Researchers have developed an oral therapy that protects healthy tissue from radiation while preserving radiation's ability to destroy cancer cells. The therapy, called XOlacta, is packaged in milk-derived extracellular vesicles and can be administered orally, reducing damage to tissues and preserving tumor treatment effectiveness.
Researchers developed a first-in-class therapy targeting MYC, a protein involved in 70% of cancers, by disrupting its relationship with GSPT1. This approach showed strong anti-cancer activity in multiple types of blood cancers, including treatment-resistant models.
A new University of Pittsburgh study found that low-frequency deep brain stimulation improves control of facial and tongue muscles involved in speaking and swallowing after traumatic brain injury. The treatment showed small but significant improvements in word intelligibility for one participant with TBI.
A team of researchers created a fishbone catalyst that efficiently converted waste agricultural film into olefin-rich bio-oil through microwave-assisted pyrolysis. The catalyst achieved a bio-oil yield of 89.32 wt.%, with olefins accounting for 84.03% of the oil and C6–C12 compounds dominating the hydrocarbon fraction.
The article proposes a new statistical governance framework to standardize energy-use tracking in global data centers. AI-driven identification workflows and non-intrusive load monitoring are used to distinguish data center workloads from mixed-use commercial premises.
Researchers developed a technique to assess the reliability of medical imaging tools, which can be used to evaluate quantitative imaging methods and build confidence in these technologies. The technique, called NGSE-Corr, was shown to accurately rank imaging methods for 91% of trials and identify the most precise method for 95% of trials.
Cool river temperatures in first 15 days after fertilization are crucial for survival, with warm years limiting survival. Research suggests strategies like reintroduction to historical habitat may be more effective in the long run than targeting specific cold water releases.
Astronomers discover that massive galaxies in the early universe contain more small stars than expected, challenging current understanding of galaxy formation. The study uses NASA's James Webb Space Telescope to reveal the hidden mass of low-mass stars in these galaxies.
Researchers developed a method to quantify individual cell damage using molecular markers, enabling detailed analysis of disease progression in tissue samples. This method can distinguish early disease mechanisms and differentiate between patient-specific and general disease progression.
A new paper by the American College of Surgeons Committee on Trauma recommends making automatic crash notification (ACN) and advanced automatic crash notification (AACN) systems standard safety features in every new vehicle. These systems can provide critical information to emergency responders, such as the vehicle's location and poten...
A Stanford Medicine study found that estrogen-only menopausal hormone therapy may reduce the risk of Alzheimer's disease in women. The study, which analyzed brain autopsies and cerebrospinal fluid samples, found a 35% reduction in Alzheimer's-related pathological deposits in women who used estrogen-only MHT.
Dr. Alkhouli brings over a decade of editorial leadership experience to JACC: Cardiovascular Interventions, a journal that has shaped interventional cardiology for nearly two decades. He aims to further the journal's role in defining the future of interventional cardiovascular medicine.
Scientists have identified multiple targets for antibodies that could treat Crimean-Congo hemorrhagic fever, a deadly virus spread by ticks. The research found that antibodies targeting the nucleocapsid protein offer protection against the virus, regardless of strain, and could lead to the development of new treatments.
Researchers create two-headed molecule that physically links a cancer-causing protein with another molecule that switches on cell death mechanisms. In mice, treatment with the molecule eliminated aggressive lymphoma tumors within 11 days, with no obvious signs of toxicity.
Researchers explore materials that can store, convert and release heat while maintaining human comfort and mechanical requirements. The review highlights emerging strategies for combining photothermal conversion with wearable technologies for thermal management and intelligent healthcare.
Researchers discovered that three bacteria, including P. inefficax, can alter the soil microbiome to protect wheat from a fungus that causes root rot. The bacteria increase root biomass, exhibit growth-promoting genes, and produce beneficial plant compounds, strengthening the plant's defenses.
Scientists at Penn State have developed a new method for seismic imaging using thunderstorms, which can be used to study the Earth's subsurface structure and image the subsurface without traditional seismic sources. This method allows for easier imaging in less accessible locations, such as the Arctic or urban areas.
Melchor Antuñano joins UCF College of Medicine to design new procedures and technologies for astronauts, pilots, and airplane passengers. He will also create a new master’s degree in aerospace medicine and a residency program for aerospace medicine physicians.
