Researchers have discovered compact viral RNA elements that can stabilize mRNA, increasing protein production. These elements, called tailons, work by extending the poly(A) tail of mRNA, slowing its degradation. This breakthrough offers a simple way to develop longer-lasting and more efficient mRNA technologies for various applications.
Researchers used CRISPR/Cas9 to eliminate the SlERF.J2 gene in tomatoes, improving drought and salt tolerance. The edited plants showed enhanced germination, root growth, and antioxidant defenses.
Researchers from the Leibniz Institute for Tropospheric Research measured sugars from seawater in the upper atmosphere over Spitsbergen, revealing their role in cloud formation and Arctic climate. The findings contribute to a better understanding of the interactions leading to above-average warming in the Arctic.
A head-to-head comparison of nine blood tests for early Alzheimer's disease revealed noticeable variations in diagnostic accuracy. The CLEAR-AD study found that seven assays demonstrated strong accuracy, while two showed lower performance, highlighting the need for platform-specific calibration.
A new framework converges soft electronics and artificial intelligence to overcome traditional sensor limitations, enabling adaptive denoising and drift-aware calibration. This synergy transforms mechanically compliant sensors into intelligent systems, achieving continuous, reliable operation in everyday settings.
Researchers classified liver cancer into three molecular subtypes based on lipid droplet-associated genes, identifying PLIN3 as a key regulator of tumor progression. The study provides insights into metabolic reprogramming and heterogeneity in HCC, offering a framework for personalized prognostic and therapeutic strategies.
Researchers at Würzburg University discovered a new approach to preventing thrombosis by reducing the density of GPVI receptors on platelets. This 'GPVI-low' phenotype maintains haemostatic function while inhibiting blood clot formation, offering a safer alternative to current treatments.
A possible biological marker of suicidal thoughts has been identified, suggesting that P2RX7 changes as suicidal thoughts become stronger or weaker. This finding may help understand why some people recover from severe suicidal thoughts, opening a new path for resilience and suicide prevention research.
The Class of 2030 includes 38 former working professionals and nearly two-thirds women, bringing skills and experiences from fields like social services, population health, traditional Chinese medicine, and engineering. This diverse cohort aims to bring a broader perspective to patient care.
Insilico Medicine introduces the Virtual Aging Cell (VAC) platform, which leverages multi-agent AI to simulate cellular processes, including differentiation, reprogramming, and aging. The VAC platform aims to support target identification, cellular fate intervention, novel drug discovery, and geroscience research.
Researchers at the University of Illinois have developed a new molecule that can replace traditional chemistry with electricity in metal recovery, reducing chemical consumption by one to two orders of magnitude. The approach simplifies the extraction cycle, making it cleaner and more energy efficient.
A new cell therapy has been developed to accelerate circadian realignment in preclinical models, reducing the time required for animals to adjust to shifts in the light-dark cycle that mimic jet lag and shift work. Encapsulated leptin-producing cells have been shown to be effective in facilitating entrainment of circadian rhythms.
A post hoc analysis of a cluster randomized clinical trial found that the Real-time Prescription Benefit Tool (RTPB) increased fill rates for high-cost medications, especially among patients from low-income communities. However, the tool's recommendations were only made for a small proportion of orders, limiting the study's applicability.
A study by Rutgers researchers found that waist circumference measures nearly as accurately as a new obesity definition incorporating multiple body measurements, identifying potential health risks earlier. Waist measurement can provide a practical tool for clinicians and patients to detect unhealthy amounts of body fat.
A cohort study of 13,585 insured patients found racial disparities in endometrial cancer survival, with greater imbalances in risk of adverse tumor types and distant disease. Younger black patients had a 43% larger disparity compared to their white counterparts.
A cohort study found that state eviction moratoria are associated with higher numbers of foster care entries across 60 US jurisdictions. The study suggests that these policies may have unintended consequences on vulnerable populations.
