A team led by Jeremy Levy and Chandralekha Singh describes the Inverse Seminar, a format that recovers hidden knowledge and decisions in scientific papers. The format involves a senior scientist listening to a junior researcher present their own paper, recovering undocumented material and uncovering new insights.
Scientists at Michigan State University and Czech Academy of Sciences have successfully recreated powerful compounds from deadly plants wolfsbane and larkspur, opening up new avenues for medicinal research. The discovery could lead to the development of new, sustainable drugs inspired by these natural products.
A Germany-wide research project aims to improve care for patients with invasive fungal infections, analyzing current treatment and developing a new care model. The project will use routine data from over 74 million insured persons.
Researchers found that female mice's microglia form prolonged contacts with neurons during recovery, leading to synaptic remodeling and plasticity. This phenomenon was not observed in male mice, highlighting differences in brain recovery processes between sexes.
Concordia researchers have developed a scalable technique that cuts waste while producing catalysts that convert carbon dioxide into valuable chemicals. The new method uses resonant acoustic mixing and dramatically reduces water usage compared to conventional methods.
Researchers developed a method to detect water ice on the moon using seismic waves, which can travel faster through frozen soil. This discovery is critical for NASA's Artemis program, which aims to send crewed landings to the moon's south polar region in 2028.
A survey study found that US women who own guns perceive themselves as safer than those who do not, with 41% believing owning a gun would increase their safety. The study suggests a need for targeted gun violence reduction interventions considering different perceptions of safety related to gun exposure.
Researchers have developed a genetic tool, mCHIRA, to study the effects of small sequence variations on gene regulation and tease apart the impact of genomic microenvironment. This approach enables scientists to test hundreds of regulatory DNA sequences and understand how cells determine which genes are active.
Researchers found that 4-phenylbutyric acid (4-PBA) restored mitochondrial balance and reduced inflammation in the septic heart. The compound lowered lactate production, limited actin-related protein 2/3 complex subunit 1B modification, and preserved cardiac contraction.
Researchers found that ESCRT-III proteins form a protective coating around exposed DNA bridges, preventing damage and ensuring genome stability. This discovery provides insight into how cells protect themselves from DNA damage events linked to cancer development.
Researchers found that women receiving beetroot juice experienced fewer serious adverse events, better kidney function after pregnancy, and reduced need for blood pressure medication. The study suggests beetroot juice could be a safe and low-cost intervention to support women with chronic kidney disease during pregnancy.
Participation in community gathering places significantly reduces the risk of cognitive disability in older adults who don't regularly exercise. The study found that these groups had approximately half the risk of developing cognitive disability compared to non-participants.
Researchers validated an AI-powered blood test that detected liver cancer in people from Guatemala and Romania with high accuracy, revealing new biological signals. The study builds on earlier research using a liquid biopsy platform and demonstrates the approach's effectiveness across different patient populations.
The University Hospitals and Clasp student loan repayment program offers up to $20,000 in employer-sponsored support for new graduate Radiologic professionals and Respiratory Therapists. The program aims to reduce financial barriers to education and attract top talent to the region.
Resonant meta-devices revolutionize imaging and display by achieving ultra-narrowband wavefront shaping and spectral decoupling. They enable multifunctional, high-purity light-field control with applications in AR/VR, LiDAR, quantum photonics, and biosensing.
A recent review suggests that consuming less protein could have greater health benefits and potentially extend lifespan. The review highlights the role of fibroblast growth factor 21 (FGF21) in slowing aging by improving metabolism, reducing cellular damage, and preserving healthy cell function.
Researchers explore how engineered lanthanide carriers can tune the optical and magnetic properties of ions for improved signal contrast and reduced background signals in biomedical imaging. The study highlights opportunities for multimodal imaging, theranostics, and AI-guided probe design.
Researchers found that adding fine biochar to natural hydraulic lime boosts its compressive strength by 35.7% and increases CO2 uptake by 14.6%. The optimized material can support carbonation through biochar's porous structure, promoting calcium carbonate formation.
Researchers at Seoul National University have developed a novel approach using porous triply periodic minimal surface (TPMS) feet and deep reinforcement learning controller, which significantly reduces battery power consumption in quadruped robots. The solution reduces energy consumption by up to 6.2% while maintaining stable locomotion.
A Pusan National University-led team evaluates and optimizes liquid-hydrogen tank insulation using cooling channels circulating cryogenic sacrificial fluid. Effective LH2 storage requires smarter placement of cooling, not just more material.
