Scientists at Gladstone Institutes and UCSF discovered a pair of genetic edits that make CAR-T cells more effective against solid tumors. The new CRISPR screening platform enables the study of gene edits on CAR-T cells inside living mice, uncovering therapeutic targets previously missed in conventional cell culture systems.
Researchers have developed an AI semiconductor device that temporarily remembers recent inputs while autonomously forgetting older information. This technology enables continuous processing of complex time-series signals without a separate reset process, representing a key innovation for low-power edge AI systems.
A 300-million-year-old event shows that volcanic activity and orbital forcing combined to trigger rapid warming. The study reveals the importance of sustained orbital forcing in triggering positive climate-carbon cycle feedbacks, leading to massive carbon release and abrupt large-scale warming.
A recent study found that maternal vaping was reported in half of the SUDI cases involving direct bed sharing, while smoking and/or vaping was present in nearly three-quarters of these cases. The researchers stress that more research is needed to establish specific risks associated with vaping during pregnancy.
Researchers have developed a new hydrogel made from peptides that can transport ions, generate electrical signals when squeezed, or interact with cells and biological molecules. The gel has tiny water channels and is electrically polarized due to its highly organized structure made from nanofibers.
Researchers at UniSC captured dolphins using shells to hunt fish off Queensland's coast, with evidence suggesting calves may learn from mothers. The behavior, called shelling, is rare and has only been documented in Western Australia before.
Researchers develop a dual-interface coordination orchestration strategy to enable high-energy aqueous zinc-iodine batteries, overcoming challenges in four-electron I chemistry. The approach improves reversibility and stabilizes the Zn electrode, leading to stable cycling and high energy density.
A major review of bird and bat collision mitigation strategies concludes that future wind energy production must balance biodiversity protection. Smarter, combined approaches are needed to maximize wildlife protection at wind farms.
In a rare study, researchers found that red-winged blackbirds consistently responded more aggressively to nonvenomous gopher snakes than venomous rattlesnakes, striking the snakes roughly half as often. The birds' unique defense strategy suggests they may be adapting to protect their nests from both types of predators.
Researchers at USC have developed a genetic tool called the Mechano-Recorder to measure tumor cell softness. This insight can help target hard-to-reach cancer stem-like cells for destruction, potentially improving cancer treatment outcomes.
Researchers have developed a new stretchable catheter that can reveal features of arterial plaque not visible with conventional imaging. The device uses electrical measurements to identify metabolically active plaques, allowing doctors to spot potentially deadly buildup before it causes a heart attack.
The KAIST research team developed an explainable AI technology that detects patterns of foreign-linked influence operations in online news comments. The model identifies 23,998 accounts exhibiting patterns consistent with public-opinion manipulation, targeting division and confrontation within Korean society.
The International Olympic Committee recommends routine screening and monitoring of elite athletes' mental health, addressing contributory factors in training and competition. The statement also emphasizes the importance of organisational culture fostering good mental health and wellbeing.
A data analysis on excess deaths was retracted by BMJ Group after concerns were raised about the quality and messaging of the research. The Princess Máxima Centre found no evidence of malicious intent or falsification of data, but concluded that the authors' explanations for excess deaths were misleading and selective.
A recent study published in the Emergency Medicine Journal found nearly 500 children were injured by e-scooters between 2019 and 2024. Most injuries occurred due to falls or collisions with vehicles, highlighting the need for clearer public health messaging and regulation.
Researchers discovered 86% of bare surface soil samples exceeded EPA's residential soil lead hazard level, with nearly 94% exceeding screening levels. In homes without interior lead-based paint, 80% of floor dust samples exceeded safety thresholds.
Dr. Lorenz Studer is known for his pioneering advances in stem cell biology, regenerative medicine, and the development of stem cell-based therapies for neurodegenerative disease.
Researchers have discovered that surface hydroxyl groups on platinum catalysts are crucial for controlling the conversion of methanol into hydrogen. The study found that hydroxyl-rich oxide supports can improve platinum-based methanol reforming catalysts, leading to higher hydrogen production rates.
A new FSU study found that a new hurricane graphic helps non-experts identify inland areas under watches and warnings, but doesn't change perceptions of risk or protective actions. The updated format also didn't improve ability to identify regions under warnings.
