Researchers have developed NovoTags, synthetic fluorescent protein tags that can bind to bright fluorescent dyes with high specificity and affinity. These tags enable multicolor imaging of proteins inside cells, expanding the toolkit for advanced light microscopy techniques.
Researchers discovered that only three water molecules are sufficient to trigger a configuration transformation of the core skeleton from Sr2(μ2-OH)2(HO)1 to Sr2(μ2-OH)3, providing new insights into hydration mechanisms. This structural transition is driven by deformation energy and stabilizes the structure through rearrangement of hyd...
Researchers developed defect-rich silicon-carbon composite anodes with initial discharge capacities exceeding 6,500 mAh g⁻¹, outperforming conventional silicon-anode expectations. AI-assisted design optimized the formulation, revealing a trade-off between capacity and efficiency.
Researchers from Tohoku University have created a stable version of boron graphene on the surface of a three-dimensional crystal, revealing a new quantum state. The discovery could lead to more energy-efficient electronic devices and unlock entirely new quantum phenomena.
Researchers developed a new monitoring method for Sea-Based Joint Precision Approach and Landing System (SB-JPALS) using multiple reference receivers and a Boolean collaborative decision rule to detect ionospheric gradients. The approach improved monitoring sensitivity by 12.0% compared to conventional methods.
Research based on China's Chang'e-6 samples reveals that Earth's magnetosphere has shaped the difference in solar wind speeds and energies striking the Moon's two hemispheres. The study found that the lunar far side underwent stronger isotopic fractionation, resulting in preferential enrichment of the heavier isotope.
A new MoS2-based catalyst has been developed to overcome the limitations of conventional MoS2 catalysts in hydrogen evolution reactions. The catalyst, created using a dual-site substitution strategy, achieves outstanding performance at large current densities in acidic electrolytes.
Scientists at Tohoku University identified an optimal lithium concentration that allows for even lithium deposition and a stronger protective layer on the battery's surface. This discovery enables the development of safer, longer-lasting, high-energy-density rechargeable batteries.
A study by Pompeu Fabra University, ONT, and Vall d'Hebron Hospital reveals that public investment in liver transplants not only improves patient survival but also generates a positive social and economic return. The study estimates that liver transplant patients contribute over 100 million euros to the Spanish economy annually.
Researchers at Tohoku University have discovered a previously unknown pathway for B-cell development in chickens, bypassing the bursa of Fabricius. The discovery reveals that B cells originate in the bone marrow and migrate to the cecal tonsils, establishing an IgA-mediated intestinal barrier.
Researchers discovered that phosphorus plays a synergistic promoter role in evolving NiFe phosphides, accelerating oxygen evolution and suppressing dissolution of iron ions. The breakthrough catalyst delivers exceptional OER activity, achieving low overpotentials and superior reaction kinetics.
Researchers at Adelaide University developed a laser-based technology to detect toxic methanol in sealed spirit bottles, even through colored glass. The system uses Raman spectroscopy to identify the unique chemical 'fingerprint' of a liquid through its packaging.
The book offers practical, research-informed strategies to help pre-service and early career teachers navigate professional challenges. It explores how teachers can prepare for new roles, embed Aboriginal perspectives, and design inclusive learning opportunities.
Researchers used trans-tympanic infrared laser stimulation of the cochlea to evoke reliable auditory-guided behaviour in awake animals, without invasive procedures or genetic modification. The study found that laser-evoked perception was processed through auditory pathways and could be controlled by changing radiant energy.
A new strategy for boosting the performance of layer-by-layer organic photovoltaics (LOPVs) has been developed by incorporating a high-mobility crystallinity material into the acceptor layer. This approach achieved a power conversion efficiency (PCE) of 19.81%.
A comprehensive review introduces a pioneering exergy-based loss function for Physics-Informed Neural Network-Digital Twins, promising real-time optimization and accurate prediction of complex thermal systems. The study provides a definitive roadmap for industries seeking to minimize energy consumption while maximizing output in the In...
University of Oregon researchers engineer molecules and control regenerative cue release to improve healing outcomes for complex injuries. A staggered sequence approach shows better blood vessel regeneration, and the method is being applied to bone healing, muscle repair, and spinal cord regeneration.
A new drug, daraxonrasib, has been identified as a potential treatment for patients with NRAS-driven melanoma. The therapy targets and inhibits RAS protein, which drives cancer growth when mutated. Early results from preclinical models suggest the drug may be effective in treating advanced disease.
Researchers argue that EU and UK wildlife protection frameworks are fragmented, selective, and exception-based, threatening biodiversity. The authors propose strengthening laws to recognize animal sentience and introducing 'ethical continuity' into the legal framework.
