A study by researchers at Science Tokyo found that non-structural disaster measures in Macau significantly improved coastal resilience and reduced storm-surge impacts. The city's emphasis on evacuation guidance, communication, monitoring systems, and public awareness helped build trust and reduce disaster impacts.
Researchers developed a miniaturized human intestine model to study EV-A71 infection, revealing the virus's ability to evade the immune system and persist for extended periods. The model showed long-term viral replication without triggering a strong immune response.
Researchers found that traumatic occlusion combined with periodontitis leads to significant bone loss due to upregulated inflammatory pathways. The study suggests that excessive bite force does not directly cause damage but exacerbates existing dysregulation, making clinical applications of occlusal adjustment in treatment more relevant.
Researchers introduce phosphonate ester groups into conductive polymer films to balance electronic charge transport and ion transport, improving OECT performance. The approach enables precise tuning of polymer properties without redesigning monomers.
Researchers at Institute of Science Tokyo genetically engineer cyanobacteria to produce sulfated polysaccharides, a sustainable route for manufacturing biomaterials. The study demonstrates the feasibility of engineering complex biosynthetic pathways in photosynthetic organisms.
Researchers have developed a single device that can harvest light and emit bright visible light, achieving high efficiency in both power conversion and electroluminescence. The device uses a novel organic semiconductor material with controlled energy flow, enabling it to operate at standard lithium-ion battery voltages.
Researchers have developed a new computational workflow combining generative AI with atomistic simulations to identify promising platinum alloy catalyst structures for hydrogen fuel cells. The method produces high-performing candidates from several material combinations, addressing a longstanding challenge in catalyst design.
A new chemical pathway has been discovered that can convert amino acids into hydrogen cyanide without requiring methane. Manganese dioxide is the key mineral involved in this reaction, which occurs under a wide range of conditions resembling those of early Earth.
Researchers develop substrate design strategy to selectively promote benzidine-type sigmatropic rearrangement of nitroarenes, enabling efficient synthesis of polyfunctionalized biaryls. The method achieves high yields without expensive transition-metal catalysts or complex prefunctionalization.
Researchers from Institute of Science Tokyo developed a 5.8 GHz foldable antenna designed to provide high antenna gain while remaining compact enough for small satellites. The system aims to improve communication capabilities of small satellites used in applications such as space-based internet services and disaster monitoring.
Researchers mapped how Sox9 guides cartilage formation in mouse embryonic limbs, finding that it dynamically targets different genes depending on developmental timing and cell type. The study provides a foundation for understanding skeletal development and may contribute to future research on bone and cartilage diseases.
Researchers propose an agnostic biosignature that detects life on a population level by analyzing patterns of planetary traits and spatial relationships. This method prioritizes reliability over completeness, minimizing false positives even if it misses some life-bearing planets.
Researchers developed a wearable scent display that can blend up to eight fragrances in real time, enhancing immersive virtual experiences. The device uses advanced components to precisely control odor intensity and delivery.
Researchers developed durable nanofilm electrodes for long-term measurement of bioelectric potentials in plants, paving the way for more resilient agriculture. These electrodes can detect stress in crops early, enabling timely warnings and improving yields.
Researchers develop hybrid photocatalyst system to overcome light-induced damage in molecular catalysts, significantly improving CO2-to-formate quantum yield from 6% to over 27%. The new design ensures selective excitation of semiconductors and prevents unwanted photochemical reactions.
Researchers from Institute of Science Tokyo discovered a unique mechanism in which conventional stem cells can temporarily switch into a specialized regenerative state called revival stem cells, driving tissue repair. This process, known as fetal reversion, enables efficient regeneration without exhausting the stem cell pool.
A study by researchers at Institute of Science Tokyo has identified a key gene, DOCK10, involved in abnormal insulin secretion in insulinomas. The findings pave the way for novel diagnostic biomarkers and treatment options.
Researchers propose using swarms of pico-satellites to form a single large antenna for reliable, high-quality data transmission. This innovative solution could lead to cheaper and more reliable network coverage worldwide, especially in remote areas.
Researchers developed a 2.4 GHz wireless receiver chip that can withstand up to 500 kGy of radiation, enabling wireless control of robots in ultra-high-radiation environments. The chip's design reduces charge trapping and increases stability under high radiation exposure.
A computational method called scSurv links individual cells to patient outcomes using bulk RNA sequencing data, identifying cell populations associated with survival across several cancers. The model estimates the contributions of over 10,000 individual cells to disease risk and prognosis, providing a foundation for precision medicine.
A study using NMR, mathematical modeling and simulations reveals the role of tryptophan-rich residues in activating the human adenosine A2A receptor, a key drug target. The research provides new insights into the mechanisms of GPCR function and could lead to next-generation pharmacology.
Researchers from Institute of Science Tokyo reveal the SPP1–CD44–Hedgehog signaling pathway as a key driver of fibrosis in liver tumors, hinting at its potential as a therapeutic target. The study provides valuable insights into how liver tumors actively shape their surroundings, driving the onset and progression of fibrosis.
A new photocatalyst design using machine learning interatomic potential calculations has successfully identified suitable dopants for a novel tin oxide material. The resulting aluminum-doped material produces 16 times more hydrogen under visible light than the undoped material, paving the way for next-generation clean energy applications.
Researchers from Institute of Science Tokyo created a system that turns spoken impressions into personalized makeup colors, combining AI and projection technology. The system shows realistic makeup previews on real skin under natural light, making it easier for users to find suitable colors.
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
A new study suggests that chemical weathering beneath thick continental ice sheets may have consumed atmospheric carbon dioxide and prolonged global glaciations during the snowball Earth event. This process could have slowed atmospheric warming and delayed deglaciation, helping to explain the long durations of some snowball Earth events.
