Researchers propose Granzyme K as a critical pathogenic node in SLE, particularly in lupus nephritis, driving inflammation and tissue damage. GZMK activates complement, drives inflammation, and disrupts vascular integrity, making it a potential target for therapy.
A real-world observational study found no significant survival benefit from post-surgery immunotherapy in NSCLC patients with pathological complete response after neoadjuvant chemoimmunotherapy. The study suggests that these patients may already derive the maximum benefit from neoadjuvant therapy alone.
A large, long-term study of 140 patients with Kikuchi-Fujimoto disease found that ANA positivity is common but transient, with minimal risk of progression to lupus or other connective tissue diseases. The study's findings provide reassuring evidence that patients with KFD can be reassured of their excellent prognosis.
Immunotherapy for gynecological tumors offers durable responses and survival benefits, but complex immune evasion mechanisms and tumor microenvironment pose challenges. Current treatment options, such as ICIs and adoptive cell therapy, show promise, but precision immunotherapy is needed to improve patient outcomes.
A 2-year multicenter cohort study found that most hospitalized survivors maintained or regained cognitive function after Omicron infection, while older and reinfected patients may face progressive decline. The study identified age, infection history, and disease severity as risk factors for progressive decline.
A prospective multicenter study found the EAP regimen delivered outstanding mobilization effects, achieving 90.8% optimal mobilization in patients. The regimen showed good clinical tolerability, with most hematological toxicities well managed, and presented a practical alternative to conventional mobilization strategies.
Researchers found that dietary tryptophan supplementation can prevent sepsis by enhancing macrophage bacterial defense through GPR37 activation, which increases phagocytic ability against bacteria. IPyA, a key metabolic product, directly binds to GPR37 on macrophages, activating RAC1/CDC42 and increasing phagocytosis.
The RENI-1 study found durable and clinically meaningful outcomes for niraparib maintenance therapy in ovarian cancer patients, with median PFS reaching 36.5 months. Long-term niraparib use was feasible, particularly in patients with BRCA1/2 mutations, and did not adversely affect quality of life.
A systematic review and meta-analysis published in Cardiology Discovery shows AI-guided spatiotemporal dispersion area ablation yields an 87% pooled 12-month freedom-from-atrial-fibrillation rate for patients living with persistent atrial fibrillation. The technique aims to standardize substrate identification while preserving patient-...
The study found that Ct-HBx upregulates PAI-1 by opening chromatin and trans-activating its expression, increasing hepatocellular carcinoma risk and prognosis. PAI-1 levels and genetic polymorphisms serve as biomarkers for predicting HCC risk and postoperative prognosis.
A new blood test detects Alzheimer's disease using plasma amyloid-β seeding activity, achieving a diagnostic accuracy exceeding 90% in the validation cohort. The test uses real-time ultrasonic protein misfolding cyclic amplification technology, marking a critical transition in AD diagnosis.
A narrative review identifies five unique clinical phenotypes for heart failure with preserved ejection fraction, guiding tailored patient care. The review highlights the importance of matching therapy to patient clinical profile for improved outcomes.
A single-arm observational study found dapagliflozin improves left ventricular ejection fraction by 19% in non-diabetic Egyptian heart failure patients. The study demonstrated significant echocardiographic improvements and a low rate of mild short-term adverse events.
Approximately 1 in 9 individuals in China will develop a digestive system cancer in their lifetime, with a staggering 1 in 12 succumbing to these diseases. The study reveals a profound 'risk transition' with colorectal cancer presenting the highest lifetime incidence risk.
This review explores the impact of tryptophan metabolism on female reproductive health, including ovarian function, fertility, and maternal-fetal health. It highlights the therapeutic potential of tryptophan metabolism in treating ovarian diseases and proposes dietary supplementation, modulation of the gut microbiota, and melatonin ant...
Researchers found that alveolar type 2 cells mount slower interferon-driven antiviral defenses than type 1 cells, enabling higher viral replication in the alveoli. This study provides new insights into the primary site of influenza virus damage and opens up potential targets for antiviral therapy.