Researchers at Wayne State University and Indiana University have developed a new class of drugs that target the Ku70/80 DNA-binding complex, a critical enzyme in DNA damage response. This approach aims to sensitize cancer cells to radiation and improve radiotherapy outcomes for lung cancer patients.
A study by Nooshin L. Warren found that small changes in sexual misconduct and gender portrayals can affect box office revenue, with adjustments adding or subtracting $8-13 million. Meanwhile, public expectations of gender roles seemed to regress after #MeToo, indicating a slower adoption of new norms.
A recent study found that human activities are fundamentally altering the chemical makeup of local coral reefs, leading to decreased coral health and resilience. The research team discovered that 25 contaminants from agricultural, industrial, and pharmaceutical sources accumulated in the soft tissues of coral around Maui, Hawai‘i.
A new study reveals that forest-dominated rivers in China regulate nitrogen removal through a combination of microbial activity, water and sediment conditions, altitude, and land use. Denitrification was the dominant nitrogen-removal pathway, accounting for up to 95% of total measured nitrogen removal in winter.
Combined exposure to copper and glyphosate causes stronger stress responses in earthworms than individual contaminants. Biochar reduces these effects, improving soil habitability and reducing earthworm response to contamination.
Researchers at Baylor College of Medicine identified a vulnerability in triple-negative breast cancers with LIG1 loss and used it to develop a new therapy for chemotherapy-resistant TNBC tumors. A combination of olaparib and ceralasertib showed significant effectiveness in reducing tumor growth in animal models.
A novel biological pathway has been uncovered that can lead to seizures when disrupted, providing a new approach for improved diagnosis. The study identifies an association between defective genes and increased glutamatergic transmission, which can increase the risk of seizures.
A new study found that baseball players with high school track experience performed better at the professional level than those who specialized solely in baseball. The research suggests that track development skills like speed and explosiveness translate directly to success in baseball, particularly in base running and fielding.
A global study analyzed 16.5 million DNA sequences from 23 cities across five continents, revealing a clear distance-decay pattern for bacterial communities. The findings show that port size, wastewater discharge, geography, and maritime activity closely associate with the structure of bacterial communities worldwide.
A University at Buffalo study has identified a link between Canadian wildfire smoke and decreased bird sightings in New York State. Analyzing air quality data with birdwatching reports, researchers found that nearly half of the studied species were less likely to be observed when PM2.5 levels rose, including many migratory forest songb...
The Endocrine Society recommends a diagnosis of hypogonadism based on low testosterone levels and symptoms. Testosterone replacement therapy (TRT) can improve quality of life for men with appropriately diagnosed hypogonadism, but its long-term safety is uncertain. Standardized testing and monitoring are crucial to minimize risks.
The coalition aims to facilitate innovative use of NAM tools, closing the gap in regulatory adoption. Crown Bioscience brings expertise in patient-derived models and biomarker analysis to support standardization of NAMs for regulatory acceptance.
Researchers at UT MD Anderson Cancer Center have made significant progress in treating rare brain infections with a virus-specific T cell therapy, achieving an overall response rate of 56.8% in patients with progressive multifocal leukoencephalopathy (PML). The center also introduced a novel CAR T cell therapy for hard-to-treat kidney ...
Researchers at Texas Children's Hospital have uncovered a novel biological pathway that can lead to seizures when disrupted. This finding provides a new approach for improving genetic diagnosis and treatment for epilepsy cases with unknown origins. The study also reveals that specific combinations of defective genes can cause seizures,...
A recent study reveals that occupations with more women pay less due to inherent societal biases, contrary to previous assumptions. The research suggests that employers can combat biases by standardizing pay criteria based on education, experience, and other factors.
Researchers expand potential of using bacterial spores for chemical reactions, biofuel production, and pollutant breakdown. New proteins fused to spore coat enable storage under extreme conditions without refrigeration.
A study published in Cancer Research identified an immune pathway that promotes the progression of oral precancerous lesions into head and neck squamous cell carcinoma. The researchers found that targeting a key inflammation signal known as interleukin-1 alpha (IL-1α) could help restore immune surveillance and prevent high-risk lesions...
Dr. Kaja Falkenhain receives the Peter J. Reeds Early Career Investigator Award for her groundbreaking work on human nutrition and metabolism. Her research focuses on cardiometabolic health and glycemic control, highlighting the impact of nutritional exposures on energy expenditure.
A clinical trial showed semaglutide improved liver scarring in patients with advanced fatty liver disease and early-stage cirrhosis. Non-invasive blood tests reflected treatment-related improvements more clearly than liver biopsies, which could reduce reliance on invasive procedures.