A new molecular compound, TOFA, identified by UC Berkeley scientists, helps cells burn extra energy with no change in food intake or exercise, improving insulin sensitivity and glucose control. The treatment, which works by increasing energy expenditure, shows promise in mouse models and may be used in combination with GLP-1 medications.
Researchers discovered that Trypanosoma cruzi, the Chagas disease parasite, alters its RNA to adapt to infect mammals, a process that could lead to new treatments. The study found that modifications in transfer RNA facilitate protein production, influencing the parasite's transformation from a non-infective to an infectious phase.
The FDA has cleared the PrecivityAD2 blood test, developed by C2N Diagnostics, to aid in the early diagnosis of Alzheimer's disease. The test uses high-resolution mass spectrometry to measure biomarkers associated with amyloid pathology, providing more accurate and reliable results than cerebrospinal fluid tests.
A new UCLA-led study finds that concrete's natural absorption of carbon dioxide is too slow and small to meaningfully offset the emissions released when cement is made. Researchers argue that the industry should prioritize active technological measures to reduce emissions, including reducing cement use and adopting alternative fuels.
UT MD Anderson recognized 58 faculty members for their exceptional contributions to cancer research, patient care, and education. The institution also honored six early-career Faculty Scholars, six recipients of the Faculty Achievement Awards, and six faculty members with UT MD Anderson's most prestigious endowed faculty awards.
Two OU-led research teams have been awarded nearly $1.4 million in funding under the DOE's Genesis Mission to develop AI for enhanced geothermal systems and quantum computing. OU's projects align with the university's impact-centers research priorities and address the Genesis Mission's pillars of Energy Dominance and Discovery Science.
Scientists in the University of California San Diego laboratory used AI to decipher the 'initiator' DNA sequence, which is responsible for gene activation. The researchers found that about 60% of human genes contain the initiator, enabling the prediction of DNA mutations that can lead to various disorders.
A study by Texas A&M University researchers found that poor housing, high crime, and underfunded schools play a bigger role in limiting access to healthy food in historically redlined neighborhoods. The study suggests that policy changes and community engagement are needed to improve food security in these areas.
Microplastic pollution in dryland dumpsites accelerates due to intense sunlight, heat, wind, and open burning, transforming plastics into smaller, more reactive particles that spread through soil, air, water, and food systems. Aging microplastics increase metal adsorption and organic pollutant partitioning, posing emerging biological r...
Researchers found that aging microplastics can increase the binding of fluorinated pesticides like fluensulfone in agricultural soils. The smallest aged particles showed the strongest effects, with 30-35% of retained fluensulfone bound to PVC microplastics.
Three UVA computer science professors, Matthew Dwyer, Sebastian Elbaum, and Mary Lou Soffa, were inducted into the ACM SIGSOFT Software Engineering Academy for their profound impact on the field through research, practice, and education. Their collective work represents decades of contributions to software engineering and the education...
A new membrane combines food waste-derived biochar, graphene, and a phase change material to store thermal energy, improve heat transfer, and manage moisture. The membrane exhibits high thermal conductivity and water vapor permeability, making it suitable for energy recovery ventilation and smart building systems.
A US national laboratory research collaboration aims to accelerate the qualification of critical nuclear components for the US energy supply chain. The project leverages additive manufacturing and AI tools to enable the rapid expansion of domestic nuclear manufacturing capabilities, boosting energy security and competitiveness.
Researchers used super-resolution microscopy to track cancer drug sunitinib inside living cells, revealing its impact on cellular systems. The study found that sunitinib triggers a cascading breakdown of the systems that power, organize, and sustain the cell, contributing to cell function loss and survival.
Researchers found that NF1 loss in ER+ breast cancer cells promotes bone metastasis by inducing osteoclast formation and immunosuppression, leading to a self-reinforcing cycle of cancer growth and bone damage.
A new book argues that adult children are cutting ties with their families of origin in favor of creating a chosen family environment. Research by Ohio State University professor Rin Reczek found that adult children who go 'no contact' with one or both parents elect estrangement as a last resort. The data shows that estrangement is dri...
Researchers studied the impact of a pharmaceutical merger on prices of over-the-counter cough and cold medicines in the Philippines. The study found that while some efficiencies were real, they did not lead to lower prices for all products, and in some cases, prices even increased.
