A new study suggests that carefully selected patients with recurrent DIPG may experience longer survival and improved quality of life after receiving a third course of radiation therapy. The study analyzed 12 patients and found that median survival was 27 months, substantially longer than typically reported for DIPG.
The new center aims to better understand diseases and treatment response by combining human genetics and microbiome research with AI. Researchers will investigate how genetic variation and the gut microbiome jointly shape disease progression and treatment response.
The study aims to improve health and quality of life for people with sickle cell disease by understanding the impact of daily life on the disease. Researchers will measure everyday exposures, including air quality, temperature, food, and stress, to develop tools for clinicians to counsel patients.
A phase 2 clinical trial found that a monoclonal antibody targeting interleukin-6 achieved sustained reductions in inflammation biomarkers for six months in patients with chronic kidney disease. The therapy, known as pacibekitug, was well-tolerated and showed favorable effects on additional biomarkers associated with cardiovascular risk.
A chemotherapy-free combination of targeted therapies showed encouraging results in patients with HR-positive, HER2-positive metastatic breast cancer, offering a potential first-line treatment option. The regimen produced durable responses while maintaining a manageable safety profile for many patients.
Mount Sinai will deliver healthcare services to elite tennis players, focusing on promoting health and wellness, preventing injuries, and meeting community needs. The partnership highlights the importance of access to specialized medical services for athletes competing at the highest level.
Mount Sinai scientists reveal how the brain represents leader and follower roles through prefrontal cortex activity, and create an AI that decodes hidden goals behind teamwork. The study shows that leadership is an asymmetric yet bidirectional partnership, and that followers play a crucial role in maintaining cooperation.
A systematic review of 35 studies involving 2,108 patients found that patients who underwent posterior spinal fusion with posterior column osteotomies had similar overall correction compared to those who underwent PSF without PCOs. PCOs may be useful in select patients with larger or stiffer curves.
Researchers identified TIMP2 as a key factor supporting healthy microglial function in the aging brain. Restoring TIMP2 in aged mice improved microglia's ability to clear debris and reduced inflammation, suggesting potential therapeutic strategies for neurodegenerative disorders.
A study published in JAMA Otolaryngology–Head & Neck Surgery found that preoperative chemo-immunotherapy was more effective than immunotherapy alone in reducing tumor size in patients with head and neck cancer. The study analyzed data from 86 adults with head and neck cancer treated between July 2024 and March 2026, and showed that pat...
Researchers at Mount Sinai have been selected as Milestone 2 Awardee teams in XPRIZE Healthspan, a global competition that aims to develop new approaches for healthy aging. The NYC-Vita clinical trial will evaluate lifestyle and pharmaceutical interventions designed to improve immune system function and support healthier aging.
Researchers identified a protective subtype of microglia that expands as Alzheimer's disease progresses, playing a key role in clearing harmful material from the brain. The study provides insights into how the brain's immune cells change across the lifespan and throughout Alzheimer's disease, paving the way for therapies that strengthe...
Researchers have found that a combination of enfortumab vedotin and pembrolizumab helps patients with muscle-invasive bladder cancer live longer while reducing the risk of recurrence after surgery. Nearly 80% of patients who received this treatment remained free of disease progression, recurrence, or death two years after treatment began.
Researchers utilized a large healthcare system biobank to identify individuals carrying rare copy number variants linked to neurodevelopmental disorders. The study found significant value in direct phenotyping, providing practical benchmarks for implementing recall-by-genotype studies in diverse healthcare systems.
Researchers have uncovered the first high-resolution structure of NBCn2, a brain protein linked to epilepsy, autism spectrum disorder, and other neurological conditions. The team developed compounds capable of inhibiting its activity, which may help advance therapeutic research for these disorders.
Researchers identified unique antibody signatures against viruses and bacteria in nearly 2,000 blood samples collected over a decade, showing immune system changes years before diagnosis. The study supports the theory of molecular mimicry and provides an important framework for understanding IBD's earliest stages.
