Researchers at Penn State College of Medicine discovered that blocking protein PIK3C3/VPS34 raises levels of GD2 on the surface of tumor cells, making them easier to detect and more vulnerable to treatment. This increase also creates a hostile environment for cancer growth.
The MARVEL microreactor project has completed key milestones, including the arrival of its primary coolant system, which has received federal safety approval. The system will now be integrated with other reactor systems before achieving criticality, expected to occur in December.
Dr. Samie Jaffrey's team will study metabolite-RNA interactions to comprehensively map and characterize their role in regulating messenger RNA levels. Their findings could lead to new therapeutic opportunities for diseases such as cancer, neurodegeneration, and metabolic disorders.
Researchers at Johns Hopkins Medicine have identified a distinct type of prostate cell concentrated in the transition zone of the prostate, where benign prostatic hyperplasia (BPH) commonly develops. The WIF1-positive basal cells may contribute to prostate enlargement and establish the unique biological environment of the transition zone.
The University of Stuttgart's SCALAR and COBRAS projects aim to increase productivity and sustainability in the construction industry with autonomous robotics. The projects will use a 'co-design' approach, integrating architecture, engineering, robotics, and computer science to create collaborative robotic systems on construction sites.
An international team of astronomers has captured the most detailed view yet of Pa 30, a supernova remnant in the Milky Way, revealing striking new features. The remnant is composed of chains of gas knots, each wide enough to fit the solar system multiple times, and a surviving 'zombie star' at its core. The discovery provides valuable...
A recent study by the HZI research team found that dietary fiber does not act alone in the gut microbiome, but rather interacts with existing bacteria to influence their growth. The presence of certain bacteria, such as Escherichia coli, can support the growth of other dominant bacteria, like Segatella copri, in the gut.
Researchers developed a novel sorbent, DPE6, to recover critical metals from organic effluents. The sorbent demonstrated high sorption performance and high maximum sorption capacity in various organic solvents. It successfully removed over 99% of lead from effluents using methanol, showcasing its potential for efficient metal recovery.
Sorghum production is expected to increase in Europe due to climate change, with potential yields of 3.4-3.8 tonnes/ha by 2050-2100. The crop's robustness in high temperatures and low water availability makes it a climate-resilient alternative to maize.
A yearlong study found that early depression and anxiety predicted later economic hardship, while financial strain went on to predict worsening depression, anxiety, and PTSD. Economic hardship was consistently associated with a higher likelihood of clinically significant depression, anxiety, and PTSD symptoms.
Binghamton University's Innovative Simulation and Practice Center has been named a SUNY Nursing Simulation Center of Excellence, receiving a $10 million investment to expand simulation space and experiences. The center will focus on faculty training and professional development in simulation-based education, addressing gaps in clinical...
A new study shows that hospitals still have far to go in implementing strategies to prevent catheter-associated urinary tract infections (CAUTIs), despite 20 years of effort. The study found that only 49% of general hospitals and 32% of VA hospitals have a system in place to remind doctors of a patient's catheter status, and that highe...
A Concordia University study demonstrates the use of simulated moon soil and recyclable thermoplastics to 3D print components for future lunar missions. The composite material, created by combining regolith with recycled poly(ether ketone ketone), showed thermal stability and improved performance.
An international study found that variants in the IDUA gene, associated with mucopolysaccharidosis type I, can cause inherited retinal disease without broader health problems. The study highlights the importance of understanding how genetic variants affect the body, potentially leading to earlier recognition and treatment opportunities.
Dr. Dennis Slamon, a pioneer in breast cancer research, has been awarded the 2026 Albany Prize for his groundbreaking work on targeted cancer treatments. His discovery of the HER2 protein and the development of Herceptin have transformed the understanding and treatment of breast cancer, saving millions of lives worldwide.
The European Cardiovascular Health Data and AI Network (CHAIN) aims to improve cardiovascular care through AI adoption. The initiative will build a federated ecosystem for the safe and effective adoption of AI and health data, enabling earlier disease detection and more consistent care.
