Researchers discovered that brain regions switch between shared and independent timing, allowing for flexibility in coordination. This finding provides a new framework for understanding how brain regions communicate and enables the development of brain-inspired artificial intelligence and robotic control systems.
A new layered crystal, TlFe1.6Se2, combines high thermoelectric power factor with exceptionally low thermal conductivity, offering a promising strategy for designing next-generation thermoelectric materials. The material's unique electronic properties and Fe-vacancy ordering enhance its performance.
Researchers develop air-stable surface electrene, BaSiN2:O, with ultralow work function and freely floating electrons. This material catalyzes ammonia synthesis under mild conditions, overcoming previous air instability limitations.
Reducing carbon dioxide concentration improves microbial production of biodegradable plastic, such as poly[(R)-3-hydroxybutyrate]. Lower CO2 levels trigger adaptive cellular responses that enhance carbon utilization efficiency.
Researchers developed a rapid biosensor for detecting polystyrene nanoparticles, enabling direct detection without labeling or extensive sample preparation. The device can detect particles as small as 50 nm in fresh water and has a low detection limit of 1.3 μg/mL.
Researchers identified ZFP384 as a key factor in diminishing microglial reparative functions after stroke. By blocking ZFP384, the study found that microglia retained their reparative properties, leading to enhanced remyelination and synaptic plasticity, and improved long-term neurological function.
Researchers demonstrate reversible switching of helimagnetic order by manipulating the polarity of an electric current under an applied magnetic field. The study provides a principle for controlling complex magnetic order using electric currents, advancing fundamental understanding of helimagnets.
Researchers develop a new strategy for producing negative thermal expansion (NTE) materials, enabling safer and more efficient synthesis. The approach combines reverse coprecipitation with oxidation in a single step, eliminating the need for harsh chemicals and reducing environmental impact.
Researchers from Institute of Science Tokyo have created a compact 300-GHz-band 4×4 bi-directional phased-array transceiver in 65-nm CMOS, achieving significant advancements in 6G wireless communication. The transceiver operates over 240–270 GHz and consumes only 26 mW per element.
Researchers at Institute of Science Tokyo developed a new transceiver that solves self-interference in full-duplex wireless systems, doubling spectrum efficiency and reducing complexity. The design enables simultaneous transmission and reception using time-division switching strategy.
A team of researchers from Science Tokyo has developed a new method to reversibly switch the chirality of semiconductor materials using electrochemistry. This innovation enables the creation of spin-polarized currents in layered non-chiral semiconductors, opening up new directions for developing ultrafast and energy-efficient devices.
Researchers developed a tandem neural network that rapidly infers key semiconductor material properties from simple transistor measurements, outperforming conventional approaches. The system produces results in under one millisecond with near-perfect accuracy.
Researchers developed a compact aperture-adjustable antenna that maintains strong performance across the 57–71 GHz 5G band and improves signal strength by up to 62.2% at both lower and upper-band-edge frequencies. The system achieves data transmission speeds of up to 56 Gb/s, supporting future Beyond 5G and 6G applications.
Researchers discovered Paneth cell metaplasia can act as a protective response in ulcerative colitis by promoting healing and regeneration of the intestinal lining through REG3A. However, persistent changes may still carry risks, including increased cancer risk.
Researchers from Institute of Science Tokyo found that postbiotic foods can improve gum health in adults with mild gingivitis, reducing gum bleeding and inflammation. The study suggests a simple way to support oral health without altering oral care habits.
Researchers developed LiON, a fluorescent reporter that visualizes biologically active iron and oxygen inside living cells. The tool revealed striking differences in iron and oxygen distribution across organs and cells, offering new opportunities to study diseases like cancer, liver disorders, and neurodegenerative conditions.
Researchers at Institute of Science Tokyo have developed a novel culture system to produce stable, scalable, and low-cost clinical-grade intestinal organoids from patient biopsy samples. The innovative approach uses clinical-grade collagen and synthetic peptides to enhance growth and improve scalability.
