element analysis pipeline to transform spine diagnostics and personalized treatment planning. The new approach enables rapid, patient-specific simulations that support preoperative planning, spinal implant optimization, and early detection of degenerative spine conditions.
New research finds that GLP-1 receptor agonists (GLP-1RAs) significantly reduce the risk of death and major cardiovascular events in psoriasis patients. GLP-1RAs also show promise in reducing alcohol and substance abuse, with a 65% lower risk of alcohol abuse.
Researchers have discovered a new type of tektite exclusively found in South Australia, recording an ancient asteroid impact event approximately 11 million years ago. The unique glasses provide valuable insights into the destructive power of past impacts and their importance for planetary defense.
Metabolic bariatric surgery shows promise as a cost-effective weight loss option for class II and III obesity patients. The study found bariatric surgery resulted in greater weight loss compared to GLP-1 receptor agonists.
A rare glimpse into Mars's north polar vortex has revealed that it produces a seasonal ozone layer. The extreme cold temperatures inside the vortex allow ozone to accumulate, making it essential for understanding Martian atmosphere chemistry. This finding has significant implications for the search for past life on Mars.
A Japanese study has identified four distinct patterns of immune response after COVID-19 vaccines, with a 'rapid-decliner' group experiencing faster decline in antibody levels. Monitoring changes in antibody levels may help identify individuals at greater risk of infection and inform more effective vaccination strategies.
The study highlights connections between tumor mechanics and extracellular vesicles, which may not be as different as they seem. Researchers are now investigating the interplay between mechanics and messaging in cancer progression.
Researchers at Boston Children's Hospital report an alternative local anesthetic, 2',6'-pipecolylxylidine (PPX), that selectively blocks pain while leaving motor function intact. PPX has been found to be less toxic than conventional anesthetics and may enable longer-lasting pain relief.
A new review article highlights the need for effective control and prevention strategies for sexually transmitted gut infections, which can persist longer and be harder to treat. The authors emphasize the importance of prompt diagnosis, appropriate treatment, and community-level education and testing.
Researchers developed a novel 3D printing technique that combines materials and design to create strong, biocompatible implants. The study found that varying printing angles and ink composition can significantly impact implant strength and bone cell growth.
Researchers at Tulane University have developed an enhanced CRISPR-based tuberculosis test that works with a simple tongue swab, detecting TB in samples with very low levels of bacteria. The new test shows high sensitivity and accuracy, offering a significant step forward toward effective diagnoses via a variety of samples.
A comprehensive review of recent advances in panel aeroelasticity in shock-dominated flow highlights the complex interplay between fluid-structure interactions and shock-boundary layer interactions. Understanding these dynamics is crucial for preventing catastrophic structural failures and improving supersonic vehicle design.
A new study reveals that small electric charges between particles play a crucial role in forming highly concentrated clusters in turbulent environments. This discovery has significant implications for climate research, medicine, engineering, and science, enabling better predictions and controls.
Researchers developed a photonic-acoustic analysis scheme that integrates dual optical combs, multi-sensor parallel processing and electronic signal processing for unparalleled capabilities in sound detection, localization and recognition.
Paperpal unveils a transformative brand strategy as an all-in-one AI toolkit for clear, confident, and ethical writing. The platform empowers students, researchers, and institutions to maximize their potential without losing their voice. With its secure and responsible approach, Paperpal enhances human expertise rather than replacing it.
A new targeted radiation approach has achieved a near-complete response in three patients with solitary fibrous tumor (SFT), a rare and aggressive form of cancer. The therapy significantly reduced cancer activity and provided symptom relief, highlighting its potential as a treatment option.
New research from Uppsala University reveals how plant-based meat alternatives became popular in Sweden through a combination of business, consumer and societal factors. Key findings include the role of documentaries like An Inconvenient Truth and the Swedish National Food Agency's sustainability recommendations.
A new algorithm developed by Núria Malats and her team can accurately predict the presence of metastasis in pancreatic cancer using medical images. The PMPD algorithm has shown promising results, classifying 56% of metastases with high accuracy and potentially avoiding unnecessary surgeries.
Keck Hospital has received the top performer recognition from Vizient for delivering high-quality care. The hospital achieved near-perfect scores in patient centeredness and ranked highly in all categories, making it one of the safest hospitals in the country.
A new study found that people are more likely to cheat when delegating tasks to AI systems, especially with ambiguous interfaces. Researchers warn of a rise in unethical behavior as AI agents become increasingly accessible.
The University of Ottawa Faculty of Medicine is awarded $1.25M in grants to support high-impact research projects focused on microbiome-informed nutritional strategies, skeletal muscle repair, and stroke recovery. The funding aims to improve health outcomes for Canadians.
Researchers have found that plastic nanoparticles can enter crops during growth, accumulating in edible parts and potentially affecting human health. The study used radishes to demonstrate the uptake of nanoplastics by plants, with nearly 5% of particles retained by the root system.
Researchers at WashU Medicine discovered a novel way brown fat burns calories and improves metabolic health by exploiting cellular parts called peroxisomes. Mice with increased peroxisome activity showed improved insulin sensitivity and weight control on high-fat diets.
A major report published by the European Society of Cardiology outlines expert recommendations for diagnosing, treating, and preventing COVID-19-related cardiovascular effects. The report emphasizes the importance of vaccination, cardiac rehabilitation programs, and equal access to services.