Researchers at UCLA have demonstrated a way to integrate terahertz functions onto a single chip using quantum well structures, paving the way for compact and scalable systems. This breakthrough could enable practical and widespread use of terahertz technology in applications such as ultrafast wireless communication, security screening,...
A new study suggests venture capital is playing a significant role in driving innovation in radiology, particularly in medical devices and artificial intelligence. The study found $11.4 billion was invested across 646 companies between 2000-2023, with funding peaking in 2021.
A new study has identified two naturally occurring microRNAs, microRNA-15a and microRNA-16, which can significantly reduce the growth and protein synthesis of non-small cell lung cancer cells. This finding suggests that these microRNAs could serve as targets for therapies designed to slow cancer progression.
A University of Houston professor is using artificial intelligence to connect roadway crash data, identifying pavement conditions associated with elevated crash risk. The study assesses pavement structure, surface condition, road geometry and crash records, helping transportation agencies select candidate pavement-safety projects.
The widespread implementation of driverless truck technology in the US could reduce transportation costs by 35%, resulting in significant increases in total interstate trade value. The impact would vary across states, with specific regions exhibiting higher percentage increases in exports.
Current federal rules based on plant age and leaf count are ineffective in predicting biological traits of American ginseng. Replacing these rules with size-based limits could better protect the wild population and simplify regulations for harvesters and forest farmers.
Researchers at Tufts University have developed thread-based integrated circuits that can bend, coil, stretch and conform to the body's contours. These devices could track biomarkers or environmental conditions, providing insights for fitness, healthcare and recovery from injury or disease.
Research on Southwest Florida cyanobacterial blooms shows that airborne cyanobacterial toxins contain the neurotoxin 2,4-DAB, which is linked to Alzheimer's disease and ALS. The study suggests chronic low-level exposure through breathing may be a significant risk factor for these diseases.
Researchers analyzed phone data from Marshall Fire evacuees, finding they chose destinations based on social connections and community resemblance. Those with stronger social networks were more likely to return home over time.
Researchers at Oregon Health & Science University mapped six major conformations of a membrane protein related to learning, memory and fear behavior. The findings provide a blueprint for designing new drugs to inhibit this channel in cases of stroke.
The Lancet Haematology Commission reports on global female health challenges, focusing on hematologic health across multiple stages of life. The report outlines recommendations for improving outcomes, particularly for women with under-recognized, underdiagnosed, and stigmatized heavy menstrual bleeding.
New research suggests dropping standardized testing requirements can expand access to underrepresented groups but worsen academic merit assessments, especially for nontraditional applicants. The study found that removing the test score requirement can have nuanced effects on diversity and merit outcomes.
A new atlas has been developed to map the potential of genes in predicting adverse drug reactions, utilizing a comprehensive analysis of genetic data from the Million Veteran Program. This genomic-led strategy aims to anticipate drug safety effects by identifying key genetic variants associated with adverse reactions.
The OU College of Medicine has received a $10.7 million NIH grant to study how cells sense their environment and respond to diseases that occur when this process malfunctions.
Researchers at the University of Arizona have demonstrated a new application for graphene nanoribbons, a material that can withstand extreme environments. The team integrated GNRs into semiconductor devices and exposed them to gamma radiation, showing that they can serve as radiation sensors for fusion reactors and in deep space.
A portable, airpod-size fluorescence analytical device has been designed to provide timely home molecular testing. The VPodDuo can measure fluorescent signals generated by various detection chemistry formats and detect quantities of genetic material from several pathogens and human cancer markers.
The HIV/AIDS response program in Brazil has lost momentum as the social movement becomes depoliticized, with activists focusing on basic issues like access to food and housing. The study suggests that technological advances and medicalization of policies have contributed to this trend.
Researchers developed an advanced generative model called ALADYNOULLI to uncover underlying disease processes and predict individual outcomes. The model reduced complex patient histories into 21 reproducible 'latent' disease signatures, which were highly similar across datasets and reproduced known disease processes.
Researchers used PET imaging to find significantly lower muscarinic acetylcholine M1 receptor availability in schizophrenia patients compared to healthy individuals. This study provides the first in vivo evidence of widespread M1 receptor deficits in schizophrenia, supporting the development of muscarinic-based therapies.
Astronomers have detected an atmosphere on a rocky planet, LHS 1140 b, in the habitable zone of its host star, which is consistent with conditions for liquid water and potentially life. The discovery was made using the WINERED spectrograph on the Magellan Clay telescope and reveals helium escaping from the upper atmosphere.
Researchers use AI models to design synthetic RNA-guided nucleases with novel properties, outperforming natural enzymes in multiple cell types. The study reveals new structures and interactions of AI-designed proteins, demonstrating their potential for genetic engineering applications.