Researchers discovered that artesunate targets glucosylceramidase (GBA) to induce apoptosis in HCC, disrupting sphingolipid homeostasis and activating caspase-dependent signaling pathways. GBA inhibition promotes α-syn accumulation, impairing CTSD maturation and triggering mitochondrial apoptosis.
A recent study found that monocyte-derived IL-1β promotes CRC progression by activating a positive feedback loop driving EMT, tumor growth, and metastasis. The p65-KRT7-ILK axis is identified as a key regulator of CRC progression.
A new intraoperative imaging platform called ULTRA combines rapid tissue clearing, stimulated Raman scattering microscopy, and AI-based virtual staining to perform deep 3D histological imaging. This enables the visualization of key histological features across different glioma subtypes and facilitates glioma margin analysis.
A comprehensive review of surgery for necrotizing enterocolitis (NEC) in premature infants highlights the importance of preserving functional bowel, reducing long-term complications, and supporting survival with better quality of life. Emerging perioperative tools and risk scores may improve assessment and recovery.
Research published in The Journal of Nuclear Medicine highlights the importance of intermediate amyloid PET uptake in Alzheimer's disease diagnosis and its association with cognitive decline. Additionally, studies show promising results for early SPECT/CT response prediction in PSMA-positive prostate cancer treatment, as well as potent...
A new method pioneered by Vanderbilt University's Ken Lau lab is poised to make previously inaccessible medical knowledge that has been locked away in old patient samples newly accessible to scientists. The method recovers whole cells instead of only their nuclei, capturing more biological information contained within each cell.
Researchers are investigating whether beneficial bacteria can prevent the body from absorbing lead. The study aims to determine if probiotic supplements containing harmless bacteria can produce aptamers that trap lead for excretion, providing a potential solution for people in high-risk environments, especially children.
The DKMS John Hansen Research Grant supports innovative cell therapy approaches and transplant immunology. The grant enables young researchers to build a network and advance lifesaving therapies for blood cancer.
Researchers highlight unanticipated benefits of GLP-1 medications, including reduced inflammation and lower risk of certain cardiovascular and musculoskeletal conditions. However, questions remain about lean body mass and nutritional health following weight loss associated with these medications.
Researchers at the University of Wisconsin-Madison have identified a new species of endangered baobab tree, Adansonia bozy, unique to Madagascar. The discovery was made possible through genetic analysis and highlights the importance of conservation efforts for this charismatic tree species.
The University of Tennessee Herbert College of Agriculture has introduced a new Bachelor of Science in Bioinformatics program, combining biological sciences and data analytics. Graduates will enter high-demand careers with unique technical skills in precision agriculture and environmental sustainability.
Researchers identified TIMP2 as a key factor supporting healthy microglial function in the aging brain. Restoring TIMP2 in aged mice improved microglia's ability to clear debris and reduced inflammation, suggesting potential therapeutic strategies for neurodegenerative disorders.
A major European study published in PLOS One found that children from disadvantaged backgrounds are more likely to die from congenital anomalies, with the risk increasing after infancy. The research highlights the influence of social and economic factors on health outcomes, particularly in countries with lower GDP per capita.
The PolyU developed AI Virtual Patient Simulation System combines multimodal data from genomic, medical imaging and clinical records to create a digital twin model tracking real-time changes in a patient's condition. It predicts the effectiveness of different cancer treatment options and supports personalized medical solutions.
Researchers used X-band phased-array radar data to improve tornado simulation capabilities, enhancing disaster risk reduction in vulnerable regions. The study found that assimilating radar wind data strengthened the storm's spinning motion, predicting the tornado's path most accurately.
The CosmoCube satellite will use the far side of the Moon as a 'shield' to block out Earth's noise and listen for the 21-centimetre line signal from hydrogen atoms in the early universe. This signal is extremely difficult to detect with Earth-based telescopes due to interference, but the Moon provides a natural shield.
A new study from the University of Copenhagen reveals that astronauts experience changes in their gut bacteria shortly after leaving Earth and gravity behind. The researchers found increased protein fermentation, which may contribute to constipation, and suggest potential interventions for future long-duration space missions.