A NYU Tandon School of Engineering study found that 97.5% of US data centers are located within metropolitan statistical areas, with many clustered near cities due to high electricity demand and existing IT infrastructure. The concentration of data centers raises questions about the future of urban development.
Simulations have revealed the strongest accelerations ever produced on earth, opening a new dimension in QCD research. The peak proper acceleration reaches several hundred MeV at both low and high collision energies, depending only weakly on the collision's head-on nature.
Researchers found that magma plumbing systems beneath volcanoes can fluctuate between solid- and liquid-dominated states, providing new insights into volcano evolution. Ancient Carlingford Mountain fossilized remnants reveal a pulsatory fashion of development, offering a unique window into modern-day volcanic processes.
A study by Texas A&M University finds that generational shifts are reshaping the healthcare workforce, with different needs and perspectives among five distinct generations of clinicians. This is complicated by staffing shortages, burnout and changing expectations about work-life balance and mental health.
Researchers found that reconstructed coal gangue can activate powerful oxidation reactions to break down persistent organic pollutants. The material's intrinsic reactivity and surface chemistry are key factors in its ability to degrade pollutants.
A study by Dawood Darbar and colleagues found that rare genetic mutations converge with common genetic variants to disrupt the heart's electrical activity, leading to early-onset atrial fibrillation. This additive effect amplifies the risk of stroke and other cardiovascular complications.
The journal publishes original research articles and reviews on AI technologies across scientific, engineering, industrial, and societal domains. Authors are encouraged to validate their proposed AI methods using publicly available datasets for transparency and reproducibility.
A new study reveals that tree felling mainly damages the crowns of remaining mature trees, while timber extraction threatens young seedlings. The research highlights practical opportunities to reduce ecological damage during logging by better planning and operator training.
Researchers found that changes to the gut microbiome in mice were linked to increased intestinal permeability and an increase in food allergy severity. The study suggests that gut health plays a crucial role in how the immune system responds to food allergies, offering new avenues for treatment.
Extracellular vesicles from liver cells can elicit a 'lipid counterstorm' that counters the effects of cytokine storms in mice. The treatment shows promise for treating inflammatory conditions such as sepsis, coagulopathy and colitis.
A Brazilian research team used synchrotron light techniques to analyze a super-deep diamond and found that goethite can withstand extreme pressures and temperatures all the way to the planet's interior. The study suggests that goethite may transport and release water into the lower mantle, reinforcing the hypothesis.
A team of researchers, including URI's Patricia Cioe, published recommendations encouraging healthcare providers to discuss nicotine e-cigarettes as a potential option for adults who smoke. The authors emphasize patient-centered discussions and suggest that completely stopping combustible cigarette smoking remains the best way to reduc...
Researchers from Pennington Biomedical Research Center propose a new framework for defining and diagnosing obesity, which considers the effects of excess adiposity on organs and tissues. This approach provides a more biologically grounded and clinically actionable method for guiding treatment decisions.
An international team of researchers from China, Australia, and New Zealand propose a collaborative approach to next-generation water quality modeling. The researchers identified four collaboration themes: emerging technologies, uncertainty quantification, tackling climate change and urbanization, and shared modeling guidelines.
A recent study found that consuming a daily blend of over 30 different plants increased populations of 'favourable' gut bacteria compared to a probiotic control. This results in improved gut health and reduced symptoms such as constipation and flatulence.
University of Rhode Island researcher William Van Nostrand will study cerebral amyloid angiopathy (CAA) using a $1.5 million grant, aiming to elucidate disease mechanisms and identify early-stage biomarkers for this prevalent disease in the elderly population and Alzheimer's patients.
Bacteria Pseudomonas putida adapts to high levels of fluoride by spontaneously mutating its regulatory gene PP_3125, which inhibits the activity of benzoate transporter BenE-I. This mechanism helps the bacteria tolerate higher intracellular concentrations of fluoride, enabling more efficient biosynthesis of fluorine compounds.
Researchers describe microneedles as a minimally invasive platform for precision health, offering timely progress in multifunctional systems for wearable devices and intelligent healthcare. Despite challenges to be overcome, the technologies hold promise for more precise, convenient, and individualized healthcare solutions.
The Sloan Digital Sky Survey has released its 20th data set, featuring over three million spectra of stars and galaxies, as well as 18 new value-added catalogs. This release marks a significant expansion of the survey's efforts, integrating full all-sky panoptic spectroscopy across both hemispheres.
Researchers used natural language processing models to analyze interviews of over 200 children aged 9-13, who discussed stressful events. The study found that the style of their speech was more predictive of future mental health issues than its content.