A new study reveals two recurring dental designs in mammals, optimizing for either cutting or crushing performance. The tradeoff between these abilities has shaped the evolution of carnassial teeth, influencing dietary adaptability.
A study published in Science reveals that dendritic cells build and maintain structures called tertiary lymphoid structures (TLSs) within tumors, which serve as local command centers for the immune system. These hubs play a key role in antitumor immunity and may be a target for future therapies.
A team of astronomers has detected the first atmosphere on an Earth-like, rocky planet orbiting within the habitable zone of another star. The discovery provides evidence that worlds with conditions similar to Earth could exist beyond our solar system.
Scientists have successfully prepared and studied radium molecules precisely with lasers in tabletop experiments, marking a breakthrough in understanding the universe's matter-antimatter asymmetry. The new method can be applied to other atoms to create similarly chilled molecules.
Researchers will examine Protein S's role in pancreatic cancer and develop new therapeutic strategies. The study aims to improve understanding of the disease and reduce mortality rates.
A recent study found that patients perceive medical professionals as more credible when AI agrees with their diagnosis. However, disagreement can increase perceptions of medical uncertainty and doctor laziness. The researchers suggest strategies to communicate AI disagreement effectively and reduce patient mistrust.
A new Cornell study found that drinking water at meals can lead to consuming more food, rather than less. The researchers also discovered that adding spice to snacks can decrease eating volume, making it a potentially effective strategy for reducing energy intake.
A new study by University of Florida Assistant Professor Jason Dittmann reveals that the rocky exoplanet LHS 1140b may have its own atmosphere. The planet's age and atmospheric composition suggest a steady-state atmosphere with water, which could persist over time.
Researchers found that tissue-resident macrophages, responsible for clearing senescent cells, become dysfunctional with age, leading to chronic inflammation and organ damage. Blocking a specific receptor on these cells preserved youthfulness of multiple organs in mice.
Three Oak Ridge National Laboratory researchers have been elevated to IEEE senior membership for their outstanding work on energy infrastructure. Shamim Hasan, Mohammad Khalid, and Deepika Patel were recognized for their research in electromagnetic transient modeling, power system protection, and microgrid controls.
Researchers discovered the brain's brief 'dual tracking' ability to process two conversations simultaneously, potentially explaining why some individuals excel in busy social situations. This finding may help improve hearing technologies and provide insight into why certain people struggle with multitasking.
A new study reconstructs the geographic origins and early-life movements of Africans liberated from slave ships on St. Helena, providing valuable insights into the transatlantic slave trade. The research found that these individuals originated from a wide geographic area, including modern-day Angola and Zimbabwe.
The rapid drying of the Aral Sea has released over 200 teragrams of carbon into the atmosphere, shifting the region's land-use carbon balance from a net sink to a significant source. Restoration efforts could help halt continued carbon loss and generate financial incentives for reflooding the lake.
A team of researchers, led by Sergey Stavisky, has developed an AI-based speech neuroprosthesis that can translate brain signals into speech with high fidelity. The device has enabled a man with amyotrophic lateral sclerosis (ALS) to generate fluent sentences and sustain full-time employment.
A study found that virtual-physical scenario simulation improves nursing students' learning immersion in home visit training, but the effects on skills need further investigation. The integrated simulation model increased students' emotional buy-in and learning experience, making the interaction feel more realistic.
A research team identified Crocin II, a natural compound derived from saffron, as a promising therapeutic candidate for metabolic dysfunction-associated steatotic liver disease. By reducing ANGPTL8 protein levels, Crocin II alleviated liver fat accumulation and improved lipid profiles.
A new monkey species, Likweli, has been discovered in the Democratic Republic of Congo's Lomami National Park. The species, a rare and cryptic Colobus monkey, was identified through physical traits, genetics, and vocalizations.
A study found that cancer care providers are more likely to be aware of the risks of cannabis use, but less comfortable discussing it with patients. In contrast, survivors feel more comfortable discussing cannabis with their care team and hold more positive attitudes towards its use.
The European Law Institute has approved its first comprehensive framework for dealing with digital assets and personal digital content after death. The rules provide a dual legal framework recognizing the need for protection, privacy, and dignity in digital inheritance.
A new analysis from the University of Illinois and the Illinois Soybean Association finds that Illinois corn and soybean farmers could lose up to $609 million per year if the state bans the weedkiller glyphosate. This would represent a 3.6% revenue loss, mainly due to the need for more expensive herbicide products.
A comprehensive review finds that climate change affects waterborne diseases differently across bacteria, viruses, and parasites, highlighting the need for tailored public health approaches. The study recommends 'no-regrets' investments to reduce risk and promote community resilience.