Brenda Betancourt is evaluating record linkage uncertainty's impact on analysis reliability and evidentiary confidence in real-world data. She received $286,130 from the FDA to study regulatory frameworks for assessing record linkage uncertainty in real-world evidence.
George Mason University's Daniel Rothbart and Karina Korostelina are studying justice in Sudan amidst the civil war. The researchers have secured $96,600 in funding from the UNDP to explore ways to promote justice for the country.
Researchers Daniel Tong and Siqi Ma investigated long-term trends in windblown dust activity in Texas and three upwind states. They analyzed environmental drivers of dust trends and improved a dust emission model, quantifying contributions from in-state and out-of-state dust sources to PM2.5 and PM10.
Researchers developed an AI model that accurately flags heart transplant rejection by combining electrocardiogram readings with blood test results, potentially sparing patients from invasive biopsies. The model correctly identified 94% of patients without rejection and incorrectly flagged 19 patients with blood test results.
ICFO researchers have increased the power conversion efficiency of organic solar cells by restricting light emission angles, narrowing Boltzmann losses. This innovation enables solar cells to approach efficiencies near 43%, overcoming the Shockley-Queisser limit.
Researchers developed mouse models to study hypophosphatasia, a rare inherited condition that weakens bones and teeth. The models showed that teeth and supporting tissues can be affected even with mild skeletal changes, highlighting the need for tailored dental care.
Researchers created an electrochemical biosensor that detects subtle differences in sugars attached to protein surfaces, converting them into electrical signals for accurate diagnosis. The sensor accurately detected CSF leaks at low concentrations and reduced analysis time to 95 minutes.
Advanced wastewater treatments can intensify endocrine-disrupting effects, despite removing parent pollutants. UV irradiation and ozonation increased androgen receptor-antagonistic activity beyond a risk threshold. Integrated, effect-based assessments are needed to ensure ecological safety.
Marine worms rely on bacteria for survival, but surprisingly, they form flexible partnerships that adapt to local environments and sources of food and energy. The study reveals that these symbioses are stable within species but variable between species, allowing the worms to thrive in diverse habitats.
Researchers discovered the role of ancient peptide signals in shaping apple root regeneration, identifying a key gene MdglRGF1 that influences root development. The study provides a genetic and molecular framework for future rootstock improvement and potential applications in breeding and biotechnology.
Researchers identified two amino-acid changes that enabled the transition from a serine decarboxylase gene to an alanine decarboxylase gene, leading to theanine biosynthesis in tea plants. These changes, specifically phenylalanine at position 106 and glycine at position 168, were crucial for the enzyme's alanine-specific activity.
A multi-omics study mapped key genetic controls behind verbascoside accumulation in olive fruit, identifying a major region on chromosome 21 and candidate genes associated with high verbascoside levels. The findings could support faster selection of olive cultivars with targeted phenolic profiles and more predictable fruit-quality traits.
A new study from the University of Copenhagen found that women who frequently bend forward at work face a 36% increased risk of miscarriage. Employers are advised to consider adjusting tasks and providing a chair to reduce the risk.
A University of Córdoba team has improved the production of green hydrogen using solar energy and metal photocatalysts. The study found that copper and platinum are the most efficient metals in converting sunlight into chemical energy and producing hydrogen.
Researchers developed an iron-modified titanium dioxide electrode that removed 92.1% of nitrobenzene within two hours, with 62.4% mineralization. The iron-modified electrode enhanced pollutant interactions and increased the effectiveness of a combined treatment process.
Researchers develop analytical framework to predict when large interconnected systems will shift from steady to oscillatory states. The study shows how network complexity, propagation delays, and interaction types jointly determine transitions between steady and oscillatory states.
Research suggests marine organic particles are underrepresented in climate models, with a bimodal size distribution and a significant impact on cloud formation and radiative effects. The findings have implications for aerosol-cloud interactions and assessments of marine cloud brightening.