The new center at Mount Sinai will join the Colton Consortium for Autoimmunity, expanding research on earlier detection, precision treatment, and disease prevention for people with autoimmune diseases. The Center aims to develop more precise, effective treatments across multiple diseases by understanding shared immune pathways.
A new review proposes a roadmap for developing cognitive brain-computer interfaces to treat cognitive disorders, integrating BCI research and clinical neuromodulation. The emerging field aims to detect dysfunctional brain states and respond with adaptive neurostimulation.
A Mount Sinai study found that single-cell atlases, used for mapping the human body and training AI models, may not accurately represent global populations. The analysis of over 13,500 samples revealed an overrepresentation of European ancestry and underrepresentation of Asian and Latino individuals, highlighting the need for diverse a...
A study published in Science reveals that dendritic cells build and maintain structures called tertiary lymphoid structures (TLSs) within tumors, which serve as local command centers for the immune system. These hubs play a key role in antitumor immunity and may be a target for future therapies.
Researchers found that prenatal and early-life exposure to PFAS is associated with increased intestinal inflammation in childhood, as measured by elevated fecal calprotectin levels. This study suggests that environmental exposures during critical stages of development may influence long-term intestinal health and future inflammatory bo...
A nationwide analysis found that many radiation oncology clinics have closed, particularly in rural communities, reducing access to lifesaving cancer treatment. The study suggests that understanding which communities are most vulnerable can help policymakers develop strategies to preserve access.
Researchers at Mount Sinai will investigate biological mechanisms driving peanut allergy desensitization, identifying biomarkers for patient prediction and advancing personalized treatment strategies. The INROADS center aims to improve treatment outcomes and accessibility for patients with peanut allergy.
Researchers found that patients with Parkinson's disease showing little to no Lewy bodies despite long-standing, clinically advanced disease. The study provides new insight into the relationship between clinical symptoms and neuropathological progression.
Researchers have developed a dual-targeting strategy to combat emerging infectious diseases. A fully human monoclonal antibody cocktail provides complete protection against lethal Nipah virus infection, even when treatment is given after infection has begun.
The Mount Sinai Adolescent Health Center has received the 2026 Community Health Improvement Award from HANYS, recognizing its decades-long leadership in comprehensive, confidential, equitable care for adolescents and young adults. The award honors the Center's commitment to improving public health and advancing health equity.
The Ross Procedure offers long-term benefits and normal quality of life due to its living pulmonary valve replacement. Excellent durability and physiologic valve function are achieved, challenging traditional conceptions around the operation.
Researchers integrated social determinants of health with genetic information to predict disease risk. Social, behavioral, and environmental factors contributed as much as genetics to disease risk for four out of six studied conditions.
A new study suggests that wearable monitoring can detect cytokine release syndrome (CRS) hours before standard hospital monitoring, potentially reducing complications and improving patient outcomes. The findings support the use of wearable technology to expand access to CAR-T therapy and reduce reliance on prolonged hospital stays.
Researchers discovered blood RNA biomarkers that could support earlier diagnosis of Alzheimer's disease, potentially reducing the need for invasive tests. They identified brain-specific markers in circulating blood nanoparticles, which may offer a minimally invasive approach for diagnosing the progressive neurodegenerative disease.
Mount Sinai Health System experts will lead discussions on innovative community-based approaches to youth mental health and emerging scientific advances transforming healthspan. The conversations will explore how collaboration, research, technology, and personalized care can improve health and well-being for people across communities t...
Researchers found that Ebola virus can persist in cerebral organoids for up to 120 days, infecting various cell types, including neurons and astrocytes. The virus can trigger local inflammation and lead to disease relapses in survivors, highlighting the need for improved treatments.
A new study suggests a novel electronic health record-based marker, MLVI, can help identify transplant patients at high risk for organ rejection due to non-adherence. The study found that using MLVI as a risk marker reduced overall rejection rates by bringing them down to levels typically seen in low-risk patients.