A new editorial highlights the need for public health leadership to build trustworthy AI in health. The authors argue that public health expertise is essential to ensure AI systems are equitable, transparent and effective across diverse populations.
Ester Sztein, GSA's Director of International Programs, receives the AGI Award for her work in expanding access to geoscience education and fostering international collaboration. The award recognizes Sztein's commitment to increasing public awareness of the critical role geoscientists play in addressing societal challenges.
Researchers identified a distinct biological subtype of obesity that responds well to GLP-1-based medications like tirzepatide. Patients in this group lost an average of 21.5% of their body weight after six months of treatment.
Researchers successfully demonstrated the Talbot effect in diatom-inspired three-dimensional structures in the terahertz range. The fabricated structures replicate the native architecture of diatom frustules and reveal distinct optical roles for each layer.
Lehigh University has joined an international research consortium to advance commercial space research and innovation, with a focus on low-Earth orbit technology and microgravity science applications. The partnership aims to develop foundational technologies for future commercial platforms, including the Starlab space station.
A new study reveals that freshwater exported from the Black Sea into the Aegean Sea during the Early Holocene triggered major environmental changes across the Eastern Mediterranean. The findings challenge previous views on the formation of Sapropel 1, a widespread organic-rich sediment layer deposited during this period.
Researchers at the German Cancer Research Center found that overweight individuals are associated with more than 10% of all cancer cases, nearly twice the previous estimate. The analysis considered accurate measures of body fat and methodological biases to reach this conclusion.
Research led by the University of Surrey found that hospitals with high EU nurse reliance before Brexit experienced the greatest decline in patient outcomes afterwards. This was due to lower hiring standards when skilled workers became harder to attract.
A new carborane-based material has been developed to improve the efficiency of perovskite solar cells. The material offers several advantages, including lower energy requirements for deposition and reduced losses at the interface between the C60 layer and the perovskite absorber.
The COSPAR 2026 press tour offers a unique opportunity for accredited media to explore the historic Villa Galileo and INAF Arcetri Astrophysical Observatory. The event is free of charge but has limited participation, with full details and schedules sent to registered participants.
Researchers have discovered that TSPAN7, linked to intellectual disability and cancer progression, senses membrane curvature and polymerizes into a helical assembly. This 'transmembrane skeleton' resists mechanical deformation and provides structural reinforcement to tubular membranes, distinct from the classical cytoskeleton.
A structure-guided peptide vaccine targeting PCSK9 induced durable anti-PCSK9 antibody responses in mice, guinea pigs, and rhesus macaques. The vaccine reduced hypercholesterolemia and atherosclerosis in animal models. Further optimization is required for potential human application.
A study by the University of Konstanz found that politicians' views on climate change are more polarized than those of their constituents, particularly on the political fringes. This disparity makes it challenging for elected representatives to accurately represent the interests of their constituents and implement effective climate pol...
Researchers measured high-energy gamma-ray emissions from unstable curium nuclei produced in fission, providing insights into pygmy resonances and the fission process. The study's results enable reliable comparisons of gamma-ray emissions across isotopes, aiding nuclear theorists in improving models describing fission dynamics.
A vaccine targeting KRAS mutations was safe and stimulated durable immune responses in high-risk individuals. After a median follow-up of 16.5 months, none of the participants developed pancreatic cancer, and some precancerous lesions shrank or stopped growing.
Researchers found that sea anemones can selectively distinguish between beneficial and harmful bacteria thanks to 'nematosomes'. This ability is crucial for maintaining a stable microbiome. The study suggests that invertebrates may have sophisticated mechanisms for supporting beneficial microorganisms.
Northwestern University engineers created a drone called Phantom Twist that harnesses motion blur to blend into its surroundings. The drone spins up to 25 times per second, making it difficult for humans to see clearly, and can potentially monitor wildlife or inspect infrastructure with less disruption.
Researchers analyzed genetic data from almost 100,000 people across eleven world regions, identifying regional differences in gene variants GBA1 and LRRK2. This study is crucial for globally equitable diagnostics and therapies as it highlights the need to consider ancestry when diagnosing Parkinson's disease.
A recent study analyzed 42 pediatric ependymomas, defining metabolic patterns associated with each molecular subtype. The research found that fatty acid oxidation and polyamine metabolism vary across subtypes, with potential implications for therapeutic vulnerability.
Scientists have developed a simple, surfactant-free hydrothermal synthesis strategy to create spherical CeO₂ abrasives with controllable particle sizes. The resulting abrasives achieved superior surface finishes and material removal rates in chemical mechanical polishing (CMP) tests, outperforming commercial products.