A large-scale study in China found the prevalence of PCOS among pregnant women increased from 0.79 to 19.0 per 10,000 between 2012 and 2021, with significantly higher risks of adverse maternal and neonatal outcomes. Women with PCOS had increased risks of diabetes, hypertension, preeclampsia, and cesarean delivery, as well as fetal risk...
A new clinical framework reorients coronary disease management toward early detection and stabilization of atherosclerotic plaques. The framework proposes a risk-stratified screening pathway for adults aged 40 or older with at least one traditional cardiac risk factor.
A new review in Cardiology Discovery provides a structured clinical framework to identify and manage residual cardiovascular risks for patients surviving acute coronary syndrome. The framework groups risks into four categories and summarizes therapeutic options, emphasizing personalized risk re-evaluation for individual patients.
A comprehensive review highlights recent progress and emerging therapies for hypertrophic cardiomyopathy, including cardiac myosin inhibitors, interventional techniques, and gene-based approaches. The treatment options now offer expanded pathways for both obstructive and non-obstructive patient subgroups, but limitations and uncertaint...
A narrative perspective calls for multidimensional patient assessment beyond risk scores to address care disparities in non-ST-elevation myocardial infarction. Younger patients with ongoing ischemia may benefit from early angiography despite moderate risk scores.
Researchers review glioma microenvironment and related therapeutic strategies, highlighting the need to disrupt neuron-tumor communication and reprogram the immune landscape. This review provides a conceptual framework for next-generation therapies and marks a fundamental shift in glioma therapeutics.
The global burden of chronic kidney disease in women has grown, with 359 million cases in 2021, driving increasing mortality rates and disability-adjusted life years. Postmenopausal women and women of reproductive age are particularly vulnerable to metabolic and behavioral drivers that can be modified to reduce risk.
Researchers reviewed the impact of circadian disruptions on muscle health, finding that imbalances in protein synthesis, mitochondrial function, and inflammation accelerate muscle deterioration. Circadian-aligned lifestyle interventions and pharmacological therapies, such as REV-ERBα agonists, hold promise for mitigating the effects of...
Researchers discovered a unique macrophage subset in pneumocystis pneumonia, which exhibited strong anti-inflammatory features and activated pro-proliferative pathways. Pharmacological inhibition of the MAPK pathway reversed this expansion, reducing immune suppression and paving the way for novel treatments.
The study found that epilepsy-associated disability-adjusted life years were concentrated in low- and lower-middle-income countries, with significant regional inequality. Progress has been made in China, including declining mortality rates, but challenges persist, particularly in rural areas where treatment gaps reach 60%–90%.
The study identified RTN4IP1 as a factor associated with poor prognosis in triple-negative breast cancer, promoting metastasis through NAD⁺ depletion and disrupting glycolysis and oxidative phosphorylation. RTN4IP1 interacts with AK4 to cause this metabolic disruption.
In a rat model of ischemic stroke, administering rapamycin immediately after blood flow restoration reduced brain damage and improved neurological recovery. The drug's protective effects extend beyond improving circulation, suggesting additional biological mechanisms that could be targeted to improve stroke recovery.
A new review article discusses how artificial intelligence can predict disease trajectories and enable precision medicine strategies for inflammatory bowel disease. AI-based systems can standardize interpretation of endoscopic images, detect mucosal healing, and support recognition of dysplasia in patients with long-standing colitis.
A new review highlights how molecular biology advances are reframing PAH as a complex vascular remodeling disease driven by endothelial dysfunction, chronic inflammation, metabolic dysregulation, and genetic susceptibility. Emerging therapies target the BMP/TGF-β pathway, growth factor signaling, and inflammatory pathways.
Researchers identify a combination of classical and emerging viral biomarkers to predict functional cure in chronic hepatitis B. Multimarker models exhibit superior predictive discrimination compared to single viral markers, enabling more accurate treatment decisions.
Non-invasive approaches are expanding options for assessing portal hypertension, with elastography techniques and biochemical markers showing high sensitivity and specificity. AI-powered predictive models combine clinical data to improve diagnosis, but should not replace invasive HVPG, which remains the gold standard.