A study of 426 university students in Nigeria found a clear association between reported chemical exposure frequency and reported symptoms, with frequent exposure linked to oxidative stress-related symptoms. The researchers also highlight the importance of laboratory safety practices and healthy dietary habits.
After 18 years of leadership, GSA CEO James C. Appleby is stepping down, leaving behind a strong foundation for the organization's continued growth and impact. The Board of Directors will begin a national search for a new CEO to build upon this foundation and guide the organization towards emerging opportunities.
A comprehensive review of nanobiochar reveals its potential to address multiple agricultural challenges simultaneously, including nutrient retention, water holding capacity, and stress tolerance. The study highlights the need for careful risk assessment and regulatory frameworks to ensure safe deployment in sustainable farming systems.
A new study from Florida International University found that students who attended public school pre-K performed better academically through high school than those in family-based childcare. The benefits of public school pre-K persisted into adolescence and were attributed to higher-quality teachers and curricula.
The Western Fire & Forest Resilience Collaborative will adapt its research tools for grasslands and shrublands, focusing on west Texas, to better protect ecosystems and communities. The collaboration aims to quantify the impact of wildfires on water resources in Colorado and inform land management decisions.
Researchers identified two immune cell populations present in both initial and recurrent arthritis flares, suggesting an immune-memory disease. These cells may serve as biomarkers for high-risk patients or to guide targeted therapies to reduce side effects.
The competition brings seven teams together to pitch optics and photonics technologies with cash prizes and industry mentorship. Previous winners include Max-IR Labs, Advanced Optronics, and Coalesenz.
Researchers have developed a machine learning model that can help clinicians assess uncertain variants in prenatal genetic testing, providing more accurate diagnoses and clearer information for families. The approach uses tissue-agnostic episignatures to overcome limitations in epigenetic testing.
Researchers used high-resolution ultrasound to measure a statistically significant reduction of 23.8% in measured scar depth after one treatment with DC microcurrent stimulation. The study found potential implications for tissue mobility and rehabilitation, but larger controlled studies are needed to confirm durability.
A new study led by McGill University researchers found that a pan-Canadian youth mental health program saved the public healthcare system an average of $4,355 per patient annually. The program, ACCESS Open Minds, shifted care from hospitals to community-based services, reducing reliance on emergency departments and inpatient programs.
A new study found that AI-assisted proposals are four percentage points more likely to receive funding from the NIH. However, these proposals tend to resemble existing funded ideas, raising concerns about the potential for AI to steer scientific funding toward safer research.
Researchers at UH College of Pharmacy are developing breakthroughs to combat sepsis, a leading cause of hospital deaths, and diseases such as Alzheimer's and sickle cell disease. A dual-action nanomedicine has shown a 100% survival rate in preclinical trials for sepsis treatment.
Researchers built a mathematical model to understand collective movement and rest in ant colonies. The findings show that a single 'first mover' ant activates a group, triggering a wave of coordinated movement involving hundreds or thousands of workers.
Researchers developed a systematic approach to evaluate the potential of forecast-informed reservoir operations (FIRO) in watersheds across the US. Applying this framework to 32 California and Nevada reservoirs, they found that operational flexibility is generally more constrained in snowmelt-dominated rivers.
Researchers analyzed millions of high-frequency turbidity measurements to reconstruct daily sediment movement, revealing a major shift: Rivers are becoming more 'bursty', with a 20-day decrease in the time it takes to transport 90% of their annual sediment. This change can overwhelm water treatment systems and damage aquatic habitats.
The report highlights chronic underinvestment in Native American communities, with recent Trump administration cuts exacerbating the issue. The current lack of funding is particularly troubling, given increased investments during the Covid pandemic.
An international study of 58,000 adolescents found that unstructured free time is strongly associated with delinquent behavior and exposure to violence. The study, published in PLOS ONE, analyzed data from 21 countries and found that association with delinquent peers was the strongest predictor of involvement in crime.
Researchers at West Virginia University are studying loss-chasing behavior in West Virginia to identify trends and triggers that cause gamblers to place risky bets. The goal is to promote responsible gaming and consumer protection in gaming markets.
