Researchers propose targeting G protein-coupled receptors to slow aging, exploring AI, systems biology, and digital twins for therapy design. The approach could work alongside senolytic, metabolic, and regenerative strategies.
Researchers studied Japanese house bats and found that mothers' heart rates increase in response to their own pups' cries, but not those of other pups, indicating strong behavioral response. The scientists also found that the call of an unfamiliar adult male elicited a strong heart rate reaction, possibly due to perceived threat.
Researchers propose novel therapies to rebalance GPCR signaling, potentially extending healthy years of life and delaying multiple age-related diseases. This network-level approach could give rise to personalized treatments and complement emerging longevity strategies.
Baby manta rays stay in safe coastal areas with abundant food and hiding spots until they're large enough to face ocean dangers, while adults migrate long distances to avoid threats. The study tracked manta rays using acoustic and satellite telemetry, finding that coastal refuges serve as critical refuges for young mantas.
Researchers propose using aging rate indicators to detect interventions that slow aging pace. The study aims to accelerate anti-aging breakthroughs, but regulatory barriers and equitable access are discussed.
Frontiers will provide AI-powered data curation for 1,000 Horizon Europe datasets and award 100 FAIR Data Publication Grants to early-career researchers. This initiative aims to make research data easier to discover, understand, and reuse, supporting the European Strategy on AI in Science.
Researchers developed a way to connect artificial sensors with biological neural systems, using brain organoids to decode Braille marks with 83% accuracy. The team found that teams of three organoids performed better than one, but the reason is still unclear.
Researchers Dr. Hutan Ashrafian and Dr. Ahmad Guni discuss the expanding capabilities of medical AI, including predictive and preventive applications, and the need for technical and health-system advances to improve health outcomes. They will explore the safeguards needed for responsible and equitable adoption of increasingly capable A...
Scientists discover aberrant antibodies in children with cancer, targeting DNA repair proteins, which may hinder normal repair and lead to cancer. The findings suggest a potential mechanism for pediatric cancer development and may lead to early screening and prevention.
A new species, Dianjunus rex, has been discovered in Chinese forests, producing vertical fruiting bodies up to 50 cm high and weighing up to 2.2 kg. The fungus represents a new family, Dianjunaceae, which arose around 65 million years ago, shortly after the mass extinction of the dinosaurs.
The agreement enables participating institutions to publish open access in Frontiers' full journal portfolio without individual author costs, streamlining budget planning and reducing administrative burdens. Institutions can join the agreement before the end of 2026, with early joiners gaining access to FAIR² Data Management offering.
Scientists found that playing patients' favorite music during a cannula insertion minimizes pain, with no significant effect from relaxation music. The study suggests that music may be a useful tool to reduce pain and discomfort during medical procedures, particularly for anxious or claustrophobic patients.
A study of 1,400 employees in the UK financial sector found that women in male-dominated workplaces are less comfortable admitting mistakes and see them as less learning opportunities. In contrast, women in low-male-share environments have more positive views of mistakes.
A new study estimates that fully restored oyster reefs in hotspot countries could yield a gross ecosystem product (GEP) of $12 trillion. Oyster reefs could deliver ecosystem services worth trillions to human wellbeing and the global economy, including water filtration, shoreline protection, and carbon sequestration.
A study of ancient Egyptian skulls reveals evidence of human sacrifice, with 39% of individuals showing fatal blunt force trauma. The research, published in Frontiers, uses modern forensic methods to reassess legacy data from Abydos, Egypt.
Temporary shades over coral reefs in the Florida Keys reduced UV and irradiance damage, mitigating heat damage and partly reversing bleaching. The study found that shading can offer temporary protection on small scales, but scaling is a limitation, and additional studies are needed to confirm its effectiveness.
Researchers found that Swiss forests are no longer shielded from the worst effects of summer droughts, despite growing at high altitudes. The study, published in Frontiers in Forests and Global Change, reveals that the number of trees per stand is reduced due to drought, causing a progressive decline of these precious forests.
A new study found that dinosaurs and their prey likely ate seaweeds, which provides an explanation for the high carbon isotope signatures in their teeth. The research used fossils from coastal sites along the Western Interior Seaway and determined that the extra carbon source must have been low in the food chain to affect both aquatic ...
A new study found that films written by women but directed by men generate higher profits than those written by men, with a 34% median profit increase. Despite this, women are still severely underrepresented in directing roles, with only 29.4% of films crediting a woman as a director or screenwriter in 2023.
A prosthetic scientist has developed technology to enhance the patient-prosthetist relationship and improve socket fit for individuals with limb loss. The technology uses sensors to quantify true socket fit in real time, replacing guesswork with data.
Researchers found that adult chimpanzees in Senegal intentionally hand over tools to infants and youngsters, facilitating learning. The study, published in Frontiers in Psychology, reveals a unique form of teaching where adults deliberately provide tools and food to younger individuals.
A large population on the Moon would quickly run out of water due to high energy demands and limited resources, but finding more water could extend sustainability. The Moon's surface and subsurface may hold more water than previously thought, providing a potential lifeline for lunar settlements.
The Frontiers Science House roadshow brings together world leaders and climate experts to address unresolved scientific disputes and policy bottlenecks in governance of climate intervention technologies and power, rewired: building the climate-energy future. The event aims to facilitate discussions and find solutions to pressing issues...
Research using GPS collars shows African lions and spotted hyenas leave a clear signature in their movements around each other, with hyenas consistently moving away and males lions approaching, suggesting a complex power dynamic.
Research in Germany found that birdsongs with narrower bandwidths and greater complexity are perceived as more pleasant, with blackbirds' songs considered most attractive. Pleasantness is also influenced by personal taste, but not by knowledge of birds.