A research team has uncovered a key antagonistic regulatory module, GhRCD1-GhMYC3, that constrains cotton improvement. GhRCD1 promotes fiber elongation, while GhMYC3 suppresses seed vigor. The module acts as a fine-tuning rheostat, adjusting ROS concentration and pectin methylesterification to modify seed coat hardness. By targeting th...
A recent study has raised concerns about the safety of antifungal treatments during pregnancy, finding potential changes in fetal hormone production and its effects on children. Researchers analyzed data from 589 Danish mother-child pairs and found altered adrenal hormone levels in children after birth.
Researchers at Institute of Science Tokyo have developed a process to recover magnesium from desalination brine using liquid tin. The process, which combines direct-contact distillation with vacuum degassing, enables the recovery of magnesium-rich precipitates with high efficiency and purity.
Artificial intelligence helps identify alternative recipes for growing carbon nanotubes with prescribed structural features, such as array height, density, and alignment. The approach allows researchers to explore routes beyond familiar recipes, accommodating practical processing constraints while preserving selected structural features.
Scientists created FINDSPINGROUP to systematically distinguish between magnetic geometry and spin-orbit effects in unconventional magnets. The platform allows researchers to compare these contributions directly and determine the physical origin of responses, enabling a better understanding of these materials.
The Juno spacecraft has revealed a rippling current sheet in Jupiter's magnetodisk, which is generated by magnetic reconnection. This wave-like structure is created by numerous small reconnection sites across the magnetosphere, causing the current sheet to break and push away from its equilibrium position.
Researchers identified two tea plant genes, CsIPT3 and CsCKX5, that regulate leaf development by altering cytokinin levels. These genes were found to increase or decrease cytokinin accumulation, producing contrasting changes in leaf cell structure and size.
Scientists at IISc created a data-driven computational framework to model 9,389 elementary reactions, predicting 40-fold increase in CO₂ conversion and identifying major products like methanol and carbon monoxide. The approach can enhance catalyst design and fuel production by uncovering mechanistic pathways.
Researchers found that CDC20 is essential for mitotic progression in rice, but has distinct roles in meiosis. Disruptions in CDC20 activity led to defects in gametophyte development and chromosome segregation during meiosis.
A recent study published in The Quarterly Journal of Economics found that noncompete agreements reduce worker mobility and earnings without providing measurable benefits in protecting trade secrets. The researchers evaluated over 14,000 job offers and found that workers often overlook fine-print noncompetes and receive no wage premium ...
A new policy analysis highlights the inadequate protection of older adults from extreme heat, as aging infrastructure and financial barriers hinder access to cooling systems and safe living conditions. Regional policies must be tailored to local climates and housing conditions to address these challenges.
A study redefines the biology of honey bee colonies as superorganisms, where individual bees contribute to the colony's development and functioning. This new perspective offers insights into dealing with parasites and challenges modern beekeeping methods.
The European biotech sector is at risk of losing its ability to build internationally competitive companies due to structural bottlenecks in innovation chains. Key findings suggest the need for reforms in financing, scaling, and technology transfer to address these challenges.
Researchers from Heinrich-Heine University Düsseldorf have identified phosphite and palladium as a novel precursor of ATP, the energy currency of cells. This discovery provides a geochemically continuous route of prebiotic phosphorylation, suggesting that life may have arisen at hydrothermal vents.
The NIH grant will support programs that pioneer lifesaving healthcare innovations and spur team science and multidisciplinary collaborations. The funding will also support workforce development programs and collaborations with experts in artificial intelligence and bioinformatics.
A new study from Virginia Commonwealth University finds that young adults consider physician-influencers on TikTok to be more accessible, credible, and altruistic than their own doctors. Followers do not verify the influencers' medical credentials, and instead, trust their authority based on their appearance and personal stories.
Dr. Michael Taylor, a pediatric neurosurgeon and researcher, has received a Texans Conquer Cancer Award from CPRIT for his work on childhood brain tumors. His research aims to identify effective treatments that improve survival while reducing long-term effects.