The UH Health initiative expands training, accelerates research and innovation, and improves access to care in Texas. It brings together medicine, nursing, pharmacy, optometry, psychology, social work, population health, and others under one interprofessional vision.
Researchers identified TaPGS1's role in increasing grain size by enriching flavonols, altering auxin distribution, and delaying endosperm cellularization. Flavonol accumulation was associated with increased endosperm cell number and larger grains.
A study published in the Journal of Medical Internet Research found that potential harms co-exist with opportunities for crisis support on social media platforms. Researchers are calling for more control over content and safe spaces for connection and support, with a focus on empowering young people to make informed online choices.
A Yale University study identifies a new mechanism of action for GLP-1 therapies like Ozempic, recruiting AgRP neurons to help sustain fat loss and challenge the brain's hunger circuitry. The findings provide new insights into the biology underlying these medications' long-term effects.
A new study found that patients from wealthier European countries tend to start biologic treatments earlier but stop or switch treatment earlier, experiencing lower disease activity. The study highlights the importance of ensuring timely and equitable access to effective treatment for patients with PsA and axSpA.
A new study on pizza delivery found that consumer impatience significantly influences market dynamics, reducing competition and allowing lower-quality providers to survive. Consumer impatience also limits price competition, with a 50% reduction in delivery time worth more than 20% of the order price.
Arkansas researchers used a machine-learning approach to study the organization of neighboring genes in bacteria. The novel method distinguished disease-causing strains of Enterococcus cecorum from nonpathogenic ones by analyzing how neighboring genes are organized within the bacterial genome. This new approach may provide valuable clu...
New research at ANESTHESIOLOGY 2026 reveals ketamine may ease early symptoms of postpartum depression during C-sections. Additionally, sleep medication before surgery can lead to better pain management and reduced opioid use after surgery. The event also highlights the risks associated with cannabis use during surgery.
Gennady Gor and his team will explore how petroleum-derived polymers swell and shrink, and the effects of hysteresis on their elasticity. The research aims to improve reliability in models of polymer performance and ensure consistent behavior across various applications.
The SHEA and APIC statement strongly criticizes the new executive order on childhood vaccine recommendations, arguing that it fails to rely on sound scientific evidence. The measures may lead to increased vaccine hesitancy and put Americans' lives at risk, according to experts.
Researchers from the University of Rochester's TraCe-bMPS have developed tissue chips that can predict dangerous immune reactions to cancer therapies. The technology, which uses human cells and sensors, has been accepted into the FDA's Innovative Science and Technology Approaches for New Drugs pilot program.
Researchers at CU Anschutz and CU Boulder developed a miniature microscope that allows observing and activating individual brain cells during natural movement. This advancement could accelerate research into brain behavior and neurological diseases.
A BCM-led team will receive a $10 million award over five years to build FORECAST, an integrated system to study the emergence and expansion of deadly pathogens in human populations. The project aims to identify never-before-seen relationships between deadly pathogens and environmental drivers.
The University of California San Diego and San Diego County have developed a tool to track the New World screwworm, a parasitic fly whose larvae feed on living tissue. The dashboard combines reports of confirmed detections, environmental suitability, and media coverage to estimate risk nationwide.
Researchers used high-resolution three-dimensional imaging to study the internal anatomy of sorghum leaves, revealing a complex ventilation system. The study found that reducing stomata size can increase air spaces beneath the leaf, improving CO2 distribution without compromising photosynthesis.
Researchers are seeking 450 participants to explore the health effects of adopting a vegetarian or vegan diet among younger adults with overweight or obesity. Over 12 months, participants will follow a plant-based diet and have regular health checks to measure their health outcomes.
A comprehensive global assessment reveals striking regional disparities in depression-obesity comorbidity, with countries in East Asia and Southeast Asia experiencing rapidly increasing trends. The study projects that the median prevalence of depression-obesity comorbidity will rise to 869 cases per 100,000 population by 2035.
A large prospective cohort study found that daytime light exposure is associated with a lower risk of dementia, with participants exposed to bright light levels above 1,000 lux having a 16% reduced risk. Longer durations of bright light exposure also showed significant reductions in dementia risk.
