cmGAD67, A compact genetic switch, could open new avenues for treating drug-resistant epilepsy

Targeted gene therapy is thought to be the way ahead for treating drug-resistant epilepsy, a condition affecting about one-third of patients with epilepsy, despite medication. Now, researchers led by Professor Hirokazu Hirai from Gunma University, Japan, have developed cmGAD67 – a compact promoter that selectively targets inhibitory neurons in the brain to restore the excitatory–inhibitory balance, essential for the brain to function normally. It offers a promising avenue as a compact and effici Credit: Professor Hirokazu Hirai from Gunma University, Japan