New study reveals that antiferroelectric materials can exhibit unique properties beyond simple up-down arrangement of electric dipoles. Researchers identified a compound with hybrid ferroelectric-antiferroelectric domain walls, opening new opportunities for energy storage and electronic technologies.
The study introduces an integrated full-chip EUV curvilinear MO framework that merges deep-learning-enabled forward modeling and gradient-based inverse optimization. It reduces model complexity and memory usage through tunable U-Net surrogate models and slice-based approximated gradient calculation schemes.
Researchers propose a multi-objective optimization framework that identifies and corrects promising infeasible solutions, significantly improving optimization efficiency for complex distillation processes. The framework achieved optimization time reductions of 35.3% and 20.8% compared to conventional methods.
FAIR² Data Management, powered by Senscience, has been named a 2026 CODiE Award Winner in the category Best AI Data and Analytics Solution. The platform enables researchers to turn data into trusted resources that can be discovered, built upon, and used responsibly with AI.
Researchers developed a KRAS-targeted vaccine and found it generated significant immune responses in participants with a hereditary predisposition to pancreatic cancer. The vaccine was safe and produced memory T cells that persisted over time.
Researchers at University of Münster and National and Kapodistrian University of Athens used cryo-electron microscopy to elucidate the structure of UapA transporter, a key fungal transporter. The study reveals a specialized 'elevator-type' transport mechanism that could lead to new antifungal drug strategies.
A study reveals that gut bacteria can process chemically modified amino acids from heated foods, such as CML. This enzyme, SpeC, is a 'Swiss pocket knife' that breaks down these compounds, which are not absorbed in the small intestine and pass to the large intestine.
Researchers discovered that certain bacteria produce an enzyme to break down antibiotics, enabling their survival. This 'altruistic cell death' mechanism allows the bacteria population to thrive, making existing and future antibiotics less effective.
A novel salvage surgical approach combining internal neurolysis and targeted glycerol injection has provided durable pain relief for a patient with severe, treatment-resistant MS-TN. The procedure was successful in preserving sensation and reducing medication use.
Researchers found that most temperature-sensitive nerve cells are activated by cooling, and their activity reduces with warming. This finding challenges the long-standing view of temperature sensing and could guide future research into pain and sensory disorders.
A study by the University of Eastern Finland found that golf players spend approximately €330 million on golf annually, generating an estimated benefit to society almost twice as high. Golf promotes physical activity and generates €80 million in savings for society, with a Social Return on Investment (SROI) ratio of 1.9.
A nationwide study by researchers at the University of Minnesota found that adhering to posted speed limits could save an average of $22 million and 6.7 million gallons of fuel daily. This could lead to significant reductions in greenhouse gas emissions and energy consumption.
A recent study discovered that Hes6, a transcriptional cofactor, drives gastric cancer progression through the regulation of EMT and PI3K/AKT signaling. Overexpression of Hes6 was associated with increased cell proliferation, migration, and invasion in gastric cancer cells.
A cross-sectional study reveals substantial commercial price variation for common cardiovascular services, influenced by payer contracting strategies and market dynamics. The findings underscore the need for greater transparency and regulatory oversight to promote efficient healthcare spending.
Theoretical physicists develop new method to order Feynman integrals based on their geometric structure, reducing computation time by a factor of 1,000. This allows for precision predictions in high-energy physics measurements, such as those made at the Large Hadron Collider.
Dr. Elaine S. Jaffe receives AMP's highest honor for pioneering contributions to lymphoma diagnosis and treatment. Dr. Laura J. Tafe is recognized for her leadership and service to the organization, while Dr. Daniel E. Sabath receives the Meritorious Service Award for his dedication to scientific excellence and organizational service.
The study found significant progress in reducing cancer mortality disparities for breast and uterine corpus cancers, but persistence in prostate cancer remains. The findings highlight the need for targeted interventions to accelerate progress in equitable cancer prevention and control.
Daniel E. Sabath, a professor at UW Department of Laboratory Medicine and Pathology, has won the Association for Molecular Pathology's 2026 Meritorious Service Award for his dedication and effort over three decades. He is being honored for his leadership roles, scientific expertise, and collaborative spirit in advancing education and s...
The Association for Molecular Pathology recognizes Dartmouth Health medical director Laura J. Tafe for her exceptional leadership and dedication to the field of molecular diagnostics. She has been a member of the organization since 2007 and has held various positions, including president in 2023.
A multidisciplinary study assesses the Guadalquivir River's water quality along its entire course, combining physicochemical and biological parameters. The results show a gradual decline in quality, with specific sections identified as deteriorated, highlighting the importance of integrated analysis for risk assessment.
A team of researchers has discovered a new genus and species of subterranean freshwater snail, Cyllena hermes, in the Peloponnese region of southern Greece. The species is highly sensitive to environmental stressors due to its reliance on a single, isolated water source.