A NIH-funded study reveals that repeated head impacts from contact sports can cause early neuron loss and inflammation in the brains of young- to middle-aged athletes. The findings suggest that these changes may occur years before CTE develops its hallmark disease features.
A new study from Penn State researchers found that submerging hands and forearms in room-temperature tap water can effectively cool older adults and reduce their heart rate during extreme heat. The study demonstrated a reduction in core body temperature by about half a degree Fahrenheit, which may help prevent heat-related illnesses.
A new study reveals that Indo-Pacific fish species are being carried into the Mediterranean Sea through the Suez Canal and sea currents. Cargo shipping is now identified as a key driver of these invasions, with targeted management needed at major shipping hubs.
A new study published in PLOS One finds that high-intensity interval training (HIIT) is more effective than moderate exercise in making adolescent lab animals avoid cocaine. The researchers observed a dose-dependent effect on the brain's reward circuit, leading to increased aversion to the drug.
Researchers have developed a new technique to create all-solid-state sodium batteries that retain performance down to subzero temperatures. The breakthrough uses metastable sodium hydridoborate, which has high ionic conductivity, allowing for thick cathodes and improved energy density.
The American College of Chest Physicians has achieved a critical milestone in its advocacy efforts, leading to changes in federal coverage guidelines for noninvasive ventilation devices used in the home. These revised guidelines reflect major recommendations submitted by CHEST and aim to enhance patient care.
Research from the University of Copenhagen shows that exercising in nature improves mood, reduces stress levels, and boosts heart rate. Participants who exercised outdoors reported greater joy, satisfaction, and optimism than those who exercised in urban or indoor environments.
The complexity of the tumor microenvironment hinders therapeutic intervention; nanomedicine emerges as a promising tool to modulate it. Researchers have systematically reviewed four primary mechanisms by which nanomaterials enhance antitumor therapy, including modulation of complex components within the TME.
Researchers have discovered how a compound called naringenin chalcone 'reprograms' a light-sensing protein in plants, activating it to send growth-regulating signals even without UV light. This unexpected interaction could lead to crops with improved tolerance to harsh environments and more efficient use of light energy.
A new study finds that a 2°C warming intensifies the Arctic's ability to absorb greenhouse gases, but reduces its capacity in alpine regions. This imbalance has significant implications for global carbon budgets and climate projections.
A team of researchers developed a new manufacturing process using bio-based solvents to reduce the production cost of perovskite solar cells by half and decrease climate impact by over 80%. AI-based reverse engineering technology was used to identify optimal conditions for efficiency and sustainability.
The project aims to strengthen community involvement in water management, improve child health and reduce under-age mortality in Ecuador, Peru, Chile, Morocco and Tunisia amid global climate change. The research team will gather socioeconomic data and information on water governance, health risks and infant mortality.
Scientists at Linköping University develop artificial neurons made of conductive plastics that perform advanced functions like biological nerve cells. They simplify the basic structure to make it compact and biologically relevant.
Researchers have developed new eDNA tools to quantify kelp-derived biomass in sediments below commercial kelp farms. The study confirms that kelp aquaculture has little impact on the seafloor community and provides evidence for using eDNA to examine 'blue carbon' accounting efforts.
Researchers at Boston University School of Medicine will create a detailed postmortem cardiac and blood vessel tissue repository to study the relation between cardiovascular risk factors and structure. The project aims to identify new biomarker signatures for cardiovascular disease, advancing our understanding of CVD risk.
Researchers at Salk Institute and UC San Diego have identified a unique sugar called HSAT as a potential therapeutic target for slowing tumor progression and metastasis in pancreatic ductal adenocarcinoma. Boosting HSAT levels may slow the formation and spread of pancreatic cancer, leading to improved survival rates among patients.
Researchers identify basal stem-like cells as the origin of small cell lung cancer, providing a major shift in understanding this deadly disease. The study's findings allow for exploration of strategies to prevent the disease before it evades the immune system and spreads.
A new study found that people with three or more symptoms of physical frailty were nearly three times more likely to develop dementia than those without frailty. The researchers also discovered changes in brain structure and biomarkers in people with frailty, which may be a mechanism underlying the pathway from frailty to dementia.
A new study uses three wearable sensors to track eating behavior and identifies five distinct patterns, including late-night snacking and stress binging. The findings lay the groundwork for personalized interventions to help individuals overcome unconscious habits that drive overeating.
Researchers from St. Jude Children's Research Hospital have made a breakthrough in treating neuroblastoma by combining immunotherapy with the drug indisulam, achieving complete therapeutic responses in laboratory models regardless of cell state.
The PANORAMA microscope overcomes challenges of traditional microscopes by capturing submicron details across an area roughly the size of a U.S. dime without moving the sample. It produces gigapixel-scale images with high resolution, ideal for medical pathology and industrial inspection.
Researchers have identified a secreted form of a protein called Clever-1 that systemically suppresses T cells essential for fighting cancer. The investigational anti-Clever-1 antibody, bexmarilimab, directly inhibits the release of sClever-1, potentially predicting treatment resistance and paving the way for new combination treatments.
Researchers have developed a novel approach to control Dirac plasmon polaritons in topological insulator metaelements, enabling tunable terahertz optical devices with lower energy loss and enhanced performance.