Researchers have discovered that cells rely on polyamines to store iron in a safe state, preventing destructive reactions. This finding has implications for cancer treatment and may offer new clues about early-onset Parkinson's disease.
A case-control study found that patients with overweight or obesity at diagnosis had better survival rates than those with normal weight. However, the apparent advantage was largely due to prediagnostic weight loss associated with cancer, and should not be taken as evidence for weight gain in healthy individuals.
A new UN University publication reveals that many people in England fail to take action to protect themselves during heatwaves despite receiving warnings. The most common reason is a lack of perception of personal risk, highlighting the need for improved communication and long-term adaptation strategies.
A new study reveals that European mountain summits are warming, leading to changes in alpine vegetation, but the link between temperature and these changes is surprisingly weak. Long-term monitoring shows that local conditions, such as the presence of warmth-associated species, play a crucial role in shaping vegetation responses.
A new AI model, EarlyDetect, can detect precursor signals of active region emergence in the Sun's acoustic activity and magnetic field, forecasting solar eruptions nearly nine hours in advance. This technology has the potential to allow satellite communications companies or power grid companies to prepare for solar storms.
A study analyzing international reporting on natural disasters found that spectacular images, high death tolls, and personal ties drive cross-border coverage. Droughts and floods, key effects of climate change, are underreported due to low newsworthiness.
The study found that epilepsy-associated disability-adjusted life years were concentrated in low- and lower-middle-income countries, with significant regional inequality. Progress has been made in China, including declining mortality rates, but challenges persist, particularly in rural areas where treatment gaps reach 60%–90%.
Researchers analyzed EBRAINS-hosted brain data to determine that whole-brain activity patterns predict stimulation outcomes better than local recordings. Targeting specific sensorimotor and visual networks reduces response variability by up to 24%. This study highlights the value of open datasets for enabling large-scale analyses.
Researchers at the University of Minnesota have discovered that low-purity iron ore from the state's Iron Range can be used to create semiconductor-quality pyrite, a process that could lead to cost-effective and sustainable applications in electronics, solar panels, batteries, and more.
Scientists create a biomimetic zona pellucida coating called BZP to mimic the natural barrier on egg cells, protecting donor islets from the immune system and reducing blood sugar levels in diabetic mice for 100 days. This approach could lead to a promising commercial cell therapy platform for treating various diseases.
Researchers at EPFL have designed acoustic cavities that convert sound waves into thrust, propelling small robots and ultralight aerial vehicles without on-board actuators or electronics. These devices utilize hollow structures to harness specific frequencies of sound waves, generating directional thrust and controlled motion.
Researchers developed an AI framework that optimizes ship routes and speed profiles to reduce fuel consumption and peak air-pollutant exposure. The system achieved 20-35% improvement in optimization performance while reducing peak pollutant exposure by 34-78%.
Researchers developed AI-powered 'tissue clocks' that estimate biological age from histological images, revealing organs age at different rates throughout life. The study identifies strong links between tissue-specific aging and medical conditions or lifestyle-associated factors.
A study of 103 European cities' climate neutral plans reveals that many rely on carbon removal to compensate for a significant portion of their emissions. Key findings include the energy and transport sectors being major contributors to residual emissions, with only 32% of cities mentioning permanent carbon removal options.
Researchers identified dormant progenitor cells in skeletal muscle that migrate to fracture sites and become bone-forming cells. Muscle is the main source of these regenerative cells, which can contribute to both normal fracture healing and heterotopic ossification.
Researchers at MIT have created a new microscope that can image electrical activity in neurons distributed across the brain, revealing patterns of neural activity from milliseconds. The technique enabled observation of single voltage spikes and rapid bursts of spikes, shedding light on how the brain is activated following a stimulus.
Researchers from the Pontificia Universidad Católica del Ecuador discovered a new species of frog, Pristimantis milpe, by reviewing historical specimens preserved at the Natural History Museum in London. The species is widely distributed and easy to detect, inhabiting the Chocó forests of western Ecuador and southern Colombia.