The authors propose a spectrum of clinical autonomy, ranging from advisory tools to navigator systems that work with minimal human oversight, to enable early prediction and prevention of disease. However, challenges related to clinical validation, integration, data quality, and regulatory approval limit widespread deployment.
A study found that yellow-morph green sea turtles in the Galápagos prefer to stay in shallow coastal waters and rarely venture far from a single island. The turtles' home ranges varied greatly, but most preferred to stay within 1,498 sq km of their starting point.
A recent study reveals that spending on microtransactions in free-to-play videogames is highly concentrated among a small minority of players, who account for the majority of revenue. Regulation is necessary to protect vulnerable players from potentially exploitative practices.
Baleen whales are taking advantage of the warming Greenland Sea, with regular feeding frenzies observed in recent years. The abundance of whales has increased significantly, with over 4,000 humpback whales, 6,000 fin whales, and 6,000 minke whales visiting the region in 2024.
Researchers found 16 mummified individuals, a dog, and disturbed deposits in Theban Tomb 209, indicating a spatial logic in reuse and a kind of funerary memory. The study suggests that cultural rites were reconfigured, but not lost, as the tomb was repeatedly reactivated over time.
A new study provides compelling evidence that cynodonts, an ancestor of true mammals, may have been viviparous, giving birth to live young. The discovery sheds light on the reproductive mode of early mammalian ancestors and raises questions about other evolutionary traits.
Researchers have successfully engineered plants to produce myoglobin, an important component of animal muscle, using a gene gun to insert the genes into chloroplasts. The yield was approximately three times higher than when inserted into the nuclear genome, paving the way for plant-grown meat production.
A recent study on orphaned grizzly bears found a high mortality rate of 83%, largely due to human-bear conflicts, illegal killings, and intraspecific killing. The study also highlights the risk of habituation to humans, which can lead to serious conflicts, particularly when combined with oversized size from excessive growth during reha...
Researchers explore how engineered lanthanide carriers can tune the optical and magnetic properties of ions for improved signal contrast and reduced background signals in biomedical imaging. The study highlights opportunities for multimodal imaging, theranostics, and AI-guided probe design.
Researchers have identified a hardy sea sponge that can thrive in polluted harbor habitats, demonstrating an exceptional ability to adapt and even reproduce asexually. The chicken kidney sponge showed outstanding resilience and was found to be particularly effective at filtering pollutants and recycling nutrients.
Recent progress in lanthanide carriers is mapped to improve biomedical imaging and diagnosis, combining optical, X-ray, and magnetic resonance imaging techniques. These carriers enable high-resolution imaging with tunability for different applications, reducing tissue damage and enhancing image clarity.
Researchers in India have identified β-esterase as the primary enzyme involved in α-cypermethrin detoxification, showing increased reactivity in response to the insecticide. This finding suggests that mosquitoes can dramatically increase production of a particularly effective enzyme when exposed to a threat.
Researchers propose using a simple GKI test to track metabolic health in noncommunicable diseases like cancer and cardiovascular disease. The test measures glucose to ketone ratio and may help assess nutritional ketosis and adherence to metabolic interventions.
A study on La Brea Tar Pits fossils found rare spinal nerve tumors and developmental abnormalities, suggesting a dwindling species was in poor genetic health. This may have made them more vulnerable to hunting, ultimately contributing to their extinction.
Researchers documented a previously undescribed orca behavior in the Gulf of California, where orcas hold and then ram sunfish to cause tissue fragmentation. The observed behavior may be a form of parental investment or simply entertainment, with potential benefits for the calf's nutrition.
Indigenous Australians gathered whole grasses from the landscape and burned them in a cave for ritual practices dating back 25,000 years. The study found that people selectively targeted specific types of grasses for burning, with over 97% coming from temperate or cool-climate grasses.
Researchers used sonar and underwater imaging systems to find a healthy mesophotic coral garden, 11.5 kilometers off the coast of Benin. The reef, home to eight types of coral and eight species of fish, challenges previous assumptions about its existence.
Researchers studied six royal mummies from the Middle Kingdom and found evidence of strong muscle attachments and healed fractures, indicating the princesses were skilled archers. The study provides insight into the daily lives of these royal women, revealing they faced hardships despite their high status.
FAIR² Data Management, powered by Senscience, has been named a 2026 CODiE Award Winner in the category Best AI Data and Analytics Solution. The platform enables researchers to turn data into trusted resources that can be discovered, built upon, and used responsibly with AI.
Researchers found that elephants' bone-conduction hearing is significantly improved due to their larger middle ear structures and ability to voluntarily close their ear canals. This allows them to transmit lower frequency sounds to the cochlea, enhancing low-frequency hearing by up to 30 times
Researchers propose using the glucose ketone index (GKI) to track metabolic health in non-communicable diseases, which cause three in four deaths worldwide. The GKI measures blood glucose and ketones and may indicate metabolic state, assess long-term nutritional adherence, and support mitochondrial function improvement.
Researchers found that smelling dark chocolate odors increased training volume and suppressed hunger, while milk chocolate had no effect. The study suggests that food scents can trigger changes in body and mind similar to actual consumption.
A new study suggests that California's wine industry is under threat from climate change and wildfires, particularly in established regions like Napa and Sonoma. However, areas like Mendocino and Monterey are expected to become increasingly favorable for premium vintages due to their projected increasing climatic suitability and decrea...
A recent Estonian study reveals that 19.7% of healthy family members of breast and ovarian cancer patients carry variants that elevate their cancer risk, including 34% of men. The findings highlight the importance of genetic testing and counseling for those with a family history of the disease.
Bottlenose dolphins spend much of their time following trawlers to scavenge for food, with up to 76% of bottom trawlers being followed. The high frequency suggests that they may be struggling to hunt normally due to the depletion of prey in the Adriatic Sea.