Cancer cell-derived small extracellular vesicles can be excreted into urine, according to researchers who tracked their journey in mouse models. The study reveals that glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.
Researchers developed a new catalyst strategy that uses BaSi2 as a support for nickel and cobalt to decompose ammonia at lower temperatures. This enables high hydrogen-production activity at reduced temperatures, matching the performance of ruthenium while relying on Earth-abundant metals.
Scientists at Institute of Science Tokyo have discovered how LGP2 and MDA5 work together to recognize viral RNA. The study reveals that LGP2 binds to the ends of a dsRNA molecule, recruiting MDA5 molecules behind it and forming filament-like structures, ultimately triggering an innate immune response.
Researchers identified multiple microRNAs linked to disease progression and built a model to distinguish high-risk patients with CKD. The M3V2 equation significantly outperformed conventional clinical markers in predicting both kidney decline and major cardiovascular events.
Researchers found that shrinking ferroelectric tunnel junctions significantly boosts their performance, producing larger resistance contrasts between 'ON' and 'OFF' states. This enables efficient and reliable memory technologies for emerging applications in AI, edge computing, and IoT.
Researchers show enzymes can actively shift reactions away from equilibrium, controlling directionality and fine metabolic regulation. Enzyme diffusion enables 'memory' of past reaction events, driving system to new steady state.
Researchers developed a compact, low-power FMCW radar signal generator chip for edge and IoT devices, enabling high-speed sensing and precise distance measurement. The chip successfully overcomes the trade-off between chirp speed and signal linearity, bringing us closer to a seamlessly connected 6G society.
Researchers developed antibody–drug conjugates that combine CD4 mimic and neutralizing antibodies to target HIV entry, showing seven times better efficacy than existing approaches. The strategy aims to block HIV before it enters the host cell, offering a more targeted therapeutic profile and potentially reducing adverse effects.
A recent study reveals that hydration and terminal chemistry of poly(ethylene) glycol (PEG) polymers influence immune recognition, providing insights into why some PEGylated drug coatings fail to evade the immune system. The findings pave the way for novel drug coatings with improved performance.
Researchers developed an AI-driven pipeline to create functional intracellular antibodies, overcoming major barriers in intrabody development. The approach successfully redesigned structures compatible within the cellular environment, enabling high target specificity and stability.
A new ceramic material overcomes long-standing limits in proton conductivity, achieving record-high performance at intermediate temperatures. The innovative donor co-doping strategy combines increased proton concentration and mobility with chemical stability under various environments.
Researchers developed a light-sensitive oligonucleotide probe that selectively detects 5-formylcytosine, an epigenetically important intermediate. The probe demonstrates stable cross-linking with 5fC across various conditions, enabling its detection in target DNA and complex biological samples.
Researchers discovered that ATG triggers rapid clotting and inflammation in the liver by activating a complement activation system and TGF-β pathway, leading to severe side effects. The study used human organoid models and imaging analysis to reveal the biphasic mechanism of ATG-induced liver injury.
Researchers achieve highly regio-, stereo-, and enantioselective 1,6-addition of aliphatic Grignard reagents to α,β,γ,δ-unsaturated carbonyl compounds using an iron catalyst with a chiral N-heterocyclic carbene ligand. The achievement offers new opportunities for drug discovery, materials chemistry, and fine-chemical synthesis.
Researchers at Science Tokyo discover that a single amino acid deletion in the antibody's lower hinge transforms it into a stable half-IgG1 molecule with altered immune activity. This finding provides a blueprint for engineering next-generation antibody therapies.
Research suggests that lower oral microbiota diversity is associated with poorer cognitive function in people with schizophrenia. The study also identified specific microbial metabolic pathways potentially linked to this relationship.
A team of researchers has observed the Einstein–de Haas effect in a Bose–Einstein condensate, demonstrating the transfer of angular momentum from atomic spins to fluid motion. This finding highlights the conservation of angular momentum between microscopic spin and macroscopic mechanical rotation in the quantum world.
Researchers developed a miniaturized solid oxide fuel cell microreactor to power edge devices like drones and AI hardware with high energy density. The device features an innovative structural design with thermal insulation and a multilayered insulation system, solving thermal stress and safety concerns.
Researchers from Mitsubishi Electric and University of Tsukuba discovered a defect complex that generates free electrons when hydrogen is present, improving IGBTs efficiency by up to 20% in power loss. The mechanism could also be applied to ultra-wide bandgap materials.
A team of researchers from Institute of Science Tokyo developed a novel enzyme, MAN, that efficiently converts common nucleotide substrates into RNA nucleotides with remarkable efficiency. This method simplifies the production of RNA building blocks by using inexpensive and stable polyphosphate as a phosphate donor.
Researchers developed an AI model called DiaCardia that accurately identifies individuals with prediabetes using only ECG data. The model achieves impressive accuracy and generalizability, even in single-lead ECG data, opening possibilities for home-based screening.
A new study suggests that physical properties guided life before genes did. Phospholipids with more unsaturated bonds were more likely to merge and grow under freeze-thaw cycles.
Researchers present novel theoretical framework explaining non-monotonic temperature dependence and sign reversal of chirality-related AHE in highly conductive metals. The study reveals clear picture of unusual transport phenomena, forming foundation for rational design of next-generation spintronic devices and magnetic quantum materials.
A new 3D model of the fault beneath the Marmara Sea reveals where a future major earthquake could take place, helping improve earthquake forecasts. The study uses magnetotelluric measurements to identify distinct high-resistivity and low-resistivity zones, shedding light on ongoing processes of fault mechanics.