Researchers developed a flexible metal–organic framework, APF-40, to analyze large pharmaceutical molecules with complex structures. The framework enables the determination of structures from microgram-scale samples, aiding drug discovery and natural products research.
A simple blending strategy enables reversible fluorescence in block copolymers, allowing visualization of mechanical stress without altering material properties. The approach preserves mechanical properties and offers a practical route for stress-sensing functions in existing polymer materials.
Researchers have discovered the underlying mechanism of Atg2-mediated lipid transfer in autophagy, revealing two distinct mechanisms that enable proper growth of the autophagosomal membrane. The phosphorylation of a specific region of Atg2, mediated by Atg1, enables its binding to the endoplasmic reticulum and subsequent lipid transfer.
Researchers created a predictive model called enzyme-gated network expansion to understand the earliest stages of enzyme evolution. The model predicts that α/β folds were predominant in early enzymes, driving metabolic reactions.
A new framework predicts AIE behavior using quantum chemical calculations, identifying key structural factors that control excited-state dynamics. The framework enables rational design of luminescent AIE materials for applications like OLEDs, bioimaging, and sensors.
A study published in Advanced Materials Interfaces reveals that proteins with exposed arginine residues selectively accumulate on protein-resistant coatings, compromising biocompatibility of medical devices. Researchers developed a new design guideline for predicting and controlling protein corona formation at the molecular level.
Researchers developed a new approach to multi-camera identity tracking by combining camera geometry and visual appearance. The method achieved high IDF1 scores on benchmarks, demonstrating improved tracking continuity across different environments, but highlighted limitations in detecting people in severe occlusion.
Researchers have discovered a simple ball-milling process that enhances the antiviral activity of manganese-based oxides, improving their ability to inactivate enveloped viruses like SARS-CoV-2. The findings suggest a promising strategy for designing low-cost, high-performance antiviral materials.
Researchers developed a spatially programmable microfluidic chip for temperature-controlled separation of particles of multiple sizes in a single device. The device successfully separated multiple particle populations and isolated viable cancer cells, white blood cells, and red blood cells from diluted whole blood.
Researchers have discovered that iron hydride may become superionic under Earth's inner-core conditions, with hydrogen moving through a solid iron lattice. This finding provides new insights into the composition and dynamics of Earth's deep interior, and has implications for our understanding of the core's formation and evolution.
Researchers used AI and geometric morphometrics to analyze 243 historic vessels, tracking changes in shape and function over time. The study reveals that Edo-period
Researchers at Science Tokyo have developed anthracene-based self-assembling nanofibers that enable excitons to migrate hundreds of nanometers, doubling exciton diffusivity. This breakthrough overcomes the limited diffusivity of singlet excitons in organic semiconductors, offering a new strategy for improving optoelectronic technologies.
Researchers from Institute of Science Tokyo and Kyoto University created hierarchical DNA networks using DNA polymerase and kinesin nanomachines. The study demonstrates the importance of active molecular motion in network formation, a step toward materials that assemble and organize themselves like living systems.
Copper sulfide catalysts reconstruct their surface during Potential-Step electrolysis, producing compounds like formic acid and suppressing hydrocarbon formation. Sulfur and oxygen play distinct roles, promoting hydrogen adsorption and generating neighboring Cu0/Cu+ sites for carbon–carbon bond formation.
A study from Institute of Science Tokyo reveals how histone variants direct DNA methylation to jumping genes, preventing accidental gene silencing in plants. This molecular framework enables plant cells to distinguish transposons from genes, ensuring precise epigenetic regulation across the genome.
A team of researchers from Institute of Science Tokyo has developed a novel, one-step synthesis method for producing highly active nickel-cerium oxide catalysts. These catalysts achieve outstanding methanation performance while being suitable for large-scale production, offering a practical route toward carbon-neutral fuel technologies.
Researchers developed a novel semiconductor integration platform, BBCube, combining advanced chip packaging, high-density interconnects, and improved thermal management. This enables more precise chip placement, faster communication, and efficient cooling for powerful and energy-efficient AI accelerators.
A high-throughput ceramic processing method using cellulose nanofiber dispersions enables rapid exploration of dielectric materials. The researchers identified a dielectric ceramic with excellent temperature stability, demonstrating its potential in advanced functional materials.
Researchers explored how the term Busseiron, meaning 'theory of the properties of matter,' became an established discipline in Japan. The study found that its scope expanded over time, absorbing new topics and forming a durable branch of physics.
Researchers developed a compact antenna-in-package wireless module that achieves 144 Gbps data transmission in the 150 GHz sub-terahertz band, paving the way for future 6G devices. The technology uses phased-array transceivers and dual-polarized MIMO to increase communication efficiency and capacity.
Scientists have developed an innovative platform to mechanically control circularly polarized luminescence, a phenomenon essential for next-generation technologies. The team created a supramolecular mechanophore that reversibly switches CPL on and off using force-induced swelling with solvents.
Researchers at Institute of Science Tokyo developed strategies to overcome xenophagocytosis, which eliminates living donor cells in interspecies organ generation. By blocking this response, they significantly improved donor cell survival and generated rat pancreas in mice.
Researchers developed a theoretical framework explaining unusual conduction behavior in magnetic materials. Quantum fluctuations affect electron transport in chiral magnets, leading to logarithmic temperature dependence at low temperatures.
Researchers at Science Tokyo developed iron-substituted calcium titanate as an environmentally friendly support material for chemical looping. The material improves CO2 conversion by accelerating ion and electron transport, enabling scalable carbon recycling with abundant, low-cost elements.