A new integrated isotope study reveals that environmental conditions, rather than human selection, drove the initial increase in cereal grain size in southwest Asia around 11,000 years ago. The research found that larger grains grew under wetter conditions, while smaller wild-sized grains grew under drier conditions.
Researchers identify H6PD as a novel causative gene for autosomal recessive Parkinson's disease, linked to disruption of ER-mitochondria connection. The study reveals that this genetic defect leads to energy failure and neuron death in dopaminergic neurons.
A single-cell atlas reveals that a balance between two macrophage states, with lipid-fueled immunesupressors, tracks clinical outcomes in gastric cancer patients. Tumors with a more permissive immune state respond better to immunotherapy and have longer progression-free survival.
The study targets microglia, brain immune cells involved in inflammation after sepsis. Evodiamine-loaded liposomes deliver anti-inflammatory treatment to the affected areas, reducing brain inflammatory signals and protecting hippocampal neurons.
Researchers discovered two families of non-Hermitian solitons, SMASs and NRDSs, differing in formation thresholds and underlying physical mechanisms. Skin-mode localization suppresses wave spreading, while band nonreciprocity enhances it, giving rise to distinct nonlinear localized states.
Astronomers have discovered water molecules in the envelope of star IRS 3, located near the supermassive black hole Sgr A*. The star's enormous envelope, fueled by rapid mass loss, has allowed water to thrive in its vicinity. This finding suggests that Sgr A* is being enriched with fundamental building blocks of life.
Researchers have discovered a new class of high-Tc superconductors among 5d transition-metal-oxides, with the highest Tc recorded at 17.8 K in ReO3. The discovery is attributed to the synergistic mechanism of pressure-enhanced orbital hybridization and oxygen-lattice-dominated electron-phonon coupling.
Researchers challenged the double water bulge model by analyzing tidal data from satellite observations. They found that only 56.84% of locations experienced low tides and 43.16% experienced high tides, contradicting the physical existence of two water bulges.
Climate change is altering the distribution of cropland nitrogen pollution in China, with emerging hotspots shifting from the south to the north. Nitrogen accumulation in soils and increased rainfall are key drivers of this shift.
Researchers at the Max Planck Institute for Chemistry have developed a new method to reconstruct daily seawater temperatures over a four-month period from single rhodoliths. The approach combines three-dimensional X-ray imaging with geochemical analyses and an algorithm to merge data from multiple branches into a continuous timeline.
A new study found that folic acid works with the enzyme ALDH1L1 to produce retinoic acid, a critical developmental signal for the nervous system. Folic acid's protective effect is lost when ALDH1L1 is disrupted, supporting its role in preventing neural tube defects.
A high-throughput ceramic processing method using cellulose nanofiber dispersions enables rapid exploration of dielectric materials. The researchers identified a dielectric ceramic with excellent temperature stability, demonstrating its potential in advanced functional materials.
In a rat model of ischemic stroke, administering rapamycin immediately after blood flow restoration reduced brain damage and improved neurological recovery. The drug's protective effects extend beyond improving circulation, suggesting additional biological mechanisms that could be targeted to improve stroke recovery.
Researchers created a programmable DNA nanodevice that penetrates lipid membranes using mechanical motion, delivering molecular cargo into synthetic cells. The device enables active control of membrane transport in space and time.
A 304-million-year-old warming event could inform scientists about rapidly changing Earth conditions. A small temperature spike led to a larger one from melting permafrost, with global sea surface temperatures rising by over 7 degrees Celsius.
The €6 million 'BabyIAXO' magnet system at the University of Bonn will search for the axion, a particle that could explain a long-standing problem in the Standard Model of particle physics. The project's success would provide proof of the axion's existence and solve the 'strong CP problem'.
Researchers found that meaning in life and healthy digital habits are strong predictors of better mental health outcomes. These factors can be strengthened through interventions, regardless of religious affiliation.
Researchers develop new CAR-T engineering strategies to address the barriers of solid tumors, including tumor access, targeting specificity, cellular resilience, and patient physiological context. The approaches aim to build cellular fitness and overcome immunosuppressive signals, with promising results in clinical trials.