A new study has found that most skin's temperature sensitive nerve cells can sense both cool and warmth, not just one. This discovery could help explain why people with certain conditions struggle to regulate their body temperature.
Elaine S. Jaffe, a distinguished investigator at the NCI Center for Cancer Research, has transformed our understanding of lymphoid malignancies through her groundbreaking research. Her work has led to significant advancements in disease classifications, diagnosis, and treatment.
Social animals exhibit a range of pre-war preparations, including environmental cues and memories of past events. These behaviors can impact socio-cognitive evolution, population dynamics, and community structures. Preemptive behavior is widespread in social species, depending on the current threat level.
Researchers developed a spider-web-like NBR nanofiber interphase to stabilize zinc metal anodes under extreme current densities. This interphase regulates ion transport, interfacial chemistry, and mechanical deformation, achieving long-life zinc metal batteries with stable cycling and high-power capability.
The researchers developed an image-aided terminal guidance attitude control scheme to tackle airframe disturbances and EFP trajectory dispersion in multirotor strikes. The system realizes finite-time convergence of attitude errors and real-time compensation of wind gusts and model uncertainties, greatly improving aiming stability.
Researchers at Gunma University have identified a compact genetic switch that could revolutionize the treatment of drug-resistant epilepsy. The discovery, published in Molecular Therapy, offers new avenues for addressing this debilitating condition.
A recent study investigates vacancy- and void-controlled hotspot formation in RDX, demonstrating how coupled defect structures regulate chemical activation and thermal localization across multiple length scales. Vacancies significantly shorten reaction initiation times and reduce decomposition barriers, accelerating the initial decompo...
Researchers discovered that senescent cells accumulate high levels of triacylglycerols and increase glycolytic activity, leading to increased lipid droplet accumulation. This finding suggests that lipid droplets may contribute to the harmful effects of senescent microglia in Alzheimer’s disease.
Researchers have developed a new ultra-low-light ghost imaging technique that achieves megapixel radiology with extremely low X-ray photon consumption. This approach has the potential to make medical X-ray diagnostics less risky and more accessible, especially for children, pregnant patients, and people needing frequent scans.
Researchers developed a coordination-regulated strategy to stabilize wide-bandgap perovskites, achieving an efficiency of 22.21% and retaining over 91% of performance after 2000 hours. The optimized cells were integrated with CIGS bottom cells to deliver an overall efficiency of 29.71%.
Researchers use CRISPR-Cas9 to edit red perilla, producing green plants with increased levels of antioxidants and anti-inflammatory compounds. The study demonstrates a new strategy for developing high-value crops for the food and pharmaceutical industries.
The emerging role of ZBP1 in cancer therapy involves converting genomic stress into potent antitumor immunity. Therapeutic activation of the ZBP1 pathway may transform immunologically "cold" tumors into "hot" tumors by inducing immunogenic necroptosis, stimulating robust immune responses.
Two Lancet papers call for Japan to redesign its health system and global health strategy by 2040. The country must adapt its approach from a hospital- and service-volume-centred system to one focused on people's lives, health outcomes, and communities.
A global vaccine trial evaluated fractional doses of COVID-19 boosters, finding they produced strong immune responses comparable to full-dose boosters. This could lead to extended vaccine supplies, improved equity in vaccination programs and reduced costs, especially in low-income countries.
A study reveals ADAR1p110 drives HCC metastasis by regulating microRNA biogenesis, particularly through post-transcriptional regulation of miR-451a. This blockade suppresses mature miR-451a, leading to increased TUBA1A expression and enhanced tumor cell migration and invasion.
Researchers at the Institute for Basic Science have developed a new strategy for electrically controlling molecular quantum systems, enabling precise control of individual molecular spins. This breakthrough offers a practical approach to building future molecular quantum technologies.
A new review of existing research found that AI-based nursing interventions can identify patients at greater risk of complications, reducing unplanned hospital visits and potentially lowering healthcare costs. However, there is a need for further research on the impact of AI on patients' emotional well-being.
A Northwestern University study found that average total payments per user for GLP-1 drugs more than doubled from 2017 to 2022. This raises concerns about the long-term affordability of these medications, which may be taken by patients for years or decades.
Researchers at Kyoto University discovered an RNA aptamer, 1R6, that targets the disordered regions of alpha-synuclein protein, inhibiting its aggregation and promoting disassembly of pre-existing aggregates. This finding offers a new therapeutic strategy for neurodegenerative disorders like Parkinson's disease.
Researchers develop air-stable surface electrene, BaSiN2:O, with ultralow work function and freely floating electrons. This material catalyzes ammonia synthesis under mild conditions, overcoming previous air instability limitations.