Researchers identified distinct brain activity patterns in people with depression, which may contribute to the experience of feeling stuck. The study suggests depression involves a form of brain-state entrapment, where the brain becomes more likely to enter certain patterns of activity and less likely to transition out of them.
Researchers identified age-related genetic changes in microglia that may drive inflammation and neurodegeneration in Alzheimer's disease. Cancer-associated mutations were found in genes commonly linked to clonal hematopoiesis, promoting inflammatory activity.
Researchers used advanced MRI techniques to evaluate kidney blood flow, oxygen utilization, and inflammation in patients undergoing surgery for kidney tumors. The study found that MRI measurements could help predict both kidney function decline and the future development of chronic kidney disease.
Researchers discovered a previously unknown binding site in a cancer-related protein that could lead to more precise cancer drugs. The study reveals the power and limitations of AI tools for drug discovery, showing that even small chemical changes can dramatically alter how molecules bind to proteins.
Researchers developed a manufacturing platform for producing targeted mixtures of beneficial gut bacteria, demonstrating comparable safety and efficacy with fecal microbiota transplants. The new approach uses defined bacterial strains isolated from donor stool and grown under controlled conditions.
Researchers at Mount Sinai discovered that focused irradiation can help CAR-T cells survive longer and work more effectively inside tumors. Irradiation turns dendritic cells into a local source of stimulation for CAR-T cells, promoting durable control of advanced lung tumors.
Mount Sinai researchers have uncovered a substantial genetic component to postpartum psychosis, a rare psychiatric illness that occurs after childbirth. The study found rare damaging mutations in the HMGCR gene and significant genetic overlap with bipolar disorder, schizophrenia, and autoimmune diseases.
Deep brain stimulation (DBS) can remodel white matter pathways in the brain and alter communication across large-scale neural networks. The therapy helps patients recover from severe depression by increasing fractional anisotropy and myelination within specific pathways, suggesting a previously unrecognized mechanism.
A new study analyzes 240 health care AI-related policies, finding accelerated oversight efforts but a lack of unified framework for clinical AI deployment. Governance challenges are emerging as AI adoption accelerates, requiring strong oversight and internal governance structures.
Researchers at Mount Sinai have found that autoimmunity is responsible for the symptoms of long COVID in a subset of people. The study suggests that therapies already validated for managing autoimmunity, such as IVIG and FcRn inhibitors, could be effective in reducing symptom burden.
Researchers from Mount Sinai will present various studies on myelofibrosis, lung cancer, multiple myeloma, urothelial cancer, gynecologic cancers, and care innovation. Key findings include selinexor plus ruxolitinib in JAK inhibitor-naïve myelofibrosis and efficacy of HLX43 in advanced non-small cell lung cancer.
A study published in Nature suggests that individuals at the extremes of certain traits, such as cholesterol and blood glucose, are more likely to have rare genetic variants with larger effects. This discovery may lead to better preventive care and treatments for those with extreme trait values.
The Mount Sinai Health System has opened the Carolyn Rowan Center for Women’s Health and Wellness, which brings together multidisciplinary clinical expertise, structured care pathways, and leading-edge research to deliver personalized, comprehensive care for women. The Center offers guided multi-visit experiences and coordinated care o...
Physicians at Mount Sinai recommend a more patient-centered approach to evaluating skin toxicities in cancer treatments, prioritizing symptom burden and quality of life over treatment type. This new framework could enhance consistency across clinical trials and improve the accuracy of reporting.
Researchers created an AI model that maps how genes work together inside human cells, helping to understand biology and disease. The Gene Set Foundation Model (GSFM) learns patterns in gene groupings and interactions across thousands of biological contexts.
Experts from Mount Sinai will present a new AI model that predicts lung nodule risk and assesses the impact of air pollution during pregnancy. The researchers also explore cognitive consequences of sleep-disordered breathing and reevaluate asthma guidelines to integrate both conditions.
Researchers discovered a flexible survival strategy among beneficial gut bacteria, allowing them to switch between functional states to withstand changes. This reversible mechanism, known as 'bet-hedging,' may help explain microbiome resilience and variability.