A statewide study of Mississippi's public universities found that nearly 1 in 4 students gamble, with 7% showing signs of a gambling problem. Students with gambling problems are more likely to report mental health concerns.
The University of Louisville's MD-PhD program has received a federal designation and funding, enabling it to amplify its curriculum and increase the number of physician-researchers trained. The National Institutes of Health (NIH) has designated UofL's program as an elite Medical Scientist Training Program.
Researchers at CERN's Large Hadron Collider have made a groundbreaking discovery that challenges the long-standing theory of how gluons behave inside atomic nuclei. The study, led by University of Kansas physicist Daniel Tapia Takaki, used incoherent J/ψ photonuclear production to probe the underlying gluon structure with unprecedented...
Researchers have discovered that proteins released from mitochondria can activate the immune system in a similar way to invading bacteria. Elevated levels of mitochondrial proteins were found circulating in the bloodstream even when no live bacteria were present, leading to excessive inflammation.
Researchers develop pangenome-guided breeding strategy to combine beneficial genes and traits for higher yields and stress tolerance in crops. The approach identifies and reintroduces lost genetic variants from wild species, resulting in improved seed size and high-altitude adaptability.
The DOE has committed funding for UNITY-3, a cutting-edge breeding blanket test facility at ORNL, with Kyoto Fusioneering relocating its US headquarters to Tennessee. This partnership establishes a shared commercial-scale testing infrastructure to validate critical systems and train digital twins of breeding blanket concepts.
Researchers at Kaunas University of Technology have created a more stable interface between the different layers of perovskite solar cells, improving their efficiency and operational lifetime. The new concept enables large-area modules to be coated with a uniform layer, allowing for practical application testing.
Researchers developed a novel imaging approach called SANDI to study microstructural brain abnormalities associated with Huntington's disease. The model revealed differences in cell density and size, correlating with disease progression and motor performance.
The Marcus Foundation has awarded $28.7 million to advance a clinical trial testing a stem cell-based therapy designed to regenerate damaged heart tissue after a heart attack. Researchers aim to develop approaches that could reduce or eliminate the need for immunosuppressive drugs.
New research articles published in The Journal of Nuclear Medicine explore intensified PSMA-targeted therapy for advanced prostate cancer, as well as novel approaches to targeted radiopharmaceutical therapy. Studies also investigate radiation doses from PSMA-targeted therapy and their relationship with treatment outcomes, while others ...
Researchers at TU Wien and University of California San Diego have discovered a new quantum regime of coherent X-ray generation with higher energies, breaking the conventional energy cutoff limit. The effect is attributed to the interaction between two electrons in helium atoms, which release their energy simultaneously.
Recent studies from the University of Gothenburg found that nicotine use is associated with symptoms of anxiety, depression, and other mental health problems in adolescents. Girls are particularly vulnerable to these effects, including increased risk of worsening sleep problems, low mood, and difficulties concentrating.
A new study identifies a parasite-specific protein TgPRO that helps Toxoplasma manage oxidative stress and energy production in crowded cells. The findings point to a possible therapeutic strategy: inhibiting pathways controlled by TgPRO could make the parasite more vulnerable to antiparasitic drugs.
The US FDA has cleared Eve, the first self-balancing personal exoskeleton, enabling eligible adults with spinal cord injury to walk and perform daily activities hands-free. Participants reported improvements in health status, psychological well-being, and quality of life, demonstrating substantial clinical relevance.
A global study of 68 specialist music programs across 25 countries reveals a spectrum of approaches to supporting musically gifted children. The research highlights the need for balancing artistic excellence with genuine care for children, with some programs prioritizing institutional prestige over child well-being.
New research at Aston University shows that mānuka honey's effectiveness against disease-causing bacteria cannot be attributed solely to its sugar content and methylglyoxal levels. The study identified additional bioactive compounds responsible for the antimicrobial activity, which may lead to the development of more effective honey-de...
A team of researchers has developed a new way to study heart valve disorders by creating miniature, working models of the heart. The models, called assembloids, were grown from pluripotent adult stem cells and can be used to simulate various types of valve disorders, including mitral valve prolapse.
Vasanthi Jayaraman has been elected President-elect of the Biophysical Society, while Harpreet Singh will serve as Secretary. The election results also include four members elected to Council for three-year terms.