A UC study found that only 15% of eligible American adults discuss lung cancer screenings with their doctors, highlighting the need for increased awareness and education about the lifesaving procedure. The study suggests that stigma and fear around lung cancer, as well as lack of information about the low-dose CT scan, may be barriers ...
The Deliverome Project aims to create a large-scale, open-access atlas of human cell surface proteins to aid in drug development. By developing new technologies and collecting data, researchers can identify surface proteins that can deliver cargo into cells, leading to more diverse and effective treatments for rare diseases.
Dr. Mina Sedrak has received a $3.6 million NIH grant to develop strategies for improving physical recovery and reducing frailty in older adults after hematopoietic cell transplantation. The grant will support a multisite randomized clinical trial testing the effectiveness of combining exercise with a senolytic therapy in improving phy...
Noah Golowich wins the Hertz Thesis Prize for his work on stable outcomes in game theory and reinforcement learning. His thesis,
A study combining three brain scans found a higher number of dopamine D2 receptors in autistic brains, suggesting a link between the dopamine system and autism. The researchers also found that the dopamine system affects communication between brain regions differently in autistic participants.
Patients with heart failure, caregivers, and providers are open to mobile health (MIH) adoption, but financial and regulatory challenges hinder its reach and sustainability. MIH programs can reduce ED transports, but their financial viability is constrained by Medicare's transport-based EMS reimbursement structure.
Researchers develop technology to capture 3D molecular snapshots of hair follicles and reconstruct time to visualize organ formation. By analyzing hair follicle development, scientists may gain insights into congenital conditions and develop new treatments for hair loss.
Researchers at Columbia University Irving Medical Center found that depression stalls neurogenesis in the adult brain's hippocampus, impairing pattern separation and memory recall. The study identified molecular programs controlling neurogenesis, which may lead to new therapies for depression.
Researchers propose a reconfigurable ferroelectric chiral nanostructure for fast-switchable optical differentiation, achieving remarkable performances in edge detection. The device can switch between optical differentiation and bright-field imaging, with a switching time of 62 microseconds.
The RACER-Knee trial found that robotic-assisted knee replacement surgery resulted in similar patient outcomes as traditional surgery, including recovery, mobility, and pain levels. Despite increased precision, the technology did not translate to improved patient outcomes within the first year after surgery.
A large-scale expansion of offshore wind energy could lead to increased precipitation over offshore wind farm areas, while precipitation in adjacent coastal regions could decrease. This is due to wind turbines extracting part of the wind's kinetic energy and increasing atmospheric turbulence.
Researchers suggest that targeting tiny protein aggregates known as oligomers, which form early in the disease process, may lead to breakthroughs in treating protein-misfolding diseases. Oligomers are increasingly believed to drive cellular damage, and their early formation may be more toxic than large protein deposits.
New research reveals that shipwrecks from WWI and WWII are leaking toxic chemicals into the North Sea, polluting the local ecosystem. The wrecks, including the German submarine UC-30, contain explosives that are harming starfish, mussels, and other marine life.
Research shows that young Bewick's swans that lose their parents during winter migration have a significantly lower survival rate, dropping from 86% to 40%. The study highlights the importance of family ties for migration and survival in these long-lived social birds.
Researchers have discovered that iron hydride may become superionic under Earth's inner-core conditions, with hydrogen moving through a solid iron lattice. This finding provides new insights into the composition and dynamics of Earth's deep interior, and has implications for our understanding of the core's formation and evolution.
Goutham Menon, a renowned expert in social work education, has been appointed interim dean of the UTA School of Social Work. Under his leadership, the school continues to thrive, with record-setting achievements in research, student success, and community engagement.
The Skala AI model, developed by Microsoft Research AI for Science, is now available through the CP2K software ecosystem. CASUS and Microsoft Research collaborated to integrate Skala into CP2K, enabling more accurate quantum mechanical simulations of larger molecular systems. The collaboration aims to improve the accuracy and efficienc...
Researchers found that alveolar type 2 cells mount slower interferon-driven antiviral defenses than type 1 cells, enabling higher viral replication in the alveoli. This study provides new insights into the primary site of influenza virus damage and opens up potential targets for antiviral therapy.