Dr. Elemento's team will develop an AI-human discovery engine to generate hypotheses from human cell and tissue data, test them using robotics testing platforms, and refine the process with human oversight. The goal is to discover new mechanisms that can be targeted pharmacologically and democratize access to AI tools for research.
A human trial has shown that the diabetes drug empagliflozin reduces inflammatory cell clumps and promotes metabolic reprogramming in patients with obesity and prediabetes. This finding suggests that the medication may have heart-protective benefits beyond weight loss.
Researchers investigated the effects of mini-GRID radiotherapy on glioma cells, finding it reduced senescence and preserved growth inhibition, whereas conventional radiotherapy induced senescence. The study suggests that mini-GRID's spatial dose distribution may be responsible for this difference.
Researchers developed a novel approach to reduce neuropathic pain by targeting specific nerve cell interactions. By disrupting the interaction between voltage-gated sodium channels and ankyrin-G, they reduced pain-like behaviors in mouse models and paved the way for new therapeutics.
A new study found that the timing of Deep Brain Stimulation (DBS) surgery is critical for preserving cognitive function in Parkinson’s disease patients with a specific genetic mutation. Performing DBS within the first seven to eight years of diagnosis delays significant cognitive decline, while early intervention optimizes physical mob...
Researchers will compare brain cells from women and men with Parkinson's disease to look for biological differences that may explain sex-specific variations in the disease. The study aims to address the underrepresentation of women in Parkinson's research and advance the understanding of the disease's biological underpinnings.
Research suggests that people with dementia who are overweight or obese at diagnosis tend to live longer, pointing to the importance of nutrition in the degenerative disease. Studies adjusting for biases found no significant contribution to the observed associations between weight status and mortality.
Researchers found that picocyanobacteria in the Baltic Sea form colonies and aggregates, influencing carbon export. This process is crucial for regulating atmospheric CO2 levels and predicting future ocean changes.
A multicentre study found patients with a rare inherited form of lupus may continue to accumulate organ damage even when disease activity appears to have declined. Long-term monitoring and more sensitive biomarkers are needed to detect ongoing subclinical inflammation and organ injury.
Researchers directly observed a heavy fermion state forming at the boundary of a one-atom-thick material and a metal, revealing new possibilities for designing quantum materials. The finding arose from hybridization between localized electrons and mobile electrons, providing direct evidence of an interfacial heavy-fermion state.
A new study published in Radiology journal found that ultrasound-guided hydrodissection provides sustained clinical and morphological improvement in patients with refractory carpal tunnel syndrome. The procedure is a steroid-free alternative that involves injecting fluid around the affected nerve to release adhesions and improve mobility.
A research team mapped individual cell types in alfalfa roots responding to cadmium, finding distinct defense mechanisms in endodermal and phloem cells. The study identified genes improving Cd tolerance, providing a molecular foundation for breeding safer forage crops.
A protein filter, MICOS, in mitochondria maintains shape and controls molecule entry/exit, crucial for energy production and disease prevention. Researchers have modeled its flexible structure, revealing gatekeeping function and potential explanation for neurodegenerative diseases.
Researchers at Kyushu University have developed a VR system that enables users to experience an immersive, theater-like view from within a compact space without wearing a headset. The system uses aerial imaging optics and a chair-mounted micromirror array to create a stereoscopic view that responds to the user's movements.
A new global definition of clinical obesity classifies far fewer children as obese, but prevalence increases with age, affecting over half of adults aged 65-74. The study suggests the new definition will help clinicians make more informed decisions about obesity assessment and treatment.
Researchers at Colorado State University have successfully planted 40,000 native sedge seedlings in Yosemite's meadows to restore ecosystem health. However, the recovery process will be slow, with the meadows still losing carbon overall, highlighting the need for continued restoration efforts.
Binghamton University researchers developed a sensor system called CoughNet, which detects coughs and identifies individuals. The system uses artificial intelligence and low-power technology, making it efficient and private, and can potentially analyze coughs for more context to detect specific diseases.