Researchers found that exercise-induced molecular changes contribute to neuronal health, improving movement and quality of life in PD patients. Exercise types such as aerobic exercises, resistance training, balance training, and multimodal exercise were found to be helpful in reducing falls, disabilities, and improving brain function.
Circulating circRNAs show high cell-type and tissue specificity, making them ideal for non-invasive cancer management. They can be detected in multiple body fluids and reflect treatment response, positioning them as functional drivers of therapy resistance.
Researchers found that bee venom can improve motor function and cognitive decline in a mouse model of Parkinson's disease when used alongside conventional therapy. The study suggests promising benefits for developing adjunct therapies to improve treatment outcomes.
A new study found that chronic pancreatitis (CP) impairs multiple quality-of-life domains, including mobility, self-care, daily activities, mental health, and pain. Employment status is a powerful protective factor, while older age correlates with milder QoL impairments.
TIGIT is a second-generation immune checkpoint that exerts immunosuppressive effects through multiple pathways, promoting a hypoxic tumor microenvironment. Combination with PD-1 inhibitors has shown remarkable promise, improving objective remission rates and progression-free survival.
Researchers highlight latest developments in pathology, diagnosis, and treatment of MASLD and IPFD, revealing correlations with chronic diseases like liver cancer and pancreatic cancer. Innovative treatments, such as AI-driven approaches and organ-targeted therapies, show promise for precision prevention and therapy.
Researchers explore contrast-enhanced ultrasonography as a safer alternative to invasive hepatic venous pressure gradient for assessing portal hypertension. CEUS uses microbubble-based ultrasound contrast agents to track blood flow through the liver and surrounding vessels.
Recent advancements in animal models, organoid models, and bioengineered organoids have provided new tools for studying primary sclerosing cholangitis. These models replicate the effects of bile retention and inflammation, enabling studies of disease mechanisms, drug screening, and preclinical evaluation.
The study found that visual occlusion triggers brain compensation characterized by enhanced functional connectivity between the right precentral and middle frontal gyri. Walking activates multiple sensorimotor pathways to support basic locomotion, and visual occlusion further strengthens this connection as a compensatory mechanism.
IEC-HS is a rare but potentially fatal complication of CAR-T therapy, characterized by sustained inflammatory response and distinct biochemical differences from CRS. Targeted therapies, such as interleukin-1 blockade, are gaining attention for its management.
A recent Chinese Medical Journal study analyzed data from 1990 to 2021, revealing a significant increase in neurological disorders such as dementia, Parkinson's disease, and ischemic stroke. The study identified a turning point coinciding with the COVID-19 pandemic, highlighting the need for coordinated national strategies to address t...
Researchers found that Rhein reduces pancreatic and intestinal damage, restores intestinal barrier integrity, and promotes repair macrophage responses. PPARγ is identified as the central mediator of Rhein's effects.
A real-world study highlights higher overall irAE incidence in lung cancer (61.0%) compared to GI tumor patients (47.9%). Skin toxicity is more frequent in GI tumors, while thyroid dysfunction prevails in lung cancer patients.
A large multicenter retrospective study found that stable gestational glucose levels and minimal fluctuations increase the likelihood of low pre-eclampsia risk. The study's key findings suggest that blood glucose management is crucial for preventing pre-eclampsia, particularly in pregnant women with no pre-pregnancy chronic conditions.
Researchers review organoid-related regulations and progress in IND approval, highlighting the prospects and limitations of organoid models. Organoids are poised to reshape drug research and development with their high clinical relevance, shorter experimental cycles, and lower costs.
Research finds GADD45B induces MST1 expression by promoting DNA demethylation, exacerbating apoptosis and intestinal injury in I/R. GADD45B/TET1/MST1 axis may represent a viable therapeutic strategy for I/R injury.
A new review proposes a prevention-focused framework for understanding Parkinson's disease risk, highlighting the role of early-life vulnerability, environmental exposures, and resilience factors. The study suggests that susceptibility to PD may begin earlier in life through interactions between biology and environment.
Researchers agree on core elements of ACLF development, including chronic liver disease triggers, acute insult, and extrahepatic organ failure. A new three-stage mouse model supports testing of potential therapies, highlighting impaired liver regeneration as a key driver of disease progression.