Researchers found that prenatal and early-life exposure to PFAS is associated with increased intestinal inflammation in childhood, as measured by elevated fecal calprotectin levels. This study suggests that environmental exposures during critical stages of development may influence long-term intestinal health and future inflammatory bo...
SLAS Discovery highlights innovative screening platforms accelerating therapeutic discovery for neurodegenerative diseases, including a newly identified link to Alzheimer's progression. The journal showcases novel technologies and approaches to understand and treat human disease, advancing life sciences discovery and technology.
A study by researchers at Kanazawa University has successfully detected 90% of early-stage pancreatic cancer using a blood-based gene expression test. The test analyzed peripheral whole blood and showed higher sensitivity than traditional tumor marker CA19-9, with 60% sensitivity and 93.3% specificity. This breakthrough may improve lon...
This volume of SLAS Technology highlights novel laboratory technologies, open-source software, and disease-specific tools for advancing life sciences research and development. The journal emphasizes the importance of education, knowledge exchange, and global community building to drive innovation in biomedical research.
Researchers found subtle patterns in brain activity while children listened to speech linked to verbal communication abilities in autistic youths. Altered brain signals suggested the brain may process speech less efficiently, with noisier signals associated with lower scores on everyday verbal communication.
A subset of cancers, known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) cancers, are more visible to the immune system than others. Researchers from the Keck School of Medicine of USC identified a biological feedback loop that helps activate the immune response against these types of cancer.
The grant supports the development of therapies with fewer side effects for triple-negative breast cancer, a highly aggressive and difficult-to-treat form of breast cancer. The researchers aim to target UBR5 protein, which is overproduced in aggressive breast cancers and several other malignancies.
Researchers identified a precise gene edit that lowers cadmium in rice grains while maintaining yield and essential mineral nutrients. The OsNramp5 I441T mutation selectively limits cadmium translocation, reducing grain cadmium by 48% without compromising zinc or manganese uptake.
Researchers analyzed 49 journal articles on bacterial cellulose-derived carbon electrodes for supercapacitors, finding that preservation of the nanofiber network and mechanical properties are crucial for performance. The study highlights BCC's potential to outperform commercial activated carbon under comparable conditions.
The 2024 Migration Pact transformed EU migration governance by increasing political bargaining among national leaders. Decisions are now shaped by high-level political forums and transactional diplomacy, reflecting a shift away from expert-led coordination.
A study of 88,037 Japanese children found exclusive breastfeeding for 6 months associated with a higher prevalence of food allergy and atopic dermatitis. However, it also showed lower rates of bronchial asthma and allergic rhinoconjunctivitis.
MIT researchers developed framework to make climate-informed energy siting choices, showing how location affects energy system resilience and reducing blackouts. Climate-informed energy siting reduces energy shortfalls by up to fivefold in regions like New England and Texas.
According to a new report, climate change has led to moderate or severe food insecurity for 2.7 million people across 26 SIDS, with heatwave days and droughts contributing to the issue. The study highlights the impact of climate change on vulnerable countries and strengthens evidence for a binding 1.5°C target.
A new study published in Nature Communications finds that a protein called saxiphilin can neutralize the potent neurotoxin saxitoxin, preventing and even reversing paralytic shellfish poisoning. The discovery could have important public health implications as saxitoxin accumulates in shellfish and causes poisoning when consumed.
Researchers estimate that audience travel is responsible for most emissions at 'mega-events' like the World Cup. To reduce emissions, organisers should reward fans with discounts for using lower-carbon transport, rather than passing on costs.
Researchers analyze the 'ringdown' phase of black hole collisions to test Einstein's theory of General Relativity and uncover secrets about these mysterious objects. Future observatories may reveal fresh evidence for new physics and challenge current models.
A study identified four major symptom patterns in women with endometriosis, revealing a more complex picture of the disease. The research found that psychological and neurological symptoms are common in active disease, while some patients may experience a lower symptom burden.
Researchers found that certain sweeteners, such as isosteviol, impaired two important gut bacteria linked to regulating blood sugar and gut health. The study suggests that artificial sweeteners can directly affect gut microbes, particularly when mixed with other substances.
Researchers at Hiroshima University have developed a new way to detect subtle, early-stage changes in human skin collagen using advanced optical imaging and chiroptical spectroscopy. The study reveals that the molecular organization and supramolecular chirality of dermal collagen collapses prior to visible fiber thinning or fragmentation.
A study of 9,996 participants found that 76.9% of smokers buy legal tobacco, while 23.1% purchase from illicit sources at least once a year. Illicit markets are often driven by financial pressures and switching to cheaper products or quitting smoking.