Researchers discovered that significant amounts of terrestrial carbon are stored in the seabed, with microorganisms preferring fresh marine carbon over ancient terrestrial sources. This knowledge is essential for assessing the climate impact of thawing permafrost and its effects on atmospheric greenhouse gas levels.
Researchers at the University of Edinburgh have developed a new theoretical framework that could help address the challenge of energy-efficient computing. The approach uses Optimal Control Theory to design ultrafast magnetic-field pulses that switch magnetic states using minimal energy.
A study found that reshaping the gut microbiome with antibiotics can significantly reduce liver clearance and double chemotherapy delivery to tumors. This approach has potential as a strategy to enhance nanoparticle-based cancer drugs.
Researchers develop biodegradable film using rapeseed-processing residues, combining chitosan with phenolic extracts and silver nanoparticles to protect fresh food from moisture, oxygen, and microorganisms. The film showed improved structural durability, active preservation, and rapid environmental degradation.
A new study discovered that an arginine-deficient diet stunts the production of MHC-1 protein, which alerts the immune system to dangers such as tumors or viral infections. Increasing arginine intake may improve immune function and potentially treat cancer and viral infections.
The article highlights the need for AI tools to provide interpretable and reportable results, with a focus on improving turnaround time, diagnostic consistency, and clinical decision-making. While AI is unlikely to replace pathologists, it can help convert tissue morphology into actionable evidence for better patient care
Daniel Hook steps down as Digital Science CEO after 11 years, handing over to Stephen Leicht, who aims to build on the company's success. Leicht has been part of the Digital Science story since 2013 and is focused on growth and innovation.
A noninferiority randomized clinical trial found that an alternative first-line regimen containing doravirine, lamivudine, and tenofovir disoproxil fumarate produced less weight gain than a combination of dolutegravir, emtricitabine, and tenofovir alafenamide. The regimen was noninferior for viral suppression at 48 weeks.
Researchers found changes in tooth enamel mineralization in rats exposed to secondhand smoke, with increased carbon content and reduced phosphorus levels. This suggests a potential impact on tooth strength and hardness.
Researchers created a detailed map of breast tumour cells, identifying distinct neighbourhoods of proliferating and dormant cells. The study reveals that protective immune and connective cells surround the hibernating cancer cells, potentially shielding them from treatments.
Researchers developed Fe-doped carbon composite catalysts to regulate the thermal decomposition and combustion behavior of DAP-4. The catalysts improved decomposition and combustion reactions by accelerating hydrogen transfer and forming reactive intermediates.
US nursing homes have seen a significant increase in closures between 1985 and 2025, with changes in ownership and capacity reconfiguration being more common than permanent facility closure. The study highlights the need for policy and oversight considerations that take into account ownership transitions and capacity changes.
Researchers at Institute of Science Tokyo developed strategies to overcome xenophagocytosis, which eliminates living donor cells in interspecies organ generation. By blocking this response, they significantly improved donor cell survival and generated rat pancreas in mice.
Co-transcriptional splicing plays a critical role in regulating chromatin structure, mRNA maturation, and protein diversity. The review identifies key detection methods, regulatory mechanisms, and therapeutic applications for this process.
Researchers combined fishing regulations and trade data to explore the complex global market for shark products. Despite significant regulatory efforts, no statistically significant effect on global trade was found.
Scientists create complex solid solutions by firing five atomic elements onto a wafer from different directions, forming chemically disordered nanocrystals. The resulting epitaxial films exhibit interesting defect structures that may influence the desired properties of catalysts.
A Boston University-led study found that the solar wind strips away Mars' atmosphere by generating Kelvin-Helmholtz waves, similar to wind on Earth. The process drives atmospheric ion escape, with plasma clouds facilitating bulk escape.
Hepatic encephalopathy recurrence can be reduced through education on precipitants correction and pharmacotherapy with lactulose and rifaximin. Nutritional support with protein-rich diets improves QOL and reduces episodes.
Researchers found that no electoral system can guarantee both local votes translate directly into local seats and total seat distribution matches overall vote shares. However, they proposed an algorithm called 'geographically ranked guaranteed proportionality' which could get around the impossibility of current systems.
A likely case of soft tick-borne relapsing fever was reported in an Austin resident, who experienced recurring high fevers and symptoms before finding an infected tick. Researchers confirmed the presence of Borrelia turicatae bacteria and emphasized the need for greater awareness and surveillance of tick populations in urban areas.