A new method analyzes AI models' learned features to group materials by structural and spectral similarity, revealing key factors influencing material properties. This approach opens up new possibilities for designing materials with specific and useful properties.
A team of researchers at Institute of Science Tokyo found that Raman optical activity can occur in nonmagnetic, centrosymmetric crystals with ferroaxial order, which introduces an internal directional property. This effect depends on the orientation of the crystal and is linked to the direction of internal rotational order.
Researchers developed a simple blood-based assessment to evaluate high-density lipoprotein's (HDL) cholesterol removal capacity from blood vessel walls. The study linked low HDL function to high-risk coronary plaques, supporting the use of this method for predicting cardiovascular risk.
LRBA deficiency, a rare inherited condition, impairs kidney function by disrupting water and sodium balance, leading to polyuria and electrolyte abnormalities. Treatment with desmopressin may help manage excessive urination in some patients.
A study by researchers at Science Tokyo found that non-structural disaster measures in Macau significantly improved coastal resilience and reduced storm-surge impacts. The city's emphasis on evacuation guidance, communication, monitoring systems, and public awareness helped build trust and reduce disaster impacts.
Researchers developed a miniaturized human intestine model to study EV-A71 infection, revealing the virus's ability to evade the immune system and persist for extended periods. The model showed long-term viral replication without triggering a strong immune response.
Researchers found that traumatic occlusion combined with periodontitis leads to significant bone loss due to upregulated inflammatory pathways. The study suggests that excessive bite force does not directly cause damage but exacerbates existing dysregulation, making clinical applications of occlusal adjustment in treatment more relevant.
Researchers introduce phosphonate ester groups into conductive polymer films to balance electronic charge transport and ion transport, improving OECT performance. The approach enables precise tuning of polymer properties without redesigning monomers.
Researchers at Institute of Science Tokyo genetically engineer cyanobacteria to produce sulfated polysaccharides, a sustainable route for manufacturing biomaterials. The study demonstrates the feasibility of engineering complex biosynthetic pathways in photosynthetic organisms.
Researchers have developed a single device that can harvest light and emit bright visible light, achieving high efficiency in both power conversion and electroluminescence. The device uses a novel organic semiconductor material with controlled energy flow, enabling it to operate at standard lithium-ion battery voltages.
Researchers have developed a new computational workflow combining generative AI with atomistic simulations to identify promising platinum alloy catalyst structures for hydrogen fuel cells. The method produces high-performing candidates from several material combinations, addressing a longstanding challenge in catalyst design.
A new chemical pathway has been discovered that can convert amino acids into hydrogen cyanide without requiring methane. Manganese dioxide is the key mineral involved in this reaction, which occurs under a wide range of conditions resembling those of early Earth.
Researchers develop substrate design strategy to selectively promote benzidine-type sigmatropic rearrangement of nitroarenes, enabling efficient synthesis of polyfunctionalized biaryls. The method achieves high yields without expensive transition-metal catalysts or complex prefunctionalization.
Researchers from Institute of Science Tokyo developed a 5.8 GHz foldable antenna designed to provide high antenna gain while remaining compact enough for small satellites. The system aims to improve communication capabilities of small satellites used in applications such as space-based internet services and disaster monitoring.
Researchers mapped how Sox9 guides cartilage formation in mouse embryonic limbs, finding that it dynamically targets different genes depending on developmental timing and cell type. The study provides a foundation for understanding skeletal development and may contribute to future research on bone and cartilage diseases.
Researchers propose an agnostic biosignature that detects life on a population level by analyzing patterns of planetary traits and spatial relationships. This method prioritizes reliability over completeness, minimizing false positives even if it misses some life-bearing planets.
Researchers developed a wearable scent display that can blend up to eight fragrances in real time, enhancing immersive virtual experiences. The device uses advanced components to precisely control odor intensity and delivery.