A new study published in Diabetes Care found that older adults with type 2 diabetes are at a higher fracture risk, but bone loss alone does not explain this increased risk. Researchers used a novel bone imaging device to analyze cortical and trabecular bone density, microarchitecture, and strength, and found that changes in these areas...
A McGill University-led study recommends cold-climate cities expand electric bus fleets and implement slow charging to optimize operations and reduce energy consumption. The approach aims to eliminate diesel reliance and minimize operating costs, making transit systems more cost-effective and eco-friendly.
A hybrid lifestyle program showed potential benefits for cardiometabolic health among adherent participants with obesity, but failed to achieve significant weight loss. The study suggests further investigation into the program's effects on metabolic health.
Researchers developed a computational framework called DANDELION to identify disease-driving genes in complex diseases like asthma. The study found that protein palmitoylation plays a key role in driving the disease, revealing a potential new target for future therapies.
Researchers develop two virtual culturally grounded interventions to address substance use among urban American Indian and Alaska Native emerging adults. The studies show reduced substance use, including cannabis and alcohol consumption, as well as social connections with tribal communities.
A new international study defines clinical obesity as a significant predictor of increased disease burden, operative risk, and cardiovascular risk in patients undergoing metabolic bariatric surgery. The study found that the majority of patients met criteria for clinical obesity, while a minority had preclinical obesity.
Researchers at Murdoch Children's Research Institute have developed a powerful platform to test and advance new treatments for childhood heart diseases. The breakthrough involves creating lab-grown heart valve tissues that closely resemble human body valves, providing a promising approach for regenerative medicine.
Patients with severe traumatic brain injury in resource-limited settings are at higher risk of mortality. The study highlights the need for improved acute and postdischarge care to reduce mortality rates.
Researchers at NUS engineered baker's yeast to sense and respond to red and blue light, enabling dynamic control over cellular behavior. The breakthrough uses optogenetics to deliver complex instructions without repeated chemical inducers.
Integrating improvisational theatre, mindfulness meditation, and board games into the classroom can help stabilize—and even improve—students' mental health. The most anxious participants showed a protective effect, with self-efficacy remaining stable.
Researchers developed a novel method to probe how mirror-image materials structure acts like a microscopic filter, influencing electron separation and movement. The approach allows for faster testing of promising materials for spintronics and optoelectronics technologies.
A study by King's College London has identified two types of white blood cells linked to survival outcomes for patients with melanoma. Effective immunotherapy treatment is associated with efficient B and T cell responses, while immature or poorly functioning B cell populations predict poorer outcomes.
Taylor & Francis introduces Plain Language Reviews to make technical information accessible to non-specialists. These open-access articles summarize multiple peer-reviewed articles on a single topic, empowering readers with complete understanding.
A multidisciplinary project combines computer modeling, particle science, and pharmaceutical science to create more effective inhalers for people who can't inhale deeply. Researchers found that improved designs can reduce deposition in the mouth and throat, increase penetration of particles into the lungs.
A new theory proposes that critical illness arises from loss of physiological coordination, not just organ failure. The Entropic Critical Illness Theory views living organisms as open systems with a continuous need to regulate entropy.
Researchers identified recurring metabolic changes associated with blood-brain barrier disruption, including disrupted glutamate and glutamine metabolism. These findings suggest that characteristic patterns of metabolic changes may be used to detect brain damage in the future.
Researchers found molecular signs of changes in the blood of people exposed to air pollution, detectable years before diagnosis with lung cancer. The study suggests potential biomarkers for early detection and prevention strategies.
A UCD study evaluates 43 studies on financial habits and mental illness, revealing significant gaps in current research. Objective financial data is rarely used, and traditional statistical methods dominate the field.
Researchers developed a full-color near-eye display using stacked holographic gratings, improving brightness and power efficiency. The new design enables lightweight, energy-efficient augmented reality glasses with clear virtual images in bright environments.
Researchers found that individuals who prefer sweet tastes are less willing to tolerate uncertainty, leading them to choose smaller immediate rewards. This suggests a different mechanism underlying impulsivity than previously thought.