A new method allows for the simulation of giant dense polymer systems on an unprecedented scale, revealing concentrated entanglements in localized knots and links. This breakthrough enables the study of dense chain systems beyond idealized polymer physics.
A new study reveals that climate change can lead to a significant increase in wheat prices, with severe water scarcity being a key driver. The researchers found that wheat prices are more closely linked to water scarcity than other crops, and that compound drought events are expected to become more common in a warmer climate.
Researchers at Michigan Medicine identified two pathways that can be targeted to treat transdifferentiated prostate tumors. Using a combination of BET bromodomain and DNMT inhibitors, the growth of prostate cancer cell lines and tumors in mice was suppressed, reversing gene expression changes and reducing tumor growth.
A recent study found that sleep traits significantly increase the risk of hemorrhoidal disease, with insomnia being a major contributor. The analysis suggests that sleep disruption acts primarily as a driver of hemorrhoidal pathology, rather than a consequence.
A new study found that microgravity causes the lower eyelid to rise in astronauts, altering corneal topography and vision. The phenomenon, known as reverse ptosis, was observed in 62% of astronauts, with changes similar to those seen in short-term parabolic flights.
China's ozone pollution has increased despite PM2.5 declines, with urban areas under VOC-limited conditions; large-scale NOx reduction is a proposed near-term control strategy. Ambient ozone direct catalytic decomposition coatings can deliver localized ozone removal at a lower projected economic cost.
LASIK surgery shows moderate improvement in quality of life but higher patient satisfaction rates compared to contact lenses. Complication rates are lower for LASIK, but dry eye issues are more prevalent with both methods.
A new method has been developed to increase tar yield from low-rank coal, resulting in improved fuel quality and reduced unwanted reactions. By redirecting volatile compounds towards a cooler central zone, the researchers were able to limit secondary cracking and increase total tar yield by approximately 8.5%.
Minimally invasive laryngeal surgery has shifted toward precision functional preservation with high-definition endoscopy and updated laser systems. Surgical strategies prioritize vocal function reconstruction with optimized microflap techniques and autologous tissue grafts.
The OSPREY trial found that proximal hypoglossal nerve stimulation significantly improved apnea-hypopnea index and oxygen desaturation in patients with moderate-to-severe obstructive sleep apnea. The treatment has expanded eligible patient populations and is now approved for use in the US.
The True Grit program, a Rutgers Health study, evaluates a model for supporting independence in young people with spinal cord injuries as they transition from high school to adulthood. Participants in the 2024 cohort demonstrated progress toward their individual goals, with gains seen in participation scores and emotional resilience.
A study by the University of Oxford has identified the brain mechanisms that help us work out whether the consequences we experience are caused by our own actions or by circumstances beyond our control. The study found that confidence in our own decisions and estimates of external circumstances provide important clues.
Researchers developed a versatile hydrogel platform that enables the design of customised biomaterials for tissue engineering, disease modelling, and regenerative medicine. The platform preserves the functionality of incorporated biomolecules and supports high cell viability, enabling the creation of tissue-specific environments.
Uwe Wolfrum's research on Usher syndrome aims to prevent vision loss in patients with the disorder. His team uses human retinal organoids and pig models to investigate the molecular mechanisms of the disease, paving the way for gene-based therapies.
Developing new complex medical conditions is associated with higher disenrollment rates among Medicare Advantage beneficiaries, particularly to traditional Medicare. States with Medigap guaranteed issue and community rating protections have higher disenrollment rates among beneficiaries with multiple new conditions.
A telemedicine-supported home-injection model for patients with breast cancer has shown to reduce treatment burden by improving convenience and saving time. Most patients who completed home injections chose to continue this approach beyond the pilot, but barriers such as insurance denials and higher copayments may limit its broader imp...
The Brexit referendum led to a sustained decline in EU-origin health care worker immigration to the UK, despite recruitment from non-EU countries. Policymakers should consider the impact of policy uncertainty, substitution dynamics, and global health equity when making decisions.
A new study finds that Brexit led to a decline in EU-trained doctors and nurses in the UK, but physician vacancies continued to rise, highlighting the need for careful consideration of immigration policies and their impact on healthcare staffing and access to care.
After the Dobbs v Jackson decision, out-of-state travel to North Carolina for abortion care increased, particularly from more restrictive Southeastern states. Patients also presented at later gestational durations and traveled farther for care, indicating increased logistical barriers after policy changes.