Researchers developed durable nanofilm electrodes for long-term measurement of bioelectric potentials in plants, paving the way for more resilient agriculture. These electrodes can detect stress in crops early, enabling timely warnings and improving yields.
Researchers develop hybrid photocatalyst system to overcome light-induced damage in molecular catalysts, significantly improving CO2-to-formate quantum yield from 6% to over 27%. The new design ensures selective excitation of semiconductors and prevents unwanted photochemical reactions.
Researchers from Institute of Science Tokyo discovered a unique mechanism in which conventional stem cells can temporarily switch into a specialized regenerative state called revival stem cells, driving tissue repair. This process, known as fetal reversion, enables efficient regeneration without exhausting the stem cell pool.
A study by researchers at Institute of Science Tokyo has identified a key gene, DOCK10, involved in abnormal insulin secretion in insulinomas. The findings pave the way for novel diagnostic biomarkers and treatment options.
Researchers propose using swarms of pico-satellites to form a single large antenna for reliable, high-quality data transmission. This innovative solution could lead to cheaper and more reliable network coverage worldwide, especially in remote areas.
Researchers developed a 2.4 GHz wireless receiver chip that can withstand up to 500 kGy of radiation, enabling wireless control of robots in ultra-high-radiation environments. The chip's design reduces charge trapping and increases stability under high radiation exposure.
A computational method called scSurv links individual cells to patient outcomes using bulk RNA sequencing data, identifying cell populations associated with survival across several cancers. The model estimates the contributions of over 10,000 individual cells to disease risk and prognosis, providing a foundation for precision medicine.
A study using NMR, mathematical modeling and simulations reveals the role of tryptophan-rich residues in activating the human adenosine A2A receptor, a key drug target. The research provides new insights into the mechanisms of GPCR function and could lead to next-generation pharmacology.
Researchers from Institute of Science Tokyo reveal the SPP1–CD44–Hedgehog signaling pathway as a key driver of fibrosis in liver tumors, hinting at its potential as a therapeutic target. The study provides valuable insights into how liver tumors actively shape their surroundings, driving the onset and progression of fibrosis.
A new photocatalyst design using machine learning interatomic potential calculations has successfully identified suitable dopants for a novel tin oxide material. The resulting aluminum-doped material produces 16 times more hydrogen under visible light than the undoped material, paving the way for next-generation clean energy applications.
Researchers from Institute of Science Tokyo created a system that turns spoken impressions into personalized makeup colors, combining AI and projection technology. The system shows realistic makeup previews on real skin under natural light, making it easier for users to find suitable colors.
Researchers developed GluBs to target ASCT2 in aggressive cancers, bypassing the LAT1 route. The agents showed efficacy in limiting tumor growth and demonstrating potential to treat cancers with limited LAT1 expression.
A new study suggests that chemical weathering beneath thick continental ice sheets may have consumed atmospheric carbon dioxide and prolonged global glaciations during the snowball Earth event. This process could have slowed atmospheric warming and delayed deglaciation, helping to explain the long durations of some snowball Earth events.
Cancer cell-derived small extracellular vesicles can be excreted into urine, according to researchers who tracked their journey in mouse models. The study reveals that glomerular cells actively transport sEVs across the filtration barrier, supporting their use in emerging urine-based cancer diagnostics.
Researchers developed a new catalyst strategy that uses BaSi2 as a support for nickel and cobalt to decompose ammonia at lower temperatures. This enables high hydrogen-production activity at reduced temperatures, matching the performance of ruthenium while relying on Earth-abundant metals.
Scientists at Institute of Science Tokyo have discovered how LGP2 and MDA5 work together to recognize viral RNA. The study reveals that LGP2 binds to the ends of a dsRNA molecule, recruiting MDA5 molecules behind it and forming filament-like structures, ultimately triggering an innate immune response.