Researchers from the University of Missouri discovered that the ratio of large and small stars in distant galaxies depends on their environment, potentially altering how scientists estimate galaxy mass and age. This breakthrough could lead to more accurate estimates and a better understanding of the universe's history.
Scientists at Cancer Research UK Scotland Institute and University of Glasgow identify a new pathway for delivering antisense oligonucleotides (ASOs) into cells, enhancing the effectiveness of ASO-based therapy for pancreatic cancer and other diseases. The researchers found that ASOs enter cells via endocytosis and bind to specific rec...
Researchers found that middle-aged individuals with a higher frequency of nocturnal micro-awakenings are more genetically prone to develop Alzheimer’s disease. In contrast, younger adults did not show this association. The study suggests that sleep analysis could complement existing tools for early identification and prevention.
A new study published in JACC suggests that waist circumference and waist-to-hip ratio provide critical information about cardiovascular risk, even among people with a normal BMI. Individuals with elevated central adiposity were associated with higher risks for most outcomes, regardless of their weight status.
A new clinical trial at HonorHealth Research Institute uses a vaccine-based on immune system dendritic cells to fight advanced melanoma. The vaccine has shown promising results in treating refractory and unresectable cases of the disease, with a 10-fold increase in immune response.
A new survey finds that opposition to local data centers has risen sharply among US adults, with 61% opposing construction in their areas. Meanwhile, views on artificial intelligence remain stable, with 39% expressing concerns about its impact.
Researchers identified seven proteins in the blood that can help diagnose Alzheimer's disease more accurately, improving treatment choices and future research. The new blood-based tests provide a clearer picture of the disease, allowing for earlier detection and better patient outcomes.
A new analysis tool helps municipalities identify areas with insufficient tree cover, enabling targeted interventions to improve livability and reduce heat exposure. The tool provides a granular diagnostic approach, allowing cities to prioritize infrastructure investments and greening initiatives where they are needed most.
A new framework, Tripartite Reactions to Emotions theory, explains how emotional posts and reviews influence perceptions of products and authors' own feelings. The theory reveals three distinct psychological reactions: pushing people toward and away from a product or brand, sometimes simultaneously.
A protein known for sensing cellular stress also acts as a cholesterol sensor in specialized immune cells, enabling them to process dying cells and maintain immune homeostasis. IRE1's removal leads to cholesterol accumulation, negatively affecting cell survival and immune function.
Researchers at UC San Diego identified a key cellular pathway that drives brain degeneration in both Sanfilippo syndrome type A and Alzheimer's disease. The study reveals how the brain's immune cells respond to waste buildup, providing a novel target for drug development.
Researchers from Tohoku University and the University of Tokyo developed super exosomes that target senescent cells, improving frailty and physical performance in aged mice. The technology has potential applications in healthy aging, cognitive function, and reproductive medicine.
The Stein Institute at UC San Diego will serve as the Central Laboratory and Biorepository for the XPRIZE Healthspan Competition. The 10 finalist teams will conduct coordinated clinical trials worldwide to test their treatment approaches, aiming for a decade-long extension of human healthspan.
Researchers found that dexamethasone reduces infection-driven macrophage metabolic activity and lowers inflammatory signals, preserving the immune system's ability to control the infection. This study suggests a new approach for managing nontuberculous mycobacterial disease.
Researchers at Mount Sinai have been selected as Milestone 2 Awardee teams in XPRIZE Healthspan, a global competition that aims to develop new approaches for healthy aging. The NYC-Vita clinical trial will evaluate lifestyle and pharmaceutical interventions designed to improve immune system function and support healthier aging.
A digital training program called Measurement-based Care Training for Resilient Implementation in a Clinical Setting (METRIC) helps clinicians consistently incorporate patient-reported outcome measures into routine care. The study found that clinicians maintained positive attitudes toward measurement-based care after completing the tra...
Researchers identified distinct axonal components, including high regenerative capacity and sympathetic nerve fibers, in painful neuromas. The formation of these neuromas is associated with increased expression of pain-related neuropeptides like calcitonin gene-related peptide (CGRP) and mechanosensitive channels.
Large language models exhibit a preference for higher-quality options first, but later options when quality decreases. Models also show unique biases in name preferences, regardless of context, making them harder to predict and prevent.