A KAIST research team has identified the molecular lock that keeps cells trapped in an altered state, opening a new path toward releasing that lock and reversing a cell's fate. The team developed a fundamental control technology called ROOT that can regulate these circuits and restore biological states to their original condition.
A new pre-rerouting strategy ensures seamless service continuity in LEO satellite networks by redefining routing metrics to account for link effective duration and available bandwidth. The strategy achieves a packet loss rate of 1% compared to 7% with conventional rerouting schemes.
The Apophis asteroid will make a rare 38,000 km flyby of Earth in 2029, offering a unique chance for planetary science and defense. The flyby will provide direct evidence for the structural evolution of rubble-pile asteroids and demonstrate the feasibility of various exploration modes.
Researchers developed a nanoplatform that addresses three barriers to TNBC immunotherapy by eliminating Tregs, destroying cancer cells, and activating innate immunity. In preclinical studies, the platform achieved 100% complete tumor regression and extended median survival beyond 70 days.
Researchers have identified a molecular switch driving the spread of aggressive triple-negative breast cancer, a subtype with poor outcomes. Restoring a naturally occurring molecule called miR-342 reduced metastatic disease in pre-clinical models.
Advances in single-cell and spatial multi-omics are helping researchers understand brain development, disease, and therapeutic opportunities by integrating molecular layers with cellular and spatial context. This approach has revealed regulatory relationships and cell-type-specific changes in Alzheimer's disease, Parkinson's disease, a...
PSMA PET/CT detected recurrent prostate cancer after minimally invasive treatments and identified malignant peripheral nerve sheath tumors with high accuracy. Researchers also found varying access to PSMA-targeted theranostics between Brazil and Europe.
A novel hierarchical motion planning method combines goal-biased RRT with sequential convex programming to plan high-quality trajectories for space redundant manipulators. The proposed method successfully satisfies obstacle avoidance, end-effector line-of-sight constraints, and joint torque limits, converging in 17 and 18 iterations fo...
Dr. Alex Aliper will share insights on how cutting-edge technological innovation can drive industrial growth at the Global Unicorn Summit, and discuss AI applications in precision medicine at MedTech World Asia. He will also present real-world case studies and explore industry challenges in applying AI to personalized healthcare.
Researchers developed a new tool, Bonsai, to visualize high-dimensional data on a tree, providing a faithful picture of the structure in the data. The tool reconstructs developmental pathways and identifies similar cells more accurately than existing methods.
A study by Keio University researchers has identified two blood proteins, beta-2-microglobulin and cystatin C, that are consistently associated with future disability in adults aged 85 years and older. These biomarkers have the potential to enable earlier interventions and preventive support.
A new study uses machine learning to predict which patients with coronary artery disease will benefit from exercise-based cardiac rehabilitation. The model accurately identifies 'non-responders' using data from cardiopulmonary exercise testing and pulse wave analysis, allowing for tailored treatment plans.
A large-scale study in China found the prevalence of PCOS among pregnant women increased from 0.79 to 19.0 per 10,000 between 2012 and 2021, with significantly higher risks of adverse maternal and neonatal outcomes. Women with PCOS had increased risks of diabetes, hypertension, preeclampsia, and cesarean delivery, as well as fetal risk...
The APCCMPD and CHEST Medical Educator Diversity Scholar Fellowship aims to improve diversity in respiratory care. Anna Brady, MD, will mentor a fellow-in-training to develop a personalized curriculum and research project. Applications for the 2027 fellowship are now open until November 2.
Researchers have mapped Indonesia's seagrass ecosystems, identifying areas of high and low quality, and found that conservation efforts are needed for hotspots, coldspots, and areas with contrasting conditions. The study provides a spatially informed framework for prioritizing conservation and restoration efforts.
A research team from KIMS developed a highly durable platinum–nickel catalyst that suppresses nickel dissolution, enabling stable operation for 3,000 hours. This technology is expected to advance the practical application of water electrolysis catalysts for green hydrogen production, reducing platinum use and costs.
A recent study reveals that spending on microtransactions in free-to-play videogames is highly concentrated among a small minority of players, who account for the majority of revenue. Regulation is necessary to protect vulnerable players from potentially exploitative practices.