A transient electronic state plays a key role in the formation of a photoinduced hidden state in a metal–organic framework, which can be controlled with light for future applications. The study provides new insights into designing materials with novel optical properties.
A new liquid-based platform called 'floatony' can form and maintain complex three-dimensional microbial structures while preserving molecular diffusion, spatial structures, and cell mobility. This approach could offer new ways to study gut microbiota, biofilms, and other spatially organized microbial communities.
Researchers found that alternating periods of nutrient-rich conditions and starvation can stabilize a self-destructive survival strategy in yeast, allowing it to persist for hundreds of millions of years. This theory suggests that changing environments play a crucial role in shaping the evolution of complex ecological strategies.
Researchers at Science Tokyo develop a Ramsey-based magnetometer that overcomes thermal limitations, enabling close-proximity detection of weak biomagnetic signals. The sensor achieves high sensitivity and safe operation near biological tissue.
Researchers found that genetic adaptations for a fruit-rich diet preceded the evolution of elaborate courtship displays in manakins. This adaptation allowed birds to detect energy-rich fruits, enabling them to support the energetic costs of performing complex behaviors.
Researchers discovered that brain regions switch between shared and independent timing, allowing for flexibility in coordination. This finding provides a new framework for understanding how brain regions communicate and enables the development of brain-inspired artificial intelligence and robotic control systems.
A new layered crystal, TlFe1.6Se2, combines high thermoelectric power factor with exceptionally low thermal conductivity, offering a promising strategy for designing next-generation thermoelectric materials. The material's unique electronic properties and Fe-vacancy ordering enhance its performance.
Researchers develop air-stable surface electrene, BaSiN2:O, with ultralow work function and freely floating electrons. This material catalyzes ammonia synthesis under mild conditions, overcoming previous air instability limitations.
Reducing carbon dioxide concentration improves microbial production of biodegradable plastic, such as poly[(R)-3-hydroxybutyrate]. Lower CO2 levels trigger adaptive cellular responses that enhance carbon utilization efficiency.
Researchers developed a rapid biosensor for detecting polystyrene nanoparticles, enabling direct detection without labeling or extensive sample preparation. The device can detect particles as small as 50 nm in fresh water and has a low detection limit of 1.3 μg/mL.
Researchers identified ZFP384 as a key factor in diminishing microglial reparative functions after stroke. By blocking ZFP384, the study found that microglia retained their reparative properties, leading to enhanced remyelination and synaptic plasticity, and improved long-term neurological function.
Researchers demonstrate reversible switching of helimagnetic order by manipulating the polarity of an electric current under an applied magnetic field. The study provides a principle for controlling complex magnetic order using electric currents, advancing fundamental understanding of helimagnets.
Researchers develop a new strategy for producing negative thermal expansion (NTE) materials, enabling safer and more efficient synthesis. The approach combines reverse coprecipitation with oxidation in a single step, eliminating the need for harsh chemicals and reducing environmental impact.
Researchers from Institute of Science Tokyo have created a compact 300-GHz-band 4×4 bi-directional phased-array transceiver in 65-nm CMOS, achieving significant advancements in 6G wireless communication. The transceiver operates over 240–270 GHz and consumes only 26 mW per element.
Researchers at Institute of Science Tokyo developed a new transceiver that solves self-interference in full-duplex wireless systems, doubling spectrum efficiency and reducing complexity. The design enables simultaneous transmission and reception using time-division switching strategy.
A team of researchers from Science Tokyo has developed a new method to reversibly switch the chirality of semiconductor materials using electrochemistry. This innovation enables the creation of spin-polarized currents in layered non-chiral semiconductors, opening up new directions for developing ultrafast and energy-efficient devices.
Researchers developed a tandem neural network that rapidly infers key semiconductor material properties from simple transistor measurements, outperforming conventional approaches. The system produces results in under one millisecond with near-perfect accuracy.
Researchers developed a compact aperture-adjustable antenna that maintains strong performance across the 57–71 GHz 5G band and improves signal strength by up to 62.2% at both lower and upper-band-edge frequencies. The system achieves data transmission speeds of up to 56 Gb/s, supporting future Beyond 5G and 6G applications.
Researchers discovered Paneth cell metaplasia can act as a protective response in ulcerative colitis by promoting healing and regeneration of the intestinal lining through REG3A. However, persistent changes may still carry risks, including increased cancer risk.
Researchers from Institute of Science Tokyo found that postbiotic foods can improve gum health in adults with mild gingivitis, reducing gum bleeding and inflammation. The study suggests a simple way to support oral health without altering oral care habits.
Researchers developed LiON, a fluorescent reporter that visualizes biologically active iron and oxygen inside living cells. The tool revealed striking differences in iron and oxygen distribution across organs and cells, offering new opportunities to study diseases like cancer, liver disorders, and neurodegenerative conditions.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
A new method analyzes AI models' learned features to group materials by structural and spectral similarity, revealing key factors influencing material properties. This approach opens up new possibilities for designing materials with specific and useful properties.
A team of researchers at Institute of Science Tokyo found that Raman optical activity can occur in nonmagnetic, centrosymmetric crystals with ferroaxial order, which introduces an internal directional property. This effect depends on the orientation of the crystal and is linked to the direction of internal rotational order.
Researchers developed a simple blood-based assessment to evaluate high-density lipoprotein's (HDL) cholesterol removal capacity from blood vessel walls. The study linked low HDL function to high-risk coronary plaques, supporting the use of this method for predicting cardiovascular risk.
LRBA deficiency, a rare inherited condition, impairs kidney function by disrupting water and sodium balance, leading to polyuria and electrolyte abnormalities. Treatment with desmopressin may help manage excessive urination in some patients.