A new study found that nearly all personal care and cleaning products contained at least one unlabeled chemical with known or suspected health hazards. Products marketed as 'natural' or 'non-toxic' frequently contained undisclosed chemicals linked to health harm.
Researchers argue that policymakers in Colombia can adopt a similar cooperative strategy to solve the country's current water management crisis. The pre-Hispanic field systems of La Mojana cover an astonishing 500,000 hectares and were likely built by local communities in a short period of time through cooperation.
A Kobe University study reveals that land hermit crabs are effective seed dispersers of a non-green parasitic plant. The animals scrape off fruits with their pincers, sometimes attaching them to their bodies, allowing seeds to survive passage through the digestive tract and travel significant distances.
Researchers identified a protective subtype of microglia that expands as Alzheimer's disease progresses, playing a key role in clearing harmful material from the brain. The study provides insights into how the brain's immune cells change across the lifespan and throughout Alzheimer's disease, paving the way for therapies that strengthe...
Researchers distinguish multiple fluorescent proteins with overlapping emission colors by their lifetime using fluorescence lifetime imaging microscopy (FLIM). FLIM successfully distinguishes several fluorescent proteins with overlapping color emissions within plant cells, enabling simultaneous analysis of multiple proteins.
Physicists at the University of Basel and Technical University of Munich developed a method to study the internal behavior of Wigner crystals, a fragile quantum state. By illuminating a single atomic layer of tungsten diselenide and measuring reflected light, they observed new optical features revealing collective electron dynamics.
A comprehensive review of bipolar disorder treatments has been published, identifying the most effective treatments across different age groups and mood phases. The review has been used to update clinical guidelines and provides a platform for clinicians and patients to make informed treatment decisions based on the latest evidence.
The new Wiley Registry/NIST Mass Spectral Library expands coverage to over 1.2 million spectra, enhancing the analysis of unknown chemical compounds in GC-MS workflows. This combined resource delivers high-confidence identification capabilities for leading laboratories worldwide.
A systematic review reveals that social media has only partially fulfilled its promise to democratize climate change communication. Established actors continue to shape the discussion, while climate-change skeptics gain visibility. This undermines public debate on climate change.
The study found that LVIS stent-assisted coiling provided effective aneurysm occlusion while producing measurable hemodynamic changes and maintaining procedural safety. Treatment reduced blood-flow activity within the aneurysm, with sustained improvements at 6 months.
Researchers explored how the term Busseiron, meaning 'theory of the properties of matter,' became an established discipline in Japan. The study found that its scope expanded over time, absorbing new topics and forming a durable branch of physics.
A new review article discusses how artificial intelligence can predict disease trajectories and enable precision medicine strategies for inflammatory bowel disease. AI-based systems can standardize interpretation of endoscopic images, detect mucosal healing, and support recognition of dysplasia in patients with long-standing colitis.
A new review highlights how molecular biology advances are reframing PAH as a complex vascular remodeling disease driven by endothelial dysfunction, chronic inflammation, metabolic dysregulation, and genetic susceptibility. Emerging therapies target the BMP/TGF-β pathway, growth factor signaling, and inflammatory pathways.
Researchers developed a method to predict how different types of breast cancer will respond to treatment using lab-grown mini tumors. The organoids mimicked a tumor's response to treatment and identified candidate combination therapies for cancers that don't respond to standard treatment.
NGR Oncology has appointed multiple new leadership members to various subcommittees, including Rebecca Arend as Gynecology Oncologist Vice Chair of the Translational Science Committee and Robin Lockhorst as Chair of the Pharmacy Subcommittee. David Miyamoto was also appointed Radiation Oncology Vice Chair of the Translational Science C...
Researchers from NUS CDE have developed a computational framework that reconstructs the genealogy of vernacular architecture, including Singapore's historic shophouses. The framework generates a detailed architectural 'family network' that reveals how different styles evolved and interacted over time.
Scientists have discovered a new coral species growing up to 1 meter tall on rocky outcrops in the Pacific Ocean. The bright yellow coral was found thriving in large numbers among brittle stars and has been classified into a new family, Laurinqueidae.