Researchers found that well-designed digital alerts can assist clinicians in high-pressure situations, prompting them to make recommended treatment decisions and recognize when patients are deteriorating. The studies demonstrated the effectiveness of electronic health record alerts in the emergency department and cardiac intensive care...
A new study using satellite data from the Surface Water and Ocean Topography (SWOT) satellite reveals significant errors in river models, particularly in areas with dams, arid climates, and Arctic rivers. These errors can lead to inaccurate climate change predictions and water resource management.
A new narrative review explores how pistachios' nutrient profile, including tryptophan, vitamin B6, magnesium, and polyphenols, may influence sleep quality, falling asleep, and the sleep-wake cycle. The review suggests that pistachios could represent a promising wholefood intervention for improving sleep, and calls for further research...
FAU is partnering with D-Wave Quantum to create a regional quantum cybersecurity workforce ecosystem in Palm Beach and Broward counties. The project will provide hands-on training and experiential learning opportunities for students and professionals, preparing them to secure systems in a quantum-enabled future.
A study on AI use in the 2024 UK election found that chatbots increased belief in true information and decreased belief in misinformation. The study also showed that chatbot research and self-directed Google search performed similarly, with no apparent impact on factual political knowledge.
A model study suggests that spatial structure can increase abiotic molecular complexity, which could be used to detect life. The researchers found that ordered structures can shift assembly indices upward, but only under certain conditions.
Researchers found that bacteria sense collisions with neighbors and reverse direction to break through congestion, allowing them to explore new spaces. This mechanism enables bacteria to navigate both crowded and structured environments, with implications for biofilm formation and robot swarm design.
Researchers found that the cancer drug zavondemstat and a closely related compound QC6352 do not primarily target KDM4, but instead work by blocking DHODH, an enzyme cancer cells rely on to produce molecules needed for rapid growth. This discovery highlights a broader challenge in cancer drug development, emphasizing the need for great...
A study by Chonnam National University explores the therapeutic potential of human dental pulp stem cell secretome in post-stroke functional recovery. The secretome attenuates oxidative stress and inflammation, enhancing recovery in a mouse model, and shows promise for a new therapeutic platform for neurological diseases.
Researchers investigated how impact direction and crystallographic texture influence the ballistic performance and fracture behavior of AZ31 Mg alloy. The study found that impact direction and crystallographic texture significantly impact the deformation, energy absorption, and fracture of Mg alloys under high-velocity impact.
A global study found ecosystems have far less 'spare' capacity than previously thought, with biodiversity playing a crucial role in providing benefits such as pollination, water purification, and carbon storage. The study suggests that functional redundancy has been overestimated, and that maintaining diversity is essential for ecosyst...
A study from MANA presents a new method to decode hidden material disorder in complex photoluminescence spectra, revealing a hierarchy of disorder in moiré heterostructures. The approach hints at a practical way to diagnose material quality issues directly from optical data.
Researchers identify key role of spatial niche in early gastric cancer initiation and progression, highlighting inflammation-associated spatial niche as fundamental regulatory unit. Targeting inflammation-associated spatial niches may enable earlier and more precise therapeutic strategies.
Researchers at Children's Hospital Colorado and the University of Colorado Anschutz School of Medicine published a comprehensive study evaluating advanced laboratory testing for mitochondrial disease. The study found that a small skin biopsy can often help diagnose mitochondrial disease, reducing the need for more invasive procedures.
MDPI's journal portfolio is now indexed in Scite and discoverable through the Scite MCP, enabling researchers to access content in AI tools like Claude, ChatGPT, and Microsoft Copilot. This collaboration provides attribution, links to the Version of Record, and article-level usage reporting.
A significant proportion of patients with HER2-positive, ER-negative breast cancer can achieve a pathologic complete response after 12 weeks of THP chemotherapy. The trial identified ER-negative or low ER-expressing tumors, low or no progesterone receptor expression, HER2 IHC 3+ tumors, and weekly paclitaxel treatment as key predictors...