Researchers identified a novel oncogenic mechanism involving DNA demethylation in hepatocellular carcinoma, promoting tumor formation without canonical driver gene mutations. Suppressing TET1 reduced tumor formation in mice, supporting the relevance of these findings in human liver disease data.
Researchers at Institute of Science Tokyo used integrated forensic methods to analyze a single tooth, revealing clues about birth year, age at death, dietary patterns, drug exposure, biological sex, and DNA profile. Stable carbon isotope analysis and amino acid racemization provided accurate estimates of birth year and age at death.
A high-calorie diet is linked to cognitive impairment through altered RNA splicing and synaptic dysfunction. Treatment with pioglitazone and gene therapy restores PQBP1 levels, improving synaptic and cognitive outcomes.
Heart failure alters the bone marrow, reducing protective cells that regulate inflammation, reports a study conducted at Science Tokyo. The bone marrow niche is found to play an important role in transmitting the effects of cardiac stress to blood cell forming stem cells.
Scientists have discovered a novel Sillén oxybromide with exceptional oxide-ion conductivity at low temperatures, chemical stability, and negligible chemical expansion. The material achieves 0.01 S cm⁻¹ bulk conductivity at 233 °C, surpassing that of leading proton conductors and conventional SOFC electrolytes.
Researchers developed high-entropy lanthanoid oxide catalyst that lowers OCM onset temperature and improves C2 hydrocarbon yield. The catalyst's surface basicity is systematically tuned to achieve moderate basicity, leading to sustained activity and long-term stability.
Researchers developed pyrene-modified polyionic complex vesicles, or Pyr-PICsomes, whose membrane stiffness directly regulates their fluorescence response to pressure. The platform's sensitivity varies depending on membrane stiffness, enabling investigation of hydrostatic pressure-dependent phenomena in diverse environments.
A new multimodal 4D dataset, InterPet4D, provides a detailed model of human–dog interactions through movement, gestures, and speech. The dataset was used to develop an AI framework, InterPetMoGen, which generates plausible dog motion from human body and hand movements and accompanying audio cues.
Researchers at Institute of Science Tokyo have developed a process to recover magnesium from desalination brine using liquid tin. The process, which combines direct-contact distillation with vacuum degassing, enables the recovery of magnesium-rich precipitates with high efficiency and purity.
Researchers discovered a way to generate photocurrent without a p–n junction, pushing solar cells beyond conventional limits. By harnessing dynamic atomic motion, they found that temporary symmetry breaking can enhance photoelectric conversion, opening new avenues for high-efficiency photovoltaic materials.
Researchers demonstrate that internal crystal structure is key in regulating generated light-induced current in 2D organic–inorganic hybrid perovskites. The study reveals a strategy for regulating spin-polarized photocurrents and advancing opto-spintronic technologies.
Researchers found that host immune status significantly influences herpesvirus retinitis phenotypes and clinical outcomes. Acute retinal necrosis (ARN) is associated with a higher risk of retinal detachment, while cytomegalovirus retinitis (CMVR) follows an indolent course.
Researchers developed the Motion Style Slider framework for continuous control of motion style intensity in generated human animation. The framework achieves consistent style control and smooth transitions using only two motion samples, allowing animators to refine character performances according to their creative vision.
A novel molecular mechanism regulating TMEM63B lipid scrambling has been discovered, with the C-terminal tail acting as a brake to keep the protein inactive under resting conditions. Disrupting this region, particularly the Leu776 residue, releases the brake and triggers constitutive lipid scrambling.
A research team found that slow freezing and fragmentation can separate salts and organics in ejected material from Enceladus' ocean. This process creates chemically diverse ice grains, with each grain enriched in different salts and compounds.
The study reveals that RebD and RebC are crucial in forming the R-body architecture, while RebA and RebB alone are insufficient. The findings provide valuable insights for engineering dynamic protein systems and designing stimuli-responsive protein materials.
Researchers from Institute of Science Tokyo successfully demonstrated a deployable phased-array transceiver in orbit, enabling satellite constellation-based wireless communications. The technology corrects non-planar deformations in the deployable membrane antenna, paving the way for next-generation satellite-based networks.
By localizing peptides at the membrane interface or within the liposome interior, researchers can promote branched structures or spherical nanoparticles, respectively. This approach offers a new strategy for controlling nanoscale reaction environments in nanoparticle synthesis.
A new protein language model, CLSS, brings together sequence and structure information to produce cohesive maps of protein relationships. The model successfully integrated sequence and structure data, reproducing expert-curated classifications and demonstrating strong performance in classification tests.
Researchers have successfully reversed magnetization in nanoscale multiferroic materials using electric fields, enabling energy-efficient magnetic memory devices. The study demonstrates a promising approach for next-generation memory technologies with potential for higher-density memory architectures.
A quantum LDPC code with a large minimum distance near 48 protects 4,612 logical qubits using 9,216 physical qubits, reducing hardware overhead. The code's design framework, inspired by classical LDPC codes, allows for strong evidence of a minimum distance and threshold phenomenon.
Researchers developed a flexible metal–organic framework, APF-40, to analyze large pharmaceutical molecules with complex structures. The framework enables the determination of structures from microgram-scale samples, aiding drug discovery and natural products research.
A simple blending strategy enables reversible fluorescence in block copolymers, allowing visualization of mechanical stress without altering material properties. The approach preserves mechanical properties and offers a practical route for stress-sensing functions in existing polymer materials.
Researchers have discovered the underlying mechanism of Atg2-mediated lipid transfer in autophagy, revealing two distinct mechanisms that enable proper growth of the autophagosomal membrane. The phosphorylation of a specific region of Atg2, mediated by Atg1, enables its binding to the endoplasmic reticulum and subsequent lipid transfer.
Researchers created a predictive model called enzyme-gated network expansion to understand the earliest stages of enzyme evolution. The model predicts that α/β folds were predominant in early enzymes, driving metabolic reactions.
A new framework predicts AIE behavior using quantum chemical calculations, identifying key structural factors that control excited-state dynamics. The framework enables rational design of luminescent AIE materials for applications like OLEDs, bioimaging, and sensors.
A study published in Advanced Materials Interfaces reveals that proteins with exposed arginine residues selectively accumulate on protein-resistant coatings, compromising biocompatibility of medical devices. Researchers developed a new design guideline for predicting and controlling protein corona formation at the molecular level.
Researchers developed a new approach to multi-camera identity tracking by combining camera geometry and visual appearance. The method achieved high IDF1 scores on benchmarks, demonstrating improved tracking continuity across different environments, but highlighted limitations in detecting people in severe occlusion.
Researchers have discovered a simple ball-milling process that enhances the antiviral activity of manganese-based oxides, improving their ability to inactivate enveloped viruses like SARS-CoV-2. The findings suggest a promising strategy for designing low-cost, high-performance antiviral materials.
Researchers developed a spatially programmable microfluidic chip for temperature-controlled separation of particles of multiple sizes in a single device. The device successfully separated multiple particle populations and isolated viable cancer cells, white blood cells, and red blood cells from diluted whole blood.
Researchers have discovered that iron hydride may become superionic under Earth's inner-core conditions, with hydrogen moving through a solid iron lattice. This finding provides new insights into the composition and dynamics of Earth's deep interior, and has implications for our understanding of the core's formation and evolution.
Researchers used AI and geometric morphometrics to analyze 243 historic vessels, tracking changes in shape and function over time. The study reveals that Edo-period
Researchers at Science Tokyo have developed anthracene-based self-assembling nanofibers that enable excitons to migrate hundreds of nanometers, doubling exciton diffusivity. This breakthrough overcomes the limited diffusivity of singlet excitons in organic semiconductors, offering a new strategy for improving optoelectronic technologies.
Researchers from Institute of Science Tokyo and Kyoto University created hierarchical DNA networks using DNA polymerase and kinesin nanomachines. The study demonstrates the importance of active molecular motion in network formation, a step toward materials that assemble and organize themselves like living systems.
Copper sulfide catalysts reconstruct their surface during Potential-Step electrolysis, producing compounds like formic acid and suppressing hydrocarbon formation. Sulfur and oxygen play distinct roles, promoting hydrogen adsorption and generating neighboring Cu0/Cu+ sites for carbon–carbon bond formation.
A study from Institute of Science Tokyo reveals how histone variants direct DNA methylation to jumping genes, preventing accidental gene silencing in plants. This molecular framework enables plant cells to distinguish transposons from genes, ensuring precise epigenetic regulation across the genome.
A team of researchers from Institute of Science Tokyo has developed a novel, one-step synthesis method for producing highly active nickel-cerium oxide catalysts. These catalysts achieve outstanding methanation performance while being suitable for large-scale production, offering a practical route toward carbon-neutral fuel technologies.
Researchers developed a novel semiconductor integration platform, BBCube, combining advanced chip packaging, high-density interconnects, and improved thermal management. This enables more precise chip placement, faster communication, and efficient cooling for powerful and energy-efficient AI accelerators.
A high-throughput ceramic processing method using cellulose nanofiber dispersions enables rapid exploration of dielectric materials. The researchers identified a dielectric ceramic with excellent temperature stability, demonstrating its potential in advanced functional materials.
Researchers explored how the term Busseiron, meaning 'theory of the properties of matter,' became an established discipline in Japan. The study found that its scope expanded over time, absorbing new topics and forming a durable branch of physics.
Researchers developed a compact antenna-in-package wireless module that achieves 144 Gbps data transmission in the 150 GHz sub-terahertz band, paving the way for future 6G devices. The technology uses phased-array transceivers and dual-polarized MIMO to increase communication efficiency and capacity.
Scientists have developed an innovative platform to mechanically control circularly polarized luminescence, a phenomenon essential for next-generation technologies. The team created a supramolecular mechanophore that reversibly switches CPL on and off using force-induced swelling with solvents.
Researchers at Institute of Science Tokyo developed strategies to overcome xenophagocytosis, which eliminates living donor cells in interspecies organ generation. By blocking this response, they significantly improved donor cell survival and generated rat pancreas in mice.
Researchers developed a theoretical framework explaining unusual conduction behavior in magnetic materials. Quantum fluctuations affect electron transport in chiral magnets, leading to logarithmic temperature dependence at low temperatures.
Researchers at Science Tokyo developed iron-substituted calcium titanate as an environmentally friendly support material for chemical looping. The material improves CO2 conversion by accelerating ion and electron transport, enabling scalable carbon recycling with abundant, low-cost elements.
A transient electronic state plays a key role in the formation of a photoinduced hidden state in a metal–organic framework, which can be controlled with light for future applications. The study provides new insights into designing materials with novel optical properties.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
Researchers found that alternating periods of nutrient-rich conditions and starvation can stabilize a self-destructive survival strategy in yeast, allowing it to persist for hundreds of millions of years. This theory suggests that changing environments play a crucial role in shaping the evolution of complex ecological strategies.
Researchers at Science Tokyo develop a Ramsey-based magnetometer that overcomes thermal limitations, enabling close-proximity detection of weak biomagnetic signals. The sensor achieves high sensitivity and safe operation near biological tissue.
Researchers found that genetic adaptations for a fruit-rich diet preceded the evolution of elaborate courtship displays in manakins. This adaptation allowed birds to detect energy-rich fruits, enabling them to support the energetic